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Razan                          Alkhouri

Razan H. Alkhouri MBBS

Department of Pediatrics

Clinical Assistant Professor

Specialty/Research Focus

Pediatric Gastroenterology; Pediatrics; Vitamins and Trace Nutrient

 
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Professional Summary:

As a clinical assistant professor of pediatrics at the University at Buffalo and an attending physician in the Digestive Diseases and Nutrition Center, the focus of my clinical work is to prevent, diagnose and treat gastrointestinal, nutritional, hepatic and pancreatic disease in children from birth through young adulthood. I provide care both on the inpatient and consultative service and in the outpatient clinic at Women and Children’s Hospital in Buffalo. I am an expert at diagnostic and therapeutic endoscopy, including, but not limited to upper endoscopies, colonoscopies, liver biopsies and gastrostomy tube placements, motility studies, pH probes interpretation and control of bleeding.

I have a special interest in inflammatory bowel disease (IBD). IBD is a chronic inflammatory condition of the gastrointestinal tract and is comprised of two major phenotypes: Crohn’s disease and ulcerative colitis. The pathogenesis of IBD is believed to be multifactorial, including genetic predisposition, immune dysregulation, dysbiosis and barrier dysfunction.

During my training in pediatric gastroenterology, I distinguished myself by publishing several important studies on IBD. I received the 2012 Young Faculty Investigator Award from the North American Society for Gastroenterology, Hepatology and Nutrition (NASPGHAN) – given to only one laboratory scientist each year − for my study titled “Paraoxonase Gene Expression in Pediatric Patients with Inflammatory Bowel Disease.” I studied the effect of IBD and steroids (used in the treatment of IBD) on the expression of the paraoxonase genes in the human normal and inflamed intestine. The paraoxonase gene family consists of PON 1, 2 and 3; all possess antioxidant properties, are located on chromosome 7 and are expressed in the human intestinal tissue. They might be a novel target for the management of IBD, something we are exploring. I have also published on IBD and the role vitamins play in the disease. In addition, I focus on identifying the important nutritional vitamin and mineral deficiencies in children with IBD. These include vitamin E, vitamin A, 25-hydroxyvitamin D, and zinc. We are studying ways to effectively treat these deficiencies.

I teach in the medical school and in the graduate medical education program, and I mentor medical students, residents and fellows. I am dedicated to educating fellows on clinical aspects of their work such as teaching them how to perform procedures. I also mentor fellows on their research projects.

Education and Training:
  • Fellowship, Pediatric Gastroenterology and Nutrition, University at Buffalo (2012)
  • Residency, Pediatrics, University at Buffalo (2009)
  • Internship, Pediatrics, Jordan University Hospital (2005)
  • MBBS, Medicine/Surgery, Jordan University of Science and Technology (2004)
  • Cert, Ahliyyah School for Girls (1998)
Employment:
  • Clinical Assistant Professor, Pediatrics, University at Buffalo (2012-present)
  • Attending Physician, Division of Gastroenterology, Pediatrics, Women and Children's Hospital of Buffalo (2012-present)
Awards and Honors:
  • NASPGHAN: Young Investigator Award (2012)
  • University at Buffalo School of Medicine and Biomedical Sciences: Theodore I. Putnam, MD Award (2009)

Research Expertise:
  • Inflammatory Bowel Disease

Journal Articles:
Abstracts:
  • Patel RA, Baker SS, Liu W, Desai S, Alkhouri RH, Kozielski R, Mastrandrea LD, Sarfraz S, Cai W, Vlassara H, Patel MS, Baker RD, Zhu L. Effect of Dietary Advanced Glycation End Products on Mouse Liver. PLoS ONE. 2012; 7(4).
Books and Book Chapters:
  • Alkhouri RH, Baker SS. "Chronic Pancreatitis". Pediatric Gastroenterology, Hepatology and Nutrition. 2011.
  • Alkhouri RH, Baker SS. "Drug Induced Bowel Injury". Pediatric Gastroenterology, Hepatology and Nutrition. 2011.

Professional Memberships:
  • North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
  • American Academy of Pediatrics
Presentations:
  • "Vitamin and Mineral Status Pre and Post Treatment in Patients with Inflammatory Bowel Disease" Digestive Diseases Week, American Gastroenterological Association (2013)
  • "Characterization of the Gut Microbiome in Nonalcoholic Steatohepatitis (NASH) Patients: a Liaison Between Endogenous Alcohol Production and NASH" Annual Meeting, American Association for the Study of Liver Disease (2012)
  • "Paraoxonase Gene Expression in Patients with Inflammatory Bowel Disease" Annual Meeting, North American Society for Pediatric Gastroeneterology, Hepatology and Nutrition, Young Investigator Award (2012)
  • "RUNX 3 Gene Expression in Pediatric IBD" Annual Meeting, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN), Pediatrics (2012)
  • "Paraoxonase Gene Regulation by Oxidative Stress and Steroids in CaCo-2 Cells" Research Day, University at Buffalo (2012)
  • "Effect of Dietary Advanced Glycation End Products on Mouse Liver" Annual Meeting, Federation of American Societies for Experimental Biology (2012)
  • "Paraoxonase Gene Expression in Patients with Inflammatory Bowel Disease" Annual Meeting, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) (2011)
  • "RUNX3 Expresson in Inflammatory Bowel Disease" Annual Meeting, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) (2011)
  • "Esophageal Anatomy and Pathophysiology" Board Review, Women and Children‘s Hospital of Buffalo (2011)
  • "Vitamin Status of Patients with Inflammatory Bowel Disease" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (2011)
  • "Vitamin Status in Patients with Inflammatory Bowel Disease" Clinical and Research Conference, Crohn‘s and Colitis Foundation of America, 2010 Advances in IBD (2010)
  • "Cap Polyposis in Pediatric Patients" Annual Meeting, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (2010)
  • "Eosinophilic Gastroenteritis in Toddlers" Annual Meeting, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) (2010)
  • "Prolapse Gastropathy" Annual Meeting, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (2010)
  • "Disorders of Carbohydrate Metabolism" Board Review, Women and Children‘s Hospital of Buffalo (2010)
  • "Immune Mechanisms in IBD" Fellowship Presentation, Women and Children‘s Hospital of Buffalo (2010)
  • "Emerging Battery Ingestion Hazard" Fellowship Presentation, Women and Children‘s Hospital of Buffalo (2010)
  • "Role of Confocal Edomicroscopy in Diagnosis of Celiac Disease" Fellowship Presentation, Women and Children‘s Hospital of Buffalo (2010)
  • "Familial Adenamatous Polyposis" Fellowship Presentation, Women and Children‘s Hospital of Buffalo (2010)
  • "Management of Hepatitis B" Fellowship Presentation, Women and Children‘s Hospital of Buffalo (2010)
  • "Irritable Bowel Syndrome" Fellowship Presentation, Women and Children‘s Hospital of Buffalo (2010)
  • "Acute Pancreatitis" Fellowship Presentation, Women and Children‘s Hospital of Buffalo (2010)
  • "Prevalence of Esophagitis in Children with Celiac Disease" Annual Meeting, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (2009)
  • "Short Bowel Syndrome" Fellowship Presentation, Women and Children's Hospital of Buffalo (2009)
  • "Prevalence of Esophagitis in Children with Celiac Disease" Annual Meeting, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (2008)
See All (25 Total) >
Service Activities:
  • Women and Children‘s Hospital of Buffalo: Division of Pediatric Gastroenterology Fellows‘ Schedule; Coordinator (2010)
  • GI/Radiology CME Planning Committee; Committee Member (2009–2010)
  • Journal of Pediatric Gastroenterology and Nutrition (JPGN); Reviewer

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

Women and Children‘s Hospital of Buffalo
Division of Gastroenterology
219 Bryant Street
Buffalo, NY 14222
Phone: (716) 878-7793
Fax: (716) 888-3682
Email: alkhouri@buffalo.edu

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