Antoine Makdissi MD
Antoine Makdissi
MD
Clinical Associate Professor of Medicine
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Endocrinology; Endocrinology, Diabetes and Metabolism; Internal Medicine
Contact Information
Patient Care
Patient Care
This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.
View this physician on UBMDEducation and Training:
- Certificate, Cleveland Clinic (2006)
- Fellowship, Endocrinology, Diabetes and Metabolism, Cleveland Clinic (2005)
- Residency, Internal Medicine, University at Buffalo (2003)
- Residency, Internal Medicine, Aleppo University Hospital (1999)
- MD, Internal Medicine, University of Aleppo Faculty of Medicine (1996)
Employment:
- Clinical Associate Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2014-present)
- Clinical Assistant Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2010–2014)
- Clinical Assistant Professor, medicine, University of Arkansas University of Arkansas School of Medicine (2006–2009)
Awards and Honors:
- Outstanding Research by Clinical Faculty (2014)
Journal Articles:
- Kuhadiya ND, Malik R, Bellini NJ, Patterson JL, Traina A, Makdissi A, Dandona P. (2013) Liraglutide as additional treatment to insulin in obese patients with type 1 diabetes mellitus. Endocr Pract (Nov), 19(6): 963-967.
- Ghanim H, Batra M, Green K, Hejna J, Abuaysheh S, Makdissi A, Chaudhuri A, Dandona P. (2021) Dapagliflozin reduces systolic blood pressure and modulates vasoactive factors. Diabetes, obesity & metabolism (Jul), 23(7): 1614-1623.
- Ghanim H, Batra M, Green K, Abuaysheh S, Hejna J, Makdissi A, Borowski R, Kuhadiya ND, Chaudhuri A, Dandona P. (2020) Liraglutide treatment in overweight and obese patients with type 1 diabetes: A 26-week randomized controlled trial; mechanisms of weight loss. Diabetes Obes Metab (May).
- Ghanim H, Dhindsa S, Batra M, Green K, Abuaysheh S, Kuhadiya ND, Makdissi A, Chaudhuri A, Sandhu S, Dandona P. (2020) Testosterone Increases the Expression and Phosphorylation of AMP Kinase α in Men With Hypogonadism and Type 2 Diabetes. J Clin Endocrinol Metab (Apr), 105(4).
- Ghanim H, Abuaysheh S, Hejna J, Green K, Batra M, Makdissi A, Chaudhuri A, Dandona P. (2020) Dapagliflozin Suppresses Hepcidin And Increases Erythropoiesis. J Clin Endocrinol Metab (Apr), 105(4).
- Dhindsa S, Ghanim H, Green K, Abuaysheh S, Batra M, Makdissi A, Chaudhuri A, Sandhu S, Dandona P. (2019) Acute effects of insulin on skeletal muscle growth and differentiation genes in men with type 2 diabetes. Eur J Endocrinol (Dec), 181(6): 55-59.
- Ghanim H, Dhindsa S, Green K, Abuaysheh S, Batra M, Makdissi A, Chaudhuri A, Dandona P. (2019) Increase in Osteocalcin Following Testosterone Therapy in Men With Type 2 Diabetes and Subnormal Free Testosterone. J Endocr Soc (Aug), 3(8): 1617-1630.
- Ghanim H, Dhindsa S, Batra M, Green K, Abuaysheh S, Kuhadiya ND, Makdissi A, Chaudhuri A, Dandona P. (2019) Effect of Testosterone on FGF2, MRF4, and Myostatin in Hypogonadotropic Hypogonadism: Relevance to Muscle Growth. J Clin Endocrinol Metab (Jan), 104(6): 2094-2102.
- Ghanim H, Dhindsa S, Abuaysheh S, Batra M, Kuhadiya ND, Makdissi A, Chaudhuri A, Dandona P. (2018) Diminished androgen and estrogen receptors and aromatase levels in hypogonadal diabetic men: reversal with testosterone. Eur J Endocrinol (Mar), 178(3): 277-283.
- Sandhu S, Desai A, Batra M, Girdhar R, Chatterjee K, Kemp EH, Makdissi A, Chaudhuri A. (2018) Severe Symptomatic Hypocalcemia from HIV Related Hypoparathyroidism. Case reports in endocrinology (Jan), 2018: 8270936. doi:10.1155/2018/8270936
- Dandona P, Ghanim H, Abuaysheh S, Green K, Dhindsa S, Makdissi A, Batra M, Kuhadiya ND, Chaudhuri A. (2018) Exenatide Increases IL-1RA Concentration and Induces Nrf-2‒Keap-1‒Regulated Antioxidant Enzymes: Relevance to β-Cell Function. J Clin Endocrinol Metab (Jan), 103(3): 1180-1187.
- Garg M, Ghanim H, Kuhadiya ND, Green K, Hejna J, Abuaysheh S, Torre B, Batra M, Makdissi A, Chaudhuri A, Dandona P. (2017) Liraglutide acutely suppresses glucagon, lipolysis and ketogenesis in type 1 diabetes. Diabetes Obes Metab (Sep), 19(9): 1306-1311.
- Ghanim H, Green K, Abuaysheh S, Patel R, Batra M, Chaudhuri A, Makdissi A, Kuhadiya ND, Dandona P. (2017) Ezetimibe and simvastatin combination inhibits and reverses the pro-inflammatory and pro-atherogenic effects of cream in obese patients. Atherosclerosis (Aug), 263: 278-286.
- Chaudhuri A, Ghanim H, Makdissi A, Green K, Abuaysheh S, Batra M, D Kuhadiya N, Dandona P. (2017) Exenatide induces an increase in vasodilatory and a decrease in vasoconstrictive mediators. Diabetes Obes Metab (May), 19(5): 729-733.
- Ghanim H, Batra M, Abuaysheh S, Green K, Makdissi A, Kuhadiya ND, Chaudhuri A, Dandona P. (2017) Antiinflammatory and ROS Suppressive Effects of the Addition of Fiber to a High-Fat High-Calorie Meal. J Clin Endocrinol Metab (Mar), 102(3): 858-869.
- Kuhadiya ND, Ghanim H, Mehta A, Garg M, Khan S, Hejna J, Torre B, Makdissi A, Chaudhuri A, Batra M, Dandona P. (2016) Dapagliflozin as Additional Treatment to Liraglutide and Insulin in Patients With Type 1 Diabetes. J Clin Endocrinol Metab (Sep), 101(9): 3506-3515.
- Kuhadiya ND, Dhindsa S, Ghanim H, Mehta A, Makdissi A, Batra M, Sandhu S, Hejna J, Green K, Bellini N, Yang M, Chaudhuri A, Dandona P. (2016) Addition of Liraglutide to Insulin in Patients With Type 1 Diabetes: A Randomized Placebo-Controlled Clinical Trial of 12 Weeks. Diabetes Care (Jun), 39(6): 1027-1035.
- Dhindsa S, Ghanim H, Batra M, Kuhadiya ND, Abuaysheh S, Green K, Makdissi A, Chaudhuri A, Dandona P. (2016) Effect of testosterone on hepcidin, ferroportin, ferritin and iron binding capacity in patients with hypogonadotropic hypogonadism and type 2 diabetes. Clin Endocrinol (Oxf) (Jun).
- Dhindsa S, Ghanim H, Batra M, Kuhadiya ND, Abuaysheh S, Sandhu S, Green K, Makdissi A, Hejna J, Chaudhuri A, Punyanitya M, Dandona P. (2016) Insulin Resistance and Inflammation in Hypogonadotropic Hypogonadism and Their Reduction After Testosterone Replacement in Men With Type 2 Diabetes. Diabetes Care (Jan), 39(1): 82-91.
- Dandona P, Ghanim H, Abuaysheh S, Green K, Batra M, Dhindsa S, Makdissi A, Patel R, Chaudhuri A. (2015) Decreased insulin secretion and incretin concentrations and increased glucagon concentrations after a high-fat meal when compared with a high-fruit and -fiber meal. Am J Physiol Endocrinol Metab (Feb), 308(3): 185-191.
- Ghanim H, Green K, Abuaysheh S, Batra M, Kuhadiya ND, Patel R, Makdissi A, Dhindsa S, Chaudhuri A, Dandona P. (2015) Suppressive effect of insulin on the gene expression and plasma concentrations of mediators of asthmatic inflammation. J Diabetes Res (Jan), 2015: 202406-202406.
- Dandona P, Ghanim H, Sia CL, Green K, Abuaysheh S, Dhindsa S, Chaudhuri A, Makdissi A. (2014) A mixed anti-inflammatory and pro-inflammatory response associated with a high dose of corticosteroids. Curr Mol Med (Jan), 14(6): 793-801.
- Makdissi A, Ghanim H, Vora M, Green K, Abuaysheh S, Chaudhuri A, Dhindsa S, Dandona P. (2012) Sitagliptin exerts an antinflammatory action. J Clin Endocrinol Metab (Sep), 97(9): 3333-3341.
- Varanasi A, Patel P, Makdissi A, Dhindsa S, Chaudhuri A, Dandona P. (2012) Clinical use of liraglutide in type 2 diabetes and its effects on cardiovascular risk factors. Endocr Pract (Mar), 18(2): 140-145.
- Chaudhuri A, Ghanim H, Vora M, Sia CL, Korzeniewski K, Dhindsa S, Makdissi A, Dandona P. (2012) Exenatide exerts a potent antiinflammatory effect. J Clin Endocrinol Metab (Jan), 97(1): 198-207.
- Varanasi A, Bellini N, Rawal D, Vora M, Makdissi A, Dhindsa S, Chaudhuri A, Dandona P. (2011) Liraglutide as additional treatment for type 1 diabetes. Eur J Endocrinol (Jul), 165(1): 77-84.
- Dandona P, Mohamed I, Ghanim H, Sia CL, Dhindsa S, Dandona S, Makdissi A, Chaudhuri A. (2011) Insulin Suppresses the Expression of Amyloid Precursor Protein, Presenilins, and Glycogen Synthase Kinase-3{beta} in Peripheral Blood Mononuclear Cells. J Clin Endocrinol Metab (Jun), 96(6): 1783-1788.
- Mulligan GB, Eray E, Faiman C, Gupta M, Pineyro MM, Makdissi A, Suh JH, Masaryk TJ, Prayson R, Weil RJ, Hamrahian AH. (2011) Reduction of false-negative results in inferior petrosal sinus sampling with simultaneous prolactin and corticotropin measurement. Endocr Pract (Jan), 17(1): 33-40.
- Kashyap SR, Ioachimescu AG, Gornik HL, Gopan T, Davidson MB, Makdissi A, Major J, Febbraio M, Silverstein RL. (2009) Lipid-induced insulin resistance is associated with increased monocyte expression of scavenger receptor CD36 and internalization of oxidized LDL. Obesity (Silver Spring) (Dec), 17(12): 2142-2148.
- Pineyro MM, Makdissi A, Faiman C, Prayson RA, Reddy SK, Mayberg MC, Weil RJ, Hamrahian AH. (2008) Poor correlation of serum alpha-subunit concentration and magnetic resonance imaging following pituitary surgery in patients with nonfunctional pituitary macroadenomas. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists (Jan), 14(4): 452-7.
- Ioachimescu AG, Makdissi A, Lichtin A, Zimmerman RS. (2007) Thyroid disease in patients with idiopathic thrombocytopenia: a cohort study. Thyroid (Nov), 17(11): 1137-1142.
- Ahmed HN, Chhaya SK, Makdissi A, Zimmerman RS. (2007) Diabetic muscle infarction: case report of a rare complication. The American journal of medicine (Jul), 120(7): e3-5.
- Makdissi A, Zimmerman RS. (2007) Humoral hypercalcemia of malignancy in a patient with large cell carcinoma of the lung: report of case and review of literature. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists (Jan), 13(4): 389-95.
Professional Memberships:
- American Association of Clinical Endocrinologists- American College of Endocrinologists (AACE- ACE); American Association of Clinical Endocrinologists- American College of Endocrinologists (AACE- ACE) The Endocrine Society American College of Physician (ACP)
Presentations:
- "Prevention and Management of Vascular Complications in Diabetes" Gates Vascular Institute Symposium; State University of New York at Buffalo (2016)
- "Evaluation of Calcium and Bone Disorders" Primary Care Update in Medicine; SUNY at Buffalo Department of Medicine; Primary Care Update in Medicine (2016)
- "Endocrine Incidentalomas" Mercy Hospital South Buffalo Lecture Series; Mercy Hospital South Buffalo Lecture Series (2015)
- "Interactive Endocrinology" Primary Care Update in Medicine; SUNY at Buffalo Department of Medicine; Primary Care Update in Medicine (2015)
- "Thyroid Disorders in the Emergency Room" SUNY- Department of Emergency Medicine Grand Rounds; State University of New York at Buffalo; SUNY- Department of Emergency Medicine Grand Rounds (2015)
- "Advances in the Management of Type 1 Diabetes" SUNY- Department of Internal Medicine Grand Rounds; State University of New York at Buffalo; SUNY- Department of Internal Medicine Grand Rounds (2014)
- "Cardiovascular Risk Reduction and Other Co- Morbidities In Type 2 Diabetes" Diabetes Day for Primary Care Providers; American Association of Clinical Endocrinologists; American Association of Clinical Endocrinologists (2013)
- "Where Do GLP-1 Receptor Agonists and DPP4 Inhibitors Fit into the Diabetes Treatment Algorithm?" Diabetes Day for Primary Care Providers; American Association of Clinical Endocrinologists; American Association of Clinical Endocrinologists (2013)
- "Osteoporosis and Parathyroid Cases" Primary Care Update in Medicine; SUNY at Buffalo Department of Medicine (2013)
- "Thyroid Cases" Primary Care Update in Medicine; SUNY at Buffalo Department of Medicine (2013)
- "Past, Present and Prospective Pharmacologic Therapies for Obesity" Upper New York Chapter of the American Association of Clinical Endocrinologists; Upper New York Chapter of the American Association of Clinical Endocrinologists; Upper New York Chapter of the American Association of Clinical Endocrinologists (2012)
- "Past, Present and Prospective Pharmacologic Therapies for Obesity" SUNY- Department of Internal Medicine Grand Rounds; State University of New York at Buffalo; SUNY- Department of Internal Medicine Grand Rounds (2012)
- "Thyroid Nodules and Cancer" SUNY - Department of Internal Medicine Grand Rounds; State University of New York at Buffalo; SUNY - Department of Internal Medicine Grand Rounds (2012)
- "Adrenal Incidentaloma" VA Primary Care Day; VA Western NY Healthcare System (2011)
- "Pheochromocytoma" SUNY- Department of Internal Medicine Grand Rounds; State University of New York at Buffalo; SUNY- Department of Internal Medicine Grand Rounds (2011)
- "New Treatment Options of Diabetes Mellitus - 2" SUNY- Department of Internal Medicine Grand Rounds; State University of New York at Buffalo; SUNY- Department of Internal Medicine Grand Rounds (2011)
- "Adrenal Incidentaloma" SUNY- Department of Internal Medicine Grand Rounds; State University of New York at Buffalo; SUNY- Department of Internal Medicine Grand Rounds (2011)
- "Type 2 Diabetes: Early Recognition and Treatment" Arkansas Chapter of the American College of Physicians; Arkansas Chapter of the American College of Physicians; Arkansas Chapter of the American College of Physicians (2009)
- "Evaluation of Osteoporosis and Fracture Risk" The 31st Annual Family Practice Intensive Review Course; Department of Family and Preventive Medicine UAMS- College of Medicine (2009)
- "Cut the Fat; Lipids in Diabetes" The 16th Annual Diabetes Update 2009; UAMS College of Medicine (2009)
- "Diabetes Care Updates" UAMS Outreach Program; UAMS Outreach Program (2009)
- "Coronary Heart Disease and Diabetes" The 2nd Annual DFPM-CME Diabetes Update; UAMS- College of Medicine; Department of Family and Preventive Medicine (2008)
- "Diabetes and Cardiovascular Disease" The 30th Annual Family Practice Intensive Review Course; UAMS- College of Medicine; Department of Family and Preventive Medicine (2008)
- "Thyroid disease in Diabetes" The 14th Annual Diabetes Update 2007; UAMS College of Medicine (2007)
Service Activities:
- UBMD Primary Care Update Conference Planning Committee UBMD Primary Care Update Conference Planning Committee; Member (2015–present)
- Chair of the Endocrinology Clinical Competency Committee Chair of the Endocrinology Clinical Competency Committee, Division of Endocrinology, University at Buffalo; Chair (2013–present)
- ; Associate Program Director of Endocrine