Anna Blumental-Perry

Anna Blumental-Perry

Anna Blumental-Perry

Assistant Professor

Department of Biochemistry

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Apoptosis and cell death; Cell growth, differentiation and development; Molecular and Cellular Biology; Molecular Basis of Disease; Protein Folding; Protein Function and Structure; Pulmonary; Regulation of metabolism; RNA; Stem Cells

Contact Information
Department of Biochemistry
955 Main Street
4225
Buffalo, NY 14203
Phone: 7168292105
Fax: 7168292105
annablum@buffalo.edu



Professional Summary:

The endoplasmic reticulum and the mitochondria are parts of a proteostasis network that undergoes age-related changes. The focus of my research has been to understand the adaptive and non-adaptive age-dependent reprogramming of cellular homeostasis in the lungs of smokers, with a focus on mitochondrial and endoplasmic reticulum age–related stress responses in local progenitor cells.

My laboratory is using exposure to cigarette smoke (CS) and to nicotine as model systems for environmentally induced physiological stressors in exposed cells, animals and humans.

We identified the first known mitochondria-encoded small non-coding RNA, mito-ncR-805, that mediates retrograde communication between the mitochondrial and nuclear genomes. During stress, mito-ncR-805 exits the mitochondria, and enters the nucleus, where it maintains the expression of nuclear-encoded mitochondrial genes, and by doing so preserves mitochondrial bioenergetics, and orchestrates adaptation of mitochondrial function to stressful conditions. Currently, we are working to understand the cell type specificity and the molecular mechanisms of the release of mito-ncR-805 from the mitochondria, the mechanism of its entrance into the nucleus, as well as the mechanism of its nuclear function, and the possibility to develop mito-ncR-805 into therapeutics for diseases that have a mitochondrial malfunction component as a leading factor in their pathogenesis.

We delineated the mechanisms of CS-effects on protein folding and identified a protein disulfide isomerase (PDI) as the first known ER target of cigarette smoke induced oxidation. PDI is one of the most abundant redox-sensitive ER resident proteins, and it plays a central role in disulfide bond formation, and redox homeostasis. CS-induced posttranslational PDI oxidation result in the induction of ER Stress Response (ERSR) in vitro and in vivo. Animals deficient in ERSR are fully protected from CS-associated fibrosis, and partially protected from inflammation and emphysema. Our current research aims to delineate redox signaling function of post-transnationally oxidized PDI, and establish which specific components of ERSR are involved and when they should be modulated by therapeutic approaches.

Our technical approach has been multidisciplinary including protein chemistry, cell and
molecular biology, advanced microscopy, genetic engineering, and animal models of disease.

Education and Training:

  • Fellowship, Cell Biology and Physiology, University of Pittsburgh (2008)
  • PhD, Yeast Genetics and Molecular Biology, The Hebrew University of Jerusalem (2002)
  • MS, Human Genetics, The Hebrew University of Jerusalem, Magna Cum Laude (1995)
  • MB, Pre-Med, Rigas Medical School, Magna Cum Laude (1992)

Employment:

  • Assistant Professor, University at Buffalo (2020-present)
  • Adjunct Assistant Professor, Case Western Reserve University (2015–2019)
  • Assistant Professor, Mercer University (2010–2014)
  • Research Instructor, Medicine, University of Pittsburgh (2008–2010)

Awards and Honors:

  • Science Daily mentioning (2016)
  • Dr Shmerler Foundation Award for Msc Thesis with distinction (1995)
  • The Golda Meir Foundation Award for Master Students with distinction (1993)
  • Rigas Medical School Dean List Scholarship (1990)

Grants and Sponsored Research:

  • September 2010–August 2015
    Smoke Induced Unfolded Protein Response in COPD
    Flight Attendant Medical Research Institute
    Role: Principal Investigator
    $324,000
  • January 2009–December 2010
    Cigarette smoke induced Endoplasmic Reticulum stress response in the pathogenesis of COPD
    American Thoracic Society
    Role: Principal Investigator
    $100,000
  • July 2003–June 2005
    Phosphoinositides as regulators of Coat protein II complex (COPII) mediated export from Endoplasmic Reticulum
    American Heart Association
    Role: Principal Investigator
    $80,000

Journal Articles:

See all (1 more)

Professional Memberships:

  • American Society of Biochemistry and Molecular Biology (2015–present)
  • National Association of Professional Women (2015–present)
  • Pitt Alumni (2009–present)
  • American Thoracic Society (2008–present)
  • The Hebrew University of Jerusalem Alumni (2002–present)

Presentations:

  • "Cigarette Smoke Exposure Alters Mitochondria Function by Regulating Expression of Mitochondrial miR804/mitosRNA-L-DL_1 in Alveolar type II Cells" ATS, ATS, Pathologic Programming of Airway Epithelium (2015)
  • "Unfolded Protein Response as a Driving Force of Tissue Loss During Virally Induced Exacerbations of Chronic Obstructive Pulmonary Disease" From Unfolded Proteins in the ER to Disease, FASEB Summer Research Conference (2013)
  • "Cigarette Smoke Exposure Induces Unfolded Protein Response in Cell Culture and in Animal Models" ATS/AAT-1 foundation meeting, ATS (2010)
  • "Unfolded Protein Response Induced by Cigarette Smoke, General Mechanisms and Implications to COPD" From Unfolded Proteins in the ER to Disease, FASEB Summer Research Conference: (2010)

Service Activities:

  • Special Issue “ Pulmonary Case Reports” Journal of Pulmonary & Respiratory Medicine, Published by OmicsGroup; Editor (2013–2014)
  • Endoplasmic Reticulum stress in Diseases Journal by De Gruyter; Editor (2012–2019)
  • Am J Respir Cell Mol Biol, Molecular Oncology, Scientific Reports Nature Publishing Group, Journal of Obesity & Weight Loss Therapy, Pulmonary Pha; Reviewer (2011–present)
  • Journal of Pulmonary & Respiratory Medicine; Editorial Board Member (2011–present)

School News:

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Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

Department of Biochemistry
955 Main Street
4225
Buffalo, NY 14203
Phone: 7168292105
Fax: 7168292105
annablum@buffalo.edu