Glenna C. Bett PhD

Glenna Bett

Glenna C. Bett
PhD

Vice Chair for Research

Department of Obstetrics and Gynecology

Jacobs School of Medicine & Biomedical Sciences

Specialty/Research Focus

Biomedical Imaging; Cardiac pharmacology; Drug Development; Drug Discovery; Electrophysiology; Ion channel kinetics and structure; Ion Transport; Membrane Biophysics; Membrane Transport (Ion Transport); Molecular and Cellular Biology; Molecular Basis of Disease; Neurobiology; Neuroscience; Stem Cells; Translational Research

Contact Information

bett@buffalo.edu
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Overview Research Publications Activities Latest News

Professional Summary:

Research in my lab focuses on ion channels. I am interested in how interventions such as ancillary subunits, mutations, drugs, and environmental changes affect the structure-function relationship, and ultimately how this affects cellular electrical activity.

We do this using a combination of techniques and approaches including 2 electrode clamp to study heterologously expressed channels, whole cell clamp to record currents in the native cell, and mathematical modelling to understand and interpret results.

Education and Training:
  • BA, Physics, Oxford University
  • BA, Physiology, Oxford University
  • PhD, Oxford University

Employment:
  • Deputy Director, Institute for Research and Education on Women and Gender (2012-present)
  • Associate Professor, Obstetrics and Gynecology, State University of New York, University at Buffalo (2011-present)
  • Vice Chair for Research, Obstetrics and Gynecology, Jacobs School of Medicine & Biomedical Sciences (2009-present)
  • Director of Resident Research, Obstetrics and Gynecology, SUNY Jacobs School of Medicine & Biomedical Sciences (2007-present)
  • Associate Director, Center for Cellular and Systems Electrophysiology (2004-present)
  • Associate Director - B-SURE Program (2004-present)
  • Research Assistant Professor, Physiology, The State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2001-present)
  • President, American Heart Association, Buffalo Niagara Region
  • President, JSMBS Faculty Council (2015–2016)
  • Assistant Professor, Obstetrics and Gynecology, SUNY, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2005–2011)
  • Postdoctoral Research Associate, Physiology, The State Unviersity of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1998–2001)
  • American Heart Association, NY State Affiliate., Biophysical Sciences, The State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1996–1998)
  • Postdoctoral Research Associate, Biophysical Sciences, The State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1995–1996)
  • Lecturer, Charing Cross and Westminster Medical School (1993–1995)
See all (4 more)

Awards and Honors:
  • Ignite Award (2017)
  • Visionary Innovator Award (2016)
  • Entrepreneurial Spirit Award (2016)
  • Women in Technology BETAS Emerging Technology Award (2016)
  • Winner, 43North (2015)
  • Fellow, American Heart Association (2010)
  • Gordon K Moe Young Investigator (2003)

Research Expertise:
  • : Research in my lab focuses on ion channels. I am interested in how interventions such as ancillary subunits, mutations, drugs, and environmental changes affect the structure-function relationship, and ultimately how this affects cellular electrical activity.

Research Centers:
  • Center for Research in Cardiovascular Medicine

UB 2020 Strategic Strengths:
  • Health and Wellness Across the Lifespan
  • Molecular Recognition in Biological Systems and Bioinformatics

Grants and Sponsored Research:
  • March 2022–February 2024
    Advanced Dynamic Clamp for Neuroscience Phase 2
    NIH NIMH
    $1,730,751
  • March 2022–February 2024
    Phase 2: Developing a platform for superior predictive analysis of HERG Ion Channel-Drug Interactions for the Comprehensive In-vitro Proarrhythmia Assay (CiPA)
    NSF
    $1,000,000
  • January 2015–January 2016
    Initial Validation of a Novel in vitro Arrhythmia Drug Safety Screening Assay
    SUNY
    Role: Principal Investigator
    $50,000
  • July 2011–June 2013
    Sex Differences in Molecular Heterogeneity of Cardiac Repolarization
    NIH
    Role: Principal Investigator
    $275,000
  • May 2011–April 2012
    Device to treat postpartum hemorrhage
    Bill and Melinda Gates Foundation
    Role: Principal Investigator
    $100,000
  • March 2008–February 2011
    Repolarizing Current in Human Myometrium
    March of Dimes Prematurity Initiative
    Role: Principal Investigator
    $241,170
  • January 2008–January 2011
    Repolarizing Currents in Human Myometrium
    March of Dimes
    Role: Principal Investigator
    $241,170
  • August 2007–July 2009
    Molecular Basis of Automaticity in the Myometrium
    NIH
    Role: Principal Investigator
    $100,000
  • June 2007–June 2009
    Automaticity in the myometrium
    NIH
    Role: Principal Investigator
    $100,000
  • January 2004–December 2007
    Pathophysiology of HERG Gating and Permeation During Ischemia: Effect of pHo and K+
    American Heart Association
    Role: Principal Investigator
    $472,728
  • November 2004–October 2005
    Role of Hyperpolarization activated cation (HCN) Channels in GnRH Neurons
    Interdisciplinary Research Creative Activities Fund
    Role: Co-Investigator
    $50,000
  • August 2014
    Optimization of a prototype for an induced pluripotent stem cell derived cardiac cybercyte to a beta testing unit.
    UBCAT
    Role: Principal Investigator
    $60,000
  • January 2007
    Molecular Basis of Automaticity in the Myometrium
    NIH
    Role: Principal Investigator
    $158,000
  • January 2006
    Ion Channels in Preterm Labor
    Department of GYN-OB Seed Funding
    Role: Principal Investigator
    $2,000
See all (4 more)

Patents:
  • Electronic expression of the inward rectifier in cardiocytes derived from human induced pluripotent stem cells
  • METHOD FOR DELAYED RECTIFIER CURRENT ENHANCEMENT, CHARACTERIZATION, AND ANALYSIS IN HUMAN INDUCED PLURIPOTENT STEM CELLS

Journal Articles:

See all (47 more)

Books and Book Chapters:

  • Bett GCL, Rasmusson RL. (2006) Fundamentals of Cellular Electrophysiology.
  • Bett GC, Rasmussson RL. (2002) In: Models of Cardiac Ion Channels. , 1-60.

Abstracts:

  • Arroyo A, Kim B, Biehl A, Bett G, Yeh J. (2008) Synaptophysin and gonadotropin-releasing hormone (GnRH) are colocalized in rat hypothalamus. Proceeding 55th Annual Meeting for Society for Gynecologic Investigation, (Jan)
  • Brar MK, Bett GC, Laube D. (2007) Effect of shortening the duration of an obstetrics-gynecology clerkship from seven weeks to six on national examination performance. PROCEEDINGS: University at Buffalo Symposium on Women‘s Health, October 2007, (Oct)
  • Arroyo A, Kim B, Peresie J, Lee M, Bett GCL, Yeh J. (2007) The Kv 4.3 potassium channel is expressed in rat hypothalamic gonadotropin-releasing hormone (GnRH) neurons and immortalized GnRH neurons. Proceeding 54th Annual Meeting for Society for Gynecologic Investigation, (Jan)
  • Arroyo A, Kim B, Biehl A, Bett GCL, Yeh J. (2007) Kv4.3 and gonadotropin-releasing hormone (GnRH) are colocalized in rat hypothalamus. Proceeding 1st Annual Neuroscience Day, University at Buffalo, (Jan)
  • Bett GC, Rasmusson RL. (2005) Molecular Mechanisms of Inactivation and Recovery of Kv1.4, an A-type current. Proceedings of the 35th Meeting of the International Union of Physiological Sciences, (Jan)
  • Bett GC, Duffey ME, Rasumsson RL. (2005) Ancillary Subunits Determine the Affinity and use-Dependence of Chromanol 293B for KCNQ1. Biophys J, (Jan)
  • Bett GC, Duffey ME, Beahm Dl, Katzer M, Morales MJ, Rasmusson RL. (2005) Ancillary subunits modulate block of KCNQ1 channels by chromanol and Ba2+. Proceedings of the 35th Meeting of the International Union of Physiological Sciences, (Jan)
  • Bett GC, Morales M, Rasmusson R. (2005) KChlP2b modulates the affinity and use-dependent block of Kv4.3 by Nifedipine. Biophys J, (Jan)
  • Bett GC, Madou ID, Bondarenko VE, Rasmusson RL. (2004) A Computer Model of N-and C-type inactivation in voltage-gated potassium channels. Proceedings of the12th Annual National McNair Research Conference, (Jan)
  • Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. (2004) A mathematical model of repolarization simulating regional heterogeneity of murine ventricular myocytes. Biophys J, (Jan) 298
  • Bett GC, Rasmusson RL. (2004) Proton Modification of HERG channels: two sites of functional regulation. Biophy J, (Jan) 281-282
  • Bett GC, Bondarenko VE, Rasmusson RL. (2004) Spatial Heterogeneity in a Computer Model of Graded Ca2 Release: Effects of Ca2 Loading and Ryanodine Receptor Adaptation. Proceedings of the 25th Meeting of the North American Society for Pacing and Electrophyisology - Heart Rhythm Society, (Jan)
  • Bett GC, Kaushal V, Rasmusson RL. (2003) Optimization and parameter identification (pH0 and K+0 in a Markov Model of the HERG channel. Proceedings Biomedical Engineering in NY, Alfred University, (Jan)
  • Bett GC, Li XY, Morales MJ, Bondarenko VE, Rasmusson RL, Jiang XJ. (2003) Transmembrane communication in cardiac potassium channels: regulation of N-and C-type inactivation by pHo and potassium in normal and mutant Kv1.4 channels. Biophys J, (Jan) 76A
  • Bett GC, Yoo K, Rasmusson RL. (2003) Site directed mutagenesis in a cloned Kv1.4 channel. Proceedings Biomedical Engineering in NY. Alfred University, (Jan)
  • Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. (2003) A mathematical model of the action potential of mouse ventricular myocytes. Biomedical Engineering in NY, Alfred University, (Jan)
  • Bett GC, Cyr V, Rasmusson RL. (2003) A mathematicl model of potassium channels permeation with two binding sites. Proceeding B-SURE Conference, SUNY@Buffalo, (Jan)
  • Bett GC, Bondarenko VE, Rasmusson RL. (2003) A model of Ca2 handling in ferret cardiac myocytes. Proceedings Biomedical Engineering in NY, Alfred University, (Jan)
  • Bett GC, Rasmusson RL. (2003) Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K channels. Proceedings of the 13th Annual Meeting of Upstate New York Cardiac Electrophysiology Society, (Jan)
  • Bett GC, Rasmusson RL. (2003) Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K Channels. Proceedings Biomedical Engineering in NY. Alfred University, (Jan)
  • Bett GC, Madou ID, Rasmusson RL. (2003) A computer model of N-and C-type inactivation in voltage-gated potassium channels. Proceedings Biomedical Engineering in NY. Alfred University, (Jan)
  • Bett GC, Cyr V, Rasmusson RL. (2003) A mathematical model of potassium channels permiation with two binding sites and drug block. Proceedings Biomedical Engineering in NY. Alfred University, (Jan)
  • Bett GC, Bondarenko VE, Rasmusson RL. (2003) Cardiac Cellular Morphology and Physiology in a model of graded Ca2 release and L-type channel inactivation. Proceedings of the 13th Annual Meeting of Upstate New York Cardiac Electrophysiology Society, (Jan)
  • Bett GC, Jiang XJ, Bondarenko VE, Li XY, Rasmusson RL. (2003) C-type Inactivation Involves A Significant Decrease in the Intracellular Aqueouspore Volume. Biophys J, (Jan) 221
  • Bett GC, Jiang XJ, Li XY, Bondarenko VE, Rasmusson RL. (2002) C-type inactivation: a pH0 and K sensitive transmembrane mechanism. Proceedings of the 12th Meeting of Upstate New York Cardiac Electrophysiology Society, (Jan)
  • Bett GC, Wang S, Morales M, Qu YJ, Rasmusson RL, Strauss HC. (2002) Kv1.4 Channel Block by quinidine: evidence for a drug-induced allosteric effect. Proceedings of the 12th Meeting of Upstate New York Cardiac Electrophysiology Society, Buffalo, NY, (Jan)
  • Bett GC, Campbell DL. (2001) Muscarinic modulation of the L-type calcium channel in ferret right ventiruclar myocytes. Biophys J, (Jan) 2865
  • Bett GC, Sachs F. (1999) Mechanosensitive currents in the Heart. Proceedings 10th Annual Meeting of the Ontario, (Jan)
  • Bett GC, Sachs F. (1998) Mechanosensitive currents in the heart. Proceeding 9th Annual Meeting of the Ontario and Western New York Ion Channel Interest Group, (Jan)
  • Bett GC, Sachs F. (1998) Mechanosensitive ion channels in mammalian ventricular myocytes. J of Physiology, (Jan)
  • Bett GC. (1998) Mechanically activated currents in isolated rat ventricular myocytes. Proceedings of the 8th Meeting of Upstate New York Cardiac Electrophysiology Society, (Jan)
  • Bett GC, Sachs F. (1998) Inactivation of Mechanosensitive Currents in Ventricular Myocytes. Biophysics J, (Jan)
See all (22 more)

Professional Memberships:
  • American Heart Association
  • Biophysical Society
  • Organization for the Study of Sex Differences
  • Physiological Society (UK)
  • Society for Gynecological Investigation
  • Upstate NY Cardiac Electrophysiology Society

Service Activities:
  • AHA Cardiac Electrophysiology Cardiology 4 committee; Reviewer (2021)
  • NIH - Interdisciplinary Molecular Sciences & Training [IMST] IRG; Reviewer (2020)
  • NSF Study Section; Reviewer (2020)
  • AHA COVID Rapid Response Committee; Reviewer (2020)
  • NIH - Special Emphasis Panel - Tobacco Regulatory Science; Reviewer (2019)
  • AHA Collaborative Science Award; Reviewer (2016–present)
  • President, Faculty Council; President (2015–2016)
  • Chair, Faculty Senate Committee on Equity and Diversity; Chair (2014–present)
  • Chair, AHA Peer Review Panel; Chair (2014–present)
  • Collaborative Sciences Award;; Grant Reviewer (2013–present)
  • Cardiac Electrophysiology BSc;; Chair (2012–present)
  • Secretary, Faculty Council; Secretary (2012–present)
  • Co-Chair, AHA Peer Review Panel; Co-Chair (2012–present)
  • NIH; NIH Bioengineering Sciences and Technologies (BST) Special Emphasis Panel;; Ad Hoc Reviewer (2011)
  • American Heart Association; Unified Peer Review Consortium, Cardiac Electrophysiology, Basic sciences 2;; Grant Reviewer (2010)
  • American Heart Association; Unified Review, Cardiac Electrophysiol & Arrhythmias Clinical/Translational;; Charter Member (2010–2014)
  • The Netherlands Organisation for Health Research and Development; ZonMw Translational Research Programme;; Grant Reviewer (2010)
  • American Heart Association; Region I Cardiac Electrophysiology;; Charter Member (2009)
  • Deputy Director, IREWG
  • OSSD Membership Committee; Chair
  • J Biomathematics; Editorial Board Member
  • NIH; Peer Reviewer
  • American Heart Association; Peer Reviewer
  • Vice Chair For Research; Vice-Chair

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Contact Information


bett@buffalo.edu
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