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Glenna                         Bett

Glenna C. Bett PhD

Department of Obstetrics and Gynecology

Associate Professor

Specialty/Research Focus

Bioinformatics; Ion channel kinetics and structure; Molecular and Cellular Biology

 
Professional Summary:

Research in my lab focuses on ion channels. I am interested in how interventions such as ancillary subunits, mutations, drugs, and environmental changes affect the structure-function relationship, and ultimately how this affects cellular electrical activity.

We do this using a combination of techniques and approaches including 2 electrode clamp to study heterologously expressed channels, whole cell clamp to record currents in the native cell, and mathematical modelling to understand and interpret results.

Education and Training:
  • PhD, Oxford University (1995)
  • BA, Physiology, Oxford University, Honors (1989)
  • BA, Physics, Oxford University, Honors (1987)
Employment:
  • Deputy Director, Institute for Education and Research on Women and Gender, Institute for Research and Education on Women and Gender (2012-present)
  • Associate Professor, Obstetrics and Gynecology, State University of New York, University at Buffalo (2011-present)
  • Vice Chair for Research, Obstetrics and Gynecology (2009-present)
  • Director of Resident Research, Obstetrics and Gynecology, SUNY (2007-present)
  • Associate Director, Center for Cellular and Systems Electrophysiology (2004-present)
  • Associate Director - B-SURE Program (2004-present)
  • Research Assistant Professor, Physiology, The State University of New York at Buffalo (2001-present)
  • President, American Heart Association, Buffalo Niagara Region
  • President, JSMBS Faculty Council (2015–2016)
  • Assistant Professor, Obstetrics and Gynecology, SUNY, University at Buffalo (2005–2011)
  • Postdoctoral Research Associate, Physiology, The State Unviersity of New York at Buffalo (1998–2001)
  • American Heart Association, NY State Affiliate., Biophysical Sciences, The State University of New York at Buffalo (1996–1998)
  • Postdoctoral Research Associate, Biophysical Sciences, The State University of New York at Buffalo (1995–1996)
  • Lecturer, Charing Cross and Westminster Medical School, United Kingdom (1993–1995)
See all (4 more)
Awards and Honors:
  • Winner, 43North (2015)
  • Fellow, American Heart Association (2010)
  • Gordon K Moe Young Investigator (2003)

Research Expertise:
  • : Research in my lab focuses on ion channels. I am interested in how interventions such as ancillary subunits, mutations, drugs, and environmental changes affect the structure-function relationship, and ultimately how this affects cellular electrical activity.
Research Centers:
  • Center for Research in Cardiovascular Medicine
UB 2020 Strategic Strengths:
  • Molecular Recognition in Biological Systems and Bioinformatics
  • Health and Wellness Across the Lifespan
Grants and Sponsored Research:
  • January 2015–January 2016
    Initial Validation of a Novel in vitro Arrhythmia Drug Safety Screening Assay
    SUNY
    Role: Principal Investigator
    $50,000
  • July 2011–June 2013
    Sex Differences in Molecular Heterogeneity of Cardiac Repolarization
    NIH
    Role: Principal Investigator
    $275,000
  • May 2011–April 2012
    Device to treat postpartum hemorrhage
    Bill and Melinda Gates Foundation
    Role: Principal Investigator
    $100,000
  • March 2008–February 2011
    Repolarizing Current in Human Myometrium
    March of Dimes Prematurity Initiative
    Role: Principal Investigator
    $241,170
  • January 2008–January 2011
    Repolarizing Currents in Human Myometrium
    March of Dimes
    Role: Principal Investigator
    $241,170
  • August 2007–July 2009
    Molecular Basis of Automaticity in the Myometrium
    NIH
    Role: Principal Investigator
    $100,000
  • June 2007–June 2009
    Automaticity in the myometrium
    NIH
    Role: Principal Investigator
    $100,000
  • January 2004–December 2007
    Pathophysiology of HERG Gating and Permeation During Ischemia: Effect of pHo and K+
    American Heart Association
    Role: Principal Investigator
    $472,728
  • November 2004–October 2005
    Role of Hyperpolarization activated cation (HCN) Channels in GnRH Neurons
    Interdisciplinary Research Creative Activities Fund
    Role: Co-Investigator
    $50,000
  • August 2014
    Optimization of a prototype for an induced pluripotent stem cell derived cardiac cybercyte to a beta testing unit.
    UBCAT
    Role: Principal Investigator
    $60,000
  • January 2007
    Molecular Basis of Automaticity in the Myometrium
    NIH
    Role: Principal Investigator
    $158,000
  • January 2006
    Ion Channels in Preterm Labor
    Department of GYN-OB Seed Funding
    Role: Principal Investigator
    $2,000
See all (2 more)

Journal Articles:
See all (34 more)
Abstracts:
  • Bett GC, Morales M, Rasmusson R. KChlP2b modulates the affinity and use-dependent block of Kv4.3 by Nifedipine. Biophys J. 2005.
  • Bett GC, Duffey ME, Rasumsson RL. Ancillary Subunits Determine the Affinity and use-Dependence of Chromanol 293B for KCNQ1.. Biophys J. 2005.
  • Bett GC, Rasmusson RL. Molecular Mechanisms of Inactivation and Recovery of Kv1.4, an A-type current.. Proceedings of the 35th Meeting of the International Union of Physiological Sciences. 2005.
  • Bett GC, Duffey ME, Beahm Dl, Katzer M, Morales MJ, Rasmusson RL. Ancillary subunits modulate block of KCNQ1 channels by chromanol and Ba2+. Proceedings of the 35th Meeting of the International Union of Physiological Sciences. 2005.
  • Bett GC, Madou ID, Bondarenko VE, Rasmusson RL. A Computer Model of N-and C-type inactivation in voltage-gated potassium channels. Proceedings of the12th Annual National McNair Research Conference. 2004.
  • Bett GC, Bondarenko VE, Rasmusson RL. Spatial Heterogeneity in a Computer Model of Graded Ca2 Release: Effects of Ca2 Loading and Ryanodine Receptor Adaptation.. Proceedings of the 25th Meeting of the North American Society for Pacing and Electrophyisology - Heart Rhythm Society. 2004.
  • Bett GC, Rasmusson RL. Proton Modification of HERG channels: two sites of functional regulation. Biophy J. 2004; 86(2).
  • Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. A mathematical model of repolarization simulating regional heterogeneity of murine ventricular myocytes. Biophys J. 2004; 86.
  • Bett GC, Jiang XJ, Bondarenko VE, Li XY, Rasmusson RL. C-type Inactivation Involves A Significant Decrease in the Intracellular Aqueouspore Volume. Biophys J. 2003; 84.
  • Bett GC, Rasmusson RL. Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K channels. Proceedings of the 13th Annual Meeting of Upstate New York Cardiac Electrophysiology Society. 2003.
  • Bett GC, Bondarenko VE, Rasmusson RL. Cardiac Cellular Morphology and Physiology in a model of graded Ca2 release and L-type channel inactivation.. Proceedings of the 13th Annual Meeting of Upstate New York Cardiac Electrophysiology Society. 2003.
  • Bett GC, Li XY, Morales MJ, Bondarenko VE, Rasmusson RL, Jiang XJ. Transmembrane communication in cardiac potassium channels: regulation of N-and C-type inactivation by pHo and potassium in normal and mutant Kv1.4 channels. Biophys J. 2003; 84.
  • Bett GC, Rasmusson RL. Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K Channels.. Proceedings Biomedical Engineering in NY. Alfred University. 2003.
  • Bett GC, Madou ID, Rasmusson RL. A computer model of N-and C-type inactivation in voltage-gated potassium channels.. Proceedings Biomedical Engineering in NY. Alfred University. 2003.
  • Bett GC, Cyr V, Rasmusson RL. A mathematical model of potassium channels permiation with two binding sites and drug block. Proceedings Biomedical Engineering in NY. Alfred University. 2003.
  • Bett GC, Kaushal V, Rasmusson RL. Optimization and parameter identification (pH0 and K+0 in a Markov Model of the HERG channel. Proceedings Biomedical Engineering in NY, Alfred University. 2003.
  • Bett GC, Yoo K, Rasmusson RL. Site directed mutagenesis in a cloned Kv1.4 channel. Proceedings Biomedical Engineering in NY. Alfred University. 2003.
  • Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. A mathematical model of the action potential of mouse ventricular myocytes.. Biomedical Engineering in NY, Alfred University. 2003.
  • Bett GC, Bondarenko VE, Rasmusson RL. A model of Ca2 handling in ferret cardiac myocytes.. Proceedings Biomedical Engineering in NY, Alfred University. 2003.
  • Bett GC, Cyr V, Rasmusson RL. A mathematicl model of potassium channels permeation with two binding sites.. Proceeding B-SURE Conference, SUNY@Buffalo. 2003.
  • Bett GC, Wang S, Morales M, Qu YJ, Rasmusson RL, Strauss HC. Kv1.4 Channel Block by quinidine: evidence for a drug-induced allosteric effect.. Proceedings of the 12th Meeting of Upstate New York Cardiac Electrophysiology Society, Buffalo, NY. 2002.
  • Bett GC, Jiang XJ, Li XY, Bondarenko VE, Rasmusson RL. C-type inactivation: a pH0 and K sensitive transmembrane mechanism. Proceedings of the 12th Meeting of Upstate New York Cardiac Electrophysiology Society. 2002.
  • Bett GC, Campbell DL. Muscarinic modulation of the L-type calcium channel in ferret right ventiruclar myocytes. Biophys J. 2001; 80(1).
  • Bett GC, Sachs F. Mechanosensitive currents in the Heart. Proceedings 10th Annual Meeting of the Ontario. 1999.
  • Bett GC. Mechanically activated currents in isolated rat ventricular myocytes. Proceedings of the 8th Meeting of Upstate New York Cardiac Electrophysiology Society. 1998.
  • Bett GC, Sachs F. Mechanosensitive ion channels in mammalian ventricular myocytes. J of Physiology. 1998; 511P(90P).
  • Bett GC, Sachs F. Mechanosensitive currents in the heart. Proceeding 9th Annual Meeting of the Ontario and Western New York Ion Channel Interest Group. 1998.
  • Bett GC, Sachs F. Inactivation of Mechanosensitive Currents in Ventricular Myocytes. Biophysics J. 1998; 74(A325).
See all (18 more)
Books and Book Chapters:
  • Bett GCL, Rasmusson RL. Fundamentals of Cellular Electrophysiology.. Springer. 2006.
  • Bett GC, Rasmussson RL. Models of Cardiac Ion Channels. Quantitative Cardiac Electrophysiology. 2002.

Professional Memberships:
  • American Heart Association
  • Biophysical Society
  • Organization for the Study of Sex Differences
  • Physiological Society (UK)
  • Upstate NY Cardiac Electrophysiology Society
  • Society for Gynecological Investigation
Service Activities:
  • President, Faculty Council; President (2015–2016)
  • Chair, Faculty Senate Committee on Equity and Diversity; Chair (2014–2016)
  • Chair, AHA Peer Review Panel; Chair (2014–present)
  • Secretary, Faculty Council; Secretary (2012–present)
  • Co-Chair, AHA Peer Review Panel; Co-Chair (2012–present)
  • President, American Heart Association Buffalo-Niagara Region; President (2011–2015)
  • American Heart Association; Peer Reviewer
  • J Biomathematics; Editorial Board Member
  • NIH; Peer Reviewer
  • OSSD Membership Committee; Chair
  • Vice Chair For Research; Vice-Chair

School News:
In the Media:

Clinical Specialties:
Clinical Offices:
Insurance Accepted:


Contact Information

133 Sherman Hall
University at Buffalo
Buffalo, NY 14214
Phone: (716) 829 2603
Fax: (716) 829-2344
Email: bett@buffalo.edu


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