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Mary                           Taub

Mary L. Taub PhD

Department of Biochemistry

Professor

Specialty/Research Focus

Cell growth, differentiation and development; Inherited Metabolic Disorders; Membrane Transport (Ion Transport); Molecular and Cellular Biology; RNA; Signal Transduction

 
Professional Summary:

Regulation of Kidney Epithelial Cell Growth, Transport and Differentiation

Our laboratory is investigating the molecular mechanisms by which hormones, growth factors and extracellular matrix proteins regulate kidney tubule epithelial cell growth and functional differentiation in vitro. An established canine kidney epithelial cell line, MDCK, and isolated "mutants" are currently being utilized to examine the actions of growth regulatory on the expression of several proteins including the Na+, K+-ATPase and laminin, a glycoprotein in the extracellular matrix. The effects of novel growth regulatory factors on the expression of proteins involved in gluconeogenesis, membrane transport, renal disease and growth control in primary renal cell cultures are being examined. Primary kidney epithelial cells differentiate into nephrons in a reconstituted extracellular matrix proteins is the subject of study.

Education and Training:
  • PhD, Biochemistry/Molecular Biology, University of California, Santa Barbara (1976)
  • MA, Biochemistry and Molecular Biology, University of California, Santa Barbara (1974)
  • BA, Biochemistry/Molecular Biology, University of California, San Diego (1971)
Employment:
  • Professor, Biochemistry, State University of New York at Buffalo (1992-present)
  • Associate Professor, Biochemistry, State University of New York at Buffalo (1985–1992)
  • Assistant Professor, Biochemistry, State University of New York at Buffalo (1979–1985)
  • Post Doctoral Fellow, Biology, University of California, San Diego (1976–1979)
Awards and Honors:
  • Service Award (2009)
  • Research Career Development Award, NIH (1983)
  • Postdoctoral Fellowship, NIH (1978)
  • Postdoctoral Fellowship, NIH (1976)

Research Expertise:
  • Genetics, Cultured Animal Cells: Isolation and Characterization of Mutants Isolation and Characterization of Transformants
  • Kidney Cell Culture, Hormonally Defined Medium: Growth of Differentiated Cells in Hormonally Defined Medium; Development of Primary Kidney Cell Cultures
  • Mechanism of Hormone, Growth Factor Action: Mechanism of Action of Effector Molecules by cyclic AMP, Calcium Protein Kinases; MAP Kinases
  • Membrane Transport: Membrane Transport Studies into Intact Cells, Isolated Basolateral Membranes
  • Molecular Biology: Transcriptional Regulation; Post-transcriptional Regulation
UB 2020 Strategic Strengths:
  • Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
  • June 2016–May 2021
    Regulation of the Kidney Cancer Epigenome by Oncometabolite L-2-Hydroxyglutarate
    National Cancer Institute
    Role: Co-Investigator
  • September 2014–August 2015
    Induced Pluripotent Stem Cells with the CTNS Mutation
    WNYStem
    Role: Principal Investigator
  • June 2008–October 2012
    Mechanisms Underlying the Fanconi Syndrome in Cystinosis
    Cystinosis Research Foundation
    Role: Principal Investigator
    $308,892
  • January 2008–June 2009
    Renal Stem Cells for Regenerative Therapy
    University at Buffalo
    Role: Principal Investigator
    $20,000
  • May 2008–April 2009
    Renal Stem Cells for Regenerative Therapy
    National Kidney Foundation of WNY
    Role: Principal Investigator
    $6,500
  • June 2001–May 2006
    Role of protein kinases in transport regulation
    NIH
    Role: Principal Investigator
    $1,092,000
  • February 2001–January 2003
    Role of Eicosanoids in the Reglation of Ion Transport: a Determinant in Hypertension
    James H. Cummings Foundation
    Role: Principal Investigator
    $40,000
  • April 2001–December 2002
    Regulation of kidney cell growth by the Wilms' Tumor gene
    Kidney Foundation of Western New York
    Role: Principal Investigator
    $6,000
  • January 1999–December 2000
    Nephrotoxicity of Ifosfamide IV
    Troup Memorial fund
    Role: Co-Investigator
    $18,000
  • March 1999–February 2000
    ErbB-2 in the Kidney
    Kidney Foundation of Western New York
    Role: Principal Investigator
    $4,500
  • November 1994–December 1999
    Assessment of Tissue Culture Substrata
    Corning, Inc.
    Role: Principal Investigator
    $169,995
  • July 1999–June 1999
    Regulation of Kidney Cell Growth by the Wilm's Tumor Gene
    Association for Research on Childhood Cancer
    Role: Principal Investigator
    $30,000
  • May 1997–April 1998
    Role of ErbB-2 in the Renal Proximal Tubule
    KidneyFoundation of Western New York
    Role: Principal Investigator
    $3,200
  • May 1997–April 1998
    Nephrotoxicity of Ifosfamide III
    Kidney Foundation of Western New York
    Role: Co-Investigator
    $3,200
  • June 1995–May 1997
    Nephrotoxicity of Ifosfamide II
    James H Cummings Foundaton
    Role: Co-Investigator
    $20,000
  • June 1994–May 1995
    Nephrotoxicity of Ifosfamide
    Children's ospital of Buffalo
    Role: Co-Investigator
    $14,000
  • March 1994–February 1995
    Primary kidney cultures in the study of nephrotoxic drugs
    State University of New York at Buffalo
    Role: Co-Principal Investigator
    $15,000
  • May 1994–April 1994
    Cloning of the Sea Urchin Cannabinoid Receptor
    Multidisciplinary Research Pilot Project
    Role: Co-Principal Investigator
    $20,000
  • February 1992–January 1994
    Development of proximal tubule cell culture system for nephrotoxin studies
    Johns Hopkiins Agency for Alternatives to Animal Testing
    Role: Principal Investigator
    $203,000
  • June 1988–August 1993
    Hormonal Regulation of Kidney Epithelial Cell Growth
    NIH
    Role: Principal Investigator
    $600,000
  • May 1992–October 1992
    In vitro kidney cell culture for nephrotoxin assays I
    NIH
    Role: Co-Investigator
    $9,000
  • August 1991–July 1991
    In vitro kidney cell culture for nephrotoxin assays
    NIH
    Role: Co-Investigator
    $36,836
  • October 1989–June 1991
    Use of extracellular matrix in biotechnology
    New York State Technology Development Foundation
    Role: Principal Investigator
    $24,000
  • February 1989–September 1989
    Role of growth factors and cell attachment factors in polycystic kidney disease
    New York State Technology Development Foundation
    Role: Principal Investigator
    $45,000
  • September 1983–August 1988
    Regulation of Kidney Epithelial Cell Growth by Hormones
    NIH
    Role: Principal Investigator
    $1,110,000
  • July 1987–June 1988
    Control of chloride transport in MDCK cell cultures
    New York State Technology Development Foundation
    Role: Principal Investigator
    $20,000
  • May 1986–April 1988
    Control of chloride transport in MDCK cell cultures
    Cystic Fibrosis Foundation
    Role: Principal Investigator
    $60,000
  • February 1987–January 1988
    Development of Primary Culture System for Toxicology Testing
    Toxicology Center, State University of New York at Buffalo
    Role: Co-Investigator
    $10,000
  • February 1986–January 1988
    Use of Primary cultures for nephrotoxicity Testing
    the Johns Hopkins Center for Alternatives to Animal testing
    Role: Co-Principal Investigator
    $40,000
  • January 1987–December 1987
    Modification and Assessment of Millipore Materials
    Millipore Corporation
    Role: Co-Investigator
    $30,000
  • July 1986–June 1987
    Effects of insulin on growth and differentiated functions of primary kidney cells
    New York Sate Research Council
    Role: Principal Investigator
    $19,000
  • January 1983–December 1986
    Hormonal Regulation of Kidney Epithelial Cell Growth II
    NIH
    Role: Principal Investigator
    $537,000
  • January 1986–July 1986
    Processing of Tissue Culture Medium
    NIH
    Role: Co-Investigator
    $90,000
  • April 1986–March 1986
    The use of renal cell cultures to study the genetics of the Lesch Nyhan Syndrom
    Arthritis Foundation
    Role: Principal Investigator
    $6,000
  • January 1983–December 1983
    Research Development Allocation
    State University of New York at Buffalo
    Role: Principal Investigator
    $2,000
  • March 1983–June 1983
    Cell Growth Conference
    Gibco
    Role: Principal Investigator
    $1,500
  • January 1980–December 1980
    Biomedical Research Support Grant
    NIH
    Role: Principal Investigator
    $7,500
See all (27 more)

Journal Articles:
  • Taub M F. Cutuli. . Data on Na,K-ATPase in primary cultures of renal proximal tubule cells treated with catecholamines. Data in Brief. 2016; 6.
  • Taub M. 59.Cancer drug troglitazone stimulates the growth and response of renal cells to hypoxia inducible factor. Biohem Biophys Res Com. 2016; 471.
  • D. Saidani F. Hammoudi-Triki F. Labara-Djebari Taub M. In vitro studies with renal proximal tubule cells show direct cytotoxicity of Androctonus australis hector scorpion venom triggered by oxidative stress, caspase activation and apoptosis. Toxicon. 2016; 120.
  • Taub M S. Garimella D. Kim T. Rajkhowa F. Cutuli. Renal proximal tubule Na,K-ATPase is controlled by CREB-regulated transcriptional coactivators as well as salt-inducible kinase 1. Cellular Signalling. 2015; 27.
  • Taub M, Cutuli F, Taub ML. Activation of AMP kinase plays a role in the increased apoptosis in the renal proximal tubule in cystinosis. Biochem Biophys Res Commun. 2012; 426(4).
  • Taub ML, Springate JE, Cutuli F. Reduced phosphate transport in the renal proximal tubule cells in cystinosis is due to decreased expression of transporters rather than an energy defect. Biochem Biophys Res Commun. 2011; 407(2).
  • Herman MB, Rajkhowa T, Cutuli F, Springate JE, Taub M, Taub ML. Regulation of renal proximal tubule Na-K-ATPase by prostaglandins. Am J Physiol Renal Physiol. 2010; 298(5).
  • Taub ML, Springate JE, Cutuli F. Targeting of Renal Na,K-ATPase by Salt-Inducible Kinase. Bichem. Biophys. Res. Com.. 2010; 393(3).
  • Taub ML, Springate JE. Infosfamide Toxicity in Cultured Renal Proximal Tubule Cells, Pediatric Nephrology. Pediatric Nephrology. 2007; 22.
  • Taub ML, Han JH, Lim MJ, Lee JH, Lee YJ, Yang, IS. Uric acid inhibits renal proximal tubule cell proliferation via at least two signaling pathyways involving PKC, MAPK, cPLA2, and NF-kB. Amer. J. Physiol. 2007; 292.
  • Taub ML, Borsick M, Rajkhowa T. Evidence for post-transcriptional regulation of Na,K-ATPase by Prostaglandin E1. Biochem. Biophys. Res. Com.. 2006; 345.
  • Taub ML, Matlhagela K,. Regulation of the Na,K-ATPase beta 1 Subunit Promoter by Multiple Prostaglandin Responsive Elements. Amer. J. Physiol.. 2006; 1091.
  • Taub ML, Matlagela, K.. Involvement of EP1 and EP2 Receptors in the Regulation of the Na,K-ATPase by Prostaglandins in MDCK Cells. Prostaglandins and Other Lipid Mediators. 2006; 79.
  • Taub ML. Prostaglandins Regulate Transcription by means of Prostaglandin Response Elements (PGREs) Located in the Promoters of Mammalian Na,K-ATPase 1 Subunit Genes. Annals New York Academy of Sciences. 2006; 1091.
  • Taub ML, Han, YJ, Heo, JS, Lee, JH, Han, HJ, Lee YJ. Dopamine Stimulates 45 Ca 2 Uptake through cAMP, PLC/PKC, and MAPKs in Renal Proximal Tubule Cells. J. Cell Physiol.. 2006; 211.
  • Han HJ, Lee YJ, Park SH, Lee JH, Taub M, Taub ML. High glucose-induced oxidative stress inhibits Na+/glucose cotransporter activity in renal proximal tubule cells. Am J Physiol Renal Physiol. 2005; 288(5).
  • Han HJ, Lee YJ, Park JY, Kim EJ, Lee JH, Taub ML. Effect of EGF on H2O2-induced inhibition of alpha-MG uptake in renal proximal tubule cells: involvement of MAPK and AA release. J Cell Physiol. 2005; 203(1).
  • Matlhagela K, Borsick M, Rajkhowa T, Taub M, Taub ML. Identification of a prostaglandin-responsive element in the Na,K-ATPase beta 1 promoter that is regulated by cAMP and Ca2+. Evidence for an interactive role of cAMP regulatory element-binding protein and Sp1. J Biol Chem. 2005; 280(1).
  • Taub M, Taub ML. Primary kidney proximal tubule cells. Methods Mol Biol. 2005; 290.
  • Taub M, Borsick M, Geisel J, Matlhagela K, Rajkhowa T, Allen C, Taub ML. Regulation of the Na,K-ATPase in MDCK cells by prostaglandin E1: a role for calcium as well as cAMP. Exp Cell Res. 2004; 299(1).
  • Jae Han H, Yeong Park J, Jung Lee Y, Taub M. Epidermal growth factor inhibits 14C-alpha-methyl-d-glucopyranoside uptake in renal proximal tubule cells: Involvement of PLC/PKC, p44/42 MAPK, and cPLA2.. J Cell Physiol. 2004; 199(2).
  • Han HJ, Sigurdson WJ, Nickerson PA, Taub M, Taub ML. Both mitogen activated protein kinase and the mammalian target of rapamycin modulate the development of functional renal proximal tubules in matrigel. J Cell Sci. 2004; 117(Pt 9).
  • Emed Zaki James E Springate Mary Taub. Comparative Toxicity of Ifosfamide Metabolites and Protective Effect of Mesna and Amifostine in Cultured Renal Tubule Cells. Toxicology In Vitro. 2003; 17.
  • Taub M, Han HJ, Rajkhowa T, Allen C, Park JH. Clonal analysis of immortalized renal proximal tubule cells: Na(+)/glucose cotransport system levels are maintained despite a decline in transport function.. Exp Cell Res. 2002; 281(2).
  • Han HJ, Lee YH, Park KM, Taub M. Estradiol-17beta stimulates phosphate uptake and is mitogenic for primary rabbit renal proximal tubule cells.. Exp Nephrol. 2002; 10(5-6).
  • Mary Taub. 17 beta estradiol stimulates proliferation and phosphate uptake by primary renal proximal tubule cells. Nephron. 2002.
  • Han HJ, Lee YH, Park KM, Taub M, Taub ML. Estradiol-17beta stimulates phosphate uptake and is mitogenic for primary rabbit renal proximal tubule cells. Exp Nephrol. 2002; 10(5-6).
  • Park S, Taub ML, Han H. Regulation of phosphate uptake in primary cultured rabbit renal proximal tubule cells by glucocorticoids: evidence for nongenomic as well as genomic mechanisms.. Endocrinology. 2001; 142(2).
  • Han HJ, Park S, Koh HJ, Taub ML. Mechanism of regulation of Na+ transport by angiotensin II in primary renal cells.. Kidney Int. 2000; 57(6).
  • Springate J, Chan K, Lu H, Davies S, Taub M. Toxicity of ifosfamide and its metabolite chloroacetaldehyde in cultured renal tubule cells.. In Vitro Cell Dev Biol Anim. 1999; 35(6).
  • Han HJ, Jung JC, Taub M. Response of primary rabbit kidney proximal tubule cells to estrogens.. J Cell Physiol. 1999; 178(1).
  • Taub M, Axelson E, Park JH. Colloidal silica-coated tissue culture dishes for primary cell cultures: growth of rabbit renal proximal tubule cells.. Biotechniques. 1998; 25(6).
  • K. Ru, M.L Taub, J.H. Wang. Specific inhibition of breast cancer cells by antisense poly DNP-oligoribonucleotides and targeted apoptosis. Oncology Research. 1998; 10.
  • Mahajan MA, Acara M, Taub M. Uptake and phosphorylation of thiamine in rabbit primary proximal tubule cells and Madin Darby canine kidney cells. II. Effect of ethanol.. J Pharmacol Exp Ther. 1994; 268(3).
  • Bashir N, Kuhen K, Taub M, Taub ML. Phospholipids regulate growth and function of MDCK cells in hormonally defined serum free medium. In Vitro Cell Dev Biol. 1992; 28A(9-10).
  • Taub ML, Wang Y, Yang IS, Fiorella P, Lee SM. Regulation of the Na,K-ATPase activity of Madin-Darby canine kidney cells in defined medium by prostaglandin E1 and 8-bromocyclic AMP.. J Cell Physiol. 1992; 151(2).
  • Jung JC, Lee SM, Kadakia N, Taub M. Growth and function of primary rabbit kidney proximal tubule cells in glucose-free serum-free medium.. J Cell Physiol. 1992; 150(2).
  • Aleo MD, Taub ML, Kostyniak PJ. Primary cultures of rabbit renal proximal tubule cells. III. Comparative cytotoxicity of inorganic and organic mercury.. Toxicol Appl Pharmacol. 1992; 112(2).
  • N. Bashir K.Kuhen M. taub. Phospholipids Reglate Growth and function of MDCK Cells in Hormonally Defined Serum-Free Medium. In Vitro Cell and Developmental Biology. 1992; 28A.
  • Taub M. Retinoic acid inhibits basement membrane protein biosynthesis while stimulating dome formation by Madin Darby canine kidney cells in hormonally defined serum-free medium.. J Cell Physiol. 1991; 148(2).
  • Wang Y, Taub M. Insulin and other regulatory factors modulate the growth and the phosphoenolpyruvate carboxykinase (PEPCK) activity of primary rabbit kidney proximal tubule cells in serum free medium.. J Cell Physiol. 1991; 147(2).
  • Taub M, Wang Y, Szczesny TM, Kleinman HK. Epidermal growth factor or transforming growth factor alpha is required for kidney tubulogenesis in matrigel cultures in serum-free medium.. Proc Natl Acad Sci U S A. 1990; 87(10).
  • Taub M, Laurie GW, Martin GR, Kleinman HK. Altered basement membrane protein biosynthesis by primary cultures of cpk/cpk mouse kidney.. Kidney Int. 1990; 37(4).
  • Aleo, MD, Mary Taub, James Olson, Paul Kostyniak. Primary cultures of rabbit renal tubule cells: II. Selected phase I and phase II metabolic capacities. Toxicol In Vitro. 1990; 4.
  • Mary Taub. The Use of Defined Media in Cell and Tissue Culture. Toxicology In Vitro. 1990; 4.
  • M.D. Aleo, M.L. Taub, J.R. Olson, P.J. Kostyniak. Primary Cultures of Rabbit Renal Tubule Cells: II. Selected Phase I and Phase II Metabolic Capacities. Toxicology In Vitro. 1990; 4.
  • Taub M, Taub ML. Primary kidney cells. Methods Mol Biol. 1990; 5.
  • Taub M, Taub ML. The use of defined media in cell and tissue culture. Toxicol In Vitro. 1990; 4(3).
  • Aleo MD, Taub ML, Olson JR, Kostyniak PJ. Primary cultures of rabbit renal proximal tubule cells: II. Selected phase I and phase II metabolic capacities. Toxicol In Vitro. 1990; 4(6).
  • Taub M. Retinoic acid modulates dome formation by MDCK cells in defined medium.. J Cell Physiol. 1989; 141(1).
  • Taub ML, Yang IS, Wang Y. Primary rabbit kidney proximal tubule cell cultures maintain differentiated functions when cultured in a hormonally defined serum-free medium.. In Vitro Cell Dev Biol. 1989; 25(9).
  • Aleo MD, Taub ML, Nickerson PA, Kostyniak PJ. Primary cultures of rabbit renal proximal tubule cells: I. Growth and biochemical characteristics.. In Vitro Cell Dev Biol. 1989; 25(9).
  • Taub ML, Syracuse JA, Cai JW, Fiorella P, Subjeck JR. Glucose deprivation results in the induction of glucose-regulated proteins and domes in MDCK monolayers in hormonally defined serum-free medium.. Exp Cell Res. 1989; 182(1).
  • Yang IS, Goldinger JM, Hong SK, Taub M. Preparation of basolateral membranes that transport p-aminohippurate from primary cultures of rabbit kidney proximal tubule cells.. J Cell Physiol. 1988; 135(3).
  • Matsuo S, Fukatsu A, Taub ML, Caldwell PR, Brentjens JR, Andres G. Glomerulonephritis induced in the rabbit by antiendothelial antibodies.. J Clin Invest. 1987; 79(6).
  • M.H. Saier Jr, P. Boerner, F.C. Grenier, J.A. Roberts, M.J. Rindler, M. Taub, H.S.U. sodium Entry Pathways in Renal Epithelial Cells. Mineral and Electrolyte Metabolism. 1986.
  • Saier MH, Boerner P, Grenier FC, McRoberts JA, Rindler MJ, Taub M, U HS, Taub ML. Sodium entry pathways in renal epithelial cell lines. Miner Electrolyte Metab. 1986; 12(1).
  • Devis PE, Grohol SH, Taub M. Dibutyryl cyclic AMP resistant MDCK cells in serum free medium have reduced cyclic AMP dependent protein kinase activity and a diminished effect of PGE1 on differentiated function.. J Cell Physiol. 1985; 125(1).
  • Waqar MA, Seto J, Chung SD, Hiller-Grohol S, Taub M. Phosphate uptake by primary renal proximal tubule cell cultures grown in hormonally defined medium.. J Cell Physiol. 1985; 124(3).
  • M.L. Taub. Primary Culture of Proximal Tubule Cells in Defined Medium. J. Tissue Culture Methods. 1985; 9.
  • Taub M, Devis PE, Grohol SH. PGE1-independent MDCK cells have elevated intracellular cyclic AMP but retain the growth stimulatory effects of glucagon and epidermal growth factor in serum-free medium.. J Cell Physiol. 1984; 120(1).
  • Sakhrani LM, Badie-Dezfooly B, Trizna W, Mikhail N, Lowe AG, Taub M, Fine LG. Transport and metabolism of glucose by renal proximal tubular cells in primary culture.. Am J Physiol. 1984; 246(6 Pt).
  • Taub M, Saier MH, Chuman L, Hiller S. Loss of the PGE1 requirement for MDCK cell growth associated with a defect in cyclic AMP phosphodiesterase.. J Cell Physiol. 1983; 114(2).
  • Chung SD, Alavi N, Livingston D, Hiller S, Taub M. Characterization of primary rabbit kidney cultures that express proximal tubule functions in a hormonally defined medium.. J Cell Biol. 1982; 95(1).
  • Taub M, Saier MH. Amiloride-resistant Madin-Darby canine kidney (MDCK) cells exhibit decreased cation transport.. J Cell Physiol. 1981; 106(2).
  • M. Taub, B.U, L Chuman, M.J. Rindler, M.H. Saier, Jr., G. Sato. Alterations in Growth Requiements of Kidney Epithelial Cells in Defined Medium Associated with Malignant Transformation. J. Supramolecular Structure and Cellular Biochemistry. 1981; 15.
  • Taub M, U B, Chuman L, Rindler MJ, Saier MH, Sato G, Taub ML. Alterations in growth requirements of kidney epithelial cells in defined medium associated with malignant transformation. J Supramol Struct Cell Biochem. 1981; 15(1).
  • Taub M, Sato G. Growth of functional primary cultures of kidney epithelial cells in defined medium.. J Cell Physiol. 1980; 105(2).
  • Rindler MJ, Taub M, Saier MH. Uptake of 22Na+ by cultured dog kidney cells (MDCK).. J Biol Chem. 1979; 254(22).
  • Taub M, Saier MH. Regulation of 22Na+ transport by calcium in an established kidney epithelial cell line.. J Biol Chem. 1979; 254(22).
  • Taub M, Chuman L, Saier MH, Sato G. Growth of Madin-Darby canine kidney epithelial cell (MDCK) line in hormone-supplemented, serum-free medium.. Proc Natl Acad Sci U S A. 1979; 76(7).
  • M. Taub, G. Sato. Growth of Kidney Epithelial Cells in Hormone-Supplemented Serum-Free Medium. J. Supramolecular Structure. 1979; 15.
  • Taub M, Saier MH, Taub ML. An established but differentiated kidney epithelial cell line (MDCK). Methods Enzymol. 1979; 58.
  • Taub M, Englesberg E. 5-fluorotryptophan resistant mutants affecting the A and L transport systems in the mouse L cell line A9.. J Cell Physiol. 1978; 97(3 Pt).
  • Taub M. Isolation of amiloride-resistant clones from dog kidney epithelial cells.. Somatic Cell Genet. 1978; 4(5).
  • Taub M. The mechanism of killing of mouse fibroblasts by the amino acid analogue 5-fluorotryptophan.. J Cell Physiol. 1977; 93(2).
  • Taub M, Englesberg E. Isolation and characterization of 5-fluorotryptophan-resistant mutants with altered L-tryptophan transport.. Somatic Cell Genet. 1976; 2(5).
  • Ru K, Taub ML, Wang JH. Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis.. Oncol Res. ; 10(8).
  • Bashir N, Kuhen K, Taub M. Phospholipids regulate growth and function of MDCK cells in hormonally defined serum free medium.. In Vitro Cell Dev Biol. ; 28A(9-10).
  • Saier MH, Boerner P, Grenier FC, McRoberts JA, Rindler MJ, Taub M, U HS. Sodium entry pathways in renal epithelial cell lines.. Miner Electrolyte Metab. ; 12(1).
  • Taub M, U B, Chuman L, Rindler MJ, Saier MH, Sato G. Alterations in growth requirements of kidney epithelial cells in defined medium associated with malignant transformation.. J Supramol Struct Cell Biochem. ; 15(1).
  • Taub M, Sato GH. Growth of kidney epithelial cells in hormone-supplemented, serum-free medium.. J Supramol Struct. ; 11(2).
  • Taub M, Saier MH. An established but differentiated kidney epithelial cell line (MDCK).. Methods Enzymol. ; 58.
See all (73 more)
Books and Book Chapters:
  • Taub ML, Springate JE, Cutuli F. Prostaglandins Regulate Growth and Transport in Cultured Renal Cells, in Prostaglandins. 2010.
  • Taub M. Primary kidney proximal tubule cells.. Methods Mol Biol. 2005; 290.
  • Mary Taub. Renal Tubule Cells. Protocols in Cell and Tissue Culture. 1997.
  • Mary Taub. Primary Kidney Cells. Basic Cell Culture Protocols. 1997.
  • Mary Taub. Immortalized Cell Lines of Renal Cells. Methods in Renal Toxicology. 1996.
  • Mary Taub. Cell Culture. Principles of Medical Biology. 1996; 4.
  • Mary Taub. Cell Cultures, Cortical Epithelial Cell, Rabbit. In Vitro Biological Systems: Preparation and Maintanence. 1995; 1.
  • Mary Taub. The Biology of Cultured Cells. Fundamentals of Medical Cell Biology. 1992; 6.
  • Mary Taub. Primary Kidney Cells. Methods in Molecular Biology. 1990.
  • M.A. Aleo, M.L. Taub, S.R. Olson, P.A. Nickerson, P.S. Kostyniak. Primary Cultures of Rabbit Renal Proximal Tubule Cells as an In Vitro Model of Nephrotoxicity: Effects of Two Mercurials. In Vitro Toxicology-Approaches to Validation. 1987.
  • Mary Taub. The Use of Kidney Cell Culture and Hormonally Defined Medium to Study Renal Cancer. In Vitro Models in the Study of Neoplasia. 1986.
  • S.M. Ford, M. Taub. Aproaches to the Development of Selective Media for Renal Epithelial Cells. Proceedings, First International Symposium on Growth and Differentiation of Cells in Defined Environments. 1985.
  • M.A. Waqar, J. Seto, S.D. Chung, M. Taub. Phosphate Transport in Renal Proximal Tubule Cells Cultured in Defined Medium. Proceedings, First International Symposium on Growth and Differentiation of Cells in Defined Environments. 1985.
  • Devis, PE. Taub, M. PGE1 Responsiveness of Dibutyryl Cyclic AMP Resistant MDCK Cells. Proceedings, First International Symposium on Growth and Differentiation of Cells in Defined Environments. 1985.
  • Mary Taub. Tissue Culture of Epithelial Cells. Plenum Publishing. 1985.
  • Mary Taub. Kidney Cell cultures in Hormonally Defined serum Free Medium. Mammalian Cell Culture: The Use of Hormonally Defined Serum-Free Medium. 1984.
  • Mary Taub. Methods for Growth of Primary and Established Kidney Cell Cultures. Cell Culture Methods for Molecular and Cell Biology. 1984; 2.
  • Mary Taub. Viruses in the Stuudy of the Polarity of Epithelial Membranes. Tissue Culture of Epithelial Cells. 1984.
  • Mary Taub. Importance of Hormonally Defined Serum-Free Medium for In Vitro Studies Concerning Epithelial Transport. Tissue Culture of Epithelial Cells. 1984.
  • J. McRoberts, M. taub, M.H. Saier, Jr.. the Madin Darby Canine Kidney (MDCK) Cell Line. Functionally Differentiated Cells. 1981.
  • M. Taub. Studies of the Na+ Channel in a Cultured Dog Kidney Epithelial Cell Line Utilizing Amiloride. Amiloride and Eithelial Sodium Transport. 1979.
  • Taub, M Saier, MH Jr. Studies with a Established but Differentiated Kidney Epithelial Cell Line. Methods in Enzymology. 1978; LVIII.
See all (12 more)

Professional Memberships:
  • American Association for Cancer Research (2007–present)
  • American Society Biochemistry and Molecular Biology (1992–present)
  • Society for In Vitro Biology (1976–present)
  • American Association for the Advancement of Science (1976–present)
  • American Society Cell Biology (1976–present)
Presentations:
  • "Mechanisms Underlying the Fanconi Syndrome in Cystinosis" Second International Conference on Cystinosis, Cystinosis Research Foundation (2010)
  • "Regulation of Growth and Function of Kidney Cells" , Invitrogen (2007)
  • "Regulation of Growth of Kidney Cells" Symposium on Aquaporins, Guangju University (2006)
  • "Regulation of Renal Na,K-ATPase by Prostaglandins" Federation of Asian and Pacific Physiological Societies (2006)
  • "Regulation of Growth and Function of Kidney Cells" Seminar, MedImmune (2003)
  • "Mechanisms underlying regulation of transport in kidney cells" , Roswell Park Memorial Institute, Department of Biophysics (2001)
  • "Regulation of Growth and Function of Renal Cells" , Abbott Laboratories (2001)
  • "Role of the substratum in renal proximal tubule cell growth" Annual Meeting, American Society for Cell Biology (1996)
  • "Role of the Substratum in the Regltion of Renal Proximal Tubule Cell Growth" , Corning, Inc (1996)
  • "Regulation of renal cell growth and function by hormones" , Canisius College, Biology Department (1996)
  • "Hormonal regulation of kidney epithelial cell growth" , State University of New York at Buffalo, Department of Biochemical Pharmacology (1995)
  • "Immortalization of rabbit kidney proximal tubule cells in serum free medium" American Tissue Culture Association, Annual Meeting, American Tissue Culture Association (1994)
  • "Regulation of growth and funcntion of kidney cells in serum free medim" , State University of New York at Buffalo, Department of Anatomical Sciences (1993)
  • "Regulation of growth and function of kidney cells in serum free medium" Staff conference, Roswell Park memorial Institute (1993)
  • "Kidney Cells in Defined Medium" NIH workshop on Establishment of Cell Lines for Hypertension Research, NIH (1991)
  • "Control of Kidney Epithelial Cell Growth and Functions in Defined Medium" , Molecular Devices Corporation (1990)
  • "Control of kidney epithelial cell growth and function in serum-free medium" Workshop on Growth Factors and the Kidney, State University of New York at Buffalo, Graduate Group for Experimental Nephrology (1990)
  • "control of Kidney epithelial cell growth and differentiation in defined medium" , Roswell Park Memorial Institute (1990)
  • "Control of kidney epithelial cell growth in defined medium" , Verax Corporation (1990)
  • "Control of extracellular matrix protein biosynthesis in normal and mutant kidney cells" , State University of New York at Buffalo, Biochemistry Department (1989)
  • "Hormonally defined serum free medium" , Intergen Corporation (1988)
  • "Expression of Differentiated Function in Primary Rabbit Kidney Proximal Tubule Cells" Symposium, Annual Meeting, American Society Toxicology (1988)
  • "Primary proximal tubule cell cultures" Toxicology Gordon Conference, Gordon Conferences (1987)
  • "Mechanism of action of hormones and other regulatory factors on growth and expression of differentiated functions of kidney cells cultured in serum free medium" , University of Nebraska Medical Center (1987)
  • "Mechanism of action of hormones and other regulatory factors on growth and expression of differnetiatted functions of kidney cells cultured in serum-free medium" , NIH, Dental Institute (1987)
  • "Mechanism of action of hormones on groth and expression of differentiated functions of kidney cells cultured in serum free medim" , State University of New York at Buffalo, Dept Pharmacology and Experimental Therapeutics (1986)
  • "Establishment of kidney epithelial cell lines" NIH kdiney cell culture meeting, NIH (1985)
  • "Mechanism of action of hormones on growth and expression of differentiated functions of kidney cells cultured in serum-free medium" , Roswell Park Memorial Institute (1985)
  • "Mechanism of Action of Hormones on Growth and Expression of Differentiated Functions of Kidney Cells Cultured in Serum-Free Medium" , University of Massachusetts, Department of Zoology (1985)
  • "Mechanism of action of ormones on growth and expression of differentiated functions of kidney cells cultured in serum-free medium" , UEast Virginia Medical School, Department of Physiology (1985)
  • "Mechanism of action of hormones on growth and exprssion of differentiated functions of kidney cells cultured in serum-free medium" , Roswell Park Memorial Institute, Department of Experimental Biology (1985)
  • "Growthof primary kidney cells in defined medium" International Symposium on Growth and Differentiation of Cells in a Defined Environment, International Cell Biology Meeting (1984)
  • "Kidney cell cultures in hormonally defined medium" , Kyung Hee University (1984)
  • "Kidney cellcultures in hormonally defined medium" , State University of New York at Stony Brook, Dept of Nephrology (1984)
  • "Responsiveness of primary kidney cell cultures to neprhotoxic drugs" , Bristol Laboratories (1984)
  • "Differentiated Functions of Kidney Cells in Serum-Free Medium" International Round Table Discussion on Serum-Free Cell Culture, American Tissue Culture Association (1984)
  • "Differentiated Functions of Primary Kidney Cells" American Tissue Culture Association, Annual Meeting, can Tissue Culture Association (1984)
  • "Primary proximal tubule cell cutures in defined medium" workshop on determinants of growth, form and function in epithelia, IXTH International Congress of Nephrology (1984)
  • "Hormones control the growth and functional properties of cultured kidney cells in serum-free medium" Membrane Workshop, University of Rochester, Department of Radiation Biology and Biophysics (1984)
  • "Growth of normal and moalignant epithelial cells in hormonally defined serum-free medium" , Roswell Park Memorial Institute (1984)
  • "Growth of normal and transformed kidney cells in defined medium" Symposium on animal cell culture; growth factors and cell proliferation, Symposium on animal cell culture (1983)
  • "Characterization of the hormone responses and functional properties of kidney cells in serum-free medium" , University of Pittsburgh, Biochemistry Dept (1983)
  • "characterization of the Hormone Responses and Functional Properties of Kidney Cells in Serum-Free Medium" , University of Texas, Galveston, Biochemistry Dept (1983)
  • "Kidney cell culture and hormonally defined serum-free medium" , University of Texas, Houston, dept of Biochemistry and Molecular Biology (1983)
  • "Primary Rabbit kidney epithelial cell cultures in hormonally defined medium" Annual Meeting, FASEB, FASEB (1983)
  • "Hormonally defined serum-free medium and kidney cell culture" Virology Group, Merck Research Laboratories (1982)
  • "Hormones regulatte the grwoth and functions of cultued kidney epithelial cells" Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder (1982)
  • "Madin Darby Canine Kidney (MDCK) Variants have Lost the PGE1 Requirement for Growth" Evolution of Hormone Receptor Systems, ICN-UCLA Symposium (1982)
  • "What is it in serum that causes cells to grow?" , Roswell Park Memorial Institute (1982)
  • "Hormones regulate the growth and functions of cultured kidney epithelial cells" Tumor Virus Laboratory, NIH (1981)
  • "Regulation of kidney epithelial cell growth" 9th Cold Spring Harbor Conference on Cell Proliferation, Cold Spring Harbor Labs (1981)
  • "Primary kidney cell cultures in hormonally defined medium" 21st Annual Scientific Symposium on Kidney Disease, ASN (1981)
  • "Growth of normal and transformed kidney cells in defined medium" Oncology Seminar Series, Roswell Park Memorial Institute (1981)
  • "Hormones regulate the growth and funcntions of cutured kidney epithelial cells" , University of California, Santa Barbara, Section of Biochemistry and Molecular Biology (1981)
  • "Use of Hormonally Defined Serum-Free Medium to grow Primary Kidney Cell Cultures" Hormonal Regulation of Ion Transport in Epithelial Tissues, New York Academy of Sciences (1980)
  • "Primary Renal Culture in Defined Medium" American Tissue Culture Association/Role and Replacement of Serum in culture medium, American Tissue Culture Association, National Meeting (1980)
  • "Alterations in cAMP metabolism in variants of MDCk cells lacking the PGE1 requirement for growth" Annual Meeting, American Society for Cell Biology, ASCB (1979)
  • "Amiloride Resistant Mutants of MDCK cells" Amiloride and the Epithelial Sodium Channel, ASN (1979)
  • "5-Fluorotryptophan Resistant Mutants" Lake Arrowhead Genetics Conference, Lake Arrowhead Genetics Conference (1976)
  • "Mechanism of action of hormones and other regulatory factos on growth and expression of differnetiatted functions of kidney cells cultured in serum-free medium" , University of Toronto, Hospital for Sick Children
See all (50 more)
Service Activities:
  • Jacobs School of Medicine & Biomedical Sciences Student Affairs & Academic Standing; Member (2000)
  • Jacobs School of Medicine & Biomedical Sciences Biomdedical Research; Member (1997)
  • Jacobs School of Medicine & Biomedical Sciences Research Promotions; Member (1993–1995)
  • Jacobs School of Medicine & Biomedical Sciences Faculty Council; Member (1984–1986)
  • Faculty Senate; Alternate Member (1981–1983)
  • reviewer abstracts SIVB meeting; Ad Hoc Reviewer (2004)
  • reviewer, abstracts; Society In Vitro Biology; Ad Hoc Reviewer (2004)
  • Reviewer Dissertation Indian Institute of Technology; Ad Hoc Reviewer (2003–2004)
  • reviewer Physiologic Reviews; Ad Hoc Reviewer (2003–2004)
  • grant reviewer, Philip Morris; grant reviewer; Ad Hoc Reviewer for Program Grants (2003)
  • reviewer, BBA Biomembranes; Ad Hoc Reviewer (2003–2004)
  • consultant, MedImmune Corp.; Consultant (2003)
  • Consultant, Corning, Inc.; Other (2002)
  • Consultant, Abbott Laboratories, Chicago, Ill; Other (2001)
  • Organizer, Workshop on Diabetic Nephropathy; Graduate Group in Experimental Nephrology; Organizing Committee Member (1997)
  • Consultant, Corning, Inc.; Other (1994–1999)
  • Chair, Sesson on "In Vitro Test Systems in Toxicology"; Organizing Committee Member (1994)
  • Member, Editorial Board, Journal of Tissue Culture Methods; Editorial Board Member (1994–present)
  • Invited Lecturer, Normal and Transformed Cells; Guest Lecturer (1991)
  • Consultant, Molecular Devices, Corp; Other (1991)
  • Invited Lecturer, Normal and Transformed Cells; Guest Lecturer (1990)
  • consultant, Verax Corp; Other (1990)
  • Invited Lecturer, Normal and Transformed Cells; Catolic University, Center for Advanced Study in Cell and Molecular Biology; Guest Lecturer (1989)
  • consultant, Intergen Corp. White Plains, NY; Other (1988)
  • Sabbatical Professor; NIH; Other (1987–1988)
  • Consultant, Abbott Laboratories, Chicago, Ill; Other (1985)
  • Organizer, conference on Cell Tissue Culture Culture Techniques in Renal Re; Organizing Committee Member (1985)
  • consultant, Bristol Laboratories, Syracuse, NY; Other (1984)
  • Invited Lecturer, Cold Spring Harbor Course; Guest Lecturer (1982)
  • Organizer, Conference; conference on Growth Factors and Cell Cutlure, Cetner for Tomorrow, SUNY Buffalo, Buffalo, NY; Organizing Committee Member (1982)
  • Invited Lecturer, Tissue Culture Course of Canada; Saskatoon, Saskatchuan; Guest Lecturer (1982)
  • Consultant, Merck, Sharp and Dome, Valley Forge, Pa; Other (1982)
  • Member, Editorial Board, In Vitro Cellular and Developmental Biology; Editorial Board Member (1982–present)
  • Invited Lecturer, Cold Spring Harbor; Guest Lecturer (1981)
  • Visiting Scientist, Institute for Advanced Studies, Mexico City; Visiting Professor (1981)
  • external reviewer, Ph.D. dissertation; Ph.D. reviewer, Indian Institute of Technology; Ad Hoc Reviewer
  • Reviewer, biochem. Biophys. Acta; Ad Hoc Reviewer
  • reviewer, biochemistry and Cell biology; Ad Hoc Reviewer
  • Reviewer, Cancer Research; Ad Hoc Reviewer
  • reviewer, Immunologic Communications; Ad Hoc Reviewer
  • Reviewer, Intl J. Radiation Biology; Ad Hoc Reviewer
  • Reviewer, J. Cell Biology; Ad Hoc Reviewer
  • Reviewer, J. Cell. Biochem; Ad Hoc Reviewer
  • Reviewer, J. Cell. Physiology; Ad Hoc Reviewer
  • Reviewer, J. Lab and Clin. Medicine; Ad Hoc Reviewer
  • Reviewer, J. Pharm. Exptl. Therapeutics; Ad Hoc Reviewer
  • Reviewer, Lipids; Ad Hoc Reviewer
  • Reviewer, Proc. Natl Acad. Sciences USA; Ad Hoc Reviewer
  • reviewer, Science; Ad Hoc Reviewer
  • Reviewer, Toxicology In Vitro; Ad Hoc Reviewer
  • Reviewer,Amer. J. Physiology; Ad Hoc Reviewer

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Phone: (716) 829-3300
Email: biochtau@buffalo.edu


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