Alan J. Lesse MD

Alan Lesse

Alan J. Lesse
MD

Associate Professor and Vice Chair for Education; Senior Associate Dean for Medical Curriculum

Department of Medicine

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Bioinformatics; Infectious Disease; Microbial Pathogenesis

Contact Information
VA Western New York Healthcare System
Research (151)
3495 Bailey Avenue
Buffalo, NY 14215
Phone: (716) 862-6532
Fax: (716) 862-6526
camlesse@buffalo.edu



Professional Summary:

My clinical interest work focuses on infectious diseases, particularly those caused by Staphylococcus aureus. I practice medicine at the VA Western New York Healthcare System, where I am Chief of the Infectious Disease Section. The service here treats veterans with a wide variety of infectious diseases, including HIV and hepatitis C. I follow both inpatients and outpatients on this clinical service. Medical students, residents, and fellows evaluate and follow infectious disease consultations with me on the inpatient service.

I teach extensively in the Medical School, and serve as Vice Chair for Education in the Department of Medicine. I enjoy working with students throughout the full spectrum of medical education, from first-year medical students to senior fellows in Infectious Disease.

My research interests dovetail with my clinical work. I study Staphylococcal infections, particularly complications related to S. aureus bloodstream infections. My laboratory uses advanced molecular biology techniques to identify bacterial virulence factors. In collaboration with Steve Gill at the University of Rochester, we are analyzing three years of clinical data on S. aureus bacteremia in the Buffalo area and sequencing hundreds of bacteremia isolates of S. aureus to identify the genomic architectures associated with more severe complications and those associated with poor clinical outcomes. This work makes use of bioinformatics and database design, techniques that support my ongoing collaborations with other investigators on bioinformatics problems, particularly with Moraxella catarrhalis and Haemophilus influenzae.

Prior to my studies in S. aureus, I conducted research on a fascinating pathogen, H. influenzae bio group aegyptius and Brazilian Purpuric Fever. Over that 10-year period my laboratory identified a unique epitope on a surface proteins associated with the disease. We were able to create the only isogenic mutant so far described with this pathogen that is highly refractory to genetic manipulation.

Education and Training:

  • Fellowship, Research Fellowship in Infectious Diseases, University of Virginina (1987)
  • Fellowship, Clinical Fellowship in Infectious Disease, University of Virginia Affiliated Program (1985)
  • Residency, Internal Medicine, Temple University (1984)
  • MD, University of Virginia (1981)
  • BA, University of Virginia (1977)

Employment:

  • Senior Associate Dean for Medical Curriculum, School of Medicine and Biomedical Sciences, University at Buffalo School of Medicine and Biomedical Sciences (2015-present)
  • Vice Chair for Education, Department of Medicine, Medicine, University at Buffalo (2012-present)
  • Chief, Infectious Disease, Infectious DIsease, VA WNY Healthcare System, VA Western NY Healthcare System (2009-present)
  • Associate Professor, Medicine, Pharmacology & Toxicology, Microbiology and Immunology, State University of New York at Buffalo (1994-present)
  • Acting Associate Chief of Staff, Research, VA Western New York Healthcare System (2010)
  • Assistant Professor of Medicine and Pharmacology and Toxicology, Medicine, Pharmacology & Therapeutics, State University of New York at Buffalo (1987–1994)
  • Research Fellow in Infectious Diseases, University of Virginia School of Medicine (1985–1987)
  • Clinical Fellow in Infectious Diseases, University of Virginia Affiliated Hospitals Program (1984–1985)
  • Medical Resident, Department of Medicine, Temple University (1982–1984)
  • Medical Intern, Department of Medicine, Temple University (1981–1982)

Awards and Honors:

  • Steven H. Noyes, MD, House Staff Teaching Award (2015)
  • Faculty AOA (2015)
  • 2014 SUNY Chancellor's Award for Excellence in Teaching (2014)
  • Letter of Commendation for Pre-Clinical Teaching, Siegel Cmte. for Teaching (2014)
  • Letter of Commendation for Pre-Clinical Teaching, Siegel Cmte. for Teaching (2012)
  • Pharmacology and Toxicology Faculty Teaching Award, Department of Pharmacol (2011)
  • Letter of Commendation for Clinical Teaching, Siegel Cmte. for Teaching Exc (2010)
  • Letter of Commendation for Clinical Teaching, Siegel Cmte. for Teaching Exc (2005)
  • Letter of Commendation for Clinical Teaching, Siegel Cmte. for Teaching Exc (2001)
  • White Coat Award, Resident Teaching Award in Medicine (1999)
  • Recipient of Recognition Award from the Eastern Paralyzed Veterans Associat (1999)
  • Letter of Commendation for Pre-Clinical Teaching, Siegel Cmte. for Teaching (1998)
  • Letter of Commendation for Pre-Clinical Teaching, Siegel Cmte. for Teaching (1997)
  • Letter of Commendation for Pre-Clinical Teaching, Siegel Cmte. for Teaching (1995)
  • Letter of Commendation for Clinical Teaching, Siegel Cmte. for Teaching Exc (1993)
  • Recipient of the Pre-Clinical Teaching Award, Siegel Committee for Teaching (1992)
  • Recipient of the first F. Carter Pannill Housestaff Teaching Award (1991)
  • Recipient of the Pre-Clinical Teaching Award, Siegel Committee for Teaching (1990)
  • Letter of Commendation for Pre-Clinical Teaching, Siegel Cmte. for Teaching (1989)

Research Expertise:

  • Infections with Staphylococcus aureus: I have both a research and clinical interest in infections caused by Staphylococcus aureus. My clinical interest involves blood stream infections and community-associated MRSA infections. My research interests center on the clinical and molecular epidemiology of blood stream isolates, including whole genomic sequencing and the bioinformatic approach to analyzing virulence factors.

Grants and Sponsored Research:

  • August 2015–September 2017
    BIG DATA SCIENTIST TRAINING ENCHANCEMENT PROGRAM (BD-STEP)-BD-STEP
    VA and National Cancer Institute
    Role: Co-Principal Investigator
    $60,000
  • September 2014–November 2015
    VA HSR&D Grant Title: Gown and Glove Use to Prevent the Spread of Infection in VA Community Living Centers
    VA HSR&D
    Role: Co-Investigator
    $72,000
  • January 2007–December 2012
    Pathogenesis of Haemophilus influenza Infections in COPD
    NIH
    Role: Co-Investigator
    $1,225,125
  • January 1987–June 2012
    Development of a vaccine for Moraxella catarrhalis (RO1AI28304)Pathogenesis of Moraxella catarrhalis in chronic obstructive pulmonary disease (2R56AI1028304)
    NIH
    Role: Co-Investigator
    $1,250,000
  • June 2007–December 2010
    A Population-Based Study of Staphylococcus aureus Bacteremia In Western New York
    Oishei Foundation
    Role: Co-Investigator
    $690,500
  • September 2002–August 2007
    Development of a vaccine for H. influenzae
    NIH
    Role: Co-Investigator
    $1,200,000
  • October 1996–September 2000
    Virulence Factors of Haemophilus influenzae biogroup aegyptius
    Veterans Administration Merit Review
    Role: Principal Investigator
    $160,400
  • April 1994–March 1996
    Virulence Factors of Haemophilus influenzae biogroup aegyptius
    Veterans Administration Merit Review
    Role: Co-Investigator
    $174,100
  • July 1987–March 1988
    Pathogenesis of Bacterial Meningitis, Basic Science Research Group
    Basic Science Research Group, SUNY Buffalo
    Role: Principal Investigator

Patents:

  • Vaccine Antigens for Moraxella catarrhalis Method for stimulating immune response against Moraxella catarrhalis (2010)

Journal Articles:

See all (34 more)

Abstracts:

  • Parameswaran GI, Sethi S, Willet A., Lesse AJ. Methicillin-Resistant Staphylococcus aureus (MRSA) in COPD. ATS International Conference, Philadephia, PA. 2013.
  • Berim I.G., Lesse AJ, Eberhardt E., Grove L.J., Wrona C., Murphy TF, Sethi S. New Strain Acquisition Of Staphylococcus Aureus In Chronic Obstructive Pulmonary Disease Is Not Associated With Exacerbations. ATS International Conference, Denver, CO. 2011.

Presentations:

  • "Faden H, Majeed K, MD, Lesse AJ. Impact of Influenza A 2009 H1N1 (IA) on S. aureus Nasal Colonization in Children" 49th Annual Meeting of the Infectious Disease Society of America, Infectious Disease Society of America (2011)
  • "Lesse AJ, Gill SR, Tsuji BT , Amsterdam D, Sellick JA, Qazi KJ, Mylotte JM Bloodstream infections with Staphylococcus aureus. New data on infections in the era of increased rates of MRSA (Methicillin-Resistant S. aureus)" General Meeting of the American Society for Microbiology, 109th Annual Meeting, ASM (2009)
  • "Tsuji BT, Harigaya Y, Lesse, AJ, Mylotte JM. Attenuation of Vancomycin Killing Activity Against Methicillin-Resistant Staphyloccocus aureus from Bloodstream Infection" Infectious Diseases Society of American 44rd Annual Meeting, IDSA (2006)
  • "Tsuji BT, Mylotte, JM, Forrest A, Lesse AJ. Relationship Between Accessory Gene Regulator (agr) Function and Complications in Staphylococcus aureus Bloodstream Infection" Infectious Diseases Society of American 44rd Annual Meeting, IDSA (2006)
  • "Soltani, K. Blake, M.P. Bratoeva, A.J. Lesse, J.F. John. Multilocus sequence typing (MLST) of nosocomial isolates of Staphylococcus epidermidis." Infectious Diseases Society of American 43rd Annual Meeting, IDSA (2005)

Service Activities:

  • SMBS Phase II Committee; Member (2015–present)
  • SMBS Phase 1 Committee; Member (2012–present)
  • VHAW WNY Institutional Review Board; VA IRB; Member (2011–2015)
  • Student Progress Committee; Member (2009–2015)
  • SMBS Curriculum Committee; Member (2009–present)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

VA Western New York Healthcare System
Research (151)
3495 Bailey Avenue
Buffalo, NY 14215
Phone: (716) 862-6532
Fax: (716) 862-6526
camlesse@buffalo.edu