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Te-Chung                       Lee

Te-Chung Lee PhD

Department of Biochemistry

Associate Professor

Specialty/Research Focus

Cardiology

 
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Professional Summary:

Research in my laboratory is focused on stem cell biology, engineering, and therapeutic applications with an emphasis on cardiovascular repair.

We have explored the immunomodulatory property of bone marrow mesenchymal stem cells (MSCs) in our cell transplantation studies, and found that large quantities of human and porcine MSCs can be implanted in immunocompetent pigs, mice, and hamsters without inducing inflammatory immune responses in the host. Our research shows that MSCs improve cardiac function in the porcine myocardial ischemia and hamster heart failure models. Implanted MSCs promote tissue regeneration by recruiting bone marrow progenitor cells and activating local host stem cell niches. These processes are mediated by inter-tissue cross-talk mechanisms involving signaling molecules such as JAK/STAT3, integrins, VEGF receptors, and Wnt/b-catenin. Our long-term goal is to generate clinically relevant stem cell information that may be used to achieve robust therapeutic effects for a broad spectrum of human diseases and lower the cost of future stem cell therapy.

Education and Training:
  • PhD, Microbiology and Immunology, Virginia Commonwealth University (1989)
  • MS, M.S. in Biochemistry, National Taiwan University (1983)
  • BS, Botany, National Taiwan University (1981)
Employment:
  • Associate Professor, SUNY at Buffalo (1999-present)
  • Assistant Professor, SUNY at Buffalo (1993-present)
  • Research Associate, Cell Biology, Baylor College of Medicine (1990-present)
  • Instructor, Cell Biology, Baylor College of Medicine (1992)
Awards and Honors:
  • Young Investigor Awards (1998)
  • Seventeenth Annual John C. Forbes Honors Day Competition, Medical College o (1989)

Research Expertise:
  • Cell and Molecular Biology
Grants and Sponsored Research:
  • August 1996–November 2014
    Chronic Adaptations to Myocardial Ischemia
    NIH
    Role: Co-Investigator
    $1,850,918
  • January 2006–January 2012
    NIH National Heart Lung and Blood Institute:Mesenchymal Stem Cell Therapeutics in Hibernating Myocardium
    NIH National Heart Lung and Blood Institute
    Role: Principal Investigator
    $1,923,795
  • March 2006–February 2011
    Mesenchymal stem therapeutics in hibernating myocardium
    Role: Co-Investigator
  • April 2008–March 2009
    Rejuvenation and regulation of adult stem cells y cyclin-dependent kinase 1 (Cdk1)
    New York State Stem Cell Board
    Role: Principal Investigator
  • January 2001–March 2002
    Calpain Regulation in Muscle Cells
    MDA
    Role: Principal Investigator
  • January 1998–December 2001
    Calcium-regulated proteolysis in cardiomyocyte apoptosis
    AHA
    Role: Co-Investigator
  • January 1995–December 1997
    Molecular mechanisms of muscle cell growth and differentiation
    MDA
    Role: Principal Investigator
  • July 1994–June 1996
    Transcriptional mechanisms governing protooncogene expression in cultured cardiac myocytes
    AHA
    Role: Principal Investigator
See All (8 Total) >

Journal Articles:
See All (16 Total) >
Abstracts:
  • Feng J, Schaus BJ, Fallavollita JA, Lee TC & Canty JM Jr. Preload induces troponin degradation independently of myocardial ischemia. Circ. Res.. 2001; 103.
  • Kositprapa C, Zhang B, Berger S, Canty JM Jr. & Lee TC. Calpain-mediated proteolytic cleavage of troponin I induced by hypoxia or metabolic inhibition in cultured neonatal cardiomyocytes. Mol. Cell. Biochem.. 2000; 214.
  • Te-Chung Lee. Immunosuppression of Concanavalin A and interferon. Bull. Chinese Oncology Soc.. ; 4.
  • Lee, T. -C. and Tung, T. -C. Studies on the toxicity of Abrin to S-180 Sarcoma cells. Bull. Chinese Oncology Soc.. ; 4.
  • Chen, S. -J., Lee, T. -C. & Tung, T. -C.. Interferon induction in inbred Balb/c mice by Abrus Agglutinin. Bull. Chinese Oncology Soc.. ; 5.
  • Woover SK, Barrett SK, Lee TC & Bear HD. Cyclophosphamide and abrogation of tumor-induced suppressor-T cells activity. Cancer Immunology and Immunotherapy. ; 31.
  • Lee, TC & Christie, GE. Purification and properties of the bacteriophage P2 ogr gene product: A prokaryotic zinc-binding transcriptional activator. J. Biol. Chem.. ; 265.
  • Lee TC, Chow KL, Fang P, Schwartz RJ. Activation of skeletal a-actin gene transcription: The cooperative formation of serum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myoblasts. Mol. Cell. Biol.. ; 11.
  • Lee TC, Shi Y & Schwartz RJ.. Displacement of BrdUrd-induced YY1 by serum response factor activates skeletal a-actin transcription in embryonic myoblasts. Proc. Natl. Acad. Sci. USA. ; 89.
  • Lee, TC & Schwartz, RJ. Differential detection of multiple DNA-binding complexes using dissimilar polyanion competitors. Nucl. Acids Res.. ; 20.
  • Lee TC, French B, Moss J, Sands A & Schwartz RJ.. Regulation of avian sarcomeric a-actin genes by myogenic helix-loop-helix regulatory factors, serum response factors and F-ACT1. Keystone Symposia on Molecular and Cellular Biology..
  • Lee, TC & Schwartz, RJ. Using protease to avoid false identification of protein-DNA complexes in gel shift assays. BioTechniques. ; 12.
  • Lee, TC & Schwartz, RJ. Novel use of a polymeric dye in detecting protein-DNA complexes in gel shift assays. BioTechniques. ; 15.
  • Lee, TC, Zhang, Y & Schwartz, RJ. Bifunctional transcriptional properties of YY1 in regulating oncogene and muscle actin gene transcription. Oncogenes. ; 9.
  • MacLellan WR, Lee TC, Schwartz RJ & Schneider MD. TGFb response elements of the skeletal a-actin gene: Cooperative action of serum response factor and the SV-40 enhancer-binding protein, TEF-1. J. Biol. Chem.. ; 269.
  • Mampuru LJ, Chen SJ, Kalenik JL, Bradley ME & Lee TC. Analysis of events associated with serum deprivation-induced apoptosis in C3H/Sol8 muscle satellite cells. Exp. Cell Res.. ; 226.
  • Kalenik JL, Chen D, Bradley ME, Chen SJ & Lee TC. Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. Nucl. Acid Res.. ; 25.
  • Lee TC, Bradley ME & Walowitz JL. Influence of promoter potency on the transcriptional effects of YY1, SRF, and Msx-1 in transient transfection analysis. Nucl. Acid Res.. ; 26.
  • Chen SJ, Bradley ME & Lee TC. Chemical hypoxia triggers apoptosis of cultured neonatal rat cardiac myocytes: Modulation by calcium-regulated proteases and protein kinases. Mol. Cell. Biochem.. ; 178.
  • Walowitz JL, Bradley ME, Chen SJ & Lee TC. Proteolytic regulation of the zinc finger transcription factor YY1, a repressor of muscle-restricted gene expression. J. Biol. Chem.. ; 273.
  • Hiltke TR, Lee TC & Bobek LA. Inhibitory profiles of human recombinant cystatins C and SN on several known cysteine proteinases. J. Dental Res.. ; 78.
See All (21 Total) >

Professional Memberships:
  • American Heart Association (1996)
  • ASBMB (1994)
Presentations:
  • "Skeletal muscle injection of plasmid VEGF165 improves myocardial flow and function in swine with hibernating myocardium" conference, American Heart Association (2002)
  • "Intracoronary administration of AdvFGF-5 improves resting function but does not alter myocardial perfusion during adenosine vasodilation in hibernating myocardium" Conference, American Heart Association (2001)
  • "Hypoxic Response in Cardiomyocytes" Conference, Great Lakes Muscle Symposium (2001)
  • "Positron emission tomography reveals viability and revascularization of cell patch cardiomyoplasty" Conference, American College of Chest Physicians (2001)
  • "Cardiomyocyte apoptosis and selective calcium-mediated proteolysis of cardiac troponin I. Scientific Conference on molecular, cellular, and integrated physiological approaches to the failing heart" Conference, American Heart Association (1999)
  • "Pharmacological preconditioning and selective degradation of contractile proteins associated with simulated hypoxia-induced apoptosis of cultured neonatal cardiomyocytes" Conference, European Heart House (1998)
  • ". Proteolytic regulation of the zinc finger factor YY1, a repressor of myogenic transcription" Conference, ASBMB (1997)
  • ". Analysis of events associated with serum deprivation-induced apoptosis in muscle satellite cells" Conference, ASBMB (1996)
Service Activities:
  • School of Medicine & Biomedical Sciences Apppointment, Promotions,Tenure & Privileges; Member (2000)
  • School of Medicine & Biomedical Sciences Admissions Committee; Department Representative (1995–2001)
  • Biomedical Research Service Center; To promote research collaborations among basic and clinical scientists and commercialize research and diagnostic reagents; Director (2002)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

140 Farber Hall
3435 Main Street
Buffalo, NY 14214
Phone: (716) 8293106
Email: chunglee@buffalo.edu


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