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Corinne                        Leach

Corinne L. Leach MD, PhD

Department of Pediatrics

Associate Professor

Specialty/Research Focus

Neonatal-Perinatal Medicine; Neonatology; Pediatrics

 

Education and Training:
  • Fellowship, Neonatal-Perinatal Medicine, Children's Hospital of Philadelphia (1988)
  • Residency, Pediatrics, Children‘s Hospital of Philadelphia (1986)
  • Internship, Pediatrics, Children‘s Hospital of Philadelphia (1984)
  • MD, Medicine, Temple University School of Medicine, Highest Honors (1983)
  • PhD, Cardiopulmonary Physiology, Temple University School of Medicine (1983)
  • BS, Biology, Mount Saint Mary College, magna cum laude (1976)
Employment:
  • Neonatologist, Faxton St. Luke's Medical Center (2014-present)
  • Director, NICU Quality Assurance, Women and Children‘s Hospital of Buffalo (2002-present)
  • Associate Professor, Pediatrics, University at Buffalo (1997-present)
  • Attending Physician, Division of Neonatology, UBMD Pediatrics, Millard Fillmore Suburban Hospital (1990-present)
  • Attending Physician, Division of Neonatology, UBMD Pediatrics, Women and Children‘s Hospital of Buffalo (1988-present)
  • Attending Neonatologist, Arnot Ogden Medical Center (2010–2013)
  • Medical Director, Respiratory Therapy, Women and Children‘s Hospital of Buffalo (1989–2005)
  • Fellowship Program Director, Division of Neonatal-Perinatal Medicine, Women and Children‘s Hospital of Buffalo (1989–1999)
  • Attending Neonatologist, Sisters of Charity Hospital (1996–1998)
  • Attending Physician, Division of Neonatology, Buffalo General Hospital (1996–1998)
  • Assistant Professor, Pediatrics, University at Buffalo (1988–1997)
  • Instructor, University of Pennsylvania, School of Medicine (1983–1988)
  • First Lieutenant, U.S. Air Force Reserves (1972–1986)
See all (3 more)
Awards and Honors:
  • Western New York Perinatal Bereavement Network: Physician of the Year (2015)
  • The Leading Physicians of the World (2010)
  • Who‘s Who Among America‘s Teachers and Educators (2006)
  • Honors Convocation Philadelphia: Keynote Speaker (1999)
  • Cardinal O‘Hara (Philadelphia, PA): Hall of Fame (1999)
  • Boston Children‘s Hospital/Harvard Medical School: Keynote Speaker (1997)
  • New York Legislature Resolution No. 21-14: Commendation for Research (1996)
  • Baylor College of Medicine: First AJ Rudolph Visiting Professorship (1996)
  • Society for Pediatric Research: House Officer Research Award (1994)
  • Society of Critical Care Medicine: House Officer Research Award (1993)
  • Mount Saint Mary College: Distinguished Alumni Award (1985)
  • Alpha Omega Alpha Honor Medical Society (1982)
  • National Honor Society (Philadelphia, PA): Keynote Speaker (1980)
  • A.N. Richards Award for Young Investigators (Finalist) (1979)
  • Temple University School of Medicine: Graduate Fellowship Award (1979)
  • U.S. Air Force: Award for Outstanding Leadership and Scholarship (1976)
  • Daughters of the American Revolution: National Military Achievement Medal (1976)
  • Delta Epsilon Sigma Honor Society (1976)
  • Beta Beta Beta National Biological Honor Society (1975)
  • America's Top Pediatricians (2009-Present)
  • Best Doctors in America (1996-Present)

Grants and Sponsored Research:
  • January 2015–January 2017
    Hypothermia in the Late Preterm Infant
    Eunice Kennedy Shriver National Institute of Child Health and Human Development
    Role: Principal Investigator
    $1,200,000
  • January 2010–January 2012
    A Phase 2b/3, Multi-Center, Randomized, Double-Blind, Placebo Controlled Trial to Evaluate the Safety and Efficacy of Pagibaximab Injection in Very Low Birth Weight (VLBW) Neonates for the Prevention of Staphylococcal Sepsis
    Biosynexus, Inc.
    Role: Principal Investigator
    $120,000
  • January 2001–January 2006
    Hydrocortisone prophylaxis for the prevention of chronic lung disease in preterm infants
    National Institutes of Health
    Role: Principal Investigator
    $1,200,000

Journal Articles:
See all (24 more)
Abstracts:
  • Watterberg K, Leach CL. Increased Risk of Intestinal Perforation in Infants Receiving Both Indocin and Hydrocortisone. Pediatr Res. 2004; 55(6).
  • Ryan RM, Leach TJ, Elder F, Holm BA, Leach CL. Ultraviolet Germicidal Irradiation of Hospital Ventilation Systems Reduces Microbial Contamination in NICU. Pediatr Res. 2003; 53(4).
  • Watterberg K, Leach CL. Prophylactic Hydrocortisone to Prevent Adrenal Insufficiency in Preterm Neonates at Risk for BPD. Pediatr Res. 2003; 53(4).
  • Leach CL, Morin FC, Fuhrman BP, Hernan LJ. Efficacy and Pharmacokinetics of Nitric Oxide Inhalation During Partial Liquid Ventilation with LiquiVent. Am J Respir Crit Care Med. 1999.
  • Leach CL, Fox WW, Greenspan JS, Fuhrman BP. Chest Radiographs in Term and Preterm Neonates Treated with PLV: Distribution of Perflubron and Patterns of Lung Recruitment. Am J Respir Crit Care Med. 1999.
  • Peregrino MA, Sukumar M, Bommaraju M, Holm BA, Hernan LJ, Fuhrman BP, Leach CL. High Frequency PLV vs. Infasurf Rescue in Preterm Lambs with RDS. Am J Respir Crit Care Med. 1999.
  • Peregrino MA, Sukumar M, Bommaraju M, Holm BA, Hernan LJ, Fuhrman BP, Morin FC, Leach CL. High Frequency Partial Liquid Ventilation vs. Surfactant Rescue in Preterm Lambs with Respiratory Distress Syndrome. Pediatr Res. 1998; 43.
  • Peregrino MA, Sukumar M, Bommaraju M, Holm BA, Hernan LJ, Fuhrman BP, Morin FC, Leach CL. High Frequency Partial Liquid Ventilation vs. Infasurf Rescue in Preterm Lambs with RDS. J Investig Med. 1998; 46.
  • Bommaraju M, Sukumar M, Holm BA, Leach CL. The Effect of Partial Liquid Ventilation on Alveolar Type II Cell Function and Surfactant Production. Pediatr Res. 1998; 43.
  • Leach CL, Fox WW, Greenspan JS, Backstrom J, LiquiVent Study Group. Serial Filling and Evaporative Patterns of Chest Radiographs in Term and Preterm Neonates Treated with Partial Liquid Ventilation with Perflubron. Pediatr Res. 1997; 41.
  • Fox WW, Greenspan JS, Leach CL, Wolfson MR, Shaffer TH, LiquiVent Study Group. Alveolar Recruitment During and After Tracheal Instillation of LiquiVent in Infants on Partial Liquid Ventilation. Pediatr Res. 1997; 41.
  • Leaderstorf M, Bloomberg D, Mauro-Schukraft PM, Leach CL. Therapist Driven Protocol in Children‘s Hospital: Enhanced Patient Care, Resource Utilization, and Medical Staff Educationa. Respir Care. 1997.
  • Toro-Figueroa LO, Meliones JN, Curtis SE, Thompson AE, Hirschl RB, Fackler JC, Newth CJL, Leach CL. Perflubron Partial Liquid Ventilation (PLV) in Children with ARDS: A Safety and Efficacy Pilot Study. Crit Care Med. 1996; 24(S1).
  • Leach CL, Holm BA, Steinhorn DM, Papo MC, Morin FC, Fuhrman BP, Hernan LJ. The Effect of Partial Liquid Ventilation on Endogenous Surfactant in Preterm Lambs with Respiratory Distress Syndrome. Am J Respir Crit Care Med. 1996; 153(4).
  • Sukumar M, Holm BA, Papo M, Morin FC, Steinhorn D, Fuhrman BP, Leach CL. The Hemodynamic Response to High Frequency Partial Liquid Ventilation (HF-PLV) and Surfactant in the Preterm Lamb with Respiratory Distress Syndrome (RDS). Am J Respir Crit Care Med. 1996; 153(4).
  • Papo M, Steinhorn DM, Enrinone M, Leach CL, Hernan LJ, Fuhrman BP, Dowhy M, Rath M, Frisacario P. The Effect of Partial Liquid Ventilation (PLV) on Protein Leak and Surface Tension in a Model of Acute Lung Injury. Am J Respir Crit Care Med. 1996; 153(4).
  • Enrinone M, Papo M, Leach CL, Hernan LJ, Fuhrman BP, Dowhy M, Rath M, Frisacario P. Distribution of Pulmonary Blood Flow During Partial Liquid Ventilation in Normal Piglets and During Acute Lung Injury. Am J Respir Crit Care Med. 1996; 153(4).
  • Steinhorn DM, Leach CL, Fuhrman BP, Holm BA. Partial Liquid Ventilation Enhances Surfactant Phospholipid Production. Am J Respir Crit Care Med. 1996; 153(4).
  • Albert GP, Leach CL, Hernan LJ, Morin FC. Pulmonary Mechanics and Hemodynamics in a Meconium Aspiration (MAS) Lamb Model Treated with Partial Liquid Ventilation (PLV) and Nitric Oxide (NO). Pediatr Res. 1996; 39.
  • Leach CL, Sukumar M, Holm BA, Papo M, Morin FC, Steinhorn D, Fuhrman BP, Hernan LJ. High Frequency Partial Liquid Ventilation and Surfactant Treatment in Preterm Lambs with Respiratory Distress Syndrome. Pediatr Res. 1996; 39.
  • Sukumar M, Morin FC, Papo MC, Steinhorn D, Holm BA, Fuhrman BP, Hernan LJ, Leach CL. The Hemodynamic Response to High Frequency Partial Liquid Ventilation in the Preterm Lamb with Respiratory Distress Syndrome (RDS). Pediatr Res. 1996; 39.
  • Steinhorn D, Smith T, Leach CL, Fuhrman BP, Holm BA. Partial Liquid Ventilation Increases Lung Phospholipid Synthesis in Healthy Adult Rabbits. Crit Care Med. 1996; 24.
  • Hernan LJ, Penfil S, Fuhrman BP, Dowhy MS, Frisacario P, Rath M, Papo MC, Leach CL. Functional FIO2 Predicts Alveolar PO2 (PAO2) During Perfluorocarbon Associated Gas Exchange (PAGE). Crit Care Med. 1996; 24.
  • Smith T, Papo M, Leach CL, Hernan LJ, Fuhrman BP, Dowhy M, Rath M, Frisacario P. Pulmonary Blood Flow Distribution During Partial Liquid Ventilation in the Oleic Acid Injury Piglet Model of ARDS. Crit Care Med. 1996; 24.
  • Penfil S, Hernan LJ, Fuhrman BP, Papo MC, Leach CL, Frisacario P, Foley CK. Relationship Between Volume of Perflubron (PFOB) and Arterial Oxygenation During Partial Liquid Ventilation. Crit Care Med. 1996; 24.
  • Leach CL, Greenspan JS, Rubenstein SD, Shaffer TH, Wolfson MR, Jackson JC, DeLemos R, Fuhrman BP. Partial Liquid Ventilation with LiquiVent: A Pilot Safety and Efficacy Study in Premature Newborns with Severe Respiratory Distress Syndrome (RDS). Pediatr Res. 1995; 37(4).
  • Leach CL, Holm BA, Morin FC, Fuhrman BP, Papo MC, Hernan LJ. Partial Liquid Ventilation with LiquiVent Increases Endogenous Surfactant Production in Premature Lambs with Respiratory Distress Syndrome (RDS). Pediatr Res. 1995; 37(4).
  • Papo MC, Enrinone M, Fuhrman BP, Hernan LJ, Leach CL, Rath M, Dowhy M. The Efficacy of Cardiopulmonary Resuscitation During Perfluorocarbon Associated Gas Exchange. Pediatr Res. 1995; 37(4).
  • Hernan LJ, Fuhrman BP, Kaiser RE, Penfil S, Foley C, Papo MC, Leach CL. Perfluorocarbon Associated Gas Exchange (PAGE) in Normal and Acid-Injured Large Sheep. Crit Care Med. 1995; 21(1 Sup).
  • Papo M, Holm BA, Fuhrman BP, Hernan LJ, Steinhorn D, Leach CL, Kahn B. Perfluorocarbon Associated Gas Exchange (PAGE) Instituted Prior to Lung Injury Decreases Intra-Alveolar Protein Flux. Crit Care Med. 1994; 21(1).
  • Salman N, Fuhrman BP, Papo M, Hernan LJ, Steinhorn D, Leach CL, Paczan P, Kahn B. Oxygenation and Lung Mechanics During Evaporation of Perflubron After Perflurocarbon Associated Gas Exchange (PAGE) in Normal Piglets. Crit Care Med. 1994; 22(1).
  • Fuhrman BP, Hernan LJ, Leach CL, Papo MC, Steinhorn DM. Determinants of Oxygenation and Airway Pressure During Volume Regulated Perfluorocarbon (P) Associated Gas Exchange (PAGE). Pediatr Res. 1994; 35(4).
  • Wilcox DT, Glick PL, Karamanoukian H, Morin FC, Fuhrman BP, Leach CL. Perfluorocarbon Associated Gas Exchange (PAGE) and Nitric Oxide in the Lamb Congenital Diaphragmatic Hernia Model. Pediatr Res. 1994; 35(4).
  • Leach CL, Morin FC, Fuhrman BP, Hernan LJ, Papo M, Steinhorn D, Steinhorn RH. Efficacy and Pharmacokinetics of Nitric Oxide Inhalation During Partial Liquid Ventilation with Perflubron (LiquiVent). Pediatr Res. 1994; 35(4).
  • Leach CL, Fuhrman BP, Morin FC, Rath MG, Hernan LJ, Holm BA, Papo MC, Steinhorn DM. Perfluorocarbon Associated Gas Exchange (PAGE) with Perflubron (LiquiVentTM) in Respiratory Distress Syndrome. Pediatr Res. 1993; 33(4).
  • Papo M, Paczan P, Burak B, Holm BA, Salman N, Steinhorn D, Hernan LJ, Leach CL, Fuhrman BP. A Medical Grade Perfluorocarbon Used During PAGE Improves Oxygenation and Ventilation in a Model of ARDS. Pediatr Res. 1993; 33(4).
  • Hernan LJ, Fuhrman BP, Paczan P, Salman N, Papo MC, Steinhorn DM, Leach CL, Holm BA, Burak B. Perfluorocarbon Associated Gas Exchange (PAGE) in Normal Piglets Using Reduced Inspired Oxygen Concentrations. Am Rev Resp Dis. 1993; 147(4).
  • Papo M, Paczan P, Burak B, Holm BA, Salman N, Steinhorn D, Hernan LJ, Leach CL, Fuhrman BP. A Medical Grade Perfluorocarbon Used During PAGE Improves Oxygenation and Ventilation in a Model of ARDS. Crit Care Med. 1993; 21(4).
  • Nesti FD, Fuhrman BP, Papo MC, Steinhorn DM, Hernan LJ, Duffy LC, Leach CL, Holm BA, Paczan P, Burak B. Perfluorocarbon Associated Gas Exchange (PAGE) in Gastric Aspiration. Crit Care Med. 1993; 21(4).
  • Nesti FD, Fuhrman BP, Papo MC, Steinhorn DM, Hernan LJ, Duffy LC, Leach CL, Holm BA, Paczan P, Burak B. Perfluorocarbon Associated Gas Exchange (PAGE) in Gastric Aspiration. Pediatr Res. 1993; 33(4).
  • Hernan LJ, Fuhrman BP, Paczan P, Salman N, Papo MC, Steinhorn DM, Leach CL, Holm BA. Determinants of PaO2 During Perfluorocarbon Associated Gas Exchange (PAGE) in Normal Piglets. Crit Care Med. 1993; 21.
  • Salman N, Fuhrman BP, Papo MC, Hernan LJ, Steinhorn DM, Leach CL, Paczan P, Burak B, Holm BA. Oxygenation and Lung Mechanics During 24 Hour Trials of Perfluorocarbon Associated Gas Exchange in Normal Piglets. Pediatr Res. 1993; 33(4 Pt2).
  • Leach CL, Fuhrman BP. Lung Mechanics and Perfluorocarbon Associated Gas Exchange (PAGE) in Surfactant Deficiency. Pediatr Res. 1992; 31(4).
  • Leach CL, Fuhrman BP. Perfluorocarbon Associated Gas Exchange (PAGE) in Surfactant Deficiency. Am Rev Resp Dis. 1992; 145(4).
  • Glick PL, Stannard VA, Leach CL. Pathophysiology of Congenital Diaphragmatic Hernia II: The Fetal Lamb CDH Model is Surfactant Deficient. Am Rev Resp Dis. 1991.
  • Glick PL, Leach CL, Besner GD. Pathophysiology of Congenital Diaphragmatic Hernia III: Surfactant Replacement for the High Risk Neonate with CDH. Am Rev Resp Dis. 1991.
  • Lowe CA, Shaffer TH, Spitzer AR. Mechanical Ventilation with Heliox Decreases Airway Resistance. Pediatr Res. 1988; 23.
  • Shaffer TH, Douglas PR, Sivieri EM, Lowe CA, Snyder SM, Bhutani VK. Liquid Ventilation: Improved Oxygenation in Meconium Stained Lambs with Persistent Fetal Circulation. Pediatr Res. 1982; 16.
  • Lowe CA, Shaffer TH. Redistribution of Blood Flow in the Fluorocarbon-filled Lung. Fed Proc. 1981; 40.
  • Douglas PR, Snyder SM, Lowe CA, Sivieri EM, Bhutani VK, Shaffer TH. Improved Lung Function in Preterm Lambs After Liquid Ventilation. Fed Proc. 1981; 40.
  • Lowe CA, Shaffer TH. Changes in Pulmonary Vascular Resistance During Liquid Ventilation. Fed Proc. 1980; 39.
  • Lowe CA, Sivieri EM, Tuma RF, Shaffer TH. Changes in Cardiac Output and Regional Blood Flow During Liquid Breathing. Fed Proc. 1979; 38.
  • Lowe CA, Tran N, Sivieri EM, Shaffer TH. Sequential Physiological Effects of Acute Meconium Obstruction on Pulmonary Mechanics. Physiologist. 1978; 21(4).
See all (43 more)
Books and Book Chapters:
  • Leach CL. "Liquid Ventilation of Newborn Babies". Neonatal Monitor 15. 1996.

Professional Memberships:
  • American Thoracic Society (1999–2000)
  • European Thoracic Society (1999–2000)
  • American Medical Association (1995–2000)
  • American Academy of Pediatrics: Fellow (FAAP) (1990–present)
  • Philadelphia Perinatal Society (1986–1988)
  • Society of Neonatal-Perinatal Medicine
  • Buffalo Pediatric Society
  • Society for Pediatric Research
Presentations:
  • "High Frequency Ventilation of the Surgical NICU Patient" Pediatric Surgery Grand Rounds, Women and Children's Hospital of Buffalo (2015)
  • "Caffeine for the Treatment of Intermittent Hypoxia in the Preterm Infant after 34 Weeks Post-Menstrual Age" Neonatology Conference, Women and Children's Hospital of Buffalo (2014)
  • "Conventional Ventilation of the Surgical NICU Patient" Pediatric Surgery Grand Rounds, Women and Children's Hospital of Buffalo (2014)
  • "Development of a Joint Ob-Neo Approach to the Periviable Pregnancy" High Risk Perinatal Medicine Conference, Women and Children's Hospital of Buffalo (2014)
  • "Kernicterus in the 21st Century" Neonatology Conference, Women and Children's Hospital of Buffalo (2014)
  • "Resuscitation and Outcome of the Periviable Infant" Joint Obstetrics/Neonatology Conference, Women and Children's Hospital of Buffalo (2014)
  • "Ethics of Decision-Making in the ELBW Newborn with Borderline Visibility" Neonatology Thruway Conference (2013)
  • "Ethics of Decision-Making for the Borderline Viable Newborn" Neonatology Conference, Women and Children's Hospital of Buffalo (2013)
  • "New Approaches to High Frequency Jet Ventilation in the ELBW Infant" NICU Transport Conference, Women and Children's Hospital of Buffalo (2013)
  • "Death and Dying in the Pediatric Patient" Pediatric Residents Conference, Women and Children‘s Hospital of Buffalo (2008)
  • "It's Here! A Cool Therapy for Brain Injury" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (2008)
  • "Be Careful What You Breathe: A 'New' Look at Nosocomial Infection" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (2007)
  • "Enhanced Ultraviolet Germicidal Irradiation in Hospital Heating Ventilation and Air Conditioning Systems Decreases Ventilator-Associated Pneumonia" Annual Meeting, Pediatric Academic Societies (2007)
  • "Effect of Enhanced Ultraviolet Germicidal Irradiation in a Heating Ventilation and Air Conditioning System on Nosocomial Infection in a Neonatal Intensive Care Unit" Annual Meeting, Society for Healthcare Epidemiology of America (SHEA) (2007)
  • "Effect of eUVGI on Ventilator-Associated Pneumonia" Pulmonary Biology Research Seminar, Women and Children‘s Hospital of Buffalo (2006)
  • "A Cosyntropin (ACTH) Dose of 0.1 mcg/kg is Inadequate to Test Adrenal Function in Extremely Low Birth Weight Infants" National Conference and Exhibition, American Academy of Pediatrics (2004)
  • "Increased Risk of Intestinal Perforation in Infants Receiving Both Indocin and Hydrocortisone" Annual Meeting, Society for Pediatric Research (2004)
  • "Epidemiology of Hospital-Acquired Staphylococcal Infection in Preterm Infants" A Biosynexus Multicenter Trial, Women and Children‘s Hospital of Buffalo (2004)
  • "UVGI (Vigilair) to Decrease NICU Contamination and Hospital-Acquired Infection" Pulmonary Biology Research Seminar, Women and Children‘s Hospital of Buffalo (2003)
  • "Prophylactic Hydrocortisone to Prevent Adrenal Insufficiency in Preterm Neonates at Risk for BPD" Annual Meeting, Society for Pediatric Research (2003)
  • "Ultraviolet Germicidal Irradiation of Hospital Ventilation Systems Reduces Microbial Contamination in NICU" Annual Meeting, Society for Pediatric Research (2003)
  • "The Effect of UVGI Applied to Heating and Air Conditioning Systems on Reducing Nosocomial Infections in the Neonatal ICU" Neonatal Research Conference, Women and Children‘s Hospital of Buffalo (2001)
  • "Liquid Ventilation - Clinical Science and Application on Transport" Pediatric Transport Conference, University of Utah Children's Medical Center (2000)
  • "Ventilator Strategies for Management of Neonatal Lung Injury" Pediatric Transport Conference, University of Utah Children's Medical Center (2000)
  • "Treatment of Neonatal Brain Injury" 23rd Ross Fellows Seminar on Perinatal Medicine (1999)
  • "Chest Radiographs in Term and Preterm Neonates Treated with PLV: Distribution of Perflubron and Patterns of Lung Recruitment" International Conference, American Thoracic Society (1999)
  • "Efficacy and Pharmacokinetics of Nitric Oxide Inhalation During Partial Liquid Ventilation with LiquiVent" International Conference, American Thoracic Society (1999)
  • "High Frequency PLV vs. Infasurf Rescue in Preterm Lambs with RDS" International Conference, American Thoracic Society (1999)
  • "Hypoxic Ischemic Encephalopathy in Infants - New Approaches to Treatment" Pediatric Transport Conference, University of Utah Children's Medical Center (1999)
  • "Transport of the Infant with a Perfluorocarbon-filled Lung" Pediatric Transport Conference, University of Utah Children's Medical Center (1999)
  • "Does Chorioamnionitis Cause Cerebral Palsy?" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (1999)
  • "The Effect of Partial Liquid Ventilation on Alveolar Type II Cell Function and Surfactant Production" Fellow Conference, Mead Johnson (1998)
  • "Partial Liquid Ventilation - Recent Advances" 20th Academic Meeting, Japan Society of Respiratory Care Medicine (1998)
  • "Partial Liquid Ventilation in Future Clinical Trials for Prevention of BPD?" National Children's Medical Research Center, National Children's Hospital (1998)
  • "Liquid Ventilation - Development and Clinical Progress" 22nd Ross Fellows Seminar on Perinatal Medicine (1998)
  • "High Frequency Partial Liquid Ventilation vs. Surfactant Rescue in Preterm Lambs with Respiratory Distress Syndrome" Annual Meeting, Society for Pediatric Research (1998)
  • "The Effect of Partial Liquid Ventilation on Alveolar Type II Cell Function and Surfactant Production" Annual Meeting, Society for Pediatric Research (1998)
  • "High Frequency Partial Liquid Ventilation vs. Infasurf Rescue in Preterm Lambs with RDS" Annual Meeting, Eastern Society for Pediatric Research (1998)
  • "Algorithm-guided Team Respiratory Care: Enhanced Patient Care, Resource Utilization, and House Staff Education" Neonatology Research Conference, Women and Children‘s Hospital of Buffalo (1998)
  • "Congenital Diaphragmatic Hernia: Current Approaches to Management" Pediatric Transport Conference, University of Utah Children's Medical Center (1998)
  • "Partial Liquid Ventilation for Transport of the Critically Ill Neonate" Pediatric Transport Conference, University of Utah Children's Medical Center (1998)
  • "Partial Liquid Ventilation - What's Ahead in Clinical Trials?" State-of-the-Art Symposium, American Academy of Pediatrics (1998)
  • "The Pediatric Patient in Respiratory Distress: A Team Approach" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (1998)
  • "Therapist Driven Protocol in Children's Hospital: Enhanced Patient Care, Resource Utilization, and Medical Staff Educationa" International Convention, American Association for Respiratory Care (1997)
  • "Liquid Ventilation - New Treatment for Respiratory Failure in Infants" Symposium: New Strategies in the Care of the High Risk Infant - An Update, New York University Medical Center (1997)
  • "Partial Liquid Ventilation in Infants with Respiratory Failure" Connecticut Perinatal Association, Yale University/University of Connecticut (1997)
  • "Status of Liquid Ventilation Trials" Neonatology Research Conference, Women and Children‘s Hospital of Buffalo (1997)
  • "Liquid Ventilation: State-of-the-Art" Perinatal Sections District V/VI, Midwest Society of Pediatric Research (1997)
  • "Partial Liquid Ventilation - Neurologic Outcome" 1997 Rose and Al Pastor Lecture Series, Women and Children‘s Hospital of Buffalo (1997)
  • "Chorioamnionitis and Cerebral Palsy" 21st Ross Fellows Seminar on Perinatal Medicine, Infectious Disease in Perinatology (1997)
  • "Liquid Ventilation: It's Not Just Science Fiction" Norwegian Pediatric Federation, University of Dragvoll (1997)
  • "Alveolar Recruitment During and After Tracheal Instillation of LiquiVent in Infants on Partial Liquid Ventilation" Annual Meeting, Society for Pediatric Research (1997)
  • "Liquid Ventilation - The First Clinical Trials" Keynote Address - Neonatology Research Symposium, Children's Hospital/Harvard Medical School (1997)
  • "Serial Filling and Evaporative Patterns of Chest Radiographs in Term and Preterm Neonates Treated with Partial Liquid Ventilation with Perflubron" Annual Meeting, Society for Pediatric Research (1997)
  • "Congenital Diaphragmatic Hernia: New Insights into Pathophysiology and Management" Neonatology Grand Rounds, University of Iowa (1997)
  • "Liquid Ventilation: It's Not Just Science Fiction" Grand Rounds, University of Iowa (1997)
  • "Congenital Diaphragmatic Hernia: Controversies in Pathophysiology and Management" Visiting Professor, University of Oslo Medical Center (1996)
  • "High Frequency Ventilation - Disease Specific Strategies in the Newborn" Annual Meeting, Norwegian Perinatal Society (1996)
  • "Liquid Ventilation: Laboratory Development and Clinical Trials" Visiting Professor, University of Oslo Medical Center (1996)
  • "Liquid Ventilation: State-of-the-Art" Annual Meeting, Norwegian Perinatal Society (1996)
  • "Liquid Breathing" National Radio Broadcast, National Public Radio (NPR) (1996)
  • "Liquid Breathing in Infants with RDS" Update, Channel 4 News (1996)
  • "Liquid Ventilation Clinical Trials" New York Neonatology Thruway Conference, University of Rochester (1996)
  • "Partial Liquid Ventilation for Respiratory Failure in Infants" British Broadcasting Network, British Broadcasting Corporation (BBC) (1996)
  • "Liquid Ventilation" 20th Ross Fellows Seminar on Perinatal Medicine, Controversies in Perinatology (1996)
  • "Liquid Ventilation Clinical Trials" Respiratory Care and Nursing Neonatology Symposium, Indiana University Medical Center (1996)
  • "Liquid Ventilation: State-of-the-Art" Pediatric Grand Rounds, Riley Children's Hospital/Indiana University Medical Center, Visiting Professor (1996)
  • "Management of the Infant with Congenital Diaphragmatic Hernia" 20th Ross Fellows Seminar on Perinatal Medicine, Controversies in Perinatology (1996)
  • "Practical Management of the Infant Receiving Partial Liquid Ventilation" International Conference - Respiratory Care of the Newborn, Columbia University College of Medicine, Visiting Professor (1996)
  • "Distribution of Pulmonary Blood Flow During Partial Liquid Ventilation in Normal Piglets and During Acute Lung Injury" International Conference, American Thoracic Society (1996)
  • "High Frequency Partial Liquid Ventilation and Surfactant Treatment in Preterm Lambs with Respiratory Distress Syndrome" Annual Meeting, Society for Pediatric Research (1996)
  • "Partial Liquid Ventilation Enhances Surfactant Phospholipid Production" International Conference, American Thoracic Society (1996)
  • "The Effect of Partial Liquid Ventilation (PLV) on Protein Leak and Surface Tension in a Model of Acute Lung Injury" International Conference, American Thoracic Society (1996)
  • "The Effect of Partial Liquid Ventilation on Endogenous Surfactant in Preterm Lambs with Respiratory Distress Syndrome" International Conference, American Thoracic Society (1996)
  • "The Hemodynamic Response to High Frequency Partial Liquid Ventilation (HF-PLV) and Surfactant in the Preterm Lamb with Respiratory Distress Syndrome (RDS)" International Conference, American Thoracic Society (1996)
  • "The Hemodynamic Response to High Frequency Partial Liquid Ventilation in the Preterm Lamb with Respiratory Distress Syndrome (RDS)" Annual Meeting, Society for Pediatric Research (1996)
  • "Functional FIO2 Predicts Alveolar PO2 (PAO2) During Perfluorocarbon Associated Gas Exchange (PAGE)" Annual Congress, Society of Critical Care Medicine (1996)
  • "Liquid Ventilation: State-of-the-Art" Grand Rounds, Texas Children‘s Hospital/Baylor College of Medicine, First Arnold J. Rudolph Visiting Professor (1996)
  • "Partial Liquid Ventilation Increases Lung Phospholipid Synthesis in Healthy Adult Rabbits" Annual Congress, Society of Critical Care Medicine (1996)
  • "Partial Liquid Ventilation: From Bench to Bedside" Pediatric Cardiology and Neonatology Conference, Texas Children's Hospital/Baylor College of Medicine (1996)
  • "Pulmonary Blood Flow Distribution During Partial Liquid Ventilation in the Oleic Acid Injury Piglet Model of ARDS" Annual Congress, Society of Critical Care Medicine (1996)
  • "Relationship Between Volume of Perflubron (PFOB) and Arterial Oxygenation During Partial Liquid Ventilation" Annual Congress, Society of Critical Care Medicine (1996)
  • "Respiratory Distress - A Liquid Solution" Management of the Tiny Baby Conference, University of Florida College of Medicine (1996)
  • "The Art and Science of Breathing Liquids" Management of the Tiny Baby Conference, University of Florida College of Medicine (1996)
  • "Liquid Ventilation - From the Laboratory to Clinical Trials" Physiology Research Day, University at Buffalo, Department of Physiology (1996)
  • "Partial Liquid Ventilation in Premature Infants - A Pilot Study" Special Conference, Ross Laboratories, Hot Topics '95 in Neonatology (1995)
  • "The Liquid Solution: Clinical Trials of Partial Liquid Ventilation" Special Conference, Ross Laboratories, Hot Topics '95 in Neonatology (1995)
  • "The First Human Experience with Partial Liquid Ventilation" The First Annual Fall Neonatology Symposium, Vanderbuilt University School of Medicine, District IV Perinatal Section of American Academy of Pediatrics (1995)
  • "Partial Liquid Ventilation (PLV) with Perflubron (LiquiVent): A Pilot Safety and Efficacy Study in Children with ARDS" 8th Pediatric Critical Care Colloquium (1995)
  • "Laboratory Development and Clinical Trials of Partial Liquid Ventilation" Research 2000, National Institutes of Health: NINCDS/Women and Children‘s Hospital of Buffalo (1995)
  • "Partial Liquid Ventilation with LiquiVent Increases Endogenous Surfactant Production in Premature Lambs with Respiratory Distress Syndrome (RDS)" Annual Meeting, Society for Pediatric Research (1995)
  • "Partial Liquid Ventilation with LiquiVent: A Pilot Safety and Efficacy Study in Premature Newborns with Severe Respiratory Distress Syndrome (RDS)" Annual Meeting, Society for Pediatric Research (1995)
  • "Respiratory Care Evaluation Service in a Pediatric Center: Improved Outcome" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (1995)
  • "The Efficacy of Cardiopulmonary Resuscitation During Perfluorocarbon Associated Gas Exchange" Annual Meeting, Society for Pediatric Research (1995)
  • "The First Clinical Trial of Partial Liquid Ventilation" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (1995)
  • "Liquid Breathing: It's Not Just Science Fiction" Advanced Practice in Neonatal Care, Emory University (1995)
  • "Partial Liquid Ventilation: From the Laboratory to the Bedside" Advanced Practice in Neonatal Care, Emory University (1995)
  • "Development of Partial Liquid Ventilation" Research 2000, March of Dimes/Women and Children's Hospital of Buffalo (1995)
  • "Liquid Ventilation, Here and Now" Respiratory Diseases 2000, Medical College of Georgia (1995)
  • "Perfluorocarbon Associated Gas Exchange (PAGE) in Normal and Acid-Injured Large Sheep" Annual Congress, Society of Critical Care Medicine (1995)
  • "Partial Liquid Ventilation and Nitric Oxide" Special Conference, Ross Laboratories, Hot Topics '94 in Neonatology (1994)
  • "Partial Liquid Ventilation in Human Neonates" Special Conference, Ross Laboratories, Hot Topics '94 in Neonatology (1994)
  • "Partial Liquid Ventilation in Preterm Infants with Respiratory Distress Syndrome" New York Neonatology Thruway Conference, Abany University (1994)
  • "Early Clinical Trials of Liquid Ventilation in Newborns" Annual Meeting, American Academy of Pediatrics, State-of-the-Art Lecture (1994)
  • "Partial Liquid Ventilation in Preterm Infants with Respiratory Distress Syndrome" National Conference and Exhibition, American Academy of Pediatrics (1994)
  • "New Roads in Respiratory Care" Evening News, Channel 4 (1994)
  • "Determinants of Oxygenation and Airway Pressure During Volume Regulated Perfluorocarbon (P) Associated Gas Exchange (PAGE)" Annual Meeting, Society for Pediatric Research (1994)
  • "Efficacy and Pharmacokinetics of Nitric Oxide Inhalation During Partial Liquid Ventilation with Perflubron (LiquiVent)" Annual Meeting, Society for Pediatric Research (1994)
  • "Perfluorocarbon Associated Gas Exchange" , Buffalo Pediatric Society (1994)
  • "Perfluorocarbon Associated Gas Exchange (PAGE) and Nitric Oxide in the Lamb Congenital Diaphragmatic Hernia Model" Annual Meeting, Society for Pediatric Research (1994)
  • "Problems of Prematurity" Laboratory Grand Rounds, University at Buffalo/Women and Children's Hospital of Buffalo (1994)
  • "Breathing Liquid in the 90's" Neonatal Respiratory Care/Nursing Symposium: The Cutting Edge, University at Buffalo, Center for Tomorrow (1994)
  • "Oxygenation and Lung Mechanics During Evaporation of Perflubron After Perflurocarbon Associated Gas Exchange (PAGE) in Normal Piglets" Annual Congress, Society of Critical Care Medicine (1994)
  • "Perfluorocarbon Associated Gas Exchange (PAGE) Instituted Prior to Lung Injury Decreases Intra-Alveolar Protein Flux" Annual Congress, Society of Critical Care Medicine (1994)
  • "Combined Partial Liquid Ventilation and Nitric Oxide Therapy in Isolated Pulmonary Hypertension and Congenital Diaphragmatic Hernia" Neonatology Research Conference, Women and Children‘s Hospital of Buffalo (1993)
  • "Hemodynamics are Unchanged by Changes in FI02 During Perfluorocarbon Associated Gas Exchange (PAGE) in Normal Piglets" National Conference and Exhibition, American Academy of Pediatrics (1993)
  • "Oxygenation During Perfluorocarbon Associated Gas Exchange in Normal and Abnormal Lungs" 6th European Congress on Pediatric Surgical and Neonatal Intensive Care (1993)
  • "Oxygenation During Perfluorocarbon Associated Gas Exchange in Normal and Abnormal Lungs" International Symposium on Blood Substitutes (1993)
  • "Partial Liquid Ventilation - The First Clinical Trial" Neonatology Research Conference, Women and Children‘s Hospital of Buffalo (1993)
  • "A Medical Grade Perfluorocarbon Used During PAGE Improves Oxygenation and Ventilation in a Model of ARDS" Annual Meeting, Society for Pediatric Research (1993)
  • "Oxygenation and Lung Mechanics During 24 Hour Trials of Perfluorocarbon Associated Gas Exchange in Normal Piglets" Annual Meeting, Society for Pediatric Research (1993)
  • "Perfluorocarbon Associated Gas Exchange (PAGE) in Gastric Aspiration" Annual Meeting, Society for Pediatric Research (1993)
  • "Perfluorocarbon Associated Gas Exchange (PAGE) with Perflubron (LiquiVentTM) in Respiratory Distress Syndrome" Annual Meeting, Society for Pediatric Research (1993)
  • "Partial Liquid Ventilation for Respiratory Failure" Morning Show, Channel 2 News (1993)
  • "Perfluorocarbon Associated Gas Exchange (PAGE) in Normal Piglets Using Reduced Inspired Oxygen Concentrations" 6th Pediatric Critical Care Colloquium (1993)
  • "A Medical Grade Perfluorocarbon Used During PAGE Improves Oxygenation and Ventilation in a Model of ARDS" Annual Congress, Society of Critical Care Medicine (1993)
  • "Determinants of PaO2 During Perfluorocarbon Associated Gas Exchange (PAGE) in Normal Piglets" Annual Congress, Society of Critical Care Medicine (1993)
  • "Perfluorocarbon Associated Gas Exchange (PAGE) in Gastric Aspiration" Annual Congress, Society of Critical Care Medicine (1993)
  • "Will We Breathe Liquid in the 90's?" 14th Annual Statewide Symposium, New York State Society for Respiratory Care (1993)
  • "Liquid Breathing" Special Conference, Ross Laboratories, Neonatal Horizons 1992 (1992)
  • "Partial Liquid Ventilation - Clinical Trial" Neonatology Research Conference, Women and Children‘s Hospital of Buffalo (1992)
  • "Perfluorocarbon Associated Gas Exchange (PAGE) in Surfactant Deficiency" 5th Pediatric Critical Care Colloquium, Columbia University College of Physicians and Surgeons (1992)
  • "Lung Mechanics and Perfluorocarbon Associated Gas Exchange (PAGE) in Surfactant Deficiency" Annual Meeting, Society for Pediatric Research (1992)
  • "Perfluorocarbon Associated Gas Exchange (PAGE) in Surfactant Deficiency" International Conference, American Thoracic Society (1992)
  • "Liquid Breathing: From Science Fiction to Clinical Application" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (1992)
  • "Fluorocarbons and Surfactant" Special Conference, Ross Laboratories, Hot Topics ‘91 in Neonatology (1991)
  • "Perfluorocarbon Associated Gas Exchange" New York Neonatology Thruway Conference, University of Syracuse (1991)
  • "Liquid Breathing: Reaching New Depths" WNY Chapter for Respiratory Care, University of Rochester/Strong Memorial Hospital (1991)
  • "The Role of Cerebrospinal Fluid Analysis in Evaluation of Sepsis in the Neonate" Neonatology Journal Club, Women and Children‘s Hospital of Buffalo (1991)
  • "Initial Experience of the Buffalo Institute of Fetal Therapy" Annual Meeting, American Society of Genetics (1990)
  • "Pathophysiology of Congenital Diaphragmatic Hernia II: The Fetal Lamb CDH Model is Surfactant Deficient" International Conference, American Thoracic Society (1990)
  • "Pathophysiology of Congenital Diaphragmatic Hernia III: Surfactant Replacement for the High Risk Neonate with CDH" International Conference, American Thoracic Society (1990)
  • "Beta-agonist Therapy for Bronchopulmonary Dysplasia" Neonatal Journal Club, Women and Children‘s Hospital of Buffalo (1990)
  • "New Frontiers: Will Man Breathe Liquid in the 90‘s?" WNY Chapter for Respiratory Care, University at Buffalo/Women and Children‘s Hospital of Buffalo (1990)
  • "The Impact of Liquid Ventilation in 1990‘s" Club Meeting, Rotary Club of Buffalo (1990)
  • "Mechanisms of Ventilation - Perfusion Matching in Surfactant Deficiency and Surfactant Replacement" Neonatology Research Conference, Women and Children‘s Hospital of Buffalo (1989)
  • "Mechanisms of Ventilation - Perfusion Matching with Exogenous Surfactant" VA/Q Club Seminar, University at Buffalo, Department of Physiology (1989)
  • "Pulmonary Hypoplasia: Pathophysiology and Medical Intervention" Perinatal Conference, Women and Children‘s Hospital of Buffalo (1989)
  • "Mechanical Ventilation with Heliox Decreases Airway Resistance" Annual Meeting, Society for Pediatric Research (1988)
  • "Improved Lung Function in Preterm Lambs After Liquid Ventilation" Annual Meeting, Federation of American Societies for Experimental Biology (FASEB) (1981)
  • "Liquid Ventilation in the Respiratory Distress Syndrome" Annual Meeting, American Physical Therapy Association (1981)
  • "Redistribution of Blood Flow in the Fluorocarbon-filled Lung" Annual Meeting, Federation of American Societies for Experimental Biology (FASEB) (1981)
  • "Changes in Pulmonary Vascular Resistance During Liquid Ventilation" Annual Meeting, Federation of American Societies for Experimental Biology (FASEB) (1980)
  • "Changes in Cardiac Output and Regional Blood Flow During Liquid Breathing" Annual Meeting, Federation of American Societies for Experimental Biology (FASEB) (1979)
  • "Sequential Physiological Effects of Acute Meconium Obstruction on Pulmonary Mechanics" Annual Conference, American Physiological Society (1978)
See all (145 more)
Service Activities:
  • Medical Liability Insurance Network: Academic Group Expert Review Panel; Panel Member (2016)
  • Resolve Through Sharing; Bereavement Coordinator (2016)
  • Society of Neonatal-Perinatal Medicine: Steering Committee for the Task Force for Guideline and Protocol Sharing; Committee Member (2016)
  • American Academy of Pediatrics: Neonatal Resuscitation Program; Teacher (2015)
  • Perinatal Bereavement Network WNY; Board of Directors (2015–present)
  • PLoS ONE Journal; Ad Hoc Reviewer (2015–present)
  • WNY Perinatal Bereavement Society; Board of Directors (2015–present)
  • Journal of Perinatology; Ad Hoc Reviewer (2013–present)
  • University at Buffalo Jacobs School of Medicine and Biomedical Sciences: Search Committee for Division Chief of Endocrinology/Diabetes; Committee Member (2002)
  • University at Buffalo Jacobs School of Medicine and Biomedical Sciences: MD/PhD Program Admissions Committee; Committee Member (2001–2004)
  • University at Buffalo Jacobs School of Medicine and Biomedical Sciences: Promotions and Tenure Ad Hoc Committee; Committee Member (2000–2004)
  • 23rd Ross Fellows Seminar on Perinatal Medicine (Santa Fe, NM); Chair (1999)
  • FP Technologies Inc./Vigilair, Inc.; Advisory Board (1998–2006)
  • Journal of Pediatric Research; Ad Hoc Reviewer (1998)
  • Mid-Atlantic Conference on Perinatal Research (Irvington, VA); Chair (1998)
  • New York State Department of Health: Committee of IRB Guidelines; Committee Member (1997–1998)
  • Critical Care Medicine Journal; Ad Hoc Reviewer (1997)
  • Journal of Pediatric Pulmonology; Ad Hoc Reviewer (1997)
  • Ross Fellows Seminar on Perinatal Medicine: National Fellows Committee; Committee Member (1996–2001)
  • Journal of Pediatrics; Ad Hoc Reviewer (1996–2000)
  • University at Buffalo: Faculty Senate; Member (1996–1998)
  • Intensive Care Medicine Journal; Ad Hoc Reviewer (1996)
  • University of Michigan: Poster Symposium - 'Liquid Ventilation'; Chair (1996)
  • Ross Laboratories National Conference: Hot Topics ‘95 in Neonatology - 'Liquid Ventilation'; Chair (1995)
  • Women and Children‘s Hospital of Buffalo: Pediatric Fellowship Ad Hoc Committee; Committee Member (1995–1998)
  • Pediatrics (Journal of the American Academy of Pediatrics); Ad Hoc Reviewer (1994–2001)
  • Organization of Neonatology: Training Program Directors; Member (1994–1999)
  • University at Buffalo Jacobs School of Medicine and Biomedical Sciences: Neonatal-Perinatal Medicine Fellowship - Core Curriculum; Director (1994–1999)
  • Pediatric Critical Care Medicine Journal; Ad Hoc Reviewer (1994–1998)
  • Alliance Pharmaceutical Corporation; Advisory Board (1994–1997)
  • Alliance Pharmaceutical Corporation: Neonatal Clinical Trials; Director (1994–1995)
  • University at Buffalo Jacobs School of Medicine and Biomedical Sciences: Pediatric Resident Recruitment Committee; Committee Member (1993–present)
  • Erie County College: Respiratory Care Education Council; Advisory Board (1991–2003)
  • Alliance Pharmaceutical Corporation; Consultant (1991–2000)
  • Women and Children‘s Hospital of Buffalo: NICU Physician Staffing; Coordinator (1991–1996)
  • Women and Children‘s Hospital of Buffalo: Liquid Ventilation Weekly Research Conference; Moderator (1991–1992)
  • Women and Children‘s Hospital of Buffalo: Liquid Ventilation Weekly Research Conference; Moderator (1990–1991)
  • Women and Children‘s Hospital of Buffalo: Neonatal Pulmonary Function Testing; Director (1989–1992)
  • Women and Children‘s Hospital of Buffalo: NICU Biomedical Equipment; Director (1989–1991)
  • Buffalo Institute of Fetal Therapy; Advisor (1988–1991)
  • Women and Children‘s Hospital of Buffalo: Buffalo Institute of Fetal Therapy; Advisor (1988–1991)
  • Temple University School of Medicine: Graduate Curriculum Committee; Committee Member (1982–1983)
  • Alberta American Lung Association: Sponsored Programs; Reviewer
  • Alliance Pharmaceutical Corporation: Sponsored Programs; Reviewer

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Contact Information

Women and Children‘s Hospital of Buffalo
Division of Neonatology
219 Bryant Street
Buffalo, NY 14222
Phone: (716) 878-7673
Fax: (716) 878-7945
Email: clleach@buffalo.edu

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