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John                           Corbelli

John C. Corbelli MD

Department of Medicine

Associate Professor of Medicine

Specialty/Research Focus

Cardiology; Cardiovascular Disease; Interventional Cardiology

 
Professional Summary:

I am an interventional and clinical cardiologist at the Buffalo VA Medical Center (Buffalo VAMC). The focus of my practice is the cardiac catheterization laboratory, though I also see outpatients in the cardiology clinic and perform inpatient clinical consultations in the hospital. I care for individuals with a spectrum of cardiovascular disease, including patients with stable coronary disease, acute coronary syndromes, valvular diseases and cardiomyopathies.

I participate as a site investigator in multicenter clinical research trials. My particular research interests are in studies of lipid management and preventive cardiology, intravascular ultrasound and plaque regression, critical care pathway development and application and outcomes research in the treatment of acute coronary syndromes. My current research involvement includes studies on lipid therapy using a PCSK9 inhibitor drug, HDL infusion therapy assessing for coronary artery atheroma regression by intravascular ultrasound, managing myocardial risk following non-cardiac surgery and assessing optimal treatment strategies for atrial fibrillation patients who have undergone coronary intervention and require a combination of antiplatelet and anticoagulation therapy. I am also involved in a supportive role with a study of novel antibiotic therapy.

I enjoy teaching. I teach cardiology fellows in the cardiac catheterization laboratory and in the cardiology clinic during initial cardiology consultations and follow-up outpatient care. I also teach fellows, medical residents and medical students during consultative rounds in the hospital.

Education and Training:
  • Fellowship, Cardiovascular Disease, Cleveland Clinic Foundation (1985)
  • MD, Millard Fillmore Hospital (1982)
  • MD, University at Buffalo (1979)
  • BA, Biology, Canisius College, Summa Cum Laude (1975)
Employment:
  • Associate Professor of Medicine, SUNY at Buffalo (2012-present)
  • Private Practice, Cardiovascular Medicine, Cardiovascular division of the group, Buffalo Cardiology and Pulmonary Associates, PC (1987–2012)
  • Assistant Clincal Professor of Medicine, Department of Medicine, SUNY at Buffalo (1985–2012)
Awards and Honors:
  • Professional recognition (2012)
  • Kaleida Health 2003 Annual Report (2004)
  • Buffalo Physician Magazine (2003)

Research Expertise:
  • Acute Coronary Syndrome Treatment: I have been a primary investigator in 13 acute coronary syndrome clinical trials, primarily assessing the efficacy of novel therapies in this regard. My publications in this area of medicine included my being author or co-author on 10 publications. Additionally, I was the first in the Western New York to introduce the concept of using guideline based order sets (the Acute Coronary Syndrome Treatment Strategies: ACSETS) to standardize the treatment of acute coronary syndrome patients with evidence based therapies at a time when such protocols were not in use. I co-developed the order sets and implemented them in the Kaleida Health System. I developed the research protocol to assess the outcomes of ACSETS on patient care and I was the first author on the publication detailing the outcomes of this patient care initiative.
  • Cardiovascular Risk Factor Management: I was a participant in the "27th Bethesda Conference: Matching the Intensity of Risk Factor Management with the Hazard for Coronary Disease Events," JACC 1996; 27(5): 957-1047.
  • Coronary Intervention: I was the major contributor to the development and direction of the interventional cardiology program at Millard Fillmore Gates Hospital, which had the best quality of care record in the area. This included establishing the initial care protocols and over time doing the protocol revisions in the cardiac cath lab and the step-down unit, formally and informally providing instruction to the nursing staffs in the lab and in the unit, taking the lead with innovative therapies (including directional atherectomy, rotational atherectomy and ablative atherectomy with laser) and being involved with quality monitoring. I was the lone cardiologist performing peripheral intervention in the cardiac cath lab. Additionally, I brought numerous research protocols into the lab. I was given the honor of performing the first case in the GVI (Gates Vascular Institute) when it opened.
  • Coumadin Clinic Director: In 1995, i developed evidence based protocols which served as the basis to form a Coumadin Clinic in my private practice, which I managed until I left the practice. When I left in 2012, the clinic census was over 1500 patients.
  • Lipid Management: While in private practice, I have been a primary investigator in 40 clinical trials in lipid management and have been author or co-author in six publications. I had developed a database for clinical research purposes with the Lipid Clinic that I had developed and had run for patient care, while at Buffalo Cardiology. At its peak, I managed the lipids of 2000 patients/year. Students, residents and providers from other medical practices spent time in my clinic. I helped develop lipid clinics in Erie, PA, Rochester, NY and New York City.
Grants and Sponsored Research:
  • January 2016–January 2021
    VA Cooperative Study # 578 Prevention of Serious Adverse Events Following Angiography (PRESERVE)
    Veterans Health Administration
    Role: Principal Investigator
    $432,000
  • January 2006–January 2008
    Kaleida Foundation Grant
    Kaleida Foundation
    Role: Co-Investigator
    $200,000
  • January 2006–January 2008
    Bristol Myers Squibb/Sanofi-Aventis Grant
    Bristol Myers Squibb/Sanofi-Aventis Pharms companies
    Role: Co-Investigator
    $350,000
  • April 2002–October 2002
    Bristol Myers Squibb Grant
    Bristol Myers Squibb Pharmaceuticals
    Role: Co-Investigator
    $20,000
  • April 2002–August 2002
    Abbott Pharmaceutical Grant
    Abbott Pharmaceuticals
    Role: Principal Investigator
    $40,000
  • February 1999–June 1999
    Pfizer Pharmaceutical Grant
    Pfizer Pharmaceuticals
    Role: Co-Investigator
    $135,000

Evaluative Studies and Case Reports:
Journal Articles:
  • Corbelli JC, DM Janicke, T Hoy, MJ Cziraky, JA Corbelli. Acute coronary syndrome emergency treatment strategies: Improved treatment and reduced mortality in patients with acute coronary syndromes using a guideline based critical care pathway. American Heart Journal. 2009; 157.
  • Tchang JE, Lincoff AM, Simon AM, Lee KL, Kitt MM, Calif RM, Topol EJ were the main writing committee, et all and Corbelli JC as co-author with IMPACT II Investigators.. Randomized Placebo-Controlled Trial of the Effect of Eptifibatide on Complications of Percutaneous Coronary Intervention - IMPACT II.. Lancet. 1997; 349(9063).
  • Deitelzweig, S, Ogvonnaya A, Berensobn K, Lamerato, L, Costas J, Makenbaeva, Corbelli JC. Prevalence of stroke/transient ischemic attack among patients with acute coronary syndromes in a real-world setting.. Hospital Practice. 2010; 38(4).
  • Berenson K, Casciano R, Makenbaeva D, Mozaffari E, Lamerato, L and Corbelli JC. Economic consequences of severe bleeding in patients with acute coronary syndrome in the USA. Adverse Therapy. 2010; 27(8).
  • Wiederkehr D, Berenson K, Casciano R, Stern L, Makenbaeva D, Mozaffari E, Lamerato L and Corbelli JC. Clinical impact of early clopidogrel discontinuation followiing acute myocardial infarction hospitalization or stent implantation: Analysis of a single integrated health network.. Current Medical Research and Opinion. 2009.
  • Widerkehr Daniel, Ogbonnaya Augustina, Casciano R, Makenbaeva D, Mozaffari E and Corbelli J. Clinical impact of early clopidogrel discontinuation following acute myocardial infarction hospitalization or stent implantation: Analysis in a nationally representative managed-care population. Current Medical Research and Opinion. 2009; 25(9).
  • Bhatt DL, Chew DP, Grines C, Mukherjee D, Leesar M, Gilchrist IC, Corbelli JC, Blankenship JC, Eres A, Steinhubl S, Tan WA, Resar JR, AlMahameed A, Abdel-Latif A, Tang WH, Tang HW, Brennan D, McErlean E, Hazen SL, Topol EJ. Peroxisome proliferator-activated receptor gamma agonists for the Prevention of Adverse events following percutaneous coronary Revascularization--results of the PPAR study. American Heart Journal. 2007; 154(1).
  • Sarawate CA, Cziraky MJ, Stanek EJ, Willey VJ, Corbelli JC, Charland SL. Achievement of optimal combined lipid values in a managed care setting: is a new treatment paradigm needed? Clinical Therapeutics. 2007; 29(1).
  • Sarawate CA, CJ Cziraky, EJ Stanek, VJ Willey, JC Corbelli, SL Charland. Achievement of optimal combined lipid values in a managed care setting: Is a new treatment paradigm needed?. Clinical Therapeutics. 2007; 29.
  • Insull W, ME McGovern, H Schrott, P Thompson, JR Crouse, F Zieve, JC Corbelli. Efficacy of extended-release niacin with Lovastatin for hypercholesterolemia. Assessing all reasonable doses with innovative surface graph analysis.. Archives in Internal Medicine. 2004; 164.
  • Corbelli JC, Janicke DM, Corbelli JA, Chow S, Pruski M. Acute coronary syndrome emergency treatment strategies: a rationale and road map for critical pathway implementation. Critical Care Pathways in Cardiology. 2003; 2(2).
  • Corbelli JA, Corbelli JC, Bullano MF, Willey VJ, Cziraky MJ, Banks LD, Cooke BE, Galla AM, Berchou KA, Drury CJ. Gender bias in lipid assessment and treatment following percutaneous coronary intervention. Journal of Gender Specific Medicine. 2003; 6(3).
  • Kerzner B, Corbelli JC, Sharp S, Lipka L, Melani L, LeBeaut A, Suresh R, Mukhopadhyay P, Veltri E for the Ezetimibe Study Group.. Efficacy and safety of ezetimibe co-administered with lovastatin in primary hypercholesterolemia.. American Journal of Cardiology. 2003; 91.
  • Corbelli JA, Corbelli JC, Bullano MF, Wiley VJ, Cziraky MJ, Banks LB, Cooke BE, Galla AM, Berchou KA. Gender bias in lipid assessment and treatment post coronary intervention.. J Gender Specific Medicine. 2003; 6(3).
  • Corbelli JC, Bullano JC, Willey VJ, Cziraky MJ, Corbelli ME, Waugh W. Effects of gemfibrozil conversion to fenofibrate on lipids in patients on statin therapy.. American Journal of Cardiology. 2002; 90.
  • Seyithanoglu BY, Zaki Masud AR, Ergene O, Morris WM, Kozan O, Corbelli JC, Wilson MF. Directional coronary atherectomy versus coronary angioplasty in vessels larger than 3 mm in diameter. Japanese Heart Journal. 1998; 39(1).
  • Hanrath P, Vom DJ, Paulus OLVW, Hendrickx G,Sosa JA, Muller D, King ISB, Resar JR,Herzog W, Silver MT, Green B, Lewis HS, Schultheiss HP, Meier B, Jang DK, Losordo DW, Palabrica T, Piana R, Monrad ES, Shani J, Rousseau MF, Co J, Corbelli JC, Vaitkus PT, et al.. Effects of Platelet Glycoprotein IIb/IIIa blockade with Tirofiban on Adverse Cardiac Events in Patients with Unstable Angina or Acute Myocardial Infarction Undergoing Angioplasty. Circulation. 1997; 96(5).
  • Franco I, Corbelli JC, Hollman J, Simpfendorfer C.. Coronary Angioplasty as an Alternative to Repeat Bypass Grafting. Cardiology Board Review. 1986; 3.
  • Franco I, Corbelli JC, Hollman J, Simpfendorfer C. Percutaneous Transluminal Coronary Angioplasty after Previous Coronary Bypass Surgery Cardiology Board Review. 1985; 56(7).
  • Corbelli JC, Philips D, Corbelli RJ, Sheldon WC. Follow-up after Successful Transluminal Angioplasty: Report of the Initial Cleveland Clinic Experience. Cleveland Clinic Quarterly. 1984; 51(4).
  • Corbelli JC, Phillips DF, Corbelli RJ, Sheldon WC. Follow-up after successful transluminal angioplasty. Report of the initial Cleveland Clinic experience. Cleveland Clinic Quarterly. 1984; 51(4).
See all (11 more)

Professional Memberships:
  • National Lipid Association, Fellow (2011–present)
  • American College of Cardiology, Fellow (1992–present)
  • Society for Cardiac Angiography and Interventions, Fellow (1991–present)
  • American Heart Association (1990–present)
  • American Society of Internal Medicine (1989–present)
  • American College of Physicians, Fellow (1988–present)
  • Medical Society of the State of New York (1985–2012)
  • Erie County Medical Society (1985–2012)
Presentations:
  • "ACC/AHA Guidelines of Preoperative Cardiovascular Evaluation and Management of Patients Undergoing Non-Cardiac Surgery" Buffalo VA Department of Primary Care Fall Teaching Day -2015, Buffalo VA Medical Center, VA Primary Care Department (2015)
  • "Pseudo aneurysm in a left internal mammary artery. one year after coronary bypass grafting" Transcatheter Therapeutics (TCT) Meeting, Cardiovascular Research Foundation (2015)
  • "Update on Lipid PharmacoTherapy" UB Department of Medicine Citi-Wide Grand Rounds, UB School of Medicine, UB department of medicine (2015)
  • "Update on Lipid PharmacoTherapy" UB Department of Medicine Citi-Wide Grand Rounds, UB School of Medicine, UB Department of Medicine (2014)
  • "Update on Lipid Therapy" Buffalo VA Department of Primary Care Spring Teaching Day -2014, Buffalo VA Medical Center, VA Primary Care Department (2014)
  • "Comparison of Low Risk Medical and General Surgical Patients Treated with Unfractionated Heparin vs. Low Molecular Weight Heparin Enoxaparin" American Heart Association Quality of Care and Outcomes Research Meeting, American Heart Association (2013)
  • "Prevalence of Stroke/Transient Ischemic Attack Among Patients with Acute Coronary Syndromes in a Real-World Setting" Academy of Managed Care Pharmacy, Academy of Managed Care Pharmacy (2009)
  • "The Role of Omega-3-Acid Ethyl Esters in the Treatment of Adult Patients with Very High Triglycerides" Diabetes and Endocrinology Center Conference, Diabetes and Endocrinology Center, Diabetes and Endocrinology Center (2009)
  • "Consequences of Early Discontinuation of Clopidogrel Therapy Following Acute Myocardial Infarction or Coronary Stent Insertion: Observations From Different Health Care Delivery Settings" Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke Conference, American Heart Association (2009)
  • "Clopidogrel Therapy Following Acute Myocardial Infarction Hospitalization or Stent Insertion: What Are the Consequences of Stopping Therapy Before One Year?" American College of Cardiology 58th Annual Scientific Session, American College of Cardiology (2009)
  • "An Evidence and Guideline-based Approach of UA/NSTEMI, Including a Case Study with a Focus on the ED" Niagara Falls Memorial Hospital Emergency Department meeting, Niagara Falls Memorial Hospital, Emergency department physicians (2009)
  • "Clinical Consequences of Suboptimal Clopidogrel Therapy After Stent Implantation in Acute Coronary Syndrome Patients: An Integrated Health Plan's Perspective" American College of Clinical Pharmacy Meeting, American College of Clinical Pharmacy (2008)
  • "Consequences of Stopping Clopidogrel Therapy Following Acute Myocardial Infarction Hospitalization or Coronary Stent Insertion" Academy of Managed Care Pharmacy 2008 Educational Conference, Academy of Managed Care Pharmacy (2008)
  • "Economic Consequences of Recurrent Acute Coronary Syndrome Related Hospitalizations" American College of Clinical Pharmacy Meeting, American College of Clinical Pharmacy (2008)
  • "The Economic Consequences of Severe Bleeding in Acute Coronary Syndrome Patients" Academy of Managed Care Pharmacy 2008 Educational Conference, Academy of Managed Care Pharmacy (2008)
  • "Effectiveness and Safety of Cardiovascular Medications" 23rd International Conference on Pharmacoepidemiology & Therapeutic Risk Management, International Society for Pharmacoepidemiology, Pharmacotherapy (2007)
  • "Improved Treatment and Reduced Mortality in Patients with Acute Coronary Syndromes Using a Guideline-based Critical Pathway" American Heart Association Scientific Sessions, American Heart Association, Cardiovascular Disease (2006)
  • "Guideline-based Critical Care Pathways' Impact on Treatment and Inpatient Mortality in Hospitalized Patients with Unstable Angina or Myocardial Infarction" 7th Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke, American Heart Association, Cardiovascular Disease (2006)
  • "Treatment of Elderly Patients Presenting to the Emergency Department with Acute Coronary Syndrome: Do Guideline Based Critical Pathways Improve Outcomes?" Society of Academic Emergency Medicine, Society of Academic Emergency Medicine (2006)
  • "Evidence Based Care of the Acute Coronary Syndrome Patient" Wyoming County Medical Symposium, Warsaw Hospital (2005)
  • "Pharmacologic Approaches to Lipid Therapy" Lecture to physicians in the Sheehan Memorial Hospital medical clinic, Sheehan Memorial Hospital, Physicians in the medical clinic (2005)
  • "Acute Coronary Syndrome Emergency Treatment Strategies" St. Joseph Hospital Medical Grand Rounds, Department of Medicine (2005)
  • "Insulin Resistance" Western New York Cardiovascular Society, Western New York Cardiovascular Society (2005)
  • "Care of the Post-Myocardial Infarction Patient" Buffalo General Hospital Medical Grand Rounds, Buffalo General Hospital, Department of Medicine (2005)
  • "The Metabolic Syndrome" ECMC Family Practice Grand Rounds, Erie County Medical Center, Family Practice Department (2005)
  • "Class Review: COX-2 Inhibitors" National Wellpoint Pharmacy and Therapeutics Meeting, National Wellpoint Pharmacy Management, Pharmacy and Therapeutics Group (2004)
  • "Class Review: HMG Co A Reductase Inhibitors" National Wellpoint Pharmacy and Therapeutics Meeting, National Wellpoint Pharmacy Management, Pharmacy and Therapeutics Group (2004)
  • "Insulin Resistance" Sister of Charity Hospital Medical Grand Rounds, Sisters of Charity Hospital, Department of Medicine (2004)
  • "Current and Evolving Approaches to Lipid Therapy" Bertem-Chaffee Hospital Medical Grand Rounds, Bertram-Chaffee Hospital, Department of Medicine (2004)
  • "Acute Coronary Syndrome Disease Management" University of Pittsburgh Department of Cardiology Meeting, University of Pittsburgh Medical Center, Cardiology Department (2004)
  • "Review of Newer Lipid Pharmacologic Therapies - The Medical Perspective" National Wellpoint Pharmacy and Therapeutics Meeting, Wellpoint Pharmacy Management, Pharmacy and Therapeutics Group (2004)
  • "Factors Associated with Elevated P-selectin in Patients with Coronary Disease" 4th Annual Conference on Atherosclerosis, Thrombosis and Vascular Biology, American Heart Association, Inflammation (2003)
  • "High Sensitivity C-reactive Protein Correlates with High Risk Lipoprotein Subfractiions but not with Standard Lipid Profile" 4th Annual Conference on Atherosclerosis, Thrombosis and Vascular Biology, American Heart Association, Inflammation (2003)
  • "Gender Bias in Lipid Assessment and Treatment Following Coronary Intervention" 4th Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke, American Heart Association, Cardiovascular Disease (2002)
  • "Elderly Age Bias in Lipid Assessment Following Coronary Intervention" Transcatheter Cardiovascular Therapeutics Meeting, Cardiovascular Research Foundation, Cardiovascular Disease (2002)
  • "A Cost-Effectiveness Analysis of Statin Therapy in a Managed Care Population" 11th International Congress of Cardiovascular Pharmacology, Society of Cardiovascular Pharmacology, Cardiovascular Disease (2002)
  • "A Retrospective, Observational Cohort Study of the Effects of Statin Therapy on Lipid Levels in a Naturalist Setting" 7th Annual International Meeting of the International Society of Pharmacoeconomics and Outcomes Research, Society for Pharmacoeconomics and Outcomes Research, Outcomes Research (2002)
  • "Ezetimibe Co-administered with Lovastatin in 548 Patients with Primary Hypercholesterolemia." XIV World Congress of Cardiology, World Congress of Cardiology, Cardiovascular Disease (2002)
  • "An Analysis of Coronary Heart Disease Risk in a Cardiology Population" National Cardiovascular Health Conference, American Heart Association, Cardiovascular Disease (2002)
  • "Fall in Antioxidant Reserve (AR) in Coronary Sinus Blood Following Angioplasty" Biomedicine Conference, Inflammation (1996)
  • "Fall In Nitric Oxice (NO) and Increase In Platelet Activation In Coronary Sinus Blood Following Angioplasty" Biomedicine Conference, Inflammation (1996)
  • "Clinical Outcome ofHigh-Risk vs Elective Patients Undergroing Percutaneous Coronary Intervention: Results from IMPACT II" American College of Cardiology Annual Scientific Session, American College of Cardiology, Cardiovascular Disease (1996)
  • "Outcome of Acute Myocardial Infarction Complicated with Cardiogenic Shock After Angioplastly Versus Supportive Management" American Heart Association Scientific Sessions, American Heart Association, Cardiovascular medicine (1995)
  • "Percutaneous Coronary Angioplasty as an Alternative to Repeat Bypass Grafting" X World Congress of Cardiology, International Society of Cardiology (1986)
  • "Coronary Angioplasty of the Origin of the Left Anterior Descending Coronary Artery" XII International Congress of Cardiology, American Society of Cardiology (1985)
See all (35 more)
Service Activities:
  • Jacobs School of Medicine & Biomedical Sciences Unqualified Promotions; Member (2012–2015)
  • Quality of care at the Gates Vascular Institute (GVI); I was the first chairman of the Gates Vascular Institute (GVI) Quality of Care Committee, answering to the GVI Board. As such, I endeavored to establish the structure for the evaluating and continually improving the quality of care on a cost effective basis that would be provided at the GVI. When I went to the VA, I left a 300 page compendium that could serve as a roadmap for a committed approach to quality at that institution.; Chair (2011–2012)
  • Alignment of clinical and financial goals; In 2010 and 2011, the Independent Health Insurance (IHA) company configured a "Cardiac Clinical Design Group, whose function was to align community and hospital incentives with those of this insurance company as much as possible to improve care and reduce costs. Eventually, IHA ended the working group.; Consultant (2010–2011)
  • Canisius College Advisory Board; I am a charter member of the Canisius College Pre-Med Advisory Board, whose function is to provide advice, serve as a community sounding board and otherwise support the pre-med department and for the pre-med students.; Advisor (2010–present)
  • Journal Reviewer - American Journal of Cardiology; I have been a reviewer for the American Journal of Cardiology; External Reviewer
  • Journal Reviewer - Critical Pathways in Cardiology; External Reviewer

School News:
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Contact Information

Buffalo VA Medical Center
3495 Bailey Avenue
Buffalo, NY 14215
Phone: 716-862-8639
Fax: 716-862-8640
Email: corbelli@buffalo.edu

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