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Paresh                         Dandona

Paresh Dandona MD, PhD

Department of Medicine

Distinguished Professor and Chief, Endocrinology

Specialty/Research Focus

Endocrinology, Diabetes and Metabolism

 
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Professional Summary:

Vascular cell reactivity encompassing platelet function, endothelial function, monocyte/macrophage function and the interactions between them (adhesion molecules viz lCAM, VCAM, P-selectin, L-selectin, E-selectin, etc.). Reactive Oxygen Species (ROS) in diabetes, atherosclerosis, hypertension, aging, infection, etc. and a consequential damage to
lipids, proteins and DNA. Regulation of aromatase, the effect of estrogen on estrogen receptor, androgen receptor and glucocortico receptor (elucidationi of pre- and post-receptor mechanisms in menopause, etc.). Venous reactivity with measurements of venous diameter and flow velocity and the effect of various drugs in NIDDM, IDDM, and IGT. Genetic regulation of aromatase and estrogen receptor. The role of nitric oxide in vascular reactivity, vis-a-vis various complications of diabetes and other factors involved with vascular reactivity. Effects of endotoxin on adhesion molecules, PAF, platelets, ROS and procalcitonin.

Education and Training:
  • PhD, Oxford University (1975)
  • MBBS, Medicine, All India Institute of Medical Sciences (1965)
  • BS, Chemistry, Allahabad University (1960)
Employment:
  • , University at Buffalo (1996-present)
  • Founder & Medical Director, Diabetes-Endocrinology Center of Western New York (1995-present)
  • Chief, Kaleida Health (1991-present)
  • Professor, University at Buffalo (1991-present)
Awards and Honors:
  • Pharmacia Award (2002)
  • Valor Award (2001)
  • Distinguished Service Award (2001)
  • Madhav Award (1997)
  • Alert Award (1996)
  • Distinguished Service Award (1993)
  • Rhodes Scholarship (1966)

Grants and Sponsored Research:
  • December 2011–November 2014
    Anti-Diabetic Effects of Liraglutide in Adolescents and Young Subjects with Type 1 Diabetes
    American Diabetes Association
    Role: Principal Investigator
    $600,000

Evaluative Studies and Case Reports:
See All (28 Total) >
Journal Articles:
See All (255 Total) >
Abstracts:
  • Al-Ghazi MN, Ciancio SG, AlJada A, Bessinger M, Mather M, Mohanty P, Dandona P. Evaluation of Efficacy of Administration of Sub-antimicrobial-dose Doxycycline in the Treatment of Generalized Adult Periodontitis in Diabetics. J Dent Res. 2003.
  • Tripathy, D., Dhindsa S, Aljada, A., Hofmeyer, D., Syed, T., Dandona P. Acute elevation of plasma free fatty acids (FFA) increases the macrophage migration inhibitory factor (MIF) in healthy subjects. Diabetes. 2003; (1).
  • Aljada, A., Ghanim, H., Mohanty, P., Dhindsa S, Bandyopadhyay, A., Dandona P. Plasma homocysteine concentrations are elevated in the obese and in males: Absence of an effect by thiazolidinediones. Endocrine Society. 2003.
  • Ciancio SG, Aljada A, Mohanty P, Ross C, Dandona P. Comparative evaluation of adjunctive oral irrigation in diabetics.. J Clin Periodontol. 2002; 29(4).
  • Tripathy, S., Dhindsa S, Garg, R., Dandona P. Hypgondotropic hypogonadism in erectile dysfunction associated with Type 2 diabetes mellitus: A common defect?. Endocrine Practice. 2002; 8.
  • Mohanty, P., Aljada, A., Ghanim, H., Hofmeyer, D., Tripathy, D., Syed, T., Dhindsa S, Dandona P. Evidence for a potent anti-inflammatory effect of rosiglitazone in obese diabetic patients. Diabetes. 2002; P2(376).
  • Mohanty, P., Aljada, A., Ghanim, H., Hofmeyer, D., Tripathy, D., Syed, T., Dhindsa S, Dandona P. Evidence for a potent anti-inflammatory of rosiglitazone in obese diabetic patients. Endocrine Society. 2002; P2(376).
  • Ciancio SG, Aljada A, Awa H, Hamouda W, Ghanim H, Zambon JJ, Dandona P, Boardman T, Ross C. Comparative evaluation of an adjunctive oral irrigation in diabetics. J Dent Res. 2001; 80(846).
  • Ciancio SG, Dandona P, Hamouda W, Ho A. Effect of irrigation on periodontal and metabolic parameters in diabetics. J Dent Res. 2000; 79(3725).
  • Ciancio SG, Al-Suwyed A, Hamouda W, Dandona P. Free radical generation in patients with periodontal disease. J Dent Res. 1998; 77(3192).

Professional Memberships:
  • American Diabetes Association; President-elect
  • Endocrine Society; Member
  • American Heart Association; Member
  • The North American Menopause Society; Member
  • International Diabetes Federation; Member
  • International Society for Hypertension in Blacks; Member
  • American Association of Clinical Endocrinologists; Member
  • American College of Cardiology; Member
  • European Association for the Study of Diabetes; Member
Presentations:
  • "Metabolic Syndrome" Annual Conference, Diabetes Association (2003)
  • "Metabolic Syndrome" Annual Meeting, Diabetes Association (2003)
  • "Metabolic Syndrome" Annual meeting, Postgraduate Medicine Symposium (2003)
  • "Metabolic Syndrome" National Meeting (2002)
  • "Insulin Resistance & Thiazolidenidiones" Consensus Meeting (2002)
  • "Metabolic Syndrome" Consensus Meeting, American College of Endocrinology (2002)
  • "Metabolic Syndrome" International Diabetes Federation (2002)
  • "Hydrocortisone inhibits the pro-inflammatory transcription factor, activator protein-1 (AP-1) & matrix metalloproteinases & 9 (MMP-2 & MMP-9)" Annual meeting, Endocrine Society (2001)
  • "Insulin inhibits the pro-inflammatory transcription factor early growth response-1 (Egr-1) in mononuclear cells & reduces plasma tissue factor & plasminogen activator inhibitor-1 concentrtions" Annual meeting, Endocrine Society (2001)
  • "Insulin reduces the pro-inflammatory transcription factor, activation protein-1 (AP-1) in mononuclear cells & plasma matrix metalloproteinase-9 concentration" Annual meeting, Endocrine Society (2001)
  • "Insulin reduces the pro-inflammatory transcription factor, activation protein-1 (AP-1), in mononuclear cells & plasma matrix metalloproteinase-9 concentration" Annual Meeting, American Diabetes Association (2001)
  • "Insuling inhibits the pro-inflammatory transcription factor erly growth response-1 (Egr-1) expression in mononuclear cells & reduces plasma tissue factor & plasminogen activator inhibitor-1 concentrations" Annual meeting, American Diabetes Association (2001)
  • "Rosiglitazone improves vascular reactivity, inhibits reactive oxygen species (ROS) generation, reduces p47phox subunit expression in mononuclear ells: Evidence of a potent anti-inflammatory effect" Annual meeting, Endocrine Society (2001)
  • "Rosiglitazone improves vascular reactivity, inhibits reactive oxygen species (ROS) generation, reduces p47phox subunit expression in mononucler cells (MNC): Evidence of a potent anti-inflammatory effect" Annual meeting, American Diabetes Association (2001)
  • "Troglitazone reduces intranuclear activator protein (AP-1) in mononuclear cells & plasma matrix metalloproteinase-9 concentration" Annual meeting, American Diabetes Association (2001)
  • "Troglitazone reduces intranuclear activator protein (AP-1) in mononuclear cells & plasma matrix metalloproteinase-9 concentration" Annual meeting, Endocrine Society (2001)
  • "Insulin inhibits intranuclear NFkB and stimulates IkB in mononucler cells in obese subjects: Evidence for an anti-inflammatory effect?" Workshop, 1st International Workshop on Insulin Resistance (2001)
  • "Rosiglitazone improves vascular reactivity, inhibits reactive oxygen species (ROS) generation, reduces p47phox subunit expressionin mononuclear cells: Evidence of a potent anti-inflammatory effect" Workshop, 1st International Workshop on Insulin Resistance (2001)
  • "Troglitazone inhibits mononuclear cell reactive oxygen species generation, NFkB & plasma pro-inflammatory factors in obese subjects: Evidence for an anti-inflammatory and anti-atherosclerotic effect" Workshop, 1st International Workshop on Insulin Resistance (2001)
  • "Troglitazone reduces the expression of PPARy while stimulating that of PPARa in mononuclear cells in obese subjects" Workshop, 1st International Workshop on Insulin Resistance (2001)
  • "Activation of signal transduction in the retina by lipid hydroperoxide" Meeting, The Association for Research in Vision and Opthalmology (2001)
  • "Insulin as an atherogenic hormone" Scientific Session, American Diabetes Association (2001)
  • "Metabolic Syndrome" , Tulane & Louisiana State Universities (2001)
  • "MetabolicSyndrome" Conference, American Association of Clinical Endocrinologists, Baylor Medical Center (2001)
  • "HRT-Cardiovascular relationships" , Albany Medical College, OB/GYN Department (1997)
  • "Maternal-fetal relationshps of calcium, vit.D & parthyroid hormone" , All India Congress of Perinatology & Reproductive Biology, All India Congress (1997)
  • "Modern Treatment of Type II diabetes" Workshop, Physicians from Poland (1997)
  • "Pathogenesis & Management of Cardiovascular Disease in Diabetes" Diabetes Update, Univ. of Arkansas for Medical Sciences (1997)
  • "Physiology of obesity & weight loss" city-wide grand rounds, SUNY @ Buffalo, OB/GYN Dept. (1997)
  • "Treatment of insulin-resistance syndrome" Worskshop, Physicians from Turkey (1997)
  • "Abnormalities in vascular reactivity in diabetes mellitus" City-wide endocrine rounds, University of Toronto, Banting & Best Diabetes Centre (1996)
  • "Insulin-resistance, diabetes & obesity" , Washinton Univ./24th Annual Diabetes Symposium, St. Louis Education Center (1996)
  • "Obesity management" , Rochester Psychiatric Society (1996)
  • "Update in the treatment of diabetes mellitus" CME, Buffalo General Hospital (1996)
  • "Initiating & managing insulin treatment" Grand Rounds, SUNY @ Buffalo, Dept. of Family Medicine (1996)
  • "Pathophysiology of type 2 diabetes" 11th Annual Conference, Hypertension in Blacks (1996)
  • "Obesity management" Grand Rounds, Millard Fillmore Hospital (1996)
  • "Update on treatment options in type 2 diabetes mellitus" , Mercy Hospital, Grand Rounds (1996)
  • "Clinical studies on soluble adhesion molecules" IBC‘s Conference on Cell Adhesion Molecules & Matrix Proteins (1996)
  • "Diabetes mellitus & its complications" Meeting, NYS, Office of Disability Determinations, Dept. of Social Services (1996)
  • "Free radicals and atherosclerosis" Meeting, Merck Frosst Canada, Medical Advisory Council (1996)
  • "Comprehensive treatment of diabetes" Grand Rounds, Millard Fillmore Hospital, Dept. of Medicine (1996)
  • "Lipids" Grand rounds, Albany Memorial Hospital (1996)
  • "Modern guidelines for diabetic care" , Niagara Falls Memorial Medical Center (1996)
  • "Cardiovascular disease and menopause" HRT Symposium, Blue Cross/Blue Shield (1996)
  • "Exploring the clinical issues in diabetes/endocrinology training" , St.Louis Univ & Bayer Corporation (1996)
  • "New treatment options for type 2 diabetes mellitus" , Niagara Society of Family Physicians (1996)
  • "Recent studies on insulin as a vasodilator" Seminar, SUNY @ Buffalo, Cardiopulmonary Dept. (1996)
  • "Update on treatment options in type 2 diabetes mellitus" , Cattaraugus County Medical Society (1996)
See All (49 Total) >
Service Activities:
  • Committee Member; Buswell Fellowship Committee; Member (1996–1998)
  • Member; American Diabetes Association, New York State Affiliate; Board of Directors (1995–1996)
  • Founder & Coordinator; Diabetci Patients' Forum (1995)
  • Committee member; Harrington Committee. This committee is responsible for the selection of the most distinguished speakers to be invited to the Universitys' Lecture Series.; Committee Member (1993–1995)
  • Coordinator; University Endocrinology Journal Club (1993)
  • Member, Steering Committee; Cardiovascular Research Group. SUNY @ Buffalo; Member (1992–1994)
  • Coordinator; Coordinator, Interdisciplinary Vascular & Metabolic Research Group (1991)
  • Board member; Roswell Park Cancer Institute Brain Tumor Board; Board Member
  • Committee Member; Millard Fillmore Hospital Medical Advisory Committee Member; Committee Member
  • Editor-in-Chief; Editor
  • Founder and Coordinator; Osteoporosis Bone Club

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

Dent Tower
3980 Sheridan Drive
Amherst, NY 14226
Phone: (716) 961-9900
Fax: (716) 961-9911
Email: dandona@buffalo.edu

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