Department of Medicine
Distinguished Professor and Chief, Endocrinology
Endocrinology, Diabetes and Metabolism
Vascular cell reactivity encompassing platelet function, endothelial function, monocyte/macrophage function and the interactions between them (adhesion molecules viz lCAM, VCAM, P-selectin, L-selectin, E-selectin, etc.). Reactive Oxygen Species (ROS) in diabetes, atherosclerosis, hypertension, aging, infection, etc. and a consequential damage to
lipids, proteins and DNA. Regulation of aromatase, the effect of estrogen on estrogen receptor, androgen receptor and glucocortico receptor (elucidationi of pre- and post-receptor mechanisms in menopause, etc.). Venous reactivity with measurements of venous diameter and flow velocity and the effect of various drugs in NIDDM, IDDM, and IGT. Genetic regulation of aromatase and estrogen receptor. The role of nitric oxide in vascular reactivity, vis-a-vis various complications of diabetes and other factors involved with vascular reactivity. Effects of endotoxin on adhesion molecules, PAF, platelets, ROS and procalcitonin.