Elie R. Chemaly MD PhD
Elie R. Chemaly
MD PhD
Clinical Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Bioinformatics; Cardiac pharmacology; Internal Medicine; Molecular Basis of Disease; Nephrology
Professional Summary:
I have a passion for challenge and an allergy to routine. This has driven my interest for research and clinical medicine, mainly internal medicine. I am currently a nephrologist at UBMD and a Faculty at the University at Buffalo Jacobs School of Medicine and Biomedical Sciences.
In my clinical practice, I manage all aspects of kidney disease, renal replacement therapies including dialytic therapies and kidney transplant, hypertension, as well as disorders of fluid and electrolytes. With my group, I also provide nephrology consultations at the Roswell Park Cancer Institute. I particularly favor this part of my clinical activity, considering the very specific and challenging nephrological problems arising in cancer patients. More recently, I have led an effort to start and grow a program of continuous renal replacement therapy (CRRT) at the Roswell Park Cancer Institute.
I have a passion for education and never say no for opportunities to teach or learn. At the expense of longer days, I always take opportunities to teach fellows, residents and students. I strongly believe in problem-based learning, in the sense that what is learned is best remembered when it is learned as a solution to a problem.
So far, my research has focused on cardiovascular disease, mainly cardiac and vascular mechanics. In this phase of my career in nephrology, I am moving towards issues interfacing the cardiovascular system and the kidneys.
Education and Training:
- Fellowship, Clinical Nephrology, Morsani College of Medicine - University of South Florida (2017)
- Fellowship, Biomedical Engineering, University of Virginia (2014)
- Fellowship, Cardiovascular Medicine and Cardiovascular Research, Icahn School of Medicine at Mount Sinai (2013)
- PhD, Physiology and Pathophysiology (cardiac), Université Pierre et Marie Curie (2012)
- Fellowship, Cardiovascular Research, Massachusetts General Hospital, Harvard Medical School (2006)
- Residency, Internal Medicine, University at Buffalo (now Jacobs) School of Medicine and Biomedical Sciences (2004)
- Internship, Internal Medicine, University at Buffalo (now Jacobs) School of Medicine and Biomedical Sciences (2002)
- MS, Cardiovascular pharmacology, Université Claude Bernard, Lyon I (2001)
- MD, Medicine, Faculté de Médecine, Université Saint Joseph de Beyrouth (2000)
- BS, Biological and Medical Sciences, Faculté de Médecine, Université Saint Joseph de Beyrouth (1997)
Employment:
- Clinical Assistant Professor, Medicine, Jacobs School of Medicine & Biomedical Sciences (2017-present)
- Senator, University at Buffalo Faculty Senate (2020–2021)
- Medical Director, Hemodialysis Unit, Wende Correctional Facility, Alden, NY (2020)
- Adjunct Assistant Professor, Physiology and Biophysics, Howard University College of Medicine (2009–2012)
- Clinical Assistant Instructor, Medicine, University at Buffalo (now Jacobs) School of Medicine and Biomedical Sciences Jacobs School of Medicine & Biomedical Sciences (2001–2004)
- Instructor, Faculté de Médecine - Université Saint Joseph de Beyrouth (1999–2000)
Awards and Honors:
- Finalist, Northwestern Cardiovascular Young Investigators' Forum, Chicago, IL, 2010 (2010)
- Travel Grant (2002)
Research Expertise:
- Cardiovascular physiology and biophysics: Extensive cardiovascular research experience. In addition, I designed curriculum and taught cardiovascular mechanics and hemodynamics for 4 years to first year medical students at the Howard University College of Medicine, based on prior teaching experience from the Health Science and Technology Program (Harvard Medical School/MIT)
- Experimental cardiac imaging: Extensive experience in rodent echocardiography, with added experience in rodent cardiac magnetic resonance imaging. Also received training in human echocardiography
- Hemodynamics: Extensive experience in rat hemodynamics, especially left ventricular pressure-volume loops, right ventricular pressure measurement, arterial pressure tracings and more recently a new interest in renal blood flow measurement. Experience in human hemodynamics as well, with publications on non-invasive pulse wave velocity and carotid tonometry, as well as publications from data collected in cardiac catheterization laboratories.
- Molecular cardiology: publications in cardiac gene delivery, molecular characterization of cardiac remodeling and fibrosis, molecular markers of cardiac hypertrophy and their modulation
- Nephrology and Internal Medicine: Board-certified in Nephrology (2017) and Internal Medicine (2004-2014). All aspects of clinical nephrology, in particular, fluid and electrolyte disorders, hypertension and clearance problems, cardiorenal interactions.
Research Centers:
- Clinical and Translational Research Center (CTRC)
UB 2020 Strategic Strengths:
- Health and Wellness Across the Lifespan
- Information and Computing Technology
- Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
- February 2009–February 2013
5T32HL007824-13 TRAINING PROGRAM IN MOLECULAR AND CELLULAR CARDIOLOGY NHLBI( PI: Bruce Gelb,MD,) Project Start Date: 1-JUL-1995; Project End Date: 31-JUL-2013
NIH-NHLBI
Role: Contributor
Journal Articles:
- Manuel Ramos-Kuri, Sri Harika Meka, Fabio Salamanca-Buentello, Roger J. Hajjar, Larissa Lipskaia, and Elie R. Chemaly. (2021) Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies. Biological Research (Aug), 54(1): 23. doi:10.1186/s40659-021-00342-6
- Chemaly ER, Troncone L, Lebeche D. (2017) SERCA control of cell death and survival. Cell Calcium (Jul)
- Chemaly ER, Kang S, Zhang S, McCollum L, Chen J, Benard L, Purushothaman KR, Hajjar RJ, Lebeche D. (2013) Differential patterns of replacement and reactive fibrosis in pressure and volume overload are related to the propensity for ischaemia and involve resistin. J Physiol (Nov), 591(21): 5337-5355.
- Arias T, Chen J, Fayad ZA, Fuster V, Hajjar RJ, Chemaly ER. (2013) Comparison of echocardiographic measurements of left ventricular volumes to full volume magnetic resonance imaging in normal and diseased rats. J Am Soc Echocardiogr (Aug), 26(8): 910-918.
- Chemaly ER, Hajjar RJ, Lipskaia L. (2013) Molecular targets of current and prospective heart failure therapies. Heart (Jul), 99(14): 992-1003.
- Khoueiry G, Azab B, Torbey E, Abi Rafeh N, Atallah JP, Ahern K, Malpeso J, McCord D, Chemaly ER. (2012) Aortic pulse pressure is associated with the localization of coronary artery disease based on coronary flow lateralization. Am J Hypertens (Oct), 25(10): 1055-1063.
- Chemaly ER, Chaanine AH, Sakata S, Hajjar RJ. (2012) Stroke volume-to-wall stress ratio as a load-adjusted and stiffness-adjusted indicator of ventricular systolic performance in chronic loading. J Appl Physiol (1985) (Oct), 113(8): 1267-1284.
- Ramos-Kuri M, Rapti K, Mehel H, Zhang S, Dhandapany PS, Liang L, GarcÃa-Carrancá A, Bobe R, Fischmeister R, Adnot S, Lebeche D, Hajjar RJ, Lipskaia L, Chemaly ER. (2015) Dominant negative Ras attenuates pathological ventricular remodeling in pressure overload cardiac hypertrophy. Biochim Biophys Acta (Nov), 1853(11 Pt): 2870-2884.
- Lipskaia L, Keuylian Z, Blirando K, Mougenot N, Jacquet A, Rouxel C, Sghairi H, Elaib Z, Blaise R, Adnot S, Hajjar RJ, Chemaly ER, Limon I, Bobe R. (2014) Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis. Biochim Biophys Acta (Nov), 1843(11): 2705-2718.
- Cook JR, Carta L, Benard L, Chemaly ER, Chiu E, Rao SK, Hampton TG, Yurchenco P, Costa KD, Hajjar RJ, Ramirez F. (2014) Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome. J Clin Invest (Mar), 124(3): 1329-1339.
- Yaniz-Galende E, Chen J, Chemaly E, Liang L, Hulot JS, McCollum L, Arias T, Fuster V, Zsebo KM, Hajjar RJ. (2012) Stem cell factor gene transfer promotes cardiac repair after myocardial infarction via in situ recruitment and expansion of c-kit+ cells. Circulation research (Nov), 111(11): 1434-45. doi:10.1161/CIRCRESAHA.111.263830
- Ishikawa K, Kawase Y, Ladage D, Chemaly ER, Tilemann L, Fish K, Sanz J, Garcia MJ, Hajjar RJ. (2012) Temporal changes of strain parameters in the progress of chronic ischemia: with comparison to transmural infarction. The international journal of cardiovascular imaging (Oct), 28(7): 1671-81.
- Ishikawa K, Chemaly ER, Tilemann L, Fish K, Ladage D, Aguero J, Vahl T, Santos-Gallego C, Kawase Y, Hajjar RJ. (2012) Assessing left ventricular systolic dysfunction after myocardial infarction: are ejection fraction and dP/dt(max) complementary or redundant?. Am J Physiol Heart Circ Physiol (Apr), 302(7): 1423-1428.
- Kairouz V, Lipskaia L, Hajjar RJ, Chemaly ER. (2012) Molecular targets in heart failure gene therapy: current controversies and translational perspectives. Ann N Y Acad Sci (Apr), 1254: 42-50.
- Chaanine AH, Jeong D, Liang L, Chemaly ER, Fish K, Gordon RE, Hajjar RJ. (2012) JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure. Cell death & disease (Feb), 3: 265. doi:10.1038/cddis.2012.5
- Chen J, Chemaly ER, Liang LF, LaRocca TJ, Yaniz-Galende E, Hajjar RJ. (2011) A new model of congestive heart failure in rats. Am J Physiol Heart Circ Physiol (Sep), 301(3): 994-1003.
- Chemaly ER, Hadri L, Zhang S, Kim M, Kohlbrenner E, Sheng J, Liang L, Chen J, K-Raman P, Hajjar RJ, Lebeche D. (2011) Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats. J Mol Cell Cardiol (Aug), 51(2): 144-155.
- Kang S, Chemaly ER, Hajjar RJ, Lebeche D. (2011) Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. J Biol Chem (May), 286(21): 18465-18473.
- Jin H, Nass RD, Joudrey PJ, Lyon AR, Chemaly ER, Rapti K, Akar FG. (2010) Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart. Biophysical journal (May), 98(10): 2063-71. doi:10.1016/j.bpj.2010.01.045
- Chen J, Chemaly E, Liang L, Kho C, Lee A, Park J, Altman P, Schecter AD, Hajjar RJ, Tarzami ST. (2010) Effects of CXCR4 gene transfer on cardiac function after ischemia-reperfusion injury. The American journal of pathology (Apr), 176(4): 1705-15. doi:10.2353/ajpath.2010.090451
- Jin H, Chemaly ER, Lee A, Kho C, Hadri L, Hajjar RJ, Akar FG. (2010) Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy. FASEB J (Feb), 24(2): 451-463.
- Lipskaia L, Chemaly ER, Hadri L, Lompre AM, Hajjar RJ. (2010) Sarcoplasmic reticulum Ca(2+) ATPase as a therapeutic target for heart failure. Expert Opin Biol Ther (Jan), 10(1): 29-41.
- Karakikes I, Kim M, Hadri L, Sakata S, Sun Y, Zhang W, Chemaly ER, Hajjar RJ, Lebeche D. (2009) Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a. PLoS One (Jul), 4(7): 6474-6474.
- Takewa Y, Chemaly ER, Takaki M, Liang LF, Jin H, Karakikes I, Morel C, Taenaka Y, Tatsumi E, Hajjar RJ. (2009) Mechanical work and energetic analysis of eccentric cardiac remodeling in a volume overload heart failure in rats. Am J Physiol Heart Circ Physiol (Feb), 296(4): 1117-1124.
- Palomeque J, Chemaly ER, Colosi P, Wellman JA, Zhou S, Del Monte F, Hajjar RJ. (2007) Efficiency of eight different AAV serotypes in transducing rat myocardium in vivo. Gene Ther (Jul), 14(13): 989-997.
- Sakata S, Lebeche D, Sakata N, Sakata Y, Chemaly ER, Liang LF, Tsuji T, Takewa Y, del Monte F, Peluso R, Zsebo K, Jeong D, Park WJ, Kawase Y, Hajjar RJ. (2007) Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins. J Mol Cell Cardiol (Apr), 42(4): 852-861.
- Sakata S, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang L, Nakajima-Takenaka C, Tsuji T, Konishi N, del Monte F, Hajjar RJ, Takaki M. (2006) Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model. American journal of physiology. Heart and circulatory physiology (Sep), 292(2): H1204-7.
- Sakata S, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang LF, Padmanabhan P, Konishi N, Takaki M, del Monte F, Hajjar RJ. (2006) Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer. Mol Ther (May), 13(5): 987-996.
- Chemaly ER, Yoneyama R, Frangioni JV, Hajjar RJ. (2005) Tracking stem cells in the cardiovascular system. Trends Cardiovasc Med (Nov), 15(8): 297-302.
- Philippe F, Chemaly E, Blacher J, Mourad JJ, Dibie A, Larrazet F, Laborde F, Safar ME. (2002) Aortic pulse pressure and extent of coronary artery disease in percutaneous transluminal coronary angioplasty candidates. American journal of hypertension (Aug), 15(8): 672-7.
- Chemaly E, London G, Benetos A, Darné B, Asmar R. (2002) [Comparison of central pulse pressure estimated from pulse wave propagation velocity and carotid pulse pressure measured by applantation tonometry]. Archives des maladies du coeur et des vaisseaux (Jul), 95(7-8): 637-40.
Books and Book Chapters:
- Chemaly ER., Kim M. (2012) Medicine: A Comptency-Based Companion, by Allan Tunkel, MD, PhD and Jessica Israel, MD. In: Chapter on Hypertension in. Elsevier
Evaluative Studies and Case Reports:
- Chemaly, E.R., Sandoval Sus, J., Hussain, F., Mogollon-Duffo, F., Laber, D.A., Durr, J.A., Khalighi, M.A. and Lopez del Valle, R. (2020) Case report: Minimal change disease and acute interstitial nephritis in a patient with Hodgkin’s lymphoma treated with nivolumab. Journal of Onco-Nephrology (Jun), 4(3): 81-86. doi:https://doi.org/10.1177/2399369320927717
- Chemaly R, Checrallah A, Trak-Smayra V, El-Kallab K, Chemaly E. (2001) [Progressive myoclonic epilepsy type Lafora]. Le Journal medical libanais. The Lebanese medical journal (May), 49(3): 170-2.
Professional Memberships:
- American College of Physicians - Fellow (2019–present)
- American Society of Nephrology (2015–present)
- Lebanese Order of Physicians (2002–present)
Presentations:
- "Cardiorenal Hemodynamics in Heart failure with preserved ejection fraction: Work in Progress" Cardiovascular Research Seminars - CTRC - UB (2021)
- "Renal Hemodynamics and the Cardiorenal Syndrome" UB Department of Medicine City-Wide Grand Rounds (2020)
Service Activities:
- ; Faculty Senate, Senator (2020–2021)
- ; Medical Director, Hemodialysis Unit, Wende Correctional Facility (2020)
- ; Implemented and developed Continuous Renal Replacement Therapy (CRRT) at the Roswell Park Cancer Institute (2019–2021)
- Clinical Faculty Active clinical nephrologist in the Department of Internal Medicine through UBMD; Clinical Staff (2017–present)