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Edward                         Snell

Edward H. Snell PhD

Department of Structural Biology

Senior Scientist, CEO of Hauptman-Woodward Medical Institute

Specialty/Research Focus

Bioinformatics; Protein Function and Structure; Proteins and metalloenzymes; Structural Biology; X-ray Crystallography

 
Professional Summary:

Dr. Edward Snell is a Senior Scientist and Cheif Executive officer at the Hauptman-Woodward Medical Research Institute and faculty at the SUNY University at Buffalo Department of Structural Biology. He is a board member on the International Organization for Biological Crystallization, a member of the MacCHESS (The Macromolecular diffraction facility at Cornell High Energy Synchrotron Source) Advisory Committee and a member of the executive committee for the Stanford Synchrotron Radiation Lightsource users organization. He serves as a reviewer for multiple international Journals and both national and international funding agencies. He is on the American Crystallographic Association Communications Committee and chair-elect of the Biological Macromolecules Scientific Interest Group. His research group uses complementary techniques to extract structural and dynamic information from biological macromolecules. This research includes the development of crystallization methodology and the resulting analysis with an emphasis on high-energy light sources. Other techniques in use include Electron Paramagnetic Resonance and spectroscopy. He is experienced in solution scattering techniques, having organized and taught at both national and international meetings. The Snell laboratory research is supported by NIH, NSF, DoD, and NASA in addition to non-federal sources.

Education and Training:
  • PhD, Chemistry, University of Manchester (1996)
  • BS, Physics, The John Moores University of Liverpool, First Class with Honors (1992)
Awards and Honors:
  • Marshall Space Flight Center DIrectors Commendation (2003)
  • Imaging Award from the Industry magazing, Advanced Imaging (2003)

Research Expertise:
  • Macromolecular Crystallization
  • Neutron crystallography
  • Small Angle X-ray Scattering
  • Structural Crystallography
Research Centers:
  • Center of Excellence in Bioinformatics and Life Sciences
UB 2020 Strategic Strengths:
  • Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
  • October 2013–September 2018
    Biology with X-ray Lasers
    National Science Foundation
    Role: Co-Investigator
  • Development of an Expert Crystal Knowledge System
    NIH
    Role: Principal Investigator
  • Exploiting on-orbit crystal properties for structural studies of medically and economically important targets
    CASIS
    Role: Principal Investigator
  • MRI-R^2: Development of STIM and DATS for Protein and Nanosystem Characterization
    NSF
    Role: Co-Investigator
  • Preventing Long-Term Brain and Lung Damage Caused by Battlefield Trauma
    DTRA
    Role: Principal Investigator
  • Combating Viruses – New Technologies to Visualize, Understand, and Enable Their Treatment
    Goode Foundation
    Role: Principal Investigator
  • Structural Understanding of the Molecular Defense against Chronic Obstructive Pulmonary Disease
    Institute of Science and Health
    Role: Principal Investigator
  • High throughput crystallography for macromolecular structure, function and design
    DOE
    Role: Co-Investigator
  • Protein Structure Initiative center Grant, Tools for High Throughput Structural Biology
    NIH
    Role: Co-Investigator
  • The Master Switch for Bone Formation: Structural Studies of RunX2
    NASA
    Role: Co-Investigator
  • Macromolecule Nucleation and Growth Rate Dispersion Studies
    NASA
    Role: Co-Investigator
  • Cool Crystals–A Physical and Biochemical Study of Macromolecular Crystal Cyropreservation
    NASA
    Role: Principal Investigator
  • Searching for the Best Protein Crystals: Integration of Synchrotron-Based Crystal Quality Measurements and Structure Determination
    NASA
    Role: Co-Investigator
  • The Study and Optimization of Flow in Solution Biological Crystal Growth
    NASA
    Role: Co-Investigator
  • Optimizing the Use of Microgravity to Improve the Diffraction Quality of Problematic Biomacromolecular Crystals and Macromolecule Nucleation
    NASA
    Role: Co-Investigator
  • Growth Rate Dispersion Studies: A Predictive Technique for Crystal Quality Improvement in Microgravity
    NASA
    Role: Co-Investigator
  • A Diffractometer for Reciprocal Space Mapping of Macromolecular Crystals to Study Their Microstructure
    NASA
    Role: Co-Investigator
  • Searching for the Best Protein Crystals: Synchrotron Based Mosaicity Measurements of Crystal Quality and Theoretical Modeling
    NASA
    Role: Co-Investigator
  • Exploiting on-orbit crystal properties for structural studies of medically and economically important targets
    CASIS
    Role: Principal Investigator
See all (9 more)
Patents:
  • Digital x-ray camera for quality evaluation three-dimensional topographic r (2008)
  • Method for measurement of physical characteristics of crystals (2002)

Journal Articles:
See all (56 more)
Books and Book Chapters:
  • Helliwell JR, Snell EH, Chayen NE, Judge RA, Boggon TJ, Pusey ML. Fluid Flows and Macromolecular Growth in Microgravity. 2002.
  • Bradbrook G, Deacon AM, Habash J, Helliwell JR, Helliwell M, Nieh YP, Snell EH, Trapini S., Thompson AW, Campbell JW, Allinson NM, Moon K, Ursby T, Wulff M.. Laue and Monochromatic Developments for Time resolved biological and pertubation chemical crystallography. 1997.
  • Helliwell JR, Snell EH, Weisgerber S. An Investigation of the perfection of lysozyme protein crystals grown in microgravity and on earth. 1996.

Professional Memberships:
  • Advisory Committee on News and Media Services for the American Institute of Physics (2013–2016)
  • Advisory Committee on News and Media Services for the American Institute of Physics (2013–2016)
  • International Organization on Biological Crystallization; Board Member
  • American Crystallographic Association Communications Committee
  • McCHESS Advisory Committee
  • Stanford Synchrotron Radiation Lightsource Users Committee
Presentations:
  • "Are X-rays damaging to Structural Biology" , University of Nancy (2008)
  • "Are X-rays damaging to structural biology? A case study with xylose isomerase" Fifth International Workshop on X-ray damage to biological Crystalline systems, Swiss Light Source, Paul Scherrer Institut (2008)
  • "Remote data collection as a user - Practical tips" Remote data collection workshop, Melbourne University (2007)
  • "Thermal imaging applied to cryocrystallography: cryocooling and beam heating (Pt I)" The Fourth International Workshop on X-ray Damage to Biological Crystalline Samples, Spring-8 (2006)
  • "Crystal Quality, the Long and the Short of It" 10th International Conference on the Crystallization of Biological Macromolecules, ICCBM (2004)
  • "Decades of Data Extracting Trends from Microgravity Crystallization History" Japan Atomic Energy Research Institute Symposium on Neutron Protein Crystallography, Japan Atomic Energy Research Institute (2004)
  • "Optimizing Crystal Volume for Neutron Diffraction Studies" Japan Atomic Energy Research Institute Symposium on Neutron Protein Crystallography, Japan Atomic Energy Research Institute (2004)
  • "Neutrons and microgravity" 3rd International Symposium on "Development of New Structural Biology Including Hydrogen and Hydration" in Organized Research Combination System, Japan Atomic Energy Research Institute (2001)
  • "Seeing the heat: Preliminary studies of cryocrystallography using infrared imaging" , Daresbury Synchrotron Radiation Source, (2001)
  • "Seeing the heat: Preliminary studies of cryocrystallography using infrared imaging" , European Synchrotron Radiation Facility (2001)
  • "Synchrotron X-ray reciprocal space mapping, topography and diffraction resolution studies of macromolecular crystal quality" Spacebound 2000, Canadian Space Agency (2000)
See all (1 more)
Service Activities:
  • 2016 Gordon Research Conference on Diffraction Methods; Chair (2014–2016)
  • Program co-chair for the 2016 American Crystallography Association Annual Meeting; Co-Chairman (2014–2016)
  • MacChess Advisory Committee; Advisory Committee (2013–present)
  • Communications committee of the American Crystallography Association; Committee Member (2013–2016)
  • Stanford Synchrotron Radiation Lightsource Users Executive Committee; Committee Member (2013–present)
  • Member of the American Institute of Physics News and Media Advisory Committee; Committee Member (2013–present)
  • 2014 Gordon Research Conference on Diffraction Methods; Co-Chair (2012–2014)
  • International Organization for the Crystallization of Biological Macromolecules; Board Member (2010–present)
  • Reviewer for Acta Crystallographica D; Reviewer
  • Reviewer for Acta Crystallographica F; Reviewer
  • Reviewer for Biophysical Journal; Reviewer
  • Reviewer for Crystal Growth and Design; Reviewer
  • Reviewer for Journal of Applied Crystallography; Reviewer
  • Reviewer for Journal of Synchrotron Radiation; Reviewer
  • Reviewer for PLOS One; Reviewer
  • Reviewer for Structure; Reviewer

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Contact Information

Hauptman-Woodward Institute
700 Ellicott St.
Buffalo, NY 14203
Phone: (716) 898-8631
Fax: (716) 898-8660
Email: esnell@buffalo.edu


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