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Steven                         Fliesler

Steven J. Fliesler PhD

Department of Ophthalmology

Meyer H. Riwchun Endowed Chair Professor, Vice-Chair and Director of Research

Specialty/Research Focus

Apoptosis and cell death; Inherited Metabolic Disorders; Molecular and Cellular Biology; Molecular Basis of Disease; Neurobiology; Regulation of metabolism; Transgenic organisms; Vision science

 
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Professional Summary:

Our lab is focused on studies of retinal degenerations caused by metabolic defects, particularly dyslipidemias involving defective cholesterol metabolism (e.g., Smith-Lemli-Opitz syndrome), using pharmacological and transgenic animal models. Current studies are focused on the role of lipid and protein oxidation in the underlying mechanisms of photoreceptor cell death in such retinal degenerations, using a combination of genomic, proteomic, and lipidomic approaches.

Education and Training:
  • Postdoctoral Fellow, lipid metabolism and biochemistry of the retina, Baylor College of Medicine (1982)
  • PhD, Biochemistry, Rice University (1980)
  • BA, Biochemistry, University of California, Berkeley (1973)
Employment:
  • Professor, Ross Eye Institute, University at Buffalo (SUNY) (2008-present)
  • Health Systems Specialist, GS-13, Research Service, VA Western NY Healthcare System (2008-present)
  • Vice Chair for Research/Ophthalmology, University at Buffalo/SUNY (2008-present)
  • Professor, Saint Louis University Eye Institute, Saint Louis University, School of Medicine (1994–2008)
  • Associate Professor, Bethesda Eye Institute, Saint Louis University, School of Medicine (1988–1994)
  • Assistant Professor, Bascom Palmer Eye Institute, University of Miami, School of Medicine (1985–1988)
  • Research Assistant Professor, Ophthalmology (Cullen Eye Institute), Baylor College of Medicine, School of Medicine (1983–1984)
Awards and Honors:
  • 2014 UB Distinguished Professor (2014)
  • 2014 SUNY Chancellor's Award for Excellence in Scholarship and Creative Activities (2014)
  • Fellow (Gold Tier) of ARVO (2014)
  • Member (elected), Board of Trustees, ARVO (2014)
  • 2013-14 Cell Biology Invited Lecture, OUHSC (2013)
  • 2013 Vanzant Lecture series, Rice University (2013)
  • 2013 Chairman's Lecture series, Duke University (2013)
  • 2013 Anwar Shah Endowed Lecture (2013)
  • Fellow (Silver Tier) of ARVO (2009)
  • Senior Scientific Investigator Award (2007)
  • Chancellor's Award in Neuroscience (2002)
  • Scientist of the Year Award (1999)
  • James S. Adams Research Scholar Award (1992)

Research Expertise:
  • animal models of human retinal degenerations
  • cholesterol metabolism
  • lipid / membrane biochemistry
  • vision research
Grants and Sponsored Research:
  • January 2012–December 2015
    Isoprenoid Metabolism in the Retina
    NEI/NIH
    Role: Contributor
    $1,955,213
  • December 2009–November 2014
    Role of Caveolin-1 in the Maintenance of Blood-Retinal Barrier Integrity(1RO1EY019494)
    NEI/NIH
    Role: Contributor
    $94,500
  • January 2007–December 2011
    Isoprenoid metabolism in the retina(2RO1EY007361)
    National Eye Institute
    Role: Principal Investigator
    $1,375,000
  • October 2009–September 2010
    Proteasome Function in the Aging Retina(1RO1EY013623)
    NEI/NIH
    Role: Contributor
    $8,742

Evaluative Studies and Case Reports:
Journal Articles:
See All (84 Total) >
Abstracts:

Professional Memberships:
  • American Soc. for Biochemistry & Molec. Biol. (ASBMB); Member (2000)
  • American Soc. of Cell Biology (ASCB); Member (1988)
  • International Society for Eye Research (ISER); Councilor for North America (2004-07) Treasurer (2007-11) President-Elect (2010-11);President(2012-14) (1985)
  • Association for Research in Vision and Ophthalmology (ARVO) (1974)
Presentations:
  • "“Impact of Cholesterol Deficiency on Retinal Development, Structure, and Function.”" European Frontiers in Ocular Pharmacology, University of Catania Medical School, (2010)
  • "“Retinal Degeneration in a Cholesterol Deficiency Syndrome: What We’ve Learned from Animal Studies.”" Grand Rounds, Department of Ophthalmology & Visual Sciences, SUNY Downstate Medical Center (2010)
  • "“Impact of Cholesterol Deficiency on Retinal Development, Structure, and Function.”" Vision Club, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center (OUHSC) (2009)
  • "“Retinal Degeneration in a Cholesterol Deficiency Syndrome: What We’ve Learned from Animal Studies.”" Vision Seminar Series, University of Pennsylvania, School of Medicine, (2009)
  • "“The Ring Trilogy: Cholesterol, Membranes, and Retinal Degeneration.”" Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, School of Medicine (2009)
  • "“The Smith-Lemli-Opitz Syndrome: It’s NOT Just About Cholesterol.”" Department of Ophthalmology, Children’s Hospital Boston/Harvard Medical School, (2009)
  • "“Transcriptional and Proteomic Changes in the Retina in a Rat Model of SLOS: The Effects of Dietary Cholesterol Supplementation.”" Scientific Symposium on Smith-Lemli-Opitz Syndrome (2009)
  • "“The Smith-Lemli-Opitz Syndrome: Thinking Beyond Sterols.”" Molecular and Developmental Genetics Seminar Series, Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, (2008)
  • "“Retinal Degeneration and Therapeutic Intervention in an Animal Model of a Hereditary Cholesterol Deficiency Syndrome.”" Symposium: Retinal Diseases- Mechanisms and Treatment; XVIII International Congress of Eye Research (ICER) (2008)
  • "“Retinal Degeneration in the AY9944-Induced Rat Model of Smith-Lemli-Opitz Syndrome: Biological, Biochemical, and Biophysical Correlates.”" Symposium: Retinal Degeneration Mechanisms & Gene Therapy- I, RD2008- XIIIth International Symposium on Retinal Degeneration (2008)
  • "“The Ring Trilogy: Cholesterol, Membranes, and Disease.”" Dept. of Ophthalmology, University of Florida (2008)
  • "Retinal Degeneration and Therapeutic Intervention in an Animal Model of a Cholesterol Deficiency Syndrome." Frontiers in Vision Science Seminar Series, Bascom Palmer Eye Institute (Dept. of Ophthalmology), University of Miami, School of Medicine (2007)
  • "The Smith-Lemli-Opitz Syndrome: It's Not Just About Cholesterol, [Grand Rounds] and “Retinal Degeneration in an Animal Model of the Smith-Lemli-Opitz Syndrome” [Research Seminar];" Scheie Eye Institute, Department of Ophthalmology, and the F.M. Kirby Center for Molecular Ophthalmology, University of Pennsylvania, School of Medicine (2007)
  • "“Retinal Degeneration and Hereditary Cholesterol Dyslipidemia: Experimental Studies.”" Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School (2007)
  • "Hereditary Cholesterol Dyslipidemia and Retinal Degeneration: Experimental Studies and Therapeutic Intervention." Beckman Vision Research Center, University of California- San Francisco (UCSF) (2007)
  • "Hereditary Cholesterol Dyslipidemia and Retinal Degeneration: Experimental Studies and Therapeutic Intervention." Department of Pathology & Cell Biology, Columbia University, College of Physicians & Surgeons (2007)
  • "“The Molecular and Metabolic Basis of SLOS: Thinking Beyond Sterols.”" Conference on Smith-Lemli-Opitz Syndrome (SLOS) and Inborn Errors of Cholesterol Synthesis (2007)
  • "Cholesterol Deficiency Syndromes: Thinking Beyond What's Missing,”" Department of Molecular Medicine, University of South Florida College of Medicine, (2007)
  • "Spare the Cholesterol and Spoil the Rod? Retinal Degeneration Caused by Deficient Cholesterol Biosynthesis" Gerald Fishman Lecture Series, Department of Ophthalmology & Visual Sciences, University of Illinois Chicago (2007)
  • "Cholesterol Deficiency and Retinal Degeneration: New Insights and Therapeutic Intervention.”" Department of Ophthalmology, University of Texas Health Sciences Center (UTHSC) at San Antonio (2007)
  • "Cholesterol-Associated Dyslipidemia and Retinal Degeneration: Experimental Studies." Department of Ophthalmology, Ulleval Hospital, University of Norway (2006)
  • "”Retinal Degeneration and Intervention in a Hereditary Dyslipidemia Model.”" First Congress, International Society for Ocular Cell Biology (ISOCB), Homerton College (2006)
  • "“Retinal Degeneration and Cholesterol Biosynthesis: Animal Model Studies and Therapeutic Intervention.”" XXI Annual Congress of the Brazilian Federation of the Societies for Experimental Biology (FeSBE) (2006)
  • "“The Ring Trilogy: Sterols, Membranes, and Disease.”" Wellman Center for Photomedicine, Massachusetts General Hospital and Dept. of Dermatology, Harvard Medical School, Boston, MA (2005)
  • "“Retinal Degeneration Associated with Defective Cholesterol Biosynthesis.”" Departments of Ophthalmology and Veterinary Medicine, Life Sciences Center, University of Missouri-Columbia (2005)
See All (25 Total) >

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

VA Western NY Healthcare System
Research Service- Bldg 20, Rm 202
3495 Bailey Avenue
Buffalo, NY 14215-1129
Phone: 716-862-6538
Fax: 716-862-6526
Email: fliesler@buffalo.edu


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