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Fumito Ito MD, PhD

Department of Surgery

Associate Professor of Surgery / Associate Professor of Oncology - Dept. of Surgery / Surgical Oncology

 

Education and Training:
  • Kyoto University (2011)
  • Fellowship, Roswell Park Cancer Institute (2010)
  • Residency, University of Wisconsin (2008)
  • Residency, University at Washington (2005)
  • PhD, Shiga University (2004)
  • Fellowship, University of Michigan (2003)
  • MD, Shiga University and Affiliated Hospital (1999)
  • MD, Shiga University (1995)
  • MB, Shiga University (1991)
  • Fellowship, Roswell Park Cancer Institute
Employment:
  • Associate Professor, Surgery, University at Buffalo (2017-present)
  • Associate Professor of Oncology, Roswell Park Cancer Institute (2017-present)
  • Member, Roswell Park Cancer Institute (2015-present)
  • Assistant Professor of Oncology, Surgery, Roswell Park Cancer Institute (2015–2017)
  • Surgeon, Surgery, Veterans Affairs Hospital (2011–2015)
  • Assistant Professor of Surgery, Surgery, University of Michigan (2011–2015)
  • Attending Physician, Kyoto Miniren Chuo Hospital, Japan (2010–2011)
  • Clinical Lecturer, Surgery, University at Buffalo (2009–2010)
Awards and Honors:
  • STL Cure Sarcoma Research Award (2017)
  • Trainee Abstract Award (2015)
  • Outstanding Poster Award (2015)
  • Young Investigator Award (2015)
  • Turcotte Enrichment Award (2014)
  • American College of Surgeons Faculty Research Fellowship Award (2014)
  • New Investigator Award (2010)
  • Basic Research Award 1st Place (2009)
  • Clinical Research Award 1st Place (Oral) (2009)
  • Travel Award: Cancer and Leukemia Group B (2008)
  • Scholarship (2000)
  • Scholarship (1998)

Grants and Sponsored Research:
  • August 2015–July 2020
    Adoptive Cell Therapy with Rejuvenated Antigen-specific T cells.
    NIH/NCI
    Role: Principal Investigator
    $810,000
  • September 2017–August 2018
    Pre-resectional Thermal Ablation as a Neoadjuvant in situ Tumor Vaccine
    Roswell Park Alliance Foundation
    Role: Co-Investigator
    $50,000
  • July 2017–June 2018
    Pluripotent Stem Cell-derived Genome-edited Sarcoma-targeted T cells for Immunotherapy.
    Sarcoma Foundation of America
    Role: Co-Investigator
    $50,000
  • July 2014–June 2016
    Induced Pluripotent Stem Cells to Generate Patient=and-Tumor-Specific T cells.
    American College of Surgeons Faculty Research Fellowships
    Role: Co-Investigator
    $80,000
  • July 2014–June 2015
    Induced Pluripotent Stem Cells to Generate Patient-and Tumor-Specific T Cells.
    Central Surgical Association Foundation
    Role: Co-Investigator
    $10,000

Journal Articles:
Abstracts:
  • Ito F, Saito, H.. Adoptive transfer of induced pluripotent stem cell-derived regenerated T cells mediates effective regression of large tumors and establishes immunological memory.. Journal of Immunology. 2016; 214(10).
  • Ito F, Saito, H.. Adoptive T cell therapy using rejuvenated antigen-specific T cells from induced pluripotent stem cells.. Journal of Immunology. 2015; 194(143).
  • Saito, H., Okita K., Noemi F., Sabel, M., Chang AE., Ito F. Generation of induced pluripotent stem cells from tumor-infiltrating lymphocytes.. Annals of Surgical Oncology. 2014; 21(1).
  • Ito F, Muhitch J., Ajith A., Evans S.. Enhancing the antitumor effects of adoptive cell transfer immunotherapy using preconditioning thermal ablation.. Journal of Immunology. 2014; 193(203.3).
  • Saito, H., Okita, K., Noemi, F., Sabel, M., Chang, AE., Ito F. Reprograming exhausted tumor-infiltrating lymphocytes by Sendai viral vectors.. New York Stem Cell Foundationn, 8th Annual, Program. 2013.
  • Muhitch J., Ito F, Fisher DT., Diehl M., Appenheimer, MM., Evans SS. Overcoming obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes.. Journal of Immunology. 2012; 188.
  • Ito F, Muhitch, J., Vardam, T., Appenheimer, MM., Fisher, DT., Wang, WC., Skitzki J, Gollnick, SO., Evans, SS.. Radiofrequency ablation augments antitumor activity of adoptive immunotherapy.. Annals of Surgical Oncology. 2011; 18(1).
  • Ito F, Muhitch, J., vardam, T., Appenheimer, MM., Fisher, DT., Wang, WC., Gollnick, SO., Evans, SS.. Improved survival with pre-resectional radiofrequency ablation is associated with enhanced CD8 T lymphocyte trafficking to tumor-draining lymph nodes and tumor sites.. Annals of Surgical Oncology. 2010; 17(1).
  • Ito F, Mukund, S., Ong, E., Alassas, M., Kane I, Skitzki J. Peritoneal lavage with distilled water is tumoricidal: science or legend?. Annals of Surgical Oncology. 2010; 17(1).
  • Ito F, Rettammel, R., Been, M., Mahvi, DM., Rikkers, LF., Weber, SM.. Hilar cholangiocarcinoma: outcome over 21 years at a tertiary referral center.. Annals of Surgical Oncology. 2007; 14(2).
  • Ito F, Li, Q., Chang, AE.. Anti-CD137 antibody administration polarizes T cells activated by tumor-lysate pulsed dendritic cells via NK cells.. American Association for Cancer Research. 2004.
  • Teitz-Tennenbaum, S., Li, Q., Rynkiewicz, S., Ito F, Davis, MA., McGinn, CJ., Chang, AE.. Radiotherapy potentiates the antitumor efficacy of intratumoral dendritic cell administration in a murine model.. Journal of Immunology. 2003.
  • Ito F, Li, Q., Chang, AE.. Anti-CD137 antibody administration enhances the efficacy of dendritic cell-based tumor vaccines.. Journal of Immunology. 2003.
  • Li, Q., Ito F, Carr, A., Chang, AE.. Adoptive immunotherapy of murine tumor MCA205 using tumor-reactive T cells generated through 4-1BB and CD28 co-stimulation.. American Association for Cancer Research. 2002.
  • Ito F, Carr, A., Svensson, H., Chang, AE., Li, Q.. Generation of tumor-specific effector T cells from tumor-bearing hosts by anti-CD3/CD28 bead activation.. American Association for Cancer Research. 2002.
See all (5 more)

Professional Memberships:
  • Association for Academic Surgery; Member (2017–present)
  • International Society for Stem Cell Research; Member #49134 (2016–present)
  • American Association of Immunologists; Member #00233537 (2014–present)
  • Central Surgical Association; Member (2012–present)
  • Society of Thermal Medicine; Member #6562 (2009–present)
  • The Society of Surgical Oncology; Member #101936 (2008–present)
  • American College of Surgeons; Member # 003085895 (2003–present)
  • American Association for Cancer Research; Member #80425 (2003–present)
  • Japan Surgical Society; Member #457483 (1995–present)
  • Japanese Society of Gastroenterological Surgey; Member #G0246840 (1995–present)
Presentations:
  • "Pluripotent stem cells as a source of adoptive T-cell therapy for Melanoma." Melanoma Disease Site Research Group Retreat (2016)
  • "Reprogramming Technology to Build The Team for Cancer Immunotherapy" Dept. of Microbiology & Immunology Seminar Series. (2016)
  • "Regeneration of antigen-specific T cells from pluripotent stem cells for immunotherapy." Roswell Park Cancer Institute Science Retreat. (2016)
  • "Adoptive transfer of induced pluripotent stem cell-derived regenerated T cells mediates effective regression of large tumors and establishes imunological memory." Annual Meeting of the American Association of Immunologists (2016)
  • "Cancer Immunotherapy with induced pluripotent stem cell-derived regenerated antigen-specific CD8+ T cells." Immuno-Oncology Young Investigator's Forum (2016)
  • "Adoptive T cell therapy using rejuvenated antigen-specific T cells from induced pluripotent stem cells." Annual Meeting of the American Association of Immunologists (2015)
  • "Generation of induced pluripotent stem cells from tumor-infiltrating lymphocytes." Annual Meeting of the Society of American Association for Cancer Research (2015)
  • "Generation of rejuvenated murine antigen-specific T cells by reprogramming to pluripotency and redifferentiation." Annual Meeting of the Society of American Association for Cancer Research (2015)
  • "Adoptive cell therapy with rejuvenated induced pluripotent stem cell-derived antigen-specific T cells." Annual Meeting of the Immuno-Hematology Symposium (2015)
  • "Generation of induced pluripotent stem cells from tumor-infiltrating lymphocytes." Moses Gunn 26th Annual Research Conference (2014)
  • "Generation of induced pluripotent sem cells from tumor-infiltrating lymphocytes." 67th Annual Meeting of the Society of Surgical Oncology (2014)
  • "Generation of induced pluripotent stem cells from tumor-infiltrating lymphocytes." 12th Annual Pathology Research Symposium (2014)
  • "Enhancing the antitumor effects of adoptive cell transfer immunotherapy using preconditioning thermal ablation." Annual Meeting of the American Association of Immunologists (2014)
  • "Overcoming hurdles to efective immunotherapy using radiofrequency ablation." 13th Annual Meeting of the Buffalo Conference on Immunology (2014)
  • "Overcoming hurdles to effective immunotherapy using radiofrequency ablation." 13th Annual Meeting of the Translational Research Cancer Center Consortium (2014)
  • "Radiofrequency ablation amplifies the efficacy of adoptive T cell transfer therapy in the generation of antitumor immunity." 31st Annual Meeting of the Society for Thermal Medicine (2014)
  • "Synergistic Antitumor Activity of Thermal Ablation and Adoptive T Cell Transfer Cancer Immunotherapy." American College of Cryosurgery Annual Meeting (2014)
  • "Preconditioning regimens overcome obstacles to CCL21-dependent T cell trafficking in tumor-draining lymph nodes." 2nd Annual Midwest Melanoma Partnership Meeting (2013)
  • "Reprogramming exhausted tumor-infiltrating lymphocytes by Sendai viral vectors." 8th Annual Meeting New York Stem Cell Foundation (2013)
  • "Overcoming obstacles to naive T lymphocyte trafficking in tumor-bearing mice." 12th Annual Buffalo Conference on Immunology (2012)
  • "Overcoming obstacles to naive T lymphocyte trafficking in tumor-bearing mice." 15th Annual Upstate New York Immunology Conference (2012)
  • "Overcoming obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." 15th Annual Translational Research Cancer Centers Consortium (2012)
  • "Overcoming obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." University of Toronto, Department of Medical Biophysics (2012)
  • "Overcoming obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." Roswell Park Cancer Institute Scientific Trainee Research Symposium, SUNY Geneseo (2012)
  • "Radio-frequency ablation augments antitumor activity of adoptive immunotherapy." 64th Annual Meeting of the Society of Surgical Oncology (2011)
  • "Systemic thermal therapy overcomes obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." 28th Annual Meeting Society Thermal Medicine (2011)
  • "Improved survival with pre-resectional radiofrequency ablation is associated with enhanced CD8 T lymphocyte trafficking to tumor-draining lymph nodes and tumor sites." 63rd Annual Meeting of the Society of Surgical Oncology (2010)
  • "Improved survival with pre-resectional radiofrequency ablation is associated with enhanced CD8 T lymphocyte trafficking to tumor-draining lymph nodes and tumor sites." 63rd Annual Meeting of the Society of Surgical Oncology (2010)
  • "Peritoneal lavage with distilled water is tumoricidal: science or legend?" 63rd Annual Meeting of the Society of Surgical Oncology (2010)
  • "Synergistic antitumor activity of radio-frequency ablation and adoptive immunotherapy." Annual Meeting of the Society for Thermal Medicine (2010)
  • "Thermal stress overcomes impediments to naive T lymphocytes trafficking across high endothelial venules in tumor-draining lymph nodes." Annual Meeting of the Society for Thermal Medicine Meeting. (2010)
  • "Improved survival with pre-resectional radiofrequency ablation is associated with enhanced CD8 T lymphocyte trafficking to tumor-draining lymph nodes and tumor sites." Western New York Chapter of the American College of Surgeons (2009)
  • "Peritoneal lavage with distilled water is tumoricidal" Western New York Chapter of the American College of Surgeons (2009)
  • "Peritoneal lavage with distilled water is tumoricidal" Western New York Chapter of the American College of Surgeons (2009)
  • "Systemic thermal therapy overcomes obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." 9th Annual Buffalo Conference on Immunology (2009)
  • "Hilar cholangiocarcinoma: outcome over 21 years at a tertiary referral center." 60th Annual Meeting of the Society of Surgical Oncology (2007)
  • "The utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid homone testing." Annual Meeting of the Wisconsin Surgical Society (2006)
  • "The utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid hormone testing." American Association of Endocrine Surgeons (2006)
  • "Anti-CD 137 antibody administration polarizes T cells activated by tumor-lysate pulsed dendritic cells via NK cells." American Association for Cancer Research (2004)
  • "Anti-CD137 antibody administration enhances the efficacy of dendritic cell-based tumor vaccines." American Association of Immunologist (2003)
  • "Radiotherapy potentiates the antitumor efficacy of intratumoral dendritic cell administration in a murine model." American Association of Immunologist (2003)
  • "Antitumor reactivity of anti-CD3/anti-CD28 bead activated lymphoid cells: implications for cell therapy." American Society of Hematology (2002)
  • "Adoptive immunotherapy of murine tumor MCA205 using tumor-reactive T cells generated through 4-1BB and CD28 co-Stimulation." American Association for Cancer Research (2002)
  • "Generation of tumor-specific effector T cells from tumor-bearing hosts by anti-CD3/CD28 bead activation." American Association for Cancer Research (2002)
See all (35 more)
Service Activities:
  • Mentor for Sunny Patel; Student Mentor (2017–present)
  • Postdoctoral Fellow Mentor; Kenichi Makino, M.D., Ph.D (2017–present)
  • Scientific Reports; Ad Hoc Reviewer (2017–present)
  • Postdoctoral Fellow Mentro; Kumiko Iwabuchi, Ph.D (Postdoctral Researcher, Center for iPS Cell Research) (2016–2017)
  • Mentor for Jacob Weltch; Student Mentor (2016–present)
  • Mentor for Joseph DiTursi; Student Mentor (2016–present)
  • Postdoctoral Fellow Mentor; Takayoshi Yamauchi, Ph.D. (2016–present)
  • Postdoctoral Fellow Mentor; Toshifumi Hoki, M.D., Ph.D (2016–present)
  • Roswell Park Cancer Institute; Scientific Review Committee of the RPCI Institutional Review Board (IRB); Member (2016–present)
  • Postdoctoral Fellows Mentor; Mentor for: Aiping Bai, M.D., Ph.D (2015–present)
  • Roswell Park Cancer Institute; RPCI-CCSG Tumor Immunology & Immunotherapy Program; Member (2015–present)
  • Postdoctoral Fellows Mentor; Mentor for Hidehito Saito, Ph.D. (Assistant Professor, Kanazawa Medical University) (2012–2015)
  • Ann Arbor Veterans Affairs Hospital; Cancer Committee; Committee Member (2011–2015)
  • Comprehensive Cancer Center; University of Michigan Medical School University of Michigan Comprehensive Cancer Center (2011–2015)
  • Journal of Surgical Oncology; Ad Hoc Reviewer (2010–present)

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Contact Information

Elm and Carlton Streets
CCC-539
Buffalo, NY 14263
Phone: 7168451300
Fax: 716-845-1595
Email: fumitoit@buffalo.edu

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