Fumito Ito MD, PhD

Fumito Ito

Fumito Ito
MD, PhD

Associate Professor of Surgery / Associate Professor of Oncology - Dept. of Surgery / Surgical Oncology

Department of Surgery

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Gene therapy; Immunology; Stem Cells; Surgery

Contact Information
Elm and Carlton Streets
CCC-539
Buffalo, NY 14263
Phone: 7168451300
Fax: 716-845-1595
fumitoit@buffalo.edu



Education and Training:

  • Center for iPS Cell Research and Application (2011)
  • Fellowship, Roswell Park Cancer Institute (2010)
  • Residency, University of Wisconsin (2008)
  • Residency, University at Washington (2005)
  • PhD, Shiga University (2004)
  • Fellowship, University of Michigan (2003)
  • General Surgery, Shiga University and Affiliated Hospital (1999)
  • MD, Shiga University (1995)
  • MB, Shiga University (1991)

Employment:

  • Associate Professor, Surgery, University at Buffalo (2017-present)
  • Associate Professor of Oncology, Roswell Park Cancer Institute (2017-present)
  • Member, Center for Immunotherapy, Roswell Park Cancer Institute (2015-present)
  • Assistant Professor of Oncology, Surgery, Roswell Park Cancer Institute (2015–2017)
  • Surgeon, Surgery, Veterans Affairs Hospital (2011–2015)
  • Assistant Professor of Surgery, Surgery, University of Michigan (2011–2015)
  • Attending Physician, Kyoto Miniren Chuo Hospital, Japan (2010–2011)
  • Clinical Lecturer, Surgery, University at Buffalo (2009–2010)

Awards and Honors:

  • STL Cure Sarcoma Research Award (2017)
  • Trainee Abstract Award (Mentee): American Association of Immunologists (2015)
  • Outstanding Poster Award (2015)
  • Young Investigator Award: Melanoma Research Alliance (2015)
  • Turcotte Enrichment Award: Central Surgical Association Foundation (2014)
  • American College of Surgeons Faculty Research Fellowship Award (2014)
  • New Investigator Award: Society of Thermal Medicine (2010)
  • Basic Research Award 1st Place: Western New York Chapter of the American College of Surgeons (2009)
  • Clinical Research Award 1st Place: Western New York Chapter of the American College of Surgeons (2009)
  • Travel Award: Cancer and Leukemia Group B (2008)
  • Scholarship: Japan-North America Medical Exchange Foundation (2000)
  • Scholarship: Japan-North America Medical Exchange Foundation (1998)

Research Expertise:

  • General Surgery
  • Stem Cell and Developmental Biology
  • Surgical Oncology
  • Tumor Immunology and Cancer Immunotherapy

Grants and Sponsored Research:

  • August 2015–July 2020
    NIH/NCI K08 Mentored Clinical Scientist Research Career Development Award
    NIH/NCI
    Role: Principal Investigator
    $810,000
  • March 2018–February 2019
    Roswell Park Alliance Foundation Grant
    Roswell Park Alliance Foundation
    Role: Principal Investigator
    $100,000
  • July 2017–June 2018
    Sarcoma Foundation of America Award
    Sarcoma Foundation of America
    Role: Principal Investigator
    $50,000
  • May 2015–April 2018
    Melanoma Research Alliance Young Investigator Award
    Melanoma Research Alliance
    Role: Principal Investigator
    $225,000
  • July 2014–June 2016
    American College of Surgeons Faculty Research Fellowships
    American College of Surgeons Faculty Research Fellowships
    Role: Principal Investigator
    $80,000
  • July 2014–June 2015
    Central Surgical Association Foundation Award
    Central Surgical Association Foundation
    Role: Principal Investigator
    $10,000

Journal Articles:


Professional Memberships:

  • Association for Academic Surgery; Member (2017–present)
  • International Society for Stem Cell Research; Member #49134 (2016–present)
  • American Association of Immunologists; Member #00233537 (2014–present)
  • Central Surgical Association; Member (2012–present)
  • Society of Thermal Medicine; Member #6562 (2009–present)
  • The Society of Surgical Oncology; Member #101936 (2008–present)
  • American College of Surgeons; Member # 003085895 (2003–present)
  • American Association for Cancer Research; Member #80425 (2003–present)
  • Japan Surgical Society; Member #457483 (1995–present)
  • Japanese Society of Gastroenterological Surgey; Member #G0246840 (1995–present)

Presentations:

  • "Pluripotent stem cells as a source of adoptive T-cell therapy for Melanoma." Melanoma Disease Site Research Group Retreat (2016)
  • "Reprogramming Technology to Build The Team for Cancer Immunotherapy" Dept. of Microbiology & Immunology Seminar Series. (2016)
  • "Regeneration of antigen-specific T cells from pluripotent stem cells for immunotherapy." Roswell Park Cancer Institute Science Retreat. (2016)
  • "Adoptive transfer of induced pluripotent stem cell-derived regenerated T cells mediates effective regression of large tumors and establishes imunological memory." Annual Meeting of the American Association of Immunologists (2016)
  • "Cancer Immunotherapy with induced pluripotent stem cell-derived regenerated antigen-specific CD8+ T cells." Immuno-Oncology Young Investigator's Forum (2016)
  • "Adoptive T cell therapy using rejuvenated antigen-specific T cells from induced pluripotent stem cells." Annual Meeting of the American Association of Immunologists (2015)
  • "Generation of induced pluripotent stem cells from tumor-infiltrating lymphocytes." Annual Meeting of the Society of American Association for Cancer Research (2015)
  • "Generation of rejuvenated murine antigen-specific T cells by reprogramming to pluripotency and redifferentiation." Annual Meeting of the Society of American Association for Cancer Research (2015)
  • "Adoptive cell therapy with rejuvenated induced pluripotent stem cell-derived antigen-specific T cells." Annual Meeting of the Immuno-Hematology Symposium (2015)
  • "Generation of induced pluripotent stem cells from tumor-infiltrating lymphocytes." Moses Gunn 26th Annual Research Conference (2014)
  • "Generation of induced pluripotent sem cells from tumor-infiltrating lymphocytes." 67th Annual Meeting of the Society of Surgical Oncology (2014)
  • "Generation of induced pluripotent stem cells from tumor-infiltrating lymphocytes." 12th Annual Pathology Research Symposium (2014)
  • "Enhancing the antitumor effects of adoptive cell transfer immunotherapy using preconditioning thermal ablation." Annual Meeting of the American Association of Immunologists (2014)
  • "Overcoming hurdles to efective immunotherapy using radiofrequency ablation." 13th Annual Meeting of the Buffalo Conference on Immunology (2014)
  • "Overcoming hurdles to effective immunotherapy using radiofrequency ablation." 13th Annual Meeting of the Translational Research Cancer Center Consortium (2014)
  • "Radiofrequency ablation amplifies the efficacy of adoptive T cell transfer therapy in the generation of antitumor immunity." 31st Annual Meeting of the Society for Thermal Medicine (2014)
  • "Synergistic Antitumor Activity of Thermal Ablation and Adoptive T Cell Transfer Cancer Immunotherapy." American College of Cryosurgery Annual Meeting (2014)
  • "Preconditioning regimens overcome obstacles to CCL21-dependent T cell trafficking in tumor-draining lymph nodes." 2nd Annual Midwest Melanoma Partnership Meeting (2013)
  • "Reprogramming exhausted tumor-infiltrating lymphocytes by Sendai viral vectors." 8th Annual Meeting New York Stem Cell Foundation (2013)
  • "Overcoming obstacles to naive T lymphocyte trafficking in tumor-bearing mice." 12th Annual Buffalo Conference on Immunology (2012)
  • "Overcoming obstacles to naive T lymphocyte trafficking in tumor-bearing mice." 15th Annual Upstate New York Immunology Conference (2012)
  • "Overcoming obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." 15th Annual Translational Research Cancer Centers Consortium (2012)
  • "Overcoming obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." University of Toronto, Department of Medical Biophysics (2012)
  • "Overcoming obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." Roswell Park Cancer Institute Scientific Trainee Research Symposium, SUNY Geneseo (2012)
  • "Radio-frequency ablation augments antitumor activity of adoptive immunotherapy." 64th Annual Meeting of the Society of Surgical Oncology (2011)
  • "Systemic thermal therapy overcomes obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." 28th Annual Meeting Society Thermal Medicine (2011)
  • "Improved survival with pre-resectional radiofrequency ablation is associated with enhanced CD8 T lymphocyte trafficking to tumor-draining lymph nodes and tumor sites." 63rd Annual Meeting of the Society of Surgical Oncology (2010)
  • "Improved survival with pre-resectional radiofrequency ablation is associated with enhanced CD8 T lymphocyte trafficking to tumor-draining lymph nodes and tumor sites." 63rd Annual Meeting of the Society of Surgical Oncology (2010)
  • "Peritoneal lavage with distilled water is tumoricidal: science or legend?" 63rd Annual Meeting of the Society of Surgical Oncology (2010)
  • "Synergistic antitumor activity of radio-frequency ablation and adoptive immunotherapy." Annual Meeting of the Society for Thermal Medicine (2010)
  • "Thermal stress overcomes impediments to naive T lymphocytes trafficking across high endothelial venules in tumor-draining lymph nodes." Annual Meeting of the Society for Thermal Medicine Meeting. (2010)
  • "Improved survival with pre-resectional radiofrequency ablation is associated with enhanced CD8 T lymphocyte trafficking to tumor-draining lymph nodes and tumor sites." Western New York Chapter of the American College of Surgeons (2009)
  • "Peritoneal lavage with distilled water is tumoricidal" Western New York Chapter of the American College of Surgeons (2009)
  • "Peritoneal lavage with distilled water is tumoricidal" Western New York Chapter of the American College of Surgeons (2009)
  • "Systemic thermal therapy overcomes obstacles to naive T lymphocyte trafficking in tumor-draining lymph nodes." 9th Annual Buffalo Conference on Immunology (2009)
  • "Hilar cholangiocarcinoma: outcome over 21 years at a tertiary referral center." 60th Annual Meeting of the Society of Surgical Oncology (2007)
  • "The utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid homone testing." Annual Meeting of the Wisconsin Surgical Society (2006)
  • "The utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid hormone testing." American Association of Endocrine Surgeons (2006)
  • "Anti-CD 137 antibody administration polarizes T cells activated by tumor-lysate pulsed dendritic cells via NK cells." American Association for Cancer Research (2004)
  • "Anti-CD137 antibody administration enhances the efficacy of dendritic cell-based tumor vaccines." American Association of Immunologist (2003)
  • "Radiotherapy potentiates the antitumor efficacy of intratumoral dendritic cell administration in a murine model." American Association of Immunologist (2003)
  • "Antitumor reactivity of anti-CD3/anti-CD28 bead activated lymphoid cells: implications for cell therapy." American Society of Hematology (2002)
  • "Adoptive immunotherapy of murine tumor MCA205 using tumor-reactive T cells generated through 4-1BB and CD28 co-Stimulation." American Association for Cancer Research (2002)
  • "Generation of tumor-specific effector T cells from tumor-bearing hosts by anti-CD3/CD28 bead activation." American Association for Cancer Research (2002)
See all (35 more)

Service Activities:

  • Mentor for Jesse Hubbard; Student Mentor (2018)
  • Journal of Surgical Research; Ad Hoc Reviewer (2017–present)
  • Mentor for Sunny Patel; Student Mentor (2017)
  • Postdoctoral Fellow Mentor; Kenichi Makino, M.D., Ph.D (2017–present)
  • Scientific Reports; Ad Hoc Reviewer (2017–present)
  • Mentor for Jacob Weltch; Student Mentor (2016)
  • Mentor for Joseph DiTursi; Student Mentor (2016)
  • IRB member Roswell Park Cancer Institute; Scientific Review Committee of the RPCI Institutional Review Board (IRB); Member (2016–present)
  • Postdoctoral Fellow Mentor; Takayoshi Yamauchi, Ph.D. (2016–present)
  • Postdoctoral Fellow Mentor; Toshifumi Hoki, M.D., Ph.D (2016–present)
  • Roswell Park Tumor Immunology & Immunotherapy Program; RPCI-CCSG; Member (2015–present)
  • Postdoctoral Fellows Mentor; Mentor for Hidehito Saito, Ph.D. (Assistant Professor, Kanazawa Medical University) (2012–2015)
  • Ann Arbor Veterans Affairs Hospital; Cancer Committee; Committee Member (2011–2015)
  • Comprehensive Cancer Center; University of Michigan Medical School University of Michigan Comprehensive Cancer Center; Member (2011–2015)
  • Journal of Surgical Oncology; Ad Hoc Reviewer (2010–present)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

Elm and Carlton Streets
CCC-539
Buffalo, NY 14263
Phone: 7168451300
Fax: 716-845-1595
fumitoit@buffalo.edu