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G. Iyer                        Parameswaran

G. Iyer Parameswaran MD

Department of Medicine

Research Assistant Professor

Specialty/Research Focus

Infectious Disease; Internal Medicine; Pulmonary Disease

Professional Summary:

My area of expertise is in infectious diseases in adults and I evaluate and treat adults with all infections, without restriction to a special area, and see patients within the Veterans Affairs hospital system. I act as a consultant for other physicians treating patients who have, or are suspected to have, infectious diseases in hospital settings or outside the hospital.

Prior to becoming an infectious disease specialist, I had training and work experience in surgery as well as internal medicine. This exposure has helped me in my current clinical practice since infections occur in patients after surgical procedures. Having a firsthand understanding of what surgeons do allows me to understand the patient’s overall situation better.

I teach first- and second-year medical students, primarily in pulmonary, in small group sessions.

My research is focused on bacterial infections in patients with chronic obstructive pulmonary disease (emphysema and chronic bronchitis, known also as COPD). I am especially interested in how the host (the human body) reacts to the pathogen (the bacteria), and how differences in the host determine the outcome of the encounter between host and pathogen. Recently, we found that airway epithelial cells from patients with COPD respond to pathogenic bacteria in a manner that is different from healthy, non-COPD people. My goal is to further characterize and understand the cellular mechanisms underlying this aberrant behavior in COPD. I expect this research to open new avenues of therapy specially tailored to intervene in the host-pathogen interaction.

Students and fellows have the opportunity to conduct research with me. I collaborate with Sanjay Sethi, MD and Charles Berenson, MD from the department of medicine and with Anders Hakansson, PhD, from the department of microbiology and immunology.

Education and Training:
  • Cert, Infectious Diseases, American Board of Internal Medicine (2008)
  • Cert, Internal Medicine, American Board of Internal Medicine (2006)
  • MBBS, Medicine, University of Kerala, India (1979)
  • Research Assistant Professor, University at Buffalo, The State University of New York (2010-present)
  • Staff Physician, VA Medical Center (2010-present)
  • Research Fellow, Division of Infectious Diseases, University at Buffalo, Division of Infectious Diseases (2008–2010)
  • Fellow in Infectious Diseases, University at Buffalo (2006–2008)
  • Faculty Physician, Primary Care Residency Program, Unity Health, Rochester (2001–2006)
  • Assistant Clinical Professor, Medicine, University of Rochester (2001–2006)
  • Internal Medicine Physician, viaHealth, Rochester (1997–2001)

Research Expertise:
  • Bacterial infection in chronic obstructive pulmonary disease (COPD): emphysema and chronic bronchitis
Grants and Sponsored Research:
  • August 2012–August 2013
    A phase 2 double-blind randomized controlled study to evaluate the efficacy of MED18969 in chronic obstructive pulmonary disease
    MedImmune Inc.
    Role: Co-Investigator
  • January 2012–December 2012
    Methicillin-resistant Staphylococcus aureus colonization and effects of Linezolid on inflammation in COPD . ASPIRE Young Investigator award 2012
    Pfizer, Inc.
    Role: Principal Investigator

Journal Articles:
See all (5 more)
Books and Book Chapters:
  • Parameswaran GI, Sethi S. Viral Pneumonia (book chapter). Clinical Respiratory Medicine. 2012.
  • Mohan A., Eberhardt E., Grove L., Murphy TF, Parameswaran GI, Sethi S. Clinical Features Of Exacerbations Of Chronic Obstructive Pulmonary Disease Are Related To Sputum Microbiology. ATS International Conference, San Diego, CA. 2014.
  • Parameswaran GI, Sethi S, Willet A., Wrona C.. Nontypeable Haemophilus influenzae induces excessive TLR2 driven NF-kb activation in COPD airway epithelial cells. ATS International Conference, Philadephia, PA. 2013.
  • Parameswaran GI, Sethi S, Willet A., Lesse AJ. Methicillin-Resistant Staphylococcus aureus (MRSA) in COPD. ATS International Conference, Philadephia, PA. 2013.
  • Parameswaran GI, Murphy TF, Yin J., Grove L., Eberhardt E., Berenson CS, Sethi S. Species Specific Susceptibility To Bacterial Colonization And Exacerbation In COPD. ATS International Conference, San Francisco, CA. 2012.
  • Parameswaran GI, Sethi S, Murphy TF. Transcriptional And Cytokine Responses Of Airway Epithelial Cells To Infection In COPD. ATS International Conference, San Francisco, CA. 2012.
  • Sethi S, Wrona C., Eberhardt E., Grove L., Parameswaran GI, Murphy TF. Distinguishing Infecting (New) From Colonizing (Pre-Existing) Nontypeable Haemophilus Influenzae Strains At Exacerbation Of COPD By Molecular And Immunological Assays. ATS International Conference, San Francisco, CA. 2012.
  • Jamil M.O., Yin J., Nag N., Eberhardt E., Grove L., Parameswaran GI, Murphy TF, Sethi S. Acquistion Of Pseudomonas Aeruginosa Is Associated With Adverse Clinical Outcomes In COPD. ATS International Conference, San Francisco, CA. 2012.
  • Parameswaran GI, Sethi S, Murphy TF. Effects Of Bacterial Infection On Airway Antimicrobial Peptides And Proteins In Chronic Obstructive Pulmonary Disease. ATS International Conference, Denver, CO. 2011.

  • "Antimicrobial polypeptides and moraxella catarrhalis in COPD" American Thoracic Society International Meeting (2009)
  • "Protease-Antiprotease balance is altered in colonization and exacerbation due to moraxella catarrhalis in COPD" American Thoracic Society International Meeting (2009)
  • "Antibacterial activity of human cathelicidin LL-37" IDSA/ICAAC Annual Meeting (2008)
  • "Can response to nitroglycerin predict coronary artery disease in patients presenting with chest pain" 13rh World Congress on Heart Disease (2007)
  • "ABI as a prediction in patients with acute chest pain not known to have CAD" SGIM Mid-Atlantic Regional Meeting (2005)
  • "American Thoracic Society International Meeting" SGIM National Meeting (2004)
  • "Validation of a clinical decision rule for survival during cardiopulmonary resuscitation after cardian arrest" SGIM Mid-Atlantic Regional Meeting (2004)
  • "Pulse oximetry as a screening tool to detect lower extremity arterial disease in diabetes" North American Primary Care Research Group Annual Session (2003)
Service Activities:
  • Western New York Branch of American Society of Microbiology; President (2009–2010)
  • Implementing electronic evaluation system for Internal Medicine Residency Program; Contributor (2002–2004)
  • Unity Health Primary Care Residency Program; Leadership role in forming ad revising methods and tools to evaluate resident performance.; Co-Director

School News:
In the Media:

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Contact Information

Room 107, Building 20
VA WNY Healthcare System
3495 Bailey Avenue
Buffalo, NY 14215
Phone: (716) 862-8924

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