G. Iyer Parameswaran MD
G. Iyer Parameswaran
MD
Clinical Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Infectious Disease; Infectious Diseases; Internal Medicine
Professional Summary:
My area of expertise is in infectious diseases in adults and I evaluate and treat adults with all infections, without restriction to a special area, and see patients within the Veterans Affairs hospital system. I act as a consultant for other physicians treating patients who have, or are suspected to have, infectious diseases in hospital settings or outside the hospital.
I teach second and third year medical students, especially in interviewing and examination of patients.
My research is focused on bacterial infections in patients with chronic obstructive pulmonary disease (emphysema and chronic bronchitis, known also as COPD). I am especially interested in how the host (the human body) reacts to the pathogen (the bacteria), and how differences in the host determine the outcome of the encounter between host and pathogen. Recently, we found that airway epithelial cells from patients with COPD respond to pathogenic bacteria in a manner that is different from healthy, non-COPD people. My goal is to further characterize and understand the cellular mechanisms underlying this aberrant behavior in COPD. I expect this research to open new avenues of therapy specially tailored to intervene in the host-pathogen interaction.
Students and fellows have the opportunity to conduct research with me. I collaborate with Sanjay Sethi, MD and Charles Berenson, MD from the department of medicine.
Education and Training:
- Fellowship, Infectious Diseases Fellowship training, University at Buffalo, The State University of New York (2008)
- Residency, Internal Medicine Residency training, St. Mary's Hospital (Unity Health System). (1997)
- Medicine, University of Kerala, India (1979)
Employment:
- Research Assistant Professor, University at Buffalo, The State University of New York Jacobs School of Medicine & Biomedical Sciences (2010-present)
- Staff Physician, VA Medical Center (2010-present)
- Research Fellow, Division of Infectious Diseases, University at Buffalo Division of Infectious Diseases (2008–2010)
- Fellow in Infectious Diseases, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2006–2008)
- Assistant Clinical Professor, Medicine, University of Rochester (2001–2006)
- Faculty Physician, Primary Care Residency Program, Unity Health, Rochester (2001–2006)
- Internal Medicine Physician, viaHealth, Rochester (1997–2001)
Research Expertise:
- Bacterial infection in chronic obstructive pulmonary disease (COPD): emphysema and chronic bronchitis
Grants and Sponsored Research:
- August 2012–August 2013
A phase 2 double-blind randomized controlled study to evaluate the efficacy of MED18969 in chronic obstructive pulmonary disease
MedImmune Inc.
Role: Co-Investigator
$135,000 - January 2012–December 2012
Methicillin-resistant Staphylococcus aureus colonization and effects of Linezolid on inflammation in COPD . ASPIRE Young Investigator award 2012
Pfizer, Inc.
Role: Principal Investigator
$100,000
Journal Articles:
- Shafiq I, Bulman ZP, Spitznogle SL, Osorio JE, Reilly IS, Lesse AJ, Parameswaran GI, Mergenhagen KA, Tsuji BT. (2017) A combination of ceftaroline and daptomycin has synergistic and bactericidal activity in vitro against daptomycin nonsusceptible methicillin-resistant Staphylococcus aureus (MRSA). Infect Dis (Lond) (Jan)1-10.
- Ruh CA, Parameswaran GI, Wojciechowski AL, Mergenhagen KA, Parameswaran G. (2015) Outcomes and Pharmacoeconomic Analysis of a Home Intravenous Antibiotic Infusion Program in Veterans. Clin Ther (Nov), 37(11): 2527-2535.
- Wojciechowski AL, Parameswaran GI, Mattappallil A, Mergenhagen KA, Parameswaran G. (2014) Corticosteroid use is associated with a reduced incidence of Clostridium difficile-associated diarrhea: a retrospective cohort study. Anaerobe (Dec), 30: 27-29.
- Parameswaran GI, Sethi S. (2014) Long term Macrolide therapy in Chronic Obstructive Pulmonary Disease. Canadian Medical Association Journal (Oct), 186(15): 1148-1152.
- Kalathil S.G., Lugade A.A., Pradhan V., Miller A., Parameswaran GI, Sethi S, Thanavala Y. (2014) T regulatory cells and PD-1 T cells contribute to effector T cell dysfunction in COPD patients. American Journal of Respiratory and Critical Care Medicine (Jul), 190(1): 40-50.
- Kalathil S.G., Lugade A.A., Pradhan V., Miller A., Parameswaran GI, Sethi S, Thanavala Y. (2014) T regulatory cells and PD-1 T cells contribute to effector T cell dysfunction in COPD patients. American Journal of Respiratory and Critical Care Medicine (Jul), 190(1): 40-50.
- Kalathil SG, Lugade AA, Pradhan V, Miller A, Parameswaran GI, Sethi S, Thanavala Y, Parameswaran G. (2014) T-regulatory cells and programmed death 1+ T cells contribute to effector T-cell dysfunction in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (Jul), 190(1): 40-50.
- Desai H., Eschberger K., Wrona C., Grove L., Agrawal A., Grant B., Yin J., Parameswaran GI, Murphy TF, Sethi S. (2014) Bacterial Colonization of the Lower Respiratory Tract Increases Daily Symptoms in Patients with Chronic Obstructive Pulmonary Disease. Annals of the American Thoracic Society (Mar), 11(3): 303-309.
- Parameswaran GI, Sethi S. (2012) Pseudomonas infection in chronic obstructive pulmonary disease. Future Microbiology. (Oct)1129-1132.
- Marks LR, Parameswaran GI, Hakansson AP. (2012) Pneumococcal interactions with epithelial cells are crucial for optimal biofilm formation and colonization in vitro and in vivo. Infect Immun (May).
- Parameswaran GI, Sethi S, Murphy TF, Parameswaran G. (2011) Effects of bacterial infection on airway antimicrobial peptides and proteins in chronic obstructive pulmonary disease. Chest (Feb).
- Döring G, Parameswaran IG, Murphy TF. (2011) Differential adaptation of microbial pathogens to airways of patients with cystic fibrosis and chronic obstructive pulmonary disease. FEMS Microbiol Rev (Jan), 35(1): 124-146.
- Parameswaran GI, Wrona CT, Murphy TF, Sethi S, Parameswaran G. (2009) Moraxella catarrhalis acquisition, airway inflammation and protease-antiprotease balance in chronic obstructive pulmonary disease. BMC Infect Dis (Nov), 9: 178-178.
- Murphy TF, Parameswaran GI. (2009) Moraxella catarrhalis, a human respiratory tract pathogen. Clin Infect Dis (Jul), 49(1): 124-131.
- Iyer Parameswaran G, Murphy TF, Parameswaran G. (2009) Chronic obstructive pulmonary disease: role of bacteria and updated guide to antibacterial selection in the older patient. Drugs Aging (Jan), 26(12): 985-995.
- Parameswaran GI, Segal BH, Almyroudis NG, Parameswaran G. (2008) Antifungal agents in hematopoietic stem cell transplantation. Curr Pharm Des (Jan), 14(20): 2011-2021.
Books and Book Chapters:
- Parameswaran GI, Sethi S. (2012) Viral Pneumonia. In: Viral Pneumonia (book chapter).
Abstracts:
- Mohan A., Eberhardt E., Grove L., Murphy TF, Parameswaran GI, Sethi S. (2014) Clinical Features Of Exacerbations Of Chronic Obstructive Pulmonary Disease Are Related To Sputum Microbiology. ATS International Conference, San Diego, CA, (May)
- Parameswaran GI, Sethi S, Willet A., Lesse AJ. (2013) Methicillin-Resistant Staphylococcus aureus (MRSA) in COPD. ATS International Conference, Philadephia, PA, (May)
- Parameswaran GI, Sethi S, Willet A., Wrona C. (2013) Nontypeable Haemophilus influenzae induces excessive TLR2 driven NF-kb activation in COPD airway epithelial cells. ATS International Conference, Philadephia, PA, (May)
- Parameswaran GI, Murphy TF, Yin J., Grove L., Eberhardt E., Berenson CS, Sethi S. (2012) Species Specific Susceptibility To Bacterial Colonization And Exacerbation In COPD. ATS International Conference, San Francisco, CA, (May)
- Parameswaran GI, Sethi S, Murphy TF. (2012) Transcriptional And Cytokine Responses Of Airway Epithelial Cells To Infection In COPD. ATS International Conference, San Francisco, CA, (May)
- Sethi S, Wrona C., Eberhardt E., Grove L., Parameswaran GI, Murphy TF. (2012) Distinguishing Infecting (New) From Colonizing (Pre-Existing) Nontypeable Haemophilus Influenzae Strains At Exacerbation Of COPD By Molecular And Immunological Assays. ATS International Conference, San Francisco, CA, (May)
- Jamil M.O., Yin J., Nag N., Eberhardt E., Grove L., Parameswaran GI, Murphy TF, Sethi S. (2012) Acquistion Of Pseudomonas Aeruginosa Is Associated With Adverse Clinical Outcomes In COPD. ATS International Conference, San Francisco, CA, (May)
- Parameswaran GI, Sethi S, Murphy TF. (2011) Effects Of Bacterial Infection On Airway Antimicrobial Peptides And Proteins In Chronic Obstructive Pulmonary Disease. ATS International Conference, Denver, CO, (May)
Presentations:
- "Antimicrobial polypeptides and moraxella catarrhalis in COPD" American Thoracic Society International Meeting (2009)
- "Protease-Antiprotease balance is altered in colonization and exacerbation due to moraxella catarrhalis in COPD" American Thoracic Society International Meeting (2009)
- "Antibacterial activity of human cathelicidin LL-37" IDSA/ICAAC Annual Meeting (2008)
- "Can response to nitroglycerin predict coronary artery disease in patients presenting with chest pain" 13rh World Congress on Heart Disease (2007)
- "ABI as a prediction in patients with acute chest pain not known to have CAD" SGIM Mid-Atlantic Regional Meeting (2005)
- "American Thoracic Society International Meeting" SGIM National Meeting (2004)
- "Validation of a clinical decision rule for survival during cardiopulmonary resuscitation after cardian arrest" SGIM Mid-Atlantic Regional Meeting (2004)
- "Pulse oximetry as a screening tool to detect lower extremity arterial disease in diabetes" North American Primary Care Research Group Annual Session (2003)
Service Activities:
- Implementing electronic evaluation system for Internal Medicine Residency Program; Contributor (2002–2004)
- Unity Health Primary Care Residency Program Leadership role in forming ad revising methods and tools to evaluate resident performance.; Co-Director
- : Faculty Council Standing Committee on Conflict of Interest; Voting member