Gen Suzuki MD, PhD

Gen Suzuki

Gen Suzuki
MD, PhD

Associate Professor

Department of Medicine

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Apoptosis and cell death; Cardiology; Cardiovascular Disease; Cell Cycle; Cell growth, differentiation and development; Gene therapy; Internal Medicine; Stem Cells

Contact Information
Clinical and Translational Research Center
875 Ellicott Street
Suite 7030
Buffalo, NY 14203
Phone: 829-2710
Fax: 854-1840
gsuzuki@buffalo.edu



Professional Summary:

I am a researcher with formal training and practice in both general and interventional cardiology. My research expertise is in coronary physiology and physiological studies in large animals with ischemic heart disease. Based on my background, my research is focused on therapeutic approaches to effect cardiac regeneration in large animals with acute and chronic ischemic heart disease.

In my laboratory, I use a preclinical porcine model of hibernating myocardium with chronic left anterior descending (LAD) coronary artery occlusion and collateral-dependent myocardium or infarcted myocardium caused by coronary ischemia-reperfusion. I have addressed the problem with several different therapeutic approaches involved in gene therapy, pharmacological and stem cell therapies. We routinely perform physiological studies on these porcine models with quantitative analyses of myocardial morphometry and immune-histochemical analyses.

The information we have collected in completed work demonstrates remarkable functional recovery and myocyte regeneration in the adult porcine heart. Intracoronary adenoviral gene transfer with fibroblast growth factor (FGF-5), the HMG-CoA inhibitor pravastatin and intracoronary mesenchymal stem cells (MSCs) all stimulate the proliferation of endogenous cardiac myocytes and, to some extent, generate new myocytes and vessels. Our current work is focused on understanding the regenerative capability of cardiosphere-derived cells (CDCs) originating from heart tissue in acute or chronic ischemic myocardium. The result of this work will play an important role in advancing the care of many patients with acute and chronic ischemic heart disease.

In my laboratory, I mentor research fellows through their rotation. Fellows who work in my laboratory have the unique opportunity of being exposed to large animal experimentation and learning skills related to it--in physiology and coronary angiography, as well as computed tomography (CT) and magnetic resonance imaging (MRI) techniques. Under my supervision, fellows also may work on independent projects and learn about cell biology and molecular biology, with the chance to present at international meetings and to publish as an author in international journals.

Education and Training:

  • FAHA, American Heart Association Council on Basic Cardiovascular Sciences (2011)
  • PhD, Akita University Graduate School of Medicine (1998)
  • MD, Akita University School of Medicine (1992)

Employment:

  • Associate Professor, Medicine, University at Buffalo (2013-present)
  • Research Assistant Professor, University at Buffalo (2004–2013)
  • Post Doctoral Fellow, University at Buffalo (2000–2004)
  • Clinical & Research Fellow, Research Institute for Brain and Blood Vessels, Japan (1998–2000)
  • Staff Physician - Cardiology, Noshiro Ishikai Hospital, Japan (1997–1998)
  • Staff Physician - Cardiology, Akita Rousai Hospital, Japan (1994–1996)
  • Resident of Internal Medicine, Yuri General Hospital, Japan (1993–1994)
  • Resident of Internal Medicine, Akita University Medical Center, Japan (1992–1993)

Awards and Honors:

  • Buswell Fellow (2007)
  • AHA BCVS Travel Award (2003)

Research Expertise:

  • Chronic adaptations to myocardial ischemia
  • Stem cell therapy
  • Sudden cardiac death

Grants and Sponsored Research:

  • November 2014–November 2019
    NIH National Heart Lung and Blood Institute, Mechanisms of cKit Cardiac Stem Cell-Mediated Repair in Ischemic Cardiomyopathy
    NIH National Heart Lung and Blood Institute
    Role: Co-Investigator
  • November 2014–October 2018
    Mechanisms of cKit+ Cardiac Stem Cell-Mediated Repair in Ischemic Cardiomyopathy
    National Heart Lung and Blood Institute
    Role: Co-Investigator
    $2,056,476
  • January 2017–January 2018
    UB IMPACT, 3D bioengineered cell sheet for cardiac
    University at Buffalo
    Role: Principal Investigator
  • July 2013–June 2015
    T3np for Cardiac Resuscitation - Pivotal Pre-Clinical Trial
    UB CAT/Pro-Al Medico Technologies
    Role: Co-Investigator
  • January 2011–January 2015
    NIH National Heart Lung and Blood Institute; Chronic Adaptation of Myocardial Ischemia
    Role: Co-Principal Investigator
  • January 2009–December 2012
    NYSTEM, IDEA in Stem Cell Research. Modification of Resident Cardiac Stem Cells by Circulating Hematopoietic Stem Cells in Ischemic Cardiomyopathy
    NYSTEM
    Role: Principal Investigator
  • January 2006–December 2011
    Department of Veterans Affairs. Merit Review, Statins and Growth Factors for Chronic Ischemic Heart Failure
    Role: Co-Principal Investigator
  • January 2007–January 2010
    Buswell Fellowship:Cell Based Cardiac Repair in Ischemic Cardiomyopathy
    State University of New York at Buffalo
    Role: Principal Investigator
  • January 2004–January 2007
    AHA Scientist Development Grant: Angiogenesis and Myocyte Repair of Hibernating Myocardium with Autologous Mesenchymal Stem Cells
    American Heart Association
    Role: Principal Investigator
  • January 2001–January 2004
    AHA Postdoctoral Research Fellowship: Modulation of Hibernating Myocardium by Gene Transfer
    American Heart Association
    Role: Principal Investigator

Journal Articles:

See all (26 more)

Professional Memberships:

  • American Heart Association; Council on Basic Cardiovascular Science Council on Arteriosclerosis, Thrombosis and Vascular Biology Interdisciplinary Group on Functional Genomics & Translation Biology (2000–present)
  • Japanese Circulation Society (1998–present)

Presentations:

  • "Allogeneic Intracoronary Mesenchymal Stem Cells (icMSCs) and Cardiosphere-Derived Cells (icCDCs) Stimulate Comparable Endogenous Myocyte Regeneration Throughout the Left Ventricle in Swine With Hibernating Myocardium." AHA2013 (2013)
  • "Global Intracoronary Infusion of Allogeneic Atrial Cardiosphere-Derived Cells (CDCs) Stimulates Myocyte Regeneration and Reverses LV Remodeling in Miniature Swine With Chronic Myocardial Infarction." AHA 2013 (2013)
  • "Blinded Head-to-Head Comparison of Intracoronary Allogeneic Cardiosphere-Derived Cells (icCDCs) Versus Allogeneic Mesenchymal Stem Cells (icMSCs) in Swine with Hibernating Myocardium." BCVS Meeting 2013 (2013)
  • "Intracoronary Cardiosphere-derived Cells (icCDCs) Produce Microcirculatory Remodeling But Do Not Increase Coronary Flow Reserve In Swine With Hibernating Myocardium." Journal of the American College of Cardiology 2013 (2013)
  • "Intracoronary Infusion of Allogeneic Cardiosphere-Derived Cells (icCDCs) Stimulates Endogenous Myocyte Proliferation and Inhibits Apoptosis in Swine with Ischemic Cardiomyopathy." AHA meeting (2012)
  • "Short-term Pravastatin Amplifies Cardiac Regeneration in Swine with Ischemic Cardiomyopathy." AHA meeting (2012)
  • "Arteriolar remodeling limits maximal perfusion after percutaneous revascularization of a chronic stenosis in pigs with hibernating myocardium." FASEB (2012)
  • "Pravastatin stimulates proliferation of endogenous cardiac progenitor cells in the heart." FASEB (2012)
  • "Intracoronary injection of cardiosphere-derived cells improves regional function by recuriting endogenous cell repair mechanisms in chronically ischemic myocardium" NYSTEM2011 science accelerating therapies, NYSTEM (2011)
  • "Allogenic Mesenchymal Stem Cells (icMSCs) and Oral Pravastatin Increase cKit+/CD45- Progenitor Cells and Synergistically Enhance Cardiomyocyte Differentiation in Swine with Chronic Ischemic Cardiomyopathy." AHA meeitng (2010)
  • "Extracardiac injection of plasmid VEGF165 improves myocardial function by stimulating myocytes to re-enter the cell cycle in swine with hibernating myocardium." ACC meeting (2010)
  • "Coronary revascularization via percutaneous intervention (PCI) improves cardiac function by stimulating endogenous cardiac repair in swine with hibernating myocardium." AHA meeting (2009)
  • "Hybrid therapy with pravastatin and nonautologous intracoronary mesenchymal stem cells (MSCs) synergistically facilitate cardiac repair in swine with ischemic cardiomyopathy." AHA meeting (2009)
  • "Rosuvastatin does not improve myocardial function, perfusion, or stimulate myocyte proliferation in swine with hibernating myocardium. Circulation." AHA meeting (2009)
  • "Pravastatin followed by intracoronary fibroblast growth factor (FGF-5) synergistically amplifies endogenous cardiac repair in swine with hibernating myocardium." ACC meeting (2009)
  • "Hibernating myocardium has reduced high energy phosphate levels and a preconditioning-like effect with slow ATP depletion in response to acute ischemia." AHA meeitng (2007)
  • "Intracoronary injection of autologous mesenchymal stem cells (MSCs) increases the myocardial localization of CD133+ hematopoietic stem cells (HSCs) in swine with hibernating myocardium." AHA meeting (2007)
  • "Intracoronary mesenchymal stem cells (MSCs) improve regional function with a differential effect on glycolytic and mitochondrial metabolic enzymes in chronic hibernating myocardium." AHA meeitng (2007)
  • "AdvFGF-5 gene transfer to swine with ischemic cardiomyopathy increases myocyte number by inhibiting apoptosis and promoting myocyte to re-enter the cell cycle." AHA meeting (2006)
  • "Dissociation between hemodymanics and electrocardiographic indices of spontaneous myocardial ischemia in telemetered swine with hibernating myocardium and sudden death." AHA meeting (2006)
  • "Intracoronary administration of AdvFGF-5 improves coronary flow reserve and myocardial function in swine with ischemic cardiomyopathy and developing coronary collaterals." AHA meeting (2006)
  • "Intracoronary fibroblast growth factor (AdvFGF-5) increases the myocardial localization of CD133+ hematopoietic stem cells (HSCs) in swine with hibernating myocardium." AHA meeting (2006)
  • "Pravastatin improves function in hibernating myocardium by restoring mitochondrial protein expression in the absence of increased perfusion." AHA meeting (2006)
  • "Intracoronary injection of autologous mesenchymal stem cells (MSCs) improves regional function by recruiting endogenous cell repair mechanisms in hibernating myocardium." ACC meeting (2006)
  • "Cardiac pyruvate dehydrogenase complex (PDC) deficiency in mice leads to myocardial hypertrophy and cardiomyopathy." AHA meeting (2005)
  • "Myocardial proteomic profiling demonstrates that overexpressing fibroblast growth factor (AdvFGF-5) normalizes metabolic and stress protein expression in swine with hibernating myocardium." AHA meeting (2005)
  • "Pravastatin improves function, increases myocardial CD133+ progenitor cells and stimulates myocytes to re-enter the cell cycle in hibernating myocardium." AHA meeting (2005)
  • "Pravastatin increases the myocardial localization of CD133+ cells expressing GATA-4 and troponin I but only stimulates myocytes to re-enter the cell cycle in swine with hibernating myocardium." AHA meeting (2005)
  • "Increases in resting flow and angiographic collateral scores are unreliable indices of angiogenesis in swine with collateral-dependent hibernating myocardium." AHA meeting (2004)
  • "Regionally altered action potential duration restitution in swine with hibernating myocardium and sudden cardiac death." ACC meeting (2004)
  • "Time-dependent upregulation of extracellular matrix proteins in chronic hibernating myocardium: Lack of progressive degeneration." ACC meeting (2004)
  • "11C-hydroxyephedrine PET demonstrates the stability of sympathetic dysinnervation in hibernating myocardium." AHA meeting (2003)
  • "AdvFGF-5 gene transfer to swine with hibernating myocardium promotes myocytes to re-enter the cell cycle and produces myocardial hypertrophy." AHA meeting (2003)
  • "Altered myocardial efficency during transient vs. graded β-adrenergic stimulation in chronic hibernating myocardium." AHA meeting (2003)
  • "Myocardial flow, function and arrhythmic mechanism of sudden death in swine with collateral-dependent hibernating myocardium." AHA meeting (2003)
  • "Transmural variations in myocyte apoptosis and myocyte loss in swine with hibernating myocardium." FASEB (2003)
  • "Acute elevations in preload induce TnI degradation, myofibrillar loss and apoptosis in vivo: Evidence for stretch-induced myocardial dysfunction in the absence of ischemia in swine." FASEB (2003)
  • "Transient -adrenergic stimulation elicits greater contractile reserve than a graded protocol in chronically stunned myocardium." FASEB (2003)
  • "11C-hydroxyephedrine PET of hibernating myocardium demonstrates extensive sympathetic denervation." AHA scientific meeting (2002)
  • "Intracoronary administration of AdvFGF-5 improves resting function but does not alter myocardial perfusion during adenosine vasodilation in hibernating myocardium." AHA scientific meeting (2001)
  • "Transmural variations in MIBG uptake in swine with viable dysfunctional myocardium: Evidence for a chronic sympathetic denervation in hibernating myocardium." AHA scientific meeting (2001)
See all (31 more)

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Contact Information

Clinical and Translational Research Center
875 Ellicott Street
Suite 7030
Buffalo, NY 14203
Phone: 829-2710
Fax: 854-1840
gsuzuki@buffalo.edu