Harvey A. Berman PhD, MPH

Harvey Berman

Harvey A. Berman
PhD, MPH

Associate Professor

Department of Pharmacology and Toxicology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Molecular and Cellular Biology; Neuropharmacology; Protein Function and Structure

Contact Information
955 Main Street
Room 3218
Buffalo, NY 14203
Phone: 716-829-2658
Fax: 716-829-2001
hberman@buffalo.edu



Education and Training:

  • MPH, Epidemiology, SUNY at Buffalo (2010)
  • PhD, Chemistry, University of Massachusetts (1974)
  • BS, Chemistry, Brooklyn College of CUNY (1966)

Employment:

  • Associate Professor, Pharmacology and Toxicology, SUNY at Buffalo (2000-present)
  • Associate Professor, Biochemical Pharmacology, SUNY at Buffalo (1987–2000)
  • Assistant Professor, Biochemical Pharmacology, SUNY at Buffalo (1981–1987)
  • Assistant Research Pharmacologist & Lecturer, Dept. of Medicine - Pharmacology Division, University of California (1978–1982)
  • NIH Postdoctoral Fellow, Department of Medicine - Pharmacology, University of California (1975–1978)


Journal Articles:

  • Kovarik Z, Radic Z, Berman HA, Taylor P. Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates. Toxicology. 2007; 233(1-3).
  • Luo ZD, Berman HA. Pb2+-mediated down-regulation of dihydropyridine receptors in skeletal muscle. Toxicol Lett. 2004; 152(2).
  • Kovarik Z, Radic Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P. Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates. Biochemistry. 2004; 43(11).
  • Kovarik Z, Radic Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P. Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonates. Biochem J. 2003; 373(Pt 1).
  • Wong L, Radic Z, Brüggemann RJ, Hosea N, Berman HA, Taylor P. Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis.. Biochemistry. 2000; 39(19).
  • Taylor P, Wong L, Radic Z, Tsigelny I, Brüggemann R, Hosea NA, Berman HA. Analysis of cholinesterase inactivation and reactivation by systematic structural modification and enantiomeric selectivity.. Chem Biol Interact. 1999; 119-1.
  • Luo ZD, Berman HA. The influence of Pb2+ on expression of acetylcholinesterase and the acetylcholine receptor.. Toxicol Appl Pharmacol. 1997; 145(2).
  • Phillips RR, Lee MY, Berman HA, Madoff MA. The Tufts partnership for managed care education.. Acad Med. 1997; 72(5).
  • Taylor P, Hosea NA, Tsigelny I, Radic Z, Berman HA. Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis. Enantiomer. 1997; 2(3-4).
  • Hosea NA, Radic Z, Tsigelny I, Berman HA, Quinn DM, Taylor P. Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates.. Biochemistry. 1996; 35(33).
  • Taylor P, Radic Z, Hosea NA, Camp S, Marchot P, Berman HA. Structural bases for the specificity of cholinesterase catalysis and inhibition.. Toxicol Lett. 1995; 82-83.
  • Hosea NA, Berman HA, Taylor P. Specificity and orientation of trigonal carboxyl esters and tetrahedral alkylphosphonyl esters in cholinesterases.. Biochemistry. 1995; 34(36).
  • Berman HA, Leonard K. Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase.. Mol Pharmacol. 1992; 41(2).
  • Jo SA, Higgins DM, Berman HA. Regulation of acetylcholinesterase in avian heart. Studies on ontogeny and the influence of vagotomy.. Circ Res. 1992; 70.
  • Nowak MW, Berman HA. Fluorescence studies on the interactions of myelin basic protein in electrolyte solutions.. Biochemistry. 1991; 30(30).
  • Berman HA, Leonard K. Ligand exclusion on acetylcholinesterase.. Biochemistry. 1990; 29(47).
  • Decker MM, Berman HA. Denervation-induced alterations of acetylcholinesterase in denervated and nondenervated muscle.. Exp Neurol. 1990; 109(2).
  • Decker MM, Berman HA. Dihydropyridine receptor regulation of acetylcholinesterase biosynthesis.. J Biol Chem. 1990; 265(20).
  • Conti CR, Williams JF, Anderson JL, Berman HA, Gunnar RM, Herman GP, Lyons FW, Passamani ER, Reid PR, Silverman ME. Ethics in cardiovascular medicine. Task Force V: The relation of cardiovascular specialists to industry, institutions and organizations.. J Am Coll Cardiol. 1990; 16(1).
  • Berman HA, Leonard K. Chiral reactions of acetylcholinesterase probed with enantiomeric methylphosphonothioates. Noncovalent determinants of enzyme chirality.. J Biol Chem. 1989; 264(7).
  • Berman HA, Decker MM. Chiral nature of covalent methylphosphonyl conjugates of acetylcholinesterase.. J Biol Chem. 1989; 264(7).
  • Johnson DA, Brown RD, Herz JM, Berman HA, Andreasen GL, Taylor P. Decidium. A novel fluorescent probe of the agonist/antagonist and noncompetitive inhibitor sites on the nicotinic acetylcholine receptor.. J Biol Chem. 1987; 262(29).
  • Berman HA, Decker MM, Nowak MW, Leonard KJ, McCauley M, Baker WM, Taylor P. Site selectivity of fluorescent bisquaternary phenanthridinium ligands for acetylcholinesterase.. Mol Pharmacol. 1987; 31(6).
  • Berman HA, Decker MM, Jo S. Reciprocal regulation of acetylcholinesterase and butyrylcholinesterase in mammalian skeletal muscle.. Dev Biol. 1987; 120(1).
  • Edery H, Geyer MA, Taylor P, Berman HA. Target sites for anticholinesterases on the ventral surface of the medulla oblongata: hypotension elicited by organophosphorus agents.. J Auton Pharmacol. 1986; 6(3).
  • Berman HA, Decker MM. Kinetic, equilibrium, and spectroscopic studies on dealkylation ('aging') of alkyl organophosphonyl acetylcholinesterase. Electrostatic control of enzyme topography.. J Biol Chem. 1986; 261(23).
  • Berman HA, Decker MM. Kinetic, equilibrium, and spectroscopic studies on dealkylation ("aging") of alkyl organophosphonyl acetylcholinesterase. Electrostatic control of enzyme topography. J Biol Chem. 1986; 261(23).
  • Berman HA, Decker MM. Kinetic, equilibrium and spectroscopic studies on cation association at the active center of acetylcholinesterase: topographic distinction between trimethyl and trimethylammonium sites.. Biochim Biophys Acta. 1986; 872(1-2).
  • Berman HA, Yguerabide J, Taylor P. Flexibility of the molecular forms of acetylcholinesterase measured with steady-state and time-correlated fluorescence polarization spectroscopy.. Biochemistry. 1985; 24(25).
  • Edery H, Berman HA. Yohimbine antagonism of the vasodepression elicited by organophosphates applied on ventral medulla oblongata.. J Auton Nerv Syst. 1985; 14(3).
  • Berman HA, Olshefski DF, Gilbert M, Decker MM. Fluorescent phosphonate labels for serine hydrolases. Kinetic and spectroscopic properties of (7-nitrobenz-2-oxa-1,3-diazole)aminoalkyl methylphosphonofluoridates and their conjugates with acetylcholinesterase molecular forms.. J Biol Chem. 1985; 260(6).
  • Zheng S, Berman HA, Geyer MA. Behavior during hippocampal microinfusions: anticholinesterase-induced locomotor activation.. Behav Brain Res. 1983; 9(3).
  • Berman HA, Becktel W, Taylor P. Spectroscopic studies on acetylcholinesterase: influence of peripheral-site occupation on active-center conformation.. Biochemistry. 1981; 20(16).
  • Berman HA, Yguerabide J, Taylor P. Fluorescence energy transfer on acetylcholinesterase: spatial relationship between peripheral site and active center.. Biochemistry. 1980; 19(10).
  • Epstein DJ, Berman HA, Taylor P. Ligand-induced conformational changes in acetylcholinesterase investigated with fluorescent phosphonates.. Biochemistry. 1979; 18(21).
  • Berman HA, Taylor P. Fluorescent phosphonate label for serine hydrolases, pyrenebutyl methylphosphonofluoridate: reaction with acetylcholinesterase.. Biochemistry. 1978; 17(9).
  • Berman HA, Barza M, Weinstein L. Serum sulfonamide concentration after oral administration: comparison of results of chemical assay with two bioassay techniques.. Antimicrob Agents Chemother. 1972; 1(3).
  • Berman HA, Weinstein L. Antibiotics and nutrition.. Am J Clin Nutr. 1971; 24(2).
  • Berman HA, Weinstein L. Search for trichinella infection in Western Samoa and Fiji.. Med J Aust. 1970; 2(13).
  • Grossman W, Berman HA. Typhoid fever in the previously immunised.. Lancet. 1968; 2(7573).
  • Klocke RA, Augerson WS, Berman HH, Burgos FL, Rivera RA. Desquamative interstitial pneumonia. A disease with a wide clinical spectrum.. Ann Intern Med. 1967; 66(3).
  • Taylor P, Hosea NA, Tsigelny I, Radic Z, Berman HA. Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis.. Enantiomer. ; 2(3-4).
  • Berman HA. Physicians must share in costs, savings.. Internist. ; 26(5).
See all (33 more)


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Contact Information

955 Main Street
Room 3218
Buffalo, NY 14203
Phone: 716-829-2658
Fax: 716-829-2001
hberman@buffalo.edu