Hui Meng PhD
Hui Meng
PhD
Professor of Mechanical & Aerospace Engineering and Neurosurgery
Department of Biomedical Engineering
Jacobs School of Medicine & Biomedical Sciences
Education and Training:
- University at Buffalo and UCSF (2009)
- PhD, University of Houston (1994)
- Technische Universität Berlin (1990)
- MS, Zhejiang University (1987)
Employment:
- Faculty, Neuroscience Program, University at Buffalo, Neuroscience Program, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2006-present)
- Associate Professor, Mechanical and Aerospace Engineering, University at Buffalo School of Engineering and Applied Sciences (2004-present)
- Professor, Professor, Mechanical & Aerospace Engineering, Mechanical and Aerospace Engineering, University at Buffalo School of Engineering and Applied Sciences (2004-present)
- Assistant Professor, Kansas State University Mechanical Engineering (1995–1999)
- Visiting Faculty, Wright Laboratory, Wright-Patterson Air Force Base (1996)
Research Expertise:
- Biofluids and hemodynamics: vascular remodeling, cerebral aneurysm pathophysiology, endovascular intervention of aneurysms and stroke
- Holographic PIV: Holographic particle image velocimetry, optical measurements of complex flows, turbulence, particulate flows
- Modeling & analysis of biological systems: image-based computational fluid dynamics (CFD)
Grants and Sponsored Research:
- February 2009–February 2014
Hemodynamic Induction of Pathologic Remodeling Leading to Intracranial Aneurysms
National Institutes of Health/National Institute of Neurological Disorder and Stroke
Role: Principal Investigator
$1,733,595
Journal Articles:
- Poppenberg KE, Jiang K, Li L, Sun Y, Meng H, Wallace CA, Hennon TR, Jarvis JN. (2019) The feasibility of developing biomarkers from peripheral blood mononuclear cell RNAseq data in children with juvenile idiopathic arthritis using machine learning approaches. Arthritis Res Ther (Nov), 21(1): 230-230.
- Jiang K, Poppenberg KE, Wong L, Chen Y, Borowitz DS, Goetz DM, Sheehan DW, Frederick CA, Tutino VM, Meng H, Jarvis JN. (2019) RNA sequencing data from neutrophils of patients with cystic fibrosis reveals potential for developing biomarkers for pulmonary exacerbations. J Cyst Fibros (Mar), 18(2): 194-202.
- Tutino VM, Poppenberg KE, Li L, Shallwani H, Jiang K, Jarvis JN, Sun Y, Snyder KV, Levy EI, Siddiqui AH, Kolega J, Meng H. (2018) Biomarkers from circulating neutrophil transcriptomes have potential to detect unruptured intracranial aneurysms. J Transl Med (Dec), 16(1): 373-373.
- Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, Greenwell H, Herrera D, Kao RT, Kebschull M, Kinane DF, Kirkwood KL, Kocher T, Kornman KS, Kumar PS, Loos BG, Machtei E, Meng H, Mombelli A, Needleman I, Offenbacher S, Seymour GJ, Teles R, Tonetti MS. (2018) Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol (Jun), 89 Su: 173-182.
- Tutino VM, Poppenberg KE, Jiang K, Jarvis JN, Sun Y, Sonig A, Siddiqui AH, Snyder KV, Levy EI, Kolega J, Meng H. (2018) Circulating neutrophil transcriptome may reveal intracranial aneurysm signature. PLoS One (Jan), 13(1).
- Xiang J, Varble N, Davies JM, Rai AT, Kono K, Sugiyama SI, Binning MJ, Tawk RG, Choi H, Ringer AJ, Snyder KV, Levy EI, Hopkins LN, Siddiqui AH, Meng H. (2017) Initial Clinical Experience with AView-A Clinical Computational Platform for Intracranial Aneurysm Morphology, Hemodynamics, and Treatment Management. World Neurosurg (Dec), 108: 534-542.
- Damiano RJ, Tutino VM, Paliwal N, Ma D, Davies JM, Siddiqui AH, Meng H. (2017) Compacting a Single Flow Diverter versus Overlapping Flow Diverters for Intracranial Aneurysms: A Computational Study. AJNR Am J Neuroradiol (Mar), 38(3): 603-610.
- Rajabzadeh-Oghaz H, Varble N, Davies JM, Mowla A, Shakir HJ, Sonig A, Shallwani H, Snyder KV, Levy EI, Siddiqui AH, Meng H. (2017) Computer-Assisted Adjuncts for Aneurysmal Morphologic Assessment: Toward More Precise and Accurate Approaches. Proc SPIE Int Soc Opt Eng (Feb), 10134.
- Paliwal N, Damiano RJ, Davies JM, Siddiqui AH, Meng H. (2017) Association between hemodynamic modifications and clinical outcome of intracranial aneurysms treated using flow diverters. Proc SPIE Int Soc Opt Eng (Feb), 10135.
- Mahajan SD, Tutino VM, Redae Y, Meng H, Siddiqui A, Woodruff TM, Jarvis JN, Hennon TR, Schwartz S, Quigg RJ, Alexander JJ. (2016) C5a Induces Caspase-dependent Apoptosis in Brain Vascular Endothelial Cells in Experimental Lupus. Immunology (Aug), 148(4): 407-419.
- Tutino VM, Liaw N, Spernyak JA, Ionita CN, Siddiqui AH, Kolega J, Meng H. (2016) Assessment of Vascular Geometry for Bilateral Carotid Artery Ligation to Induce Early Basilar Terminus Aneurysmal Remodeling in Rats. Curr Neurovasc Res (Jan), 13(1): 82-92.
- Tutino VM, Mandelbaum M, Takahashi A, Pope LC, Siddiqui A, Kolega J, Meng H. (2015) Hypertension and Estrogen Deficiency Augment Aneurysmal Remodeling in the Rabbit Circle of Willis in Response to Carotid Ligation. Anat Rec (Hoboken) (Nov), 298(11): 1903-1910.
- Liaw N, Fox JM, Siddiqui AH, Meng H, Kolega J. (2014) Endothelial nitric oxide synthase and superoxide mediate hemodynamic initiation of intracranial aneurysms. PLoS One (Jul), 9(7): 101721-101721.
- Tutino VM, Mandelbaum M, Choi H, Pope LC, Siddiqui A, Kolega J, Meng H. (2014) Aneurysmal remodeling in the circle of Willis after carotid occlusion in an experimental model. J Cereb Blood Flow Metab (Mar), 34(3): 415-424.
- Ma D, Dumont TM, Kosukegawa H, Ohta M, Yang X, Siddiqui AH, Meng H, Siddiqui A. (2013) High Fidelity Virtual Stenting (HiFiVS) for Intracranial Aneurysm Flow Diversion: In Vitro and In Silico. Ann Biomed Eng (Oct), 41(10): 2143-2156.
- Mandelbaum M, Kolega J, Dolan JM, Siddiqui AH, Meng H, Siddiqui A. (2013) A critical role for proinflammatory behavior of smooth muscle cells in hemodynamic initiation of intracranial aneurysm. PLoS One (Sep), 8(9): 74357-74357.
- Alfano JM, Kolega J, Natarajan SK, Xiang J, Paluch RA, Levy EI, Siddiqui AH, Meng H, Siddiqui A. (2013) Intracranial aneurysms occur more frequently at bifurcation sites that typically experience higher hemodynamic stresses. Neurosurgery (Sep), 73(3): 497-505.
- Wang Y, Li Y, Jiang C, Wu Z, Jiang F, Meng H, Siddiqui AH, Yang X, Siddiqui A. (2013) Could the types of paraclinoid aneurysm be used as a criterion in choosing endovascular treatment? Neuro-radiologists' view. Acta Neurochir (Wien) (Aug).
- Dolan JM, Meng H, Sim FJ, Kolega J. (2013) Differential Gene Expression by Endothelial Cells Under Positive and Negative Streamwise Gradients of High Wall Shear Stress. Am J Physiol Cell Physiol (Jul)C854-C866.
- Dolan JM, Kolega J, Meng H. (2013) High wall shear stress and spatial gradients in vascular pathology: a review. Ann Biomed Eng (Jul), 41(7): 1411-1427.
- Meng H, Tutino VM, Xiang J, Siddiqui A. (2013) High WSS or Low WSS? Complex Interactions of Hemodynamics with Intracranial Aneurysm Initiation, Growth, and Rupture: Toward a Unifying Hypothesis. AJNR Am J Neuroradiol (Jul).
- Xiang J, Tremmel M, Kolega J, Levy EI, Natarajan SK, Meng H. (2012) Newtonian viscosity model could overestimate wall shear stress in intracranial aneurysm domes and underestimate rupture risk. J Neurointerv Surg (Sep), 4(5): 351-357.
- Dolan JM, Sim FJ, Meng H, Kolega J. (2012) Endothelial cells express a unique transcriptional profile under very high wall shear stress known to induce expansive arterial remodeling. Am J Physiol Cell Physiol (Apr), 302(8): 1109-1118.
- Xiang J, Tremmel M, Kolega J, Levy EI, Natarajan SK, Meng H. (2011) Newtonian viscosity model could overestimate wall shear stress in intracranial aneurysm domes and underestimate rupture risk. J Neurointerv Surg (Sep).
- Meng H, Metaxa E, Gao L, Liaw N, Natarajan SK, Swartz DD, Siddiqui AH, Kolega J, Mocco J. (2011) Progressive aneurysm development following hemodynamic insult. J Neurosurg (Apr), 114(4): 1095-1103.
- Xiang J, Natarajan SK, Tremmel M, Ma D, Mocco J, Hopkins LN, Siddiqui AH, Levy EI, Meng H. (2011) Hemodynamic-morphologic discriminants for intracranial aneurysm rupture. Stroke (Jan), 42(1): 144-152.
- Tremmel M, Xiang J, Natarajan SK, Hopkins LN, Siddiqui AH, Levy EI, Meng H. (2010) Alteration of intra-aneurysmal hemodynamics for flow diversion using enterprise and vision stents. World Neurosurg (Aug), 74(2-3): 306-315.
- Ma D, Tremmel M, Paluch RA, Levy EI, Meng H, Mocco J. (2010) Size ratio for clinical assessment of intracranial aneurysm rupture risk. Neurol Res (Jun), 32(5): 482-486.
- Cao L, Pan G, de Jong J, Woodward S, Meng H. (2008) Hybrid digital holographic imaging system for three-dimensional dense particle field measurement. Appl Opt (Sep), 47(25): 4501-4508.
- Dhar S, Tremmel M, Mocco J, Kim M, Yamamoto J, Siddiqui AH, Hopkins LN, Meng H, Siddiqui A. (2008) Morphology parameters for intracranial aneurysm rupture risk assessment. Neurosurgery (Aug), 63(2): 185-196.
- Szymanski MICHAEL, Metaxa E, Meng H, Kolega JP. (2008) Endothelial Cell Layer Subjected to Impinging Flow Mimicking the Apex of an Arterial Bifurcation. Ann Biomed Eng (Jul).
- Metaxa E, Meng H, Kaluvala SR, Szymanski MP, Paluch RA, Kolega JP. (2008) Nitric oxide-dependent stimulation of endothelial cell proliferation by sustained high flow. Am J Physiol Heart Circ Physiol (Jun).
- Kim M, Taulbee DB, Tremmel M, Meng H. (2008) Comparison of two stents in modifying cerebral aneurysm hemodynamics. Ann Biomed Eng (May), 36(5): 726-741.
- Meng H, Wang Z, Hoi Y, Gao L, Metaxa E, Swartz DD, Kolega JP. (2007) Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation. Stroke (Jun), 38(6): 1924-1931.
- Hoi Y, Woodward SH, Kim M, Taulbee DB, Meng H. (2006) Validation of CFD simulations of cerebral aneurysms with implication of geometric variations. J Biomech Eng (Dec), 128(6): 844-851.
- Meng H, Swartz DD, Wang Z, Hoi Y, Metaxa EM, Szymanski MP, Yamamoto J, Sauvageau E, Levy EI, Kolega JP. (2006) A model system for mapping vascular responses to complex hemodynamics at arterial bifurcations in vivo. Neurosurgery (Nov), 59(5): 1094-1100.
- Hashimoto T, Meng H, Young WL. (2006) Intracranial aneurysms: links among inflammation, hemodynamics and vascular remodeling. Neurol Res (Jun), 28(4): 372-380.
Abstracts:
- Ionita CN, Mokin M, Varble N, Bednarek DR, Xiang J, Snyder KV, Siddiqui AH, Levy EI, Meng H, Rudin S. (2014) Challenges and limitations of patient-specific vascular phantom fabrication using 3D Polyjet printing. Proc SPIE Int Soc Opt Eng, (Mar) 90380
- Hoi Y, Ionita CN, Tranquebar RV, Hoffmann KR, Woodward SH, Taulbee DB, Meng H, Rudin S. (2006) Flow modification in canine intracranial aneurysm model by an asymmetric stent: studies using digital subtraction angiography (DSA) and image-based computational fluid dynamics (CFD) analyses. Proc SPIE Int Soc Opt Eng, (Mar) 61430-61430
- Kim M, Ionita C, Tranquebar R, Hoffmann KR, Taulbee DB, Meng H, Rudin S. (2006) Evaluation of an asymmetric stent patch design for a patient specific intracranial aneurysm using Computational Fluid Dynamic (CFD) calculations in the Computed Tomography (CT) derived lumen. Proc SPIE Int Soc Opt Eng, (Jan)
- Ionita CN, Hoi Y, Meng H, Rudin S. (2004) Particle image velocimetry (PIV) evaluation of flow modification in aneurysm phantoms using asymmetric stents. Proc SPIE Int Soc Opt Eng, (Jan) 295-306