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James                          Jarvis

James N. Jarvis MD

Department of Pediatrics

Clinical Professor and Chief, Allergy/Immunology and Rheumatology

Specialty/Research Focus

Pediatric Rheumatology; Pediatrics

 
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Professional Summary:

I have a broad interest in rheumatic diseases in children. I am particularly interested in juvenile idiopathic arthritis (JIA) and improving the time frame over which we can achieve remission in this family of illnesses. With newer medications, we are making significant progress, but we still have much to learn.

I also have a keen interest in children with systemic lupus and inflammatory muscle disease. Over time, because of my own Native American ancestry (Mohawk), I have particularly enjoyed the opportunity to work with indigenous American children, whose expression of rheumatic disease and treatment response are slightly different from the broader population. We hope that tribal health systems will see our pediatric rheumatology service as the “go-to” place for children with arthritis and related illnesses.

I spend most of my time doing research, and my laboratory focuses on mechanisms through which genes and so called “DNA dark matter” are turned off and on through the course of successful therapy in JIA. We study these processes using state-of-the-art ChIP-sequencing, DNA methylation sequencing, and RNA sequencing techniques. These projects consist of collaborating with colleagues at the New York State Center of Excellence in Bioinformatics (COE).

I also spend considerable time working with indigenous American communities on a broad range of child health issues. I currently chair the American Academy of Pediatrics Committee on Native American Child Health, which has a strong interest in why rheumatic diseases are so common and severe in indigenous American children. We are particularly focused on so-called epigenetic factors, stemming from historical traumas and cultural dislocation that may play a role in how rheumatic diseases are expressed in indigenous children.

One of the most rewarding parts of my career has been the opportunity to mentor talented Native American students and assist them in developing their interests in science and medicine. Previous students include a veritable “Who’s Who” among young Native American physicians, and I am working to establish and foster partnerships for UB with local colleges and tribes to develop a rich resource of Native American physician scientists in New York State.

Education and Training:
  • Fellowship, Rheumatology and Immunogenetics, Washington University School of Medicine (1989)
  • Chief Resident, Pediatrics, St. Louis Children‘s Hospital (1986)
  • Residency, Pediatrics, St. Louis Children‘s Hospital (1982)
  • Internship, Pediatrics, St. Louis Children's Hospital (1980)
  • MD, Medicine, University of Vermont College of Medicine (1979)
  • BA, Liberal Arts, St. John‘s College, cum laude (1975)
Employment:
  • Clinical Professor, Pediatrics, University at Buffalo (2012-present)
  • Chief, Division of Allergy/Immunology and Rheumatology, Pediatrics, Women and Children‘s Hospital of Buffalo (2012-present)
  • Professor, Clinical Pediatrics, Columbia University Medical Center (2011–2012)
  • Endowed Chair, Children‘s Medical Research Institute/Arthritis Foundation, Oklahoma Chapter (2009–2011)
  • Professor, Pediatrics, University of Oklahoma, College of Medicine (2006–2011)
  • Consultant Rheumatologist, W.W. Hastings Indian Hospital (2003–2011)
  • Director, Pediatric Rheumatology, Children‘s Hospital of Oklahoma/University of Oklahoma Children‘s Physicians (1997–2011)
  • Adjunct Associate Professor, Pediatrics, University of Oklahoma, College of Medicine (1997–2011)
  • Clinical Professor, Pediatrics, University of Oklahoma, College of Medicine (2005)
  • Clinical Associate Professor, Pediatrics, University of Oklahoma, College of Medicine (1997–2005)
  • Chief, Division of Rheumatology, Pediatrics, University of Oklahoma College of Medicine (1997–2002)
  • Associate Professor, Pediatrics, Wayne State University, School of Medicine (1996–1997)
  • Associate, Molecular Medicine and Genetics, Wayne State University, School of Medicine (1994–1997)
  • Associate, Immunology/Microbiology, Wayne State University, School of Medicine (1992–1997)
  • Associate, Clinical Immunology/Rheumatology, Children's Hospital of Michigan (1989–1997)
  • Assistant Professor, Pediatrics, Wayne State University, School of Medicine (1989–1996)
  • Clinical Instructor, Washington University in St. Louis, School of Medicine (1985–1989)
  • Attending Pediatrician, Little River Medical Center (1983–1984)
  • Attending Pediatrician/Chief of Pediatrics, Loris Community Hospital (1982–1984)
See All (19 Total) >
Awards and Honors:
  • OU Medical Center: Golden Pillar (2011)
  • Consumer Research Council of America: America's Top Pediatricians (2009)
  • Arthritis Foundation, Oklahoma Chapter: John A. Blashke Award (2006)
  • Who‘s Who in America (2003)
  • IBC Cambridge: One Thousand Great Scientists (2003)
  • Guide to America‘s Top Pediatricians (2002)
  • Who's Who in Science and Engineering (1996)
  • Wayne State Alumni Association: Dr. Jack Ryan Award for Medical Research (1996)
  • Michigan State University Department of Pediatrics: William Weil Award (1995)
  • American Rheumatism Association: Central Region Fellows‘ Award (1988)
  • American College of Rheumatology: Clinician Scholar-Educator Award (2002-2005)
  • Who‘s Who in America (2005-2009)

Grants and Sponsored Research:
  • February 2011–January 2016
    Microarray-based Biomarkers in Juvenile Idiopathic Arthritis
    NIH
    Role: Principal Investigator
    $1,250,000
  • January 2013–December 2014
    Epigenetic Regulation of JIA Neutrophils
    Arthritis Foundation (National) Innovative Research Grant Program
    Role: Principal Investigator
    $200,000
  • January 2011–December 2013
    Epigenetic Alterations in JIA Neutrophils
    McBride Foundation
    Role: Principal Investigator
    $75,000
  • January 2010–December 2012
    Genome-Wide Mapping of Hepatocyte Nuclear Factor 4a in Human T Cells
    McBride Foundation
    Role: Principal Investigator
    $75,000
  • September 2009–September 2011
    Dynamics of Therapeutic Response within the TREAT Trial
    NIH
    Role: Principal Investigator
    $400,000
  • September 2010–August 2011
    Dynamics of Therapeutic Response within the TREAT Trial (Administrative Supplement)
    NIH
    Role: Principal Investigator
    $378,306
  • September 2010–August 2011
    Dynamics of Therapeutic Response within the TREAT Trial (Workforce Diversity Supplement)
    NIH
    Role: Principal Investigator
  • July 2009–June 2010
    Trophoblast Responses to Inflammation: A Genomic Approach
    College of Medicine Alumni Association Funding
    Role: Principal Investigator
    $26,000
  • July 2007–June 2010
    Neutrophil Biomarkers in Polyarticular JRA
    Oklahoma Center for the Advancement of Science and Technology
    Role: Principal Investigator
    $135,000
  • Microarray-based Biomarkers in Juvenile Idiopathic Arthritis (Workforce Diversity Supplement)
    NIH
    Role: Principal Investigator
See All (10 Total) >

Journal Articles:
See All (52 Total) >
Abstracts:
  • Jarvis JN, Levine RP, Kishore NS. IgM Rheumatoid Factor Inhibits the Covalent Binding of C4b to Immune Complexes. Arthritis Rheum. 1989; 32.
  • Knowlton N, Frank MB, Armstrong NE, Chen Q, Jiang K, Chen Y, Osban J, Jarvis JN. Gene Expression Profiling in Peripheral Blood Mononuclear Cells Predicts Disease Flares in Children with Polyarticular Juvenile Idiopathic Arthritis who Have Achieved Inactive Disease Status. Arthritis Rheum. 2010; 62(Sup10).
  • Frank MB, Jiang K, Chen Y, Jarvis JN. Differences in Transcription Profiles in Juvenile Idiopathic Arthritis (JIA) Patients who Achieved Remission Using Different Therapies. Arthritis Rheum. 2010; 62(Sup10).
  • Frank MB, Jiang K, Chen Y, Osban J, Wallace CA, Thompson S, Jarvis JN. A Whole Blood Gene Expression Profile of Untreated Children with Polyarticular Juvenile Idiopathic Arthritis Enrolled in the TREAT Trial. Arthritis Rheum. 2010; 62(Sup10).
  • Frank MB, Jiang K, Chen Y, Osban J, Gellert P, Jarvis JN. Characterization of Granulocyte Transcriptome in Polyarticular Juvenile Idiopathic Arthritis (JIA). Arthritis Rheum. 2010; 62(Sup10).
  • Jiang K, Chen Y, Frank MB, Jarvis JN. Leukocyte Expression of the Transcription Factor HNF4a, a Regulator of Gene Expression in Polyarticular Juvenile Idiopathic Arthritis. Arthritis Rheum. 2010; 62(Sup10).
  • Wang SY, Knowlton N, Aggarwal A, McGhee T, Jiang K, Chen Y, Frank MB, Centola M, Jarvis JN. Gene Expression Profiling in Juvenile Dermatomositis Suggests Complex Interactions Between Innane and Adaptive Immunity. Arthritis Rheum. 2008; 58(Suppl).
  • Jarvis JN, Frank MB, Knowlton NS, Jiang K, Chen Y, O'Neil K, McKee R, Chaser B, McGhee JL, Centola M. Defining Remission in Polyarticular JIA: A Systems Biology Approach. Ann Rheum Dis. 2008; 67(Sup 2).
  • Brown B, Frank MB, Knowlton NS, Jiang K, Chen Y, Centola M, Jarvis JN. Neutrophil Regulation of Adaptive Immunity: An In Vitro Model Identifies Hubs and Nodes with Similarities to Those Seen in Polyarticular JIA. Ann Rheum Dis. 2008; 67(Sup 2).
  • Jarvis JN, Frank MB, Knowlton NS, Jiang K, Chen Y, Centola M. In Silico Models of Leukocyte Gene Expression Data in Children with Polyarticular JIA Show Hub-and-Node Structures Typical of Scale-free Networks: Implications for Pathogenesis and Treatment. Ann Rheum Dis. 2008; 67(Sup 2).
  • Jarvis JN, Knowlton N, Frank MB, Aggarwal A, Jiang K, Chen Y, McKee R, McGhee T, O‘Neil KM, Chaser B, Centola M. A Systems Biology Approach to JIA: Gene Expression Profiling Detects Only Small Differences Between Children with Pauciarticular and Polyarticular Disease. Arthritis Rheum. 2007; 56(Suppl).
  • Jarvis JN, Knowlton N, Frank MB, Aggarwal A, Jiang K, Chen Y, McKee R, McGhee JL, O'Neil KM, Chaser B, Centola M. The Biological Meaning of Clinical Remission in JIA: A Systems Biology Approach. Arthritis Rheum. 2007; 56(Suppl).
  • Wang SY, Knowlton N, Aggarwal A, McGhee T, Jiang K, Chen Y, Frank MB, Centola M, Jarvis JN. Gene Expression Profiling in Neutrophils and PBMC in Juvenile Dermatomyositis. Arthritis Rheum. 2007; 56(Suppl).
  • O'Neil KM, Dozmorov I, Neff J, Kickingbird LM, Jarvis JN, Cadwell C, Centola M, Frank MB. Pathway Analysis of Genes Differentially Expressed in Peripheral Blood Mononuclear Cells of Children with Stable, Flaring, or Improving Systemic Lupus Erythematosus. Arthritis Rheum. 2007; 56(Suppl).
  • O'Neil KM, Nguyen AB, Frank MB, Cadwell C, Jarvis JN, Centola M, Dozmorov I. Gene Expression Profiles in Children with SLE: Abnormal Regulation of Apoptosis-related Genes Suggests a Role for Neutrophils in SLE. Arthritis Rheum. 2007; 56(Suppl).
  • Aggarwal A, Dozmorov I, Frank MB, Jiang K, Chen Y, Centola M, Jarvis JN. Neutrophils from Children with Polyarticular and Pauciarticular Juvenile Rheumatoid Arthritis (JRA) Shown Distinct Gene Expression Profiles. Arthritis Rheum. 2006; 54(Suppl).
  • Chaser B, Dozmorov I, Frank MB, Tang Y, Cadwell C, McGhee JL, Centola M, Jarvis JN. Discriminant Function Analysis of Gene Expression Arrays Reveals Distinct Subsets of Children with Polyarticular-Onset Juvenile Rheumatoid Arthritis. Arthritis Rheum. 2005; 12.
  • Jarvis JN, Petty HR, Kindzelski A, Tessier P, Jiang K, Tang Y, McGhee JL, Centola M. Is Polyarticular JRA a Disease of Neutrophils? Evidence for an Intrinsic Defect in Neutrophil Activation in Polyarticular JRA. Arthritis Rheum. 2005; 52(Suppl).
  • Jiang K, Chen Y, Jarvis JN. Soluble Factors from LPS-Activated PBMC Induce MAPK and STAT3 Phosphorylation in Primary Cultures of Human Placental Trophoblasts: Implications for Infection and Prematurity. PAS Meeting Abstracts. 2005; 57.
  • Jiang K, Chen Y, Jarvis JN. HCG Secretion in Human Choriocarcinoma Jar Cells is MAPK but Not STAT3 Dependent: Contributions of TNF Alpha and IL-1-Beta Inflammation-induced hCG Secretion. PAS Meeting Abstracts. 2005; 57.
  • Jarvis JN, Tang Y, Dozmorov D, Jiang K, Frank MB, Chen Y, McGhee JL, Centola M. Gene Expression Arrays Reveal Chronic, Intrinsic Activation of Neutrophils in Children with Polyarticular JRA. Is JRA Primarily a Neutrophil Disorder?. PAS Meeting Abstracts. 2005; 57.
  • Jarvis JN, Cobb E, Evard M, Jiang K. Evidence for Chronic Dysregulation in Neutrophils of Children with Polyarticular JRA. PAS Meeting Abstracts. 2005; 57.
  • O‘Neil KM, Kickingbird L, Madduri D, McGhee JL, Jarvis JN. Clinical and Laboratory Associations in Childhood Systemic Lupus Erythematosus. PAS Meeting Abstracts. 2005; 57.
  • Jarvis JN, Tang Y, Dozmorov I, Jiang K, Frank MB, Chen Y, McGhee JL, Centola M. Gene Expression Arrays Reveal Chronic, Intrinsic Activation of Neutrophils in Children with Polyarticular JRA. Is JRA a Neutrophil Disorder?. Arthritis Rheum. 2004.
  • O'Neil KO, Kickingbird LN, Jarvis JN. Characteristics of Children with SLE: Clinical and Laboratory Associations. Arthritis Rheum. 2004.
  • Jarvis JN, Zospah R, Tang Y, Dozmorov I, Jiang K, Chen Y, Frank MB, Centola M. Gene Expression Arrays Exclude Immune Complex Accumulation as a Critical Factor in the Leukocyte Activation of Polyarticular JRA. Arthritis Rheum. 2004.
  • Lawrence S, Tang Y, Dozmorov I, Jiang K, Chen Y, Frank MB, Turner S, Centola M, Jarvis JN. Gene Expression Arrays Reveal Distinct Patterns of Activation that Differ Between Adult and Neonatal Monocytes. Pediatr Res. 2004.
  • Jiang K, Chen Y, Jarvis JN. Cord Blood and Adult T Cells Show Different Responses to C1q-bearing Immune Complexes. Pediatr Res. 2004; 55.
  • Jiang K, Chen Y, Jarvis JN. Soluble Factors from Activated Lymphocytes Induce MAPK and STAT3 Phosphorylation in Primary Cultures of Human Placental Trophoblasts. Pediatr Res. 2004; 55.
  • Jarvis JN, Dozmorov I, Jiang K, Chen Y, Frank MB, Turner S, Centola M. Using a Gene Microarray to Dissect Immunologic Responses in a Trophoblast Model: Evidence that Immunologic Challenge Enhances Trophoblast Growth and Differentiation. Pediatr Res. 2004; 55.
  • McGhee JL, Kickingbird LM, Jarvis JN. Use of ANA Tests and Clinical Findings to Identify Children with Systemic Lupus Erythematosus. Arthritis Rheum. 2003; 48.
  • Jiang K, Chen Y, Jarvis JN. Activated Lymphocytes Induce p44/42 MAP Kinase Phosphorylation in Trophoblast-like JAR Cells, but the Capacity of JAR Cells to Inhibit IL-2 Expression is Not MAPK Dependent. Pediatr Res. 2003; 53.
  • Jarvis JN, Jiang K, Chen Y, Dozmorov I, Frank MB, Centola M. Cocultivation of Trophoblast-like JAR Cells Results in Transcriptional Activation of Multiple Genes: Further Evidence for Maternal-Fetal Immunologic Cross-Talk. Pediatr Res. 2003; 53.
  • Cleland SY, Fishinghawk B, Burks FN, Sullivan K, Jarvis JN. A Clinical and Immunogenetic Comparison of Caucasian and Native American Children with Juvenile Rheumatoid Arthritis. Pediatr Res. 2003; 53.
  • Dozmorov I, Jarvis JN, Frank MB, Jiang K, Cadwell C, Centola M. Novel and Mathematical Modeling Identifies Leukocyte Gene Expression Patterns that are Disrupted in Polyarticular JRA. Arthritis Rheum. 2002; 46.
  • Jarvis JN, Frank MB, Dozmorov I, Jiang K, Cadwell C, McGhee JL, Centola M. Gene Expression Analysis of Children with Active Polyarticular JRA. Arthritis Rheum. 2002; 46.
  • Jarvis JN, Solomon G, Menifee L. Juvenile Rheumatoid Arthritis in Native Americans in Oklahoma. Arthritis Rheum. 2000; 43.
  • Jarvis JN, Xiao S, Xu C-S. Regulation of IL-8 Secretion from Immune Complex Activated Human Umbilical Vein Endothelial Cells. Arthritis Rheum. 2000; 43.
  • Jarvis JN, Xiao S, Xu C-S, Ramachandaran V, McEver R. Activation of Human Umbilical Vein Endothelial Cells by C1q-bearing Immune Complexes: Mechanisms Leading to Neutrophil Adhesion. Arthritis Rheum. 2000; 43.
  • Quintero Del-Rio A, Jarvis JN. Lymphocyte Activation by Immune Complexes. FASEB J. 1999; 13.
  • Jarvis JN, Xiao S, Ramachandaran V, McEver R. Activation of Cultured Human Vein Endothelial Cells by C1q-bearing Immune Complexes. FASEB J. 1999; 13.
  • Jarvis JN, Xiao S. Activation of Human Umbilical Vein Endothelial Cells by C1q-bearing Immune Complexes. Pediatr Res. 1999; 45.
  • Jarvis JN, Wang S-H. Phosphorylation of the Complement Receptor, CR1 (CD35) and Its Association with the Syk Protein Tyrosine Kinase in Immune Complex-stimulated HL-60 Cells. Pediatr Res. 1999; 45.
  • Quintero Del-Rio A, Jarvis JN. Lymphocyte Activation by Immune Complexes: A Possible Role for CR1 (CD35). Arthritis Rheum. 1998; 41.
  • Jarvis JN, Solomon G. High Incidence of Juvenile Dermatomyositis in Native American Children in Oklahoma. Arthritis Rheum. 1998; 41.
  • Jarvis JN, Xiao S. Immune Complexes Induce IL-8 Secretion from Human Umbilical Vein Endothelial Cells by a Tyrosine Phosphokinase-dependent Mechanism. Arthritis Rheum. 1998; 41.
  • Jarvis JN, Wang S-H, Xu C-S. Immune Complex Binding to Human Monocytes and Monocytic Cell Lines Leads to Serine/Threonine Phosphorylation of the C3b Receptor, CR1 (CD35). Arthritis Rheum. 1998; 41.
  • Jarvis JN, Wang W, Amit A, Xu C-S. Role of Immune Complex Size and Complement in Regulating Monocyte Responses to Immune Complexes. Pediatr Res. 1998; 43.
  • Jarvis JN, Wang W, Amit A, Xu C-S. Regulation of Monocytes Through Complement Receptor CR1: Binding of C4b to Immune Complexes Enhances IL-1Beta Secretion. Arthritis Rheum. 1997.
  • Schwartz M, Davis P, Simpson P, Wooley P, Kerr KL, Jarvis JN. Juvenile Rheumatoid Arthritis in African-American Children. Pediatr Res. 1997; 41.
  • Jarvis JN, Xu C-S, Wang W, Amit A, Kindzelski A, Petty HR. Complement Opsonization Reduces the Pro-Inflammatory Capacity of Immune Complexes. Pediatr Res. 1997; 41.
  • Jarvis JN, Xu C-S, Amit A. Direct Quantification of Complement Binding to Immune Complexes. Pediatr Res. 1997; 41.
  • Jarvis JN, Amit A, McLaughlin J, Xu C-S, Wang W. Influence of Size and C4b Binding on the Pro-Inflammatory Properties of Immune Complexes. Pediatr Res. 1997; 41.
  • Kerr KL, Jarvis JN. Comparison of the Cost-Effectiveness of EMLA Cream vs. Oral Midazolam for Analgesia During Pediatric Anthrocentesis. Arthritis Rheum. 1996; 39.
  • Kerr KL, Jarvis JN, Moore EC, Spencer L, Abramson J. Development of a Critical Pathway for IV Cyclophosphamide Therapy in the Treatment of Pediatric Systemic Lupus Erythematosus. Arthritis Rheum. 1996; 39.
  • Erlandson D, Kerr KL, Jarvis JN, Bowyer S, Marsh M, Miller M, Miller J, Peterson K, Singsen B. Research Issues Associated with the Study of Ethnically-Diverse Chronically-Ill Children. Arthritis Rheum. 1996; 39.
  • Schwartz MM, Simpson P, Kerr KL, Jarvis JN. Juvenile Rheumatoid Arthritis in African-Americans. Arthritis Rheum. 1996; 39.
  • Jarvis JN, Xu C-S, Wang W, Amit A. Complement Reduces the Capacity of Immune Complexes to Induce Pro-Inflammatory Cytokines from Leukocytes. Arthritis Rheum. 1996; 39.
  • Cuesta I, Simpson P, Kerr KL, Jarvis JN. Orthopedics Referral for Pauciarticular JRA. Arthritis Rheum. 1996; 39.
  • Jarvis JN, Wang W, Xu C-S. Juvenile Rheumatoid Arthritis Synovial Fluid Immune Complexes Induce a Broad Spectrum of Pro-Inflammatory Cytokines from Peripheral Blood Mononuclear Cells. Arthritis Rheum. 1996; 39.
  • Jarvis JN, Xu C-S. Complement Regulates the Capacity of Immune Complexes to Elicit Cytokine Secretion from Leukocytes. Mol Immunol. 1996; 33.
  • Petty HR, Kindzelski AL, Amit A, Jarvis JN. Effect of Complement on Immune Complex-induced Metabolic Oscillations in Migrating Neutrophils. FASEB J. 1996; 10.
  • Jarvis JN, Wang W, Xu C-S, Zhao L. JRA Synovial Fluid IgG Fractions Induce a Broad Spectrum of Pro-Inflammatory Cytokines from Peripheral Blood Mononuclear Cells. Pediatr Res. 1996; 39.
  • Jarvis JN, Xu C-S. Induction of IL-8 from Promonocytic U937 Cells and Peripheral Blood Mononuclear Cells by Soluble Immune Complexes. Pediatr Res. 1996; 39.
  • Jarvis JN, Moore HT, Zhao L, Xu C-S. Trophoblast-like JAR Cells Contain Pro-IL-1Beta which is Released with FcyR Engagement. Pediatr Res. 1996; 39.
  • Duncan D, Taylor H, Cohen F, Jarvis JN. Deposition of C4 onto Lymphocytes of Children with JRA: Comparison with Congenital HIV Infection. Arthritis Rheum. 1992; 35.
  • Jarvis JN, Taylor H, Iobidze M, Cohen F. IgA Rheumatoid Factor Expression Associated with Alternative Complement Pathway Activation in Congenital HIV Infection. Arthritis Rheum. 1992; 35.
  • Mayes MD, Jarvis JN, Long PM, Gutta V. Membrane Cofactor Protein in Scleroderma. Arthritis Rheum. 1990; 33.
See All (68 Total) >
Books and Book Chapters:
  • Jarvis JN. "Rheumatologic Disorders". Chronic Complex Diseases of Childhood, a practical guide for clinicians. 2011.
  • Jarvis JN. "Juvenile Idiopathic Arthritis". Conn‘s Current Therapy. 2011.
  • Jarvis JN. "Arthritis in Children". Pediatric Orthopaedics and Sports Injuries: A Quick Reference Guide. 2010.

Professional Memberships:
  • American Pediatric Society
  • American Society for Pediatric Research
  • American Association of Immunologists
Presentations:
  • "Developing a Career as a Physician-Scientist" Annual Meeting, American College of Rheumatology, Fellows (2011)
  • "A Whole Blood Gene Expression Profile of Untreated Children with Polyarticular JIA Enrolled in the TREAT Trial" Annual Meeting, Pediatric Academic Societies (2011)
  • "Differences in Transcription Profiles in Juvenile Idiopathic Arthritis (JIA) Patients who Achieved Remission Using Different Therapies" Annual Meeting, Pediatric Academic Societies (2011)
  • "Interferon Gamma Priming Alone Does Not Alter the Methylation Status of CpG Islands in CD4+ T Cells" Annual Meeting, Pediatric Academic Societies (2011)
  • "LPS-Driven Inflammation Alters Gene Expression and Methylation Patterns in Trophoblast-like JEG-3 Cells, but Methylation Alterations Occur Distal from Differentially Expressed Genes" Annual Meeting, Pediatric Academic Societies (2011)
  • "Rheumatoid Factor-Positive and Rheumatoid Factor-Negative Children with Polyarticular Juvenile Idiopathic Arthritis Display Extensive Differences in Whole Blood Gene Expression Profiles" Annual Meeting, Pediatric Academic Societies (2011)
  • "Functional Genomics and Complex Childhood Diseases" Department of Pediatrics Meeting, Columbia University (2011)
  • "Complex Human Traits: Is Functional Genomics Ready to Take Them On?" School of Medicine Meeting, Washington University (2011)
  • "A Whole Blood Gene Expression Profile of Untreated Children with Polyarticular Juvenile Idiopathic Arthritis Enrolled in the TREAT Trial" Annual Meeting, American College of Rheumatology (2010)
  • "Characterization of Granulocyte Transcriptome in Polyarticular Juvenile Idiopathic Arthritis (JIA)" Annual Meeting, American College of Rheumatology (2010)
  • "Developing a Career in Basic Research" Annual Meeting, American College of Rheumatology, Fellows (2010)
  • "Differences in Transcription Profiles in Juvenile Idiopathic Arthritis (JIA) Patients who Achieved Remission Using Different Therapies" Annual Meeting, American College of Rheumatology (2010)
  • "Gene Expression Profiling in Peripheral Blood Mononuclear Cells Predicts Disease Flares in Children with Polyarticular Juvenile Idiopathic Arthritis who Have Achieved Inactive Disease Status" Annual Meeting, American College of Rheumatology (2010)
  • "Leukocyte Expression of the Transcription Factor HNF4a, a Regulator of Gene Expression in Polyarticular Juvenile Idiopathic Arthritis" Annual Meeting, American College of Rheumatology (2010)
  • "Fever Syndromes: Common and Unusual" National Conference and Exhibition, American Academy of Pediatrics (2010)
  • "Update on the Laboratory Evaluation of Potential Rheumatic Diseases" National Conference and Exhibition, American Academy of Pediatrics (2010)
  • "Rheumatoid Arthritis and Its Effects on the Native American Family" 5th Annual Family Preservation Conference, Association of American Indian Physicians (2010)
  • "Functional Genomics and Complex Traits: Are We Ready to Take Them On?" Institutional Meeting, Cold Spring Harbor Laboratory (2010)
  • "Arthritis in Indigenous North American Populations" Public Lecture, Royal University Hospital (2010)
  • "Systems Biology of Complex Diseases" Pediatric Grand Rounds, University of Saskatchewan (2010)
  • "Systems Biology and Complex Traits" Advances in Medicine Conference (2010)
  • "Systems Biology Approaches to Rheumatic Disease" Rheumatic Disease Research Institute Meeting, University of Guadalajara (2010)
  • "Systems Biology Approaches to Rheumatic Disease" Association Meeting, Japanese Immunology Association (2009)
  • "Juvenile Idiopathic Arthritis in Native American Children" Rheumatic Disease in Indigenous Populations: From Molecules to Communities, Rheumatic Disease in Indigenous Populations (2009)
  • "The Perils and Promise of Genetic Research with Indigenous Americans" Rheumatic Disease in Indigenous Populations: From Molecules to Communities (2009)
  • "Control of Inflammation at the Maternal-Fetal Interface: A Systems Biology Approach" Ottawa Health Research Institute Meeting, University of Ottawa (2009)
  • "Juvenile Idiopathic Arthritis as a Complex Trait" Annual Meeting, Japanese College of Rheumatology (2009)
  • "Defining Phenotypes in Childhood Arthritis: Beyond the Text Books" Rheumatology Meeting, Congreso: Colegio Mexicano de Reumatologia (2009)
  • "Systems Biology and Complex Traits: The Future of Pediatric Rheumatology" Rheumatology Meeting, Congreso: Colegio Mexicano de Reumatologia (2009)
  • "Systems Biology Approaches to Complex Illnesses in Children" Pediatric Grand Rounds, University of West Virginia (2008)
  • "Systems Biology Approaches to Chronic Arthritis in Children" University Lecture, St. Louis University (2008)
  • "Systemic Lupus in Indigenous Americans: Special Concerns in a Unique Population" Wellness Meeting, The Shakopee Mdewakanton Sioux (Dakota) Community (2008)
  • "Systems Biology and Juvenile Arthritis" Hospital Meeting, Cincinnati Children‘s Hospital (2008)
  • "Systems Biology Approaches to Complex Illnesses in Children" Pediatric Grand Rounds, State University of New York at Stony Brook (2008)
  • "Systems Biology Approaches to Complex Illnesses in Children" Pediatric Grand Rounds, University of Minnesota School of Medicine (2008)
  • "Evaluation of a Prolonged, Persistent, or Otherwise Annoying Fever" National Conference and Exhibition, American Academy of Pediatrics (2007)
  • "Systemic Lupus in Children" Symposium for Health Professionals, Arthritis Foundation (2007)
  • "Systems Biology Approaches to Complex Traits" Institute for Child Health Meeting, Institute for Child Health, Great Ormand Street Hospital for Children (2007)
  • "Use of Laboratory in Evaluating Children with Musculoskeletal Complaints" National Conference and Exhibition, American Academy of Pediatrics (2007)
  • "Evaluation of Musculoskeletal Complaints in Children: An Evidence-Based Approach" Department of Pediatrics Alumni Day, Monmouth Medical Center (2007)
  • "Healthy Children: The Foundation for Healthy Communities" Native Youth in Distress Conference, National American Indian Court Judges and Association of American Indian Physicians (2007)
  • "Systems Biology Approaches to Complex Traits in Children" Department of Pediatrics Meeting, Monmouth Medical Center (2007)
  • "Systemic Lupus in Indigenous Teenagers and Young Adults: Special Concerns in a Unique Population" Annual Meeting, Association of American Indian Physicians (2007)
  • "Genomic Evidence that Juvenile Dermatomyositis is a Neutrophil-driven Auto-Inflammatory Disorder" Annual Meeting, Pediatric Academic Societies (2007)
  • "Poly- and Pauci-Articular JRA Show Distinct Neutrophil Gene Expression Profiles but More Closely Resemble Each Other than They Do Healthy Controls" Annual Meeting, Pediatric Academic Societies (2007)
  • "STAT3 is a Transcriptional Repressor in Choriocarcinoma-like Jeg-3 Cells" Annual Meeting, Pediatric Academic Societies (2007)
  • "Diagnostic Genomics: Ready for Clinical Implementation?" 13th International Vasculitis and ANCA Workshop, Vasculitis Foundation (2007)
  • "Proteomics: Complementing Systems Biology Approaches to Vasculitis" 13th International Vasculitis and ANCA Workshop, Vasculitis Foundation (2007)
  • "Diagnosing Common and Uncommon Rheumatic Diseases-Not a Trivial Pursuit" National Conference and Exhibition, American Academy of Pediatrics (2006)
  • "Juvenile Rheumatoid Arthritis in Native American Children" Annual Meeting, Association of American Indian Physicians (2006)
  • "Gene Microarrays in Rheumatic Disease: Will the Blind Men Finally See the Elephant?" Annual Meeting, European League Against Rheumatism (EULAR) (2006)
  • "Genomic Approaches to Rheumatic Diseases: The Blind Men Finally See the Elephant" Immunology Research Seminar, Boston Children‘s Hospital (2006)
  • "Lupus Nephritis: The Rheumatologist‘s Point of View" Annual Meeting, American Society for Pediatric Nephrology/Pediatric Academic Societies (2006)
  • "Rashes You Will See: Or Why Pediatric Rheumatologists Frequently Give Dermatology Grand Rounds" Pediatric Grand Rounds, University of Arizona School of Medicine (2006)
  • "Neutrophils in Juvenile Rheumatoid Arthritis: Time to Revise the Pathogenic Paradigm?" Hospital Meeting, DuPont Children‘s Hospital (2006)
  • "Evaluation of Musculoskeletal Complaints in Children" Pediatric Grand Rounds, Robert Wood Johnson School of Medicine (2006)
  • "Is Polyarticular JRA a Disease of Neutrophils? Evidence for an Intrinsic Defect in Neutrophil Activation in Polyarticular JRA" Annual Meeting, American College of Rheumatology (2005)
  • "Clinical and Laboratory Associations in Childhood Systemic Lupus Erythematosus" Annual Meeting, Pediatric Academic Societies (2005)
  • "Evidence for Chronic Dysregulation in Neutrophils of Children with Polyarticular JRA" Annual Meeting, Pediatric Academic Societies (2005)
  • "Gene Expression Arrays Reveal Chronic, Intrinsic Activation of Neutrophils in Children with Polyarticular JRA. Is JRA Primarily a Neutrophil Disorder?" Annual Meeting, Pediatric Academic Societies (2005)
  • "Gene Expression Studies in JRA: Promises and Pitfalls" Annual Meeting, Pediatric Academic Societies (2005)
  • "HCG Secretion in Human Choriocarcinoma Jar Cells is MAPK but Not STAT3 Dependent: Contributions of TNF Alpha and IL-1-Beta Inflammation-induced hCG Secretion" Annual Meeting, Pediatric Academic Societies (2005)
  • "Pediatric Rheumatology: The Future is Here" Annual Meeting, Pediatric Academic Societies (2005)
  • "Soluble Factors from LPS-Activated PBMC Induce MAPK and STAT3 Phosphorylation in Primary Cultures of Human Placental Trophoblasts: Implications for Infection and Prematurity" Annual Meeting, Pediatric Academic Societies (2005)
  • "Rheumatic Disease in Native American Children" Hospital Meeting, Hospital for Special Surgery (2004)
  • "Health Status of American Indian Children" Urban Indian Health Summit, Urban Indian Health Institute (2004)
  • "Autonomy and the Enlightenment Origins of Medical Ethics" Annual Meeting, Pediatric Academic Societies, Ethics Special Interest Group (2004)
  • "Ethical Considerations in Research with Socially Identifiable Populations" Annual Meeting, Pediatric Academic Societies, Ethics Special Interest Group (2004)
  • "Evaluation of Children with Musculoskeletal Complaints" Pediatric Grand Rounds, University of Arizona (2004)
  • "Genomic Approaches to Complex Disease" Faculty Seminar, University of Arizona (2004)
  • "Genomic Approaches to Complex Disease" Pediatric Grand Rounds, Seattle Children‘s Hospital (2004)
  • "Rheumatic Disease in Native American Children" Hospital Meeting, Seattle Children‘s Hospital (2004)
  • "Evaluation of Children with Musculoskeletal Complaints" Pediatric Grand Rounds, Rapid City Hospital (2003)
  • "Evaluating Children with Musculoskeletal Complaints" Pediatrics Meeting, Indian Health Service, Workshop (2003)
  • "Rheumatic Disease in Native American Children" Primary Care Conference, Billings Area Indian Health Service (2003)
  • "Juvenile Rheumatoid Arthritis: A Comparison of European and Non-European Populations" Pediatric Grand Rounds, University of Vermont College of Medicine (2003)
  • "Rheumatic Disease in Native American Children" Medical School Meeting, Dartmouth College (2003)
  • "Juvenile Rheumatoid Arthritis: A Guide for Practitioners" Oklahoma Chapter Meeting, Pediatric Nurse Practictioners Association (2002)
See All (78 Total) >
Service Activities:
  • NIH/NIAMS: Arthritis Connective Tissue and Skin Disorders (ACTS) Study Section; Grant Reviewer (2012)
  • Native American Child Health (CONACH); American Academy of Pediatrics; Chair (2012)
  • American Association for the Advancement of Science/State of Washington Life Sciences Development Fund; Grant Reviewer (2009)
  • Colegio Mexicano Reumatologia; Talks on systems biology and arthritis in indigenous Americans; Visiting Professor (2008)
  • Bioinformatics and Biology Insights; Editorial Board Member (2008)
  • NIH/NICHD: Pregnancy and Neonatology Study Section; Grant Reviewer (2007–2011)
  • American Academy of Pediatrics: Section on Rheumatology; Executive Committee; Chair (2007–2011)
  • 2nd International American Indian/First Nations/Inuit Child Health Meeting Planning Committee; Committee Member (2007)
  • Monmouth Children's Medical Center; American College of Rheumatology/Immunex; Visiting Professor (2007)
  • American College of Rheumatology: Research and Education Foundation - Study Section B; Grant Reviewer (2007)
  • BMC Medical Genomics; Editorial Board Member (2007)
  • J of Med Case Reports; Editorial Board Member (2007)
  • American Academy of Pediatrics: Section on Rheumatology; Executive Committee; Chair-Elect (2006–2007)
  • Pediatric Rheumatology. Curr Probl Pediatr Adolesc Health Care 2006: Vol. 36, No. 3; Guest Editor (2006)
  • University of Arizona Department of Pediatric Rheumatology; American Academy of Pediatrics; Visiting Professor (2006)
  • Medical College of Georgia: Department of Pediatric Rheumatology; Amgen/Immunex/American College of Rheumatology; Visiting Professor (2005)
  • Pediatric Academic Societies: Annual Meeting; Mini-Course: "Rheumatic Diseases in Children: Frontiers in Research and Clinical Care"; Chair (2005)
  • 2nd International American Indian/First Nations/Inuit Child Health Meeting Planning Committee; Co-Chair (2005)
  • National Children‘s Study Federal Advisory Committee; Committee Member (2005–2009)
  • Department of Defense - Prostate Cancer Research Section: Immunological Sciences; Ad Hoc Reviewer for Program Grants (2005)
  • National Institutes of Health: Pregnancy and Neonatology Study Section; Ad Hoc Reviewer for Program Grants (2005)
  • NIAMS: Special Emphasis Panel; Grant Reviewer (2005)
  • BMC Musculoskeletal Disorders; Editorial Board Member (2005)
  • University of Arizona Health Center; American College of Rheumatology/Immunex; Visiting Professor (2004)
  • Indian Health Special Interest Group; American Academy of Pediatrics; Committee Member (2004)
  • Henry Ford Hospital Department of Pediatric Rheumatology; American College of Rheumatology/Immunex; Visiting Professor (2002)
  • National Arthritis Foundation: Inflammation Study Section; Grant Reviewer (2002–2010)
  • National Human Genome Research Institute: "Developing a Haplotype Map of the Human Genome"; Invited Participant (2001)
  • New York University: Intramural Research Program; Grant Reviewer (2001)
  • U.S. Army Research and Material Command Breast Cancer Research Program; Grant Reviewer (2000)
  • Wellcome Trust, London, UK; Grant Reviewer (2000)
  • International Registry of Who‘s Who; Lifetime Member (2000)
  • National Institute of General Medical Science: "American Indian Research Training Needs"; Invited Participant (1999)
  • Native American Child Health (CONACH); American Academy of Pediatrics; Committee Member (1999–2005)
  • National Institutes of Arthritis and Musculoskeletal Disorders; Ad Hoc Reviewer for Program Grants (1999)
  • NIAMS: T32 Training Grants and K-Awards; Grant Reviewer (1999)
  • Society for Pediatric Research: Annual Meeting - Rheumatology; Chair (1998)
  • American Academy of Pediatrics: Section on Rheumatology; Executive Board (1998–2004)
  • American Society for Pediatric Research: National Meeting Abstract Selection Committee; Committee Member (1997)
  • Society for Pediatric Research: Annual Meeting - Neonatal Hematology/Immunology; Chair (1996)
  • "Controlling the Complement System: Exploiting the Pathogenic Understanding for Novel Drug Development" National Meeting; Sponsored by IBC; Chair (1995)
  • National Institutes of Health: Toxicology-1 Study Section; Grant Reviewer (1995)
  • United States Department of Veterans‘ Affairs; Ad Hoc Reviewer for Program Grants (1994)
  • Arthritis Foundation, Michigan Chapter; Grant Reviewer (1993–1996)
  • American College of Rheumatology: National Meeting Abstract Selection Committee (1996, 2001, 2004, 2011); Committee Member
  • Pediatric Academic Societies: Meeting Abstract Selection Committee (2008, 2010); Committee Member

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Contact Information

Clinical and Translational Research Center
875 Ellicott Street
Room 8026
Buffalo, NY 14203
Phone: (716) 878-7105
Fax: (716) 888-3841
Email: jamesjar@buffalo.edu

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