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John                           Hay

John Hay PhD

Department of Microbiology and Immunology

Specialty/Research Focus

Virology

 
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Professional Summary:

-There are two main research interests in the Hay lab:

1. Varicella zoster virus (VZV)

This human virus causes chickenpox and shingles, but we have no clear idea of the mechanisms through which disease is caused. Our work focuses on a molecular approach to these mechanisms. For example, we have identified sequences in the promoter of the major viral gene regulatory protein which on the one hand allow the protein to be expressed only in neural cells and on the other hand allow self-regulation of transcription. In collaborative work with colleagues at Stanford University, we have shown that the major transactivator protein is a strong T-cell immunogen; this could be a candidate for a novel VZV vaccine.

2. Molecular epidemiology of EDPs (especially dangerous pathogens)

We are studying three important viruses that cause serious disease in humans: crimean-congo hemorrhagic fever virus, hantaviruses and tick-borne encephalitis virus. Our approach is to travel to countries where we know or suspect that theses viruses circulate. There we collect potential animal reservoirs, insect vectors (where applicable) and human sera. We run assays for the immune status of animals and humans with respect to these viruses, and sequence viral genomes from animals and vectors. These data are assembled as phylogeographic information and used as risk assessment tools. We recently found new tick-borne viruses in Kyrgyzstan and hantaviruses in Siberia. We plan to revisit Kazakhstan in 2011.

These projects are supported by NIH and by the US and UK Defense Departments

Education and Training:
  • PhD, Virology, Glasgow University (1966)
  • BS, Biochemistry, Glasgow University, Magna Cum Laude (1963)
Employment:
  • Associate Director, NY State Center for Bioinformatics (2003-present)
  • Associate Dean of Medicine, Research and Biomedical Education, SUNY Buffalo (2001–2003)
  • Grant T. Fisher Chair and Professor, SUNY Buffalo (1992–2002)
  • Associate Provost for Research, SUNY Buffalo (1999–2001)
  • Coordinator, SUNY Buffalo, Microbial Pathogenesis (1994–1996)
  • Adjunct Professor, USUHS (1993–1996)
Awards and Honors:
  • Koepf MD Award for Scientific Achievement (2007)
  • Professor of Biology, Birla Institute of Technology and Science (2000)
  • Senior Fellowship, Ministry of Science, France (1994)
  • Fellow, Fondation pour la Recherche Medicale (1991)
  • Dept. of Defense "Outstanding Performance" rating (1990)
  • NATO Senior Fellowship (1989)
  • Dept. of Defense "Outstanding Performance" rating (1989)
  • Dept. of Defense "Outstanding Performance" rating (1988)
  • Dept. of Defense "Outstanding Performance" rating (1987)
  • Dept. of Defense "Outstanding Performance" rating (1986)
  • Dept. of Defense Commendable Service Medal (1985)
  • Dept. of Defense "Outstanding Performance" rating (1985)
  • Yoshigawa-Yoshida Memorial Cancer Fellowship (1976)
  • EMBO Award (1973)
  • Fullbright-Hayes Scholarship (1967)
  • Damon Runyon Fellowship (1967)
  • Medical Research Council Scholarship (1963)

Grants and Sponsored Research:
  • September 1999–August 2004
    Training in microbial pathogenesis
    National Institutes of Health
    Role: Principal Investigator
    $162,556
  • July 1999–June 2004
    Training in Microbial Pathogenesis
    National Institute of Allergy and Infectious Diseases
    Role: Principal Investigator
    $856,496

Journal Articles:
  • Briggs BJ, Atkinson B, Czechowski DM, Larsen PA, Meeks HN, Carrera JP, Duplechin RM, Hewson R, Junushov AT, Gavrilova ON, Breininger I, Phillips CJ, Baker RJ, Hay J. Tick-borne encephalitis virus, Kyrgyzstan. Emerg Infect Dis. 2011; 17(5).
  • Yashina LN, Abramov SA, Gutorov VV, Dupal TA, Krivopalov AV, Panov VV, Danchinova GA, Vinogradov VV, Luchnikova EM, Hay J, Kang HJ, Yanagihara R. Seewis virus: phylogeography of a shrew-borne hantavirus in Siberia, Russia. Vector Borne Zoonotic Dis. 2010; 10(6).
  • White K, Peng H, Hay J, Ruyechan WT. Role of the IE62 consensus binding site in transactivation by the varicella-zoster virus IE62 protein. J Virol. 2010; 84(8).
  • Yamamoto S, Eletsky A, Szyperski T, Hay J, Ruyechan WT. Analysis of the varicella-zoster virus IE62 N-terminal acidic transactivating domain and its interaction with the human mediator complex. J Virol. 2009; 83(12).
  • Yang M, Hay J, Ruyechan WT. Varicella-zoster virus IE62 protein utilizes the human mediator complex in promoter activation. J Virol. 2008; 82(24).
  • Khalil MI, Hay J, Ruyechan WT. Cellular transcription factors Sp1 and Sp3 suppress varicella-zoster virus origin-dependent DNA replication. J Virol. 2008; 82(23).
  • Cilloniz C, Jackson W, Grose C, Czechowski D, Hay J, Ruyechan WT. The varicella-zoster virus (VZV) ORF9 protein interacts with the IE62 major VZV transactivator. J Virol. 2007; 81(2).
  • Yang M, Peng H, Hay J, Ruyechan WT. Promoter activation by the varicella-zoster virus major transactivator IE62 and the cellular transcription factor USF. J Virol. 2006; 80(15).
  • Zuranski T, Nawar H, Czechowski D, Lynch JM, Arvin A, Hay J, Ruyechan WT. Cell-type-dependent activation of the cellular EF-1alpha promoter by the varicella-zoster virus IE63 protein. Virology. 2005; 338(1).
  • Ito H, Sommer MH, Zerboni L, Baiker A, Sato B, Liang R, Hay J, Ruyechan W, Arvin AM. Role of the varicella-zoster virus gene product encoded by open reading frame 35 in viral replication in vitro and in differentiated human skin and T cells in vivo. J Virol. 2005; 79(8).
  • Yang M, Hay J, Ruyechan WT. The DNA element controlling expression of the varicella-zoster virus open reading frame 28 and 29 genes consists of two divergent unidirectional promoters which have a common USF site. J Virol. 2004; 78(20).
  • Baiker A, Bagowski C, Ito H, Sommer M, Zerboni L, Fabel K, Hay J, Ruyechan W, Arvin AM. The immediate-early 63 protein of Varicella-Zoster virus: analysis of functional domains required for replication in vitro and for T-cell and skin tropism in the SCIDhu model in vivo. J Virol. 2004; 78(3).
  • Peng H, He H, Hay J, Ruyechan WT. Interaction between the varicella zoster virus IE62 major transactivator and cellular transcription factor Sp1. J Biol Chem. 2003; 278(39).
  • Ito H, Sommer MH, Zerboni L, He H, Boucaud D, Hay J, Ruyechan W, Arvin AM. Promoter sequences of varicella-zoster virus glycoprotein I targeted by cellular transactivating factors Sp1 and USF determine virulence in skin and T cells in SCIDhu mice in vivo. J Virol. 2003; 77(1).
  • Ito, H., Sommer, M.H., Zerboni, L., He, H., Boucaud, D., Hay J, Ruyechan W, Arvin, A.M.. Promoter sequences of varicella-zoster virus glycoprotein 1 targeted by cellular transcription factors Sp1 and USF determine virulence in skin and T cells in SCIDhu mice in vivo. J. Virol.. 2003; 77.
  • Ruyechan W, Peng, H., Yang, M., Hay J. Cellular factors and IE62 activation of VZV promoters. J. Med. Virol.. 2003.
  • Lynch JM, Kenyon TK, Grose C, Hay J, Ruyechan WT. Physical and functional interaction between the varicella zoster virus IE63 and IE62 proteins. Virology. 2002; 302(1).
  • Lynch, J.M., Kenyon, T.K., Grose, C., Hay J, Ruyechan W. Physical and functional interaction between the varicella zoster virus IE63 and IE62 proteins. Virology. 2002; 302.
  • Arvin, A.M., Sharp, M., Moir, M., Kinchington, P.E., Sadeghi-Zadah, M., Ruyechan W, Hay J. Memory cytotoxic T cell responses to viral tegument and regulatory proteins encoded by open reading frames 4, 10, 29, and 62 of varicella zoster virus. Viral Immunology. 2002; 15.
  • Kenyon TK, Lynch J, Hay J, Ruyechan W, Grose C. Varicella-zoster virus orf47 protein serine kinase: characterization of a cloned, biologically active phosphotransferase and two viral substrates, orf62 and orf63.. J Virol. 2001; 75(18).
  • Kenyon TK, Lynch J, Hay J, Ruyechan W, Grose C. Varicella-zoster virus orf47 protein serine kinase: characterization of a cloned, biologically active phosphotransferase and two viral substrates, orf62 and orf63.. J Virol. 2001; 75(18).
  • Kenyon TK, Lynch J, Hay J, Ruyechan W, Grose C. Varicella-zoster virus orf47 protein serine kinase: characterization of a cloned, biologically active phosphotransferase and two viral substrates, orf62 and orf63.. J Virol. 2001; 75(18).
  • Sommer MH, Zagha E, Serrano OK, Ku CC, Zerboni L, Baiker A, Santos R, Spengler M, Lynch J, Grose C, Ruyechan W, Hay J, Arvin AM. Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus.. J Virol. 2001; 75(17).
  • Sommer MH, Zagha E, Serrano OK, Ku CC, Zerboni L, Baiker A, Santos R, Spengler M, Lynch J, Grose C, Ruyechan W, Hay J, Arvin AM. Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus.. J Virol. 2001; 75(17).
  • Sommer MH, Zagha E, Serrano OK, Ku CC, Zerboni L, Baiker A, Santos R, Spengler M, Lynch J, Grose C, Ruyechan W, Hay J, Arvin AM. Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus.. J Virol. 2001; 75(17).
  • Santos, R.A., Hatfield, C.C., Faga, B.P., Padilla, J.A., Cole, N.L., Moffat, J.F., Arvin, A.M., Spengler, M., Ruyechan W, Hay J, Grose, C.. Varicella zoster virus gE escape mutant VZV-MSP exhibits a novel genotype with an accelerated cell-to-cell spread phenotype in both infected cell cultures and SCID-hu mice. Virology. 2001; 75.
  • Sommer, M.H., Zagha, E., Serrano, O.K., Ku, C.C., Zerboni, L., Baiker, A., Santos, R., Spengler, M., Lynch, J., Grose, C., Ruyechan W, Hay J, Arvin, A.M.. Mutational analysis of the repeated open reading frames ORFs 63 and 70 and ORFs 64 and 69 of varicella zoster virus. J. Virol.. 2001; 75.
  • Kenyon, T.K., Lynch, J., Hay J, Ruyechan W, Grose, C.. Varicella-zoster virus ORF47 protein kinase: characterization of a cloned, biologically active phosphotransferase and its viral substrates the ORF62 and ORF63 proteins. J. Virol.. 2001; 75.
  • He, H., Boucaud, D., Hay J, Ruyechan W. Cis and trans elements regulating expression of the varicella zoster virus gl gene. Arch. Virol.. 2001; 17.
  • Spengler, M., Ruyechan W, Hay J. Interactions among structural proteins of varicella zoster virus. Arch. Virol.. 2001; 17.
  • Santos RA, Hatfield CC, Cole NL, Padilla JA, Moffat JF, Arvin AM, William Ruyechan, Hay J, Grose C. Varicella-zoster virus gE escape mutant VZV-MSP exhibits an accelerated cell-to-cell spread phenotype in both infected cell cultures and SCID-hu mice.. Virology. 2000; 275(2).
  • Spengler ML, William Ruyechan, Hay J. Physical interaction between two varicella zoster virus gene regulatory proteins, IE4 and IE62.. Virology. 2000; 272(2).
  • Boulton M, Flessner M, Armstrong D, Mohamed R, Hay J, Johnston M. Contribution of extracranial lymphatics and arachnoid villi to the clearance of a CSF tracer in the rat.. Am J Physiol. 1999; 276(3 Pt).
  • Wallace HL, Natelson B, Gause W, Hay J. Human herpesviruses in chronic fatigue syndrome.. Clin Diagn Lab Immunol. 1999; 6(2).
  • Wallace, H., Natelson, B., Gause, W., John Hay. Human herpesviruses in chronic fatigue syndrome. Clin. Diag. Lab. Immunol.. 1999; 6.
  • Teach, S.J., Wallace, H., Evans, M.J., Duffner, P.K., John Hay, Faden, H.. HHV-6 and HHV-7 in children with febrile convulsions. Pediatric Neurol.. 1999; 21.
  • Boucaud D, Yoshitake H, Hay J, William Ruyechan. The varicella-zoster virus (VZV) open-reading frame 29 protein acts as a modulator of a late VZV gene promoter.. J Infect Dis. 1998; 178 S.
  • Natelson BH, LaManca JJ, Denny TN, Vladutiu A, Oleske J, Hill N, Bergen MT, Korn L, Hay J. Immunologic parameters in chronic fatigue syndrome, major depression, and multiple sclerosis.. Am J Med. 1998; 105(3A).
  • Natelson BH, LaManca JJ, Denny TN, Vladutiu A, Oleske J, Hill N, Bergen MT, Korn L, Hay J. Immunologic parameters in chronic fatigue syndrome, major depression, and multiple sclerosis.. Am J Med. 1998; 105(3A).
  • Natelson BH, LaManca JJ, Denny TN, Vladutiu A, Oleske J, Hill N, Bergen MT, Korn L, Hay J. Immunologic parameters in chronic fatigue syndrome, major depression, and multiple sclerosis.. Am J Med. 1998; 105(3A).
  • Natelson, B., LaManca, J., Denny, T., Vladutiu, A., Oleske, J., Hill, N., Bergen, Korn, L., John Hay. Immunological parameters in chronic fatigue syndrome, major depression and multiple sclerosois. Am. J. Med.. 1998; 105.
  • Zhao, X., John Hay. The epidemiology of hantavirus infections. Clin. Microbiol. Newsletter. 1997; 19.
  • John Hay. Vaccinia, vaccination, vaccinology: Jenner, Pasteur and their successors. Clin. Inf. Dis.. 1997; 24.
  • Zhao, X., John Hay. The evolution of hantaviruses. Immun. Invest.. 1996; 26.
  • Stevenson D, Xue M, Hay J, William Ruyechan. Phosphorylation and nuclear localization of the varicella-zoster virus gene 63 protein.. J Virol. 1996; 70(1).
  • Kantakamalakul W, William Ruyechan, Hay J. Analysis of varicella-zoster virus promoter sequences.. Neurology. 1995; 45(12 Su).
  • Maheshwari, R.K., Sidhu, G.S., Singh, A.K., Sivaram, S.S., Kinchington, P.R., John Hay, Friedman, R.M.. Defective transport of HSV-1 glycoprotein in interferon-treated cells: role of intracellular pH. J. Interferon Res.. 1995; 14.
  • John Hay, William Ruyechan. Varicella zoster virus-a different kind of herpesvirus latency?. Virology. 1994; 5.
  • John Hay, Arvin, A.M.. Proceedings of the Second VZVRF Conference, Bethesda, MD. Annals of Neurology. 1994; 35.
  • John Hay, William Ruyechan. Varicella zoster virus. Seminars in Virology. 1994; 5.
  • Hay J, Ruyechan W. Varicella zoster virus - a different kind of herpesvirus latency?. Seminars in Virology. 1994; 5.
  • Sabella C, Lowry PW, Abbruzzi GM, Koropchak CM, Kinchington PR, Sadegh-Zadeh M, Hay J, William Ruyechan, Arvin AM. Immunization with the immediate-early tegument protein (open reading frame 62) of varicella-zoster virus protects guinea pigs against virus challenge.. J Virol. 1993; 67(12).
  • Perera LP, Mosca JD, William Ruyechan, Hayward GS, Straus SE, Hay J. A major transactivator of varicella-zoster virus, the immediate-early protein IE62, contains a potent N-terminal activation domain.. J Virol. 1993; 67(8).
  • Perera LP, Mosca JD, Sadeghi-Zadeh M, William Ruyechan, Hay J. The varicella-zoster virus immediate early protein, IE62, can positively regulate its cognate promoter.. Virology. 1992; 191(1).
  • Pensiero MN, Sharefkin JB, Dieffenbach CW, Hay J. Hantaan virus infection of human endothelial cells.. J Virol. 1992; 66(10).
  • Perera LP, Mosca JD, William Ruyechan, Hay J. Regulation of varicella-zoster virus gene expression in human T lymphocytes.. J Virol. 1992; 66(9).
  • Ling P, Kinchington PR, Sadeghi-Zadeh M, William Ruyechan, Hay J. Transcription from varicella-zoster virus gene 67 (glycoprotein IV).. J Virol. 1992; 66(6).
  • Lowry PW, Solem S, Watson BN, Koropchak CM, Thackray HM, Kinchington PR, William Ruyechan, Ling P, Hay J, Arvin AM. Immunity in strain 2 guinea-pigs inoculated with vaccinia virus recombinants expressing varicella-zoster virus glycoproteins I, IV, V or the protein product of the immediate early gene 62.. J Gen Virol. 1992; 73 (.
  • Pensiero MN, Hay J. The Hantaan virus M-segment glycoproteins G1 and G2 can be expressed independently.. J Virol. 1992; 66(4).
  • Kinchington PR, Hougland JK, Arvin AM, Ruyechan WT, Hay J. The varicella-zoster virus immediate-early protein IE62 is a major component of virus particles.. J Virol. 1992; 66(1).
  • John Hay, William Ruyechan. Regulation of herpes simplex virus Type 1 gene expression. Current Topics in Microbiol. and Immunol.. 1992; 179.
  • Ling P, Kinchington PR, Ruyechan WT, Hay J. A detailed analysis of transcripts mapping to varicella zoster virus gene 14 (glycoprotein V).. Virology. 1991; 184(2).
  • Arvin AM, Sharp M, Smith S, Koropchak CM, Diaz PS, Kinchington P, Ruyechan W, Hay J. Equivalent recognition of a varicella-zoster virus immediate early protein (IE62) and glycoprotein I by cytotoxic T lymphocytes of either CD4+ or CD8+ phenotype.. J Immunol. 1991; 146(1).
  • Kinchington, P.R., Ling, P., Pensiero, M., Moss, B., William Ruyechan, John Hay. The glycoprotein products of varicella-zoster virus gene 14 and their defective accumulation in a vaccine strain (Oka). J. Virol.. 1990; 64.
  • Kinchington, P.R., Ling, P., Pensiero, M., Gershon, A., John Hay, William Ruyechan. A possible role for glycoprotein gpV in the pathogenesis of varicella-zoster virus. Advances in Exp. Med. Biol.. 1990; 278.
  • Feuerstein, N., Mond, J., Kinchington, P.R., Hickey, R., Lindsbert, M.-L., John Hay, William Ruyechan. Evidence for DNA binding activity of numatrin (B23), a cell cycle-regulated nuclear matrix protein. Biochem. Biophys. Acta.. 1990; 1087.
  • Kinchington, P.R., Ling, P., Pensiero, M., Gershon, A., Hay J, Ruyechan W. A possible role for glycoprotein gpV in the pathogenesis of varicella-zoster virus. Adv. Exptl. Med. Biol.. 1990; 278.
  • Morokoff, P.J., Myers, L., John Hay, Flora, M.M.. Effectiveness of a procedure for disinfecting the vaginal photoplethysmograph contaminated with herpes simplex virus type 2. Arch. Sex. Behavior. 1988; 17.
  • Pensiero, M.N., Jennings, G.B., Schmaljohn, C.S., John Hay. Expression of the Hantaan virus M genome segment by using a vaccinia virus recombinant. J. Virol.. 1988; 62.
  • Kinchington, P.R., Inchuaspe, G., Subak-Sharpe, J.H., Robey, F., John Hay, William Ruyechan. Identification and characterization of a varicella-zoster virus DNA-binding protein by using antiseera directed against a predicted synthetic oligopeptide. J. Virol.. 1988; 62.
  • Ostrove, J.M., Reinhold, W., Fan, C.-M., Zorn, S., John Hay, Straus, S.E.. Transcription mapping of the varicella-zoster virus genome. J. Virol.. 1986; 56.
  • Steven, A.C., Roberts, C.R., John Hay, Bisher, M., Pun, T., Trus, B.. Hexavalent capsomers of herpes simplex virus type 2: Symmetry, shape, dimensions and oligomeric status. J. Virol.. 1986; 57.
  • Kinchington, P.R., Remenick, J., Ostrove, J.M., Straus, S.E., William Ruyechan, John Hay. Putative glycoprotein gene of varicella-zoster virus with variable copy numbers of a 42-base- pair repeat sequence has homology to herpes simplex virus glycoprotein C.. J. Virol.. 1986; 59.
  • Schmaljohn, C.S., Jennings, G.B., John Hay, Dalrymple, J.M.. Coding strategy of the S genome segment of Hantaan virus. Virology. 1986; 155.
  • Wohlrab, F., Jamieson, A.T., John Hay, Mengel, R., Guschlbauer, W.. the effect of 2'-fluoro-2'-deoxycytidine on herpes virus growth. Biochem. Biophys.. 1985; 824.
  • William Ruyechan, Casey, T.A., Reinhold, W., Weir, A.C., Wellman, M., Straus, S.E., John Hay. Distribution of G+C-rich regions in varicella-zoster virus DNA. J. Gen. Virol.. 1985; 66.
  • Roberts, C.R., Weir, A.C., John Hay, Straus, S.E., William Ruyechan. DNA-binding proteins present in varicella-zoster virus-infected cells. J. Virol.. 1985; 55.
  • Casey, T.A., William Ruyechan, Flora, M.N., Reinhold, W., Straus, S.E., John Hay. Fine mapping and sequencing of a variable setment in the inverted repeat region of varicella zoster virus DNA. J. Virol.. 1985; 54.
  • Kinchington, P.R., Reinhold, W.C., Casey, T.A., Straus, S.E., John Hay, William Ruyechan. inversion and circularization of the varicella zoster virus genome. J. Virol.. 1985; 56.
  • Seidlein, M., Takiff, H.E., Smith, H.A., Straus, S.E., John Hay. Rapid diagnosis of varicella zoster virus infections by hybridization using a molecularly cloned viral DNA probe. J. Med. Virol.. 1984; 13.
  • Wathen, M.W., John Hay. Physical mapping of the herpes simplex virus type 2 nuc lesion affecting alkaline exonuclease activity by using herpes simplex virus type 1 deletion clones. J. Virol.. 1984; 51.
  • Straus, S.E., Reinhold, W., Smith, H.A., William Ruyechan, Henderson, D.K., Blaese, R.M., John Hay. Endonuclease analysis of viral DNA from varicella and subsequent zoster infections in the same patient. N. Engl. J. Med.. 1984; 311.
  • Ruyechan W, Casey, T.A., Reinhold, W., Weir, A.C., Wellman, M., Straus, S.E., Hay J. Distribution of G+C-rich regions in varicella zoster virus DNA. J. Gen. Virol.. 1984; 66.
  • Straus, S.E., John Hay, Smith, H., Owens, J.. Genome differences among varicella zoster virus isolates. J. Gen. Virol.. 1983; 64.
  • Rixon, F.J., Atkinson, M.A., John Hay. Intranuclear distribution of herpes simplex virus type 2 DNA synthesis: Examination by light and electron microscopy. J. Gen. Virol.. 1983; 64.
  • Straus, S.E., Owens, J., William Ruyechan, Takiff, H., Casey, T.A., Vande Woude, G.F., John Hay. Molecular cloning and physical mapping of varicella zoster virus DNA. Proc. Nat. Acad. Sci. (Wash). 1982; 79.
  • Maheshwari, R.K., Sreelvasen, T., Silverman, R.H., John Hay, Friedman, R.M.. tunicamycin treatment enhances the antiviral action of interferon. Science. 1982; 219.
  • Hay, R.T., John Hay. Characteristics of chromatin preparations from herpes simplex virus infected cells. Biochem. Biophys. Acta. 1981; 655.
  • Straus, S.E., Aulakh, H.S., William Ruyechan, John Hay, Casey, T.A., Vande Woude, G.F., Owens, J., Smith, H.A.. Structure of varicella zoster virus DNA. J. Virol.. 1981; 40.
  • John Hay, Bartkoski, M.J.. Virus pathogenesis. Handbook of Molecular Pharmacology. 1981; 61.
  • McNab, J.C.M., Visser, L., Jamieson, A.T., John Hay. Virus antigens in cells transformed by herpes simplex virus. Cancer Res.. 1980; 40.
  • Hay, R.T., John Hay. Properties of herpesvirus-induced "immediate early" polypeptides. Virology. 1980; 104.
  • Moss, H., Chartrand, R., Timbury, M.D., John Hay. A mutant of herpes simplex virus type 2 with temperature-sensitive lesions affecting virion thermolability and deoxyribonuclease activity: Identification of the lethal mutation and physical mapping of the nuc-lesion. J. Virol.. 1979; 32.
  • Francke, B., Moss, H., Timbury, M.C., John Hay. Alkaline exonuclease activity in cells infected with a temperature-sensitive mutant of herpes simplex virus type 2. J. Virol.. 1978; 26.
  • Hay, R.T., John Hay. Synthesis of herpes simplex virus DNA in preparations of chromatin from infected cell nuclei. J. Gen. Virol.. 1978; 41.
  • John Hay, Brown, S.M., Jamieson, A.T., Rixon, F.J., Moss, H., Darjan, D.A., Subak-Sharpe, J.H.. The effect of phosphonoacetic acid on herpes viruses. J. Antimicrob. Chemother.. 1977; 3.
  • Clements, J.B., John Hay. RNA and protein synthesis in herpesvirus-infected cells. J. Gen. Virol.. 1977; 35.
  • John Hay, Moss, H., Jamieson, A.T., Timbury, M.. Herpesvirus proteins: DNA polymerase and pyrimidine deosynucleoside kinase activities in temperature-sensitive mutants of herpes simplex virus type 2. J. Gen. Virol.. 1976; 31.
  • John Hay, Subak-Sharpe, H.. Mutants of herpes simplex virus types 1 and 2 that are resistant to phosphonoacetic acid induce altered DNA polymerase activities in infected cells. J. Gen. Virol.. 1976; 31.
  • Jamieson, A.T., John Hay, Subak-Sharpe, H.. Phosphotransferase activity induced by herpes simplex virus. J. Virol.. 1976; 17.
  • Timbury, M.C., John Hay. Biochemical and genetic behavior of mutants of herpes simplex type 2. Herpesviruses and Oncogenesis. 1975; 86.
  • Subak-Sharpe, J.H., John Hay, Timbury, M.C., Ritchie, D.A., Brown, S.M., Macnab, J.M., Marsden, J.S.. Genetic studies with herpes simplex virus. Cold Spr. Harb. Symp. Quant. Biol.. 1975; 39.
  • Bayliss, G.J., Marsden, H.S., John Hay. Herpex simplex virus proteins: DNA-binding proteins in infected cells and in the virus structure. Virology. 1975; 68.
  • Tyler, Sheila, J., John Hay, Stevely, W.S.. The effect of pseudorabies virus infection on nuclear protein synthesis in hamster kidney cells. Arch. Ges. Virusforsch.. 1974; 44.
  • Howard, D.K., John Hay, Melvin,W.T., Durham, J.P.. Changes in DNA and RNA synthesis and associated enzyme activities after the stimulation of serum-depleted BHK21/C13 cells by the addition of serum. Exptl. Cell Res.. 1974; 86.
  • Pringle, C.R., Howard, D.K., John Hay. Temperature-sensitive mutants of pseudorabies virus with differential effects on viral and host DNA synthesis. Virology. 1973; 55.
  • John Hay, Perera, P.A.J., Morrison, J.M., Gentry, G.A., Subak-Sharpe, J.H.. Herpesvirus-specified proteins. Strategy of the Viral genome. 1971.
  • Jarrett, O., Pitts, J.D., Whalley, J.M., Clason, A.E., John Hay. Isolation of the nucleic acid of feline leukemia virus. Virology. 1971; 43.
  • John Hay, Pillinger, D.J., Borek, E.. The effect of hypermethylation on the functional properties of transfer ribonucleic acid: II. Ribosome binding and polypeptide synthesis. Biochem. J.. 1970; 119.
  • Pillinger, D.J., John Hay, Borek, E.. The effect of hypermethylation on the functional properties of transfer ribonucleic acid: Formation of aminoacyl-transfer-ribonucleic acid. Biochem. J.. 1969; 114.
  • Low, M., John Hay, Keir, H.M.. DNA of herpes simplex virus is not a substrate for methylation in vivo. J. Molec. Biol.. 1969; 46.
  • John Hay. the origin of viruses. Queen Elizabeth College Microbiology Soc. Journal. 1969; 1.
  • Subak-Sharpe, H., John Hay. Analysis of nearest neighbour base frequencies in the RNA of a mammalian virus: Encephalomyocarditis virus. J. Gen. Virol.. 1968; 2.
  • John Hay, Koteles, G.J., Keir, H.M., Subak-Sharpe, H.. Herpes virus specified ribonucleic acids. Nature. 1966; 210.
  • Keir, H.M., John Hay, Morrison, J.M., Subak-Sharpe, H.. Altered properties of deoxynucleic acid nucleotidyltransferase after infection of mammalian cells with herpes simplex virus. Nature. 1966; 210.
  • Subak-Sharpe, H., Burk, R.R., Crawford, L.V., Morrison, J.M., John Hay, Keir, H.M.. An approach to evolutionary relationships of mammalian DNA viruses through analysis of the pattern of nearest neighbour base sequences. Cold Spr. Harb. Symp. Quant. Biol.. 1966; 31.
  • Subak-Sharpe, H., Shepherd, W.M., John Hay. Studies on sRNA coded by herpes virus. Cold Spr. Harb. Symp. Quant. Biol.. 1966; 31.
  • Subak-Sharpe, H., John Hay. An animal virus with DNA of high guanine+cytosine content which codes for SRNA. J. Molec. Biol.. 1965; 12.
  • Zhao X, Hay J. The evolution of hantaviruses.. Immunol Invest. ; 26(1-2).
  • Spengler M, Niesen N, Grose C, William Ruyechan, John Hay. Interactions among structural proteins of varicella zoster virus.. Arch Virol Suppl. ; (17).
  • He H, Boucaud D, John Hay, William Ruyechan. Cis and trans elements regulating expression of the varicella zoster virus gI gene.. Arch Virol Suppl. ; (17).
See All (121 Total) >
Books and Book Chapters:
  • William Ruyechan, John Hay. VZV DNA replication. Varicella Zoster Virus. 2001.
  • Ruyechan W, Hay J. Varicella Zoster Virus: DNA Replication. Varicella Zoster virus: virology and clinical management. 2000.
  • William Ruyechan, John Hay. Varicella zoster virus: molecular biology. Encyclopedia of Virology. 1999.
  • Applegate, K.L., John Hay, Cacioppo, J.T., Kiecolt-Claser, J.K., Glaser, R.. The effects of stress on the immune system - implications for reactivation of latent herpesviruses. Psychoneuroimmunology. 1999.
  • Ruyechan W, Hay J. Varicella zoster virus: Molecular Biology. Encyclopedia of Virology. 1994; 2.
  • William Ruyechan, John Hay. Varicella zoster; molecular biology. Encyclopedia of Virology. 1994; 2.
  • John Hay, Jenkins, F.J.. Herpesviruses. Chronic Fatigue Syndrome. 1993.
  • John Hay, William Ruyechan. Expression and function of herpes simplex virus gene products. The Immunobiology of Herpes Simplex Infections. 1992.
  • Ruyechan W, Hay J. Regulation of herpes simplex virus type 1 gene expression. The Immunobiology of Herpes Simplex Infections. 1992.
  • Ruyechan W, Ling, P., Kinchington, P.R., Hay J. The correlation between varicella-zoster virus transcription and the sequence of the viral genome. Herpesvirus Transcription and Its Regulation. 1991.
  • Kinchington, P.R., Ruyechan W, Hay J. Herpesvirus vaccines. Vaccines and Immunotherapy, The Swiss Vaccine Institute. 1991.
  • Kinchington, P.R., William Ruyechan, John Hay. Herpesvirus vaccines. Vaccines and Immunotherapy. 1991.
  • Kinchington, P.R., Ling, P., Pensiero, M., Gershon, A., John Hay, William Ruyechan. A possible role for glycoprotein gpV in the pathogenesis of varicella-zoster virus. Immunobiology and Prophylaxis of Human Herpesvirus Infections. 1990.
  • William Ruyechan, Ling, P., Kinchington, P.R., John Hay. The correlation between varicella zoster virus transcription and the sequence of the viral genome. Herpesvirus Transcription and Its Regulation. 1990.
  • John Hay, Roberts, C.R., William Ruyechan, Steven, A.C.. Herpesviridae. Animal Virus Structure. 1987.
  • Watson, R.J., John Hay. Herpesvirus structural components. Viruses Associated with Human Cancer. 1982.
  • Subak-Sharpe, H., John Hay. Virus-induced enzymes. Proc. Int. Congress Chemotherapy. 1976.
See All (17 Total) >

Professional Memberships:
  • Review panel for US Army ID research (tropical diseases); Chair, 2001 (1999)
  • Association of Medical School Microbiology/Immunology Chairs (AMSMIC); President-elect 2000 President 2001 (1997)
  • Immunology/Virology/Pathology Study Section (NIH) (1994–1996)
  • Editorial Board, CDLI (ASM) (1994)
  • Microbiology and Infectious Diseases Study Section (1992)
  • VZVRF, NIH/CDC Liaison Committee (1992)
  • Experimental Virology Study Section (1991)
  • NIMH Special Panel on Future Research Directions (1991)
  • Herpes Latency Special Review Board, NIH (1991)
  • Chronic Fatigue Syndrome Ad Hoc Study Section (NIH); Chair, 1995, 1998-present (1991)
  • Varicella Zoster Foundation Scientific Advisory Board (1991)
  • Organizing Committee, 15th International Herpesvirus Workshop (1990)
  • NIH Reviewers Reserve (1989)
  • Indo-US Workshop on Viruses and Human Cancer, Trichur, India, sponsored by NIH (1986)
  • Virology Study Section, NIH (1985–1989)
  • Immunology/Virology Small Busines Study Section, NIH (1984–1986)
  • Virology Study Section, NIH (1984)
  • Site Visit Team, nIH, at Cancer Research Institute, Kerala State, India (1984)
  • Virology Study Section, NIH (1983)
  • American Society for Virology (1981)
  • Editorial Board, Journal of General Virology (1980–1985)
  • NIH Committees assessing applications for Meeting Funding (1980)
  • Co-organizer, EMBO Workshop on "Isolated Nuclear Systems" (1977)
  • Editor, Large DNA Viruses, Journal of General Virology (1975–1980)
  • Editorial Board, Journal of General Virology (1974–1975)
  • Society for General Microbiology
  • American Society for Microbiology
Service Activities:
  • School of Medicine & Biomedical Sciences Admissions Committee; Member (1979–1985)
  • First Presbyterian Church of Clarence; Ruling Elder; Other (1993)
  • Supervising director, Witebsky Center for Immunology; Director (1992–2000)
  • Chair, Microbiology; Chair (1992)
  • St. Mark Presbyterian Church; Ruling Elder; Other (1990–1992)
  • St. Mark Presbyterian Church, Bethesda; Other (1986–1989)
  • Mobile Medical Care; a volunteer (free) clinic for the poor and homeless in Montgomery County, Maryland, run by a board of twelve health care and associated personnel; Board Member (1985–1988)
  • Potomac Curling Club; Secretary (1984–1987)
  • Vice Chair, Uniformed Services University; Co-Chair (1980–1992)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

138 Farber Hall
SUNY at Buffalo
34354 Main Street
Buffalo, NY 14214
Phone: (716) 829-2907
Email: jhay@buffalo.edu


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