(1) Role of the sympathoadrenal system in hypertension, postural adaptation, and long-term cardiovascular adaptation (2) Control of regional and systemic blood flow during acute stress responses (3) Mechanisms of stress responses and vacoreactivity, both in vivo and in vitro, including metabolic interactions (4) Cardiovascular drug effects (5) Outcomes of drug therapies
Education and Training:
MD, Internal Medicine, Johns Hopkins University (1972)
AB, Biology/Biochemistry, Princeton University (1968)
Employment:
Professor of Pharmacology and Toxicology, University at Buffalo, The State University of New York (1991-present)
Professor of Medicine, University at Buffalo, The State University of New York (1990-present)
Associate Professor, State University of New York at Buffalo (1988–1990)
Associate Professor, Department of Medicine, University of Rochester, School of Medicine (1984–1988)
Director, Hypertension Service, University of Rochester School of Medicine (1980–1988)
Assistant Professor, (Nephrology), University of Rochester, School of Medicine (1979–1984)
Staff Associate, Experimental Therapeutics Section, Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, NIH (1975–1979)
Attending Physician, National Institutes of Health (1975–1979)
Intern and Assistant Resident, Straight Medicine, Washington University, Barnes Hospital (1972–1979)
Awards and Honors:
American Society of Hypertension, Marvin Moser Clinical Hypertension Award (2012)
Who's Who (2011)
American Society of Hyptertension, Fellow (2010)
American Society of Hyptertension, Hypertension Specialist (1999)
Best Doctors in America (1996)
American Heart Association, Fellow (1995)
American College of Physicians, Fellow (1990)
Who's Who in Science (1984)
Who's Who in the East (1984)
Fellow, High Blood Pressure Research Council, AHA (1984)
Sinsheimer Scholar Award (1982)
Clinical Associate Physician Award, University of Rochester (1979)
Buswell Fellow, University of Rochester (1979)
National Merit Scholarship Finalist (1964)
Hearst Foundation Senate Youth Fellow (1964)
Research Expertise:
New Research Expertise
Grants and Sponsored Research:
June 2001–December 2002 Hemodynamic Profiling of Carvedilol Glaxo Smith-Kline Role: Principal Investigator $195,000
October 1992–September 2002 Pilot Clinical Pharmacology Training Program US Food and Drug Administration and USPHS Role: Principal Investigator $2,055,000
January 1989–December 1994 Coronary Arrhythmia Suppression Trial NHLBI, NIH Role: Principal Investigator $125,000
January 1986–January 1988 Seasonal Blood Pressure Variation American Heart Association, NYS Affiliate Role: Principal Investigator $49,000
Joseph Izzo. Aging and systolic hypertension: cluster patterns and problem-solving strategies to answer the genetic riddle (editorial). Hypertension. 2001; 37.
Allen, K., Shykoff, B.E., Joseph Izzo. Pet ownership, but not ACE inhibitor therapy, blunts home blood pressure responses to mental stress. Hypertension. 2001; 38.
Joseph Izzo, Manning, T.S., Shykoff, B.E.. Office blood pressures, arterial compliance characteristics, and estimated cardiac load. Hypertension. 2001; 38.
Chow, S.L., Luzier, A.B., DiTusa, L., Snyder, B.D., Joseph Izzo. Acid suppressive therapy use associated with antihypertensive agents. Pharmacoepidemiology. 2001; 41.
DiTusa L, Luzier AB, Jarosz DE, Snyder BD, Joseph Izzo. Treatment of hypertension in a managed care setting.. Am J Manag Care. 2001; 7(5).
Joseph Izzo, Shykoff, B.E.. Arterial stiffness: clinical relevance, measurement, and treatment. Reviews in Cardiovascular Medicine. 2001; 2.
Chaudhuri, A. and Izzo, J.L. Jr.. Insulin resistance and hypertension in the absence of subcutaneous fat. Reviews in Cardiovascular Medicine. 2001; 1.
Izzo, J.. A Challenge to JNC VI: Should guidelines for treatment be modified? Blood pressure guidelines and tight blood pressure control is essential. Medical Crossfire. 2000; 2(9).
Izzo, J.. Systolic hypertension, arterial stiffness and vascular damage: Role of the renin-angiotensin system. Blood Pressure Monitoring. 2000; 5(suppl).
Joseph Izzo. Vascular disease and the renin-system in the patient with hypertension: panel discussion and questions to the audience. Blood Pressure Monitoring. 2000; 5(suppl).
Izzo, J.. The role of the renin-angiotensin system in vascular health. Use of ACE inhibition to improve vascular function. Heart Disease. 2000; 2(5).
Joseph Izzo, Levy D, Black HR. Clinical Advisory Statement. Importance of systolic blood pressure in older Americans.. Hypertension. 2000; 35(5).
Luzier AB, Feuerstein SG, Uldrich P, Schentag JJ, Izzo JL Jr.. Containment of heart failure hospitalizations and cost by angiotensin-converting enzyme inhibitor dosage optimization: A demonstration project. Am J Cardiol. 2000; 86.
Joseph Izzo, Taylor AA. The sympathetic nervous system and baroreflexes in hypertension and hypotension.. Curr Hypertens Rep. 1999; 1(3).
Bong Sung, Ching M, Joseph Izzo, Dandona P, Wilson MF. Estrogen improves abnormal norepinephrine-induced vasoconstriction in postmenopausal women.. J Hypertens. 1999; 17(4).
Huang MH, Knight PR, Joseph Izzo. Ca2+-induced Ca2+ release involved in positive inotropic effect mediated by CGRP in ventricular myocytes.. Am J Physiol. 1999; 276(1 Pt).
Huang, M., Knight, P., Joseph Izzo. Ionotropic mechanisms of calcitonin gene-related peptide in isolated ventricular myocytes. Am J Physiol. 1999; 276.
Joseph Izzo. Risk stratification: a key to managing hypertension in the managed care setting. Am J Managed Care. 1999; 5(Suppl).
Bong Sung, Joseph Izzo, Paresh Dandona, Michael Wilson. Vasodilatory effects of troglitazone improve blood pressure at rest and during mental stress in type 2 diabetes mellitus. Hypertension. 1999; 34.
Luzier AB, Forrest A, Adelman M, Hawari FI, Schentag JJ, Joseph Izzo. Impact of angiotensin-converting enzyme inhibitor underdosing on rehospitalization rates in congestive heart failure.. Am J Cardiol. 1998; 82(4).
Sung BH, Ching M, Joseph Izzo, Dandona P, Wilson MF. Insulin-mediated venodilation is impaired in patients with high cholesterol.. Hypertension. 1998; 31(6).
Joseph Izzo. The microcirculation in hypertension. Current Concepts in Hypertension. 1998; 2(3).
Ching MI, Sung BH, Forrest A, Wilson MF, Izzo JL. Vasoreactivity in pre- and postmenopausal women: evaluation by pharmacodynamic modeling.. J Clin Pharmacol. 1998; 38(2).
Bong Sung, Ching, M., Joseph Izzo, Paresh Dandona, Michael Wilson. Insulin-mediated venodilation is impaired in patients with high cholesterol. Hypertension. 1998; 31.
Hawari, F., Shyoff, B., Joseph Izzo. Heparin attenuates norepinephrine-induced vasoconstriction by a cyclic-GMP-mediated mechanism. Vascular Medicine. 1998; 3.
Sung BH, Wilson MF, Izzo JL, Ramirez L, Dandona P. Moderately obese, insulin-resistant women exhibit abnormal vascular reactivity to stress.. Hypertension. 1997; 30(4).
Sung BH, Izzo JL, Wilson MF. Effects of cholesterol reduction on BP response to mental stress in patients with high cholesterol.. Am J Hypertens. 1997; 10(6).
Carr JR, Fitzpatrick P, Izzo JL, Cumbo TJ, Birmingham MC, Adelman MH, Paladino JA, Hanson SC, Schentag JJ. Changing the infection control paradigm from off-line to real time: the experience at Millard Fillmore Health System.. Infect Control Hosp Epidemiol. 1997; 18(4).
Creager, M.A., Joseph Izzo. Coronary and peripheral vasoreactivity: role of endothelial dysfunction. Current Concepts in Hypertension. 1997; 2(2).
Joseph Izzo. Vasoreactivity and high risk hypertension. Current Concepts in Hypertension. 1997; 2(2).
Harris LM, Faggioli GL, Shah R, Koerner N, Lillis L, Dandona P, Izzo JL, Snyder B, Ricotta JJ. Vascular reactivity in patients with peripheral vascular disease.. Am J Cardiol. 1995; 76(3).
Grover A, Padginton C, Wilson MF, Sung BH, Izzo JL, Dandona P. Insulin attenuates norepinephrine-induced venoconstriction. An ultrasonographic study.. Hypertension. 1995; 25(4 Pt).
Joseph Izzo. Cardiorenal interactions in regulation of blood pressure and volume. Choices in Cardiology. 1992; 6(suppl).
Izzo JL, Swislocki AL. Workshop III--Insulin resistance: is it truly the link?. Am J Med. 1991; 90(2A).
Izzo JL, Larrabee PS, Sander E, Lillis LM. Hemodynamics of seasonal adaptation.. Am J Hypertens. 1990; 3(5 Pt).
Izzo JL, Sander E, Larrabee PS. Effect of postural stimulation on systemic hemodynamics and sympathetic nervous activity in systemic hypertension.. Am J Cardiol. 1990; 65(5).
Izzo JL. Sympathoadrenal activity, catecholamines, and the pathogenesis of vasculopathic hypertensive target-organ damage.. Am J Hypertens. 1989; 2(12 Pt).
Izzo JL. The sympathoadrenal system: friend and foe?. Am J Hypertens. 1989; 2(12 Pt).
Licht MR, Izzo JL. Humoral effect of norepinephrine on renin release in humans.. Am J Hypertens. 1989; 2(10).
Joseph Izzo. Pathophysiology of "volume-dependent hypertension". IM - Internal Medicine for the Subspecialist. 1988.
Joseph Izzo. Suitable and unsuitable agents for volume-dependent hypertension. IM - Internal Medicine for the Subspecialist. 1988.
Joseph Izzo. Selective screening for renovascular disease. Diagnosis. 1988; 10.
Izzo JL, Smith RJ, Larrabee PS, Kallay MC. Plasma norepinephrine and age as determinants of systemic hemodynamics in men with established essential hypertension.. Hypertension. 1987; 9(4).
Blair ML, Chen YH, Izzo JL. Influence of renal perfusion pressure on alpha- and beta-adrenergic stimulation of renin release.. Am J Physiol. 1985; 248(3 Pt).
Chen YH, Blair ML, Izzo JL. Renal norepinephrine overflow during graded renal nerve stimulation before and after beta-adrenoceptor blockade.. J Auton Nerv Syst. 1984; 11(3).
Daugirdas JT, Ing TS, Chen WT, Vestal RE, Izzo JL, Hano JE, Norusis MJ. Hemodynamic response to volume depletion in acutely uremic dogs.. Am J Physiol. 1984; 247(2 Pt).
Joseph Izzo. The sympathoadrenal system in maintenance of elevated arterial pressure. J Cardiovasc Pharm. 1984; 6.
Izzo JL, Sterns RH. Abnormal norepinephrine release in uremia.. Kidney Int Suppl. 1983; 16.
Izzo JL, Horwitz D, Lawton WJ, Keiser HR. Fludrocortisone suppression of sympathetic nervous activity.. Clin Pharmacol Ther. 1983; 33(1).
Joseph Izzo. Renovascular hypertension: diagnostic problems and therapeutic implications. JAMA. 1983; 249.
Joseph Izzo, Greulich, D. Radioenzymatic assay for plasma dihydroxyphenylglycol, dihydroxymandelic acid and dihydroxyphenyl acetic acid in plasma. Life Sci. 1983; 33.
Joseph Izzo. Cardiovascular hormonal effects of circulating norepinephrine. Hypertension. 1983; 5.
Joseph Izzo, Sterns, RH. Abnormal norepinephrine release in uremia. Kidney International. 1983; 24(Suppl).
Joseph Izzo, Horwitz, D., Lawton, W.J., Keiser, H.R.. Fluorocortisone suppression of synpathetic nervous activity. Clin. Pharmacol. Ther.. 1983; 33.
Joseph Izzo, Ghosal, A., Kwong, T., Freeman, R.B., Jaenike, J.R.. Age and prior caffeine use alter the cardiovascular and adrenomedullary responses to oral caffeine. Am. J. Cardiology. 1983; 52.
Colgan, F.J., Sawa, T., Ten Eyck, L.G., Joseph Izzo. Protective effects of beta blockade on pulmonary function when intracranial pressure is elevated. Crit. Care Medicine. 1983; 11.
Joseph Izzo, Izzo, MS, Sterns, RH, Freeman, RB. Sympathetic nervous hyperactivity in maintenance hemodialysis patients. Trans Am Soc Artif Int Organs. 1982; 28.
Daugirdas, JT, Ing, TS, Chen, WT, Vestal, RE, Joseph Izzo, Hano, JE, Liu, P. Ultrafiltration hemodynamics in conscious, uremic dogs: effect of using a bicarbonate-buffered, plasma-resembling dialysate. Trans Am Soc Artif Int Organs. 1982; 28.
Joseph Izzo. Hypertension in the elderly: a pathophysiological approach to therapy. J Am Geriatrics Soc. 1982; 30.
Gutierrez OH, Izzo JL, Burgener FA. Transluminal recanalization of an occluded renal artery: reversal of anuria in a patient with a solitary kidney.. AJR Am J Roentgenol. 1981; 137(6).
Goldstein DS, Feuerstein G, Izzo JL, Kopin IJ, Keiser HR. Validity and reliability of liquid chromatography with electrochemical detection for measuring plasma levels of norepinephrine and epinephrine in man.. Life Sci. 1981; 28(5).
Izzo JL, Horwitz D, Keiser HR. Physiologic mechanisms opposing the hemodynamic effects of prazosin.. Clin Pharmacol Ther. 1981; 29(1).
Goldstein DS, Harris AH, Izzo JL, Turkkan JS, Keiser HR. Plasma catecholamines and renin during operant blood pressure conditioning in baboons.. Physiol Behav. 1981; 26(1).
Nesbitt GH, Izzo J, Peterson L, Wilkins RJ. Canine hypothyroidism: a retrospective study of 108 cases.. J Am Vet Med Assoc. 1980; 177(11).
Izzo JL, Roncone AM, Helton DL, Izzo MJ. Subcellular distribution of intraportally injected 125I-labeled insulin in rat liver.. Arch Biochem Biophys. 1979; 198(1).
Izzo JL, Horwitz D, Keiser HR. Reduction in human urinary MHPG excretion by guanethidine: urinary MHPG as index of sympathetic nervous activity.. Life Sci. 1979; 24(15).
Vinci JM, Zusman RM, Izzo JL, Bowden RE, Horwitz D, Pisano JJ, Keiser HR. Human urinary and plasma kinins: relationship to sodium-retaining steroids and plasma renin activity.. Circ Res. 1979; 44(2).
Vinci JM, Gill JR, Bowden RE, Pisano JJ, Izzo JL, Radfar N, Taylor AA, Zusman RM, Bartter FC, Keiser HR. The kallikrein-kinin system in Bartter's syndrome and its response to prostaglandin synthetase inhibition.. J Clin Invest. 1978; 61(6).
Vinci JM, Zusman RM, Izzo JL, Bowden RE, Horwitz D, Pisano JJ, Keiser HR. Relationship of human urinary and plasma kinins to sodium-retaining steroids and plasma renin activity.. Adv Exp Med Biol. ; 120B.
Izzo JL, Izzo MS, Sterns RH, Freeman RB. Sympathetic nervous system hyperactivity in maintenance hemodialysis patients.. Trans Am Soc Artif Intern Organs. ; 28.
Izzo J. Cardiovascular hormonal effects of circulating norepinephrine.. Hypertension. ; 5(5).
Izzo JL. The sympathoadrenal system in the maintenance of elevated arterial pressure.. J Cardiovasc Pharmacol. ; 6 Sup.
Izzo JL, Santarosa RP, Larrabee PS, Smith RJ, Kallay MC. Increased plasma norepinephrine and sympathetic nervous activity in essential hypertensive and uremic humans: effects of clonidine.. J Cardiovasc Pharmacol. ; 10 Su.
Zambraski EJ, Ciccone CD, Izzo JL. The role of the sympathetic nervous system in 2-kidney DOCA-hypertensive Yucatan miniature swine.. Clin Exp Hypertens A. ; 8(3).
Allen K, Golden LH, Joseph Izzo, Ching MI, Forrest A, Niles CR, Niswander PR, Jared Barlow. Normalization of hypertensive responses during ambulatory surgical stress by perioperative music.. Psychosom Med. ; 63(3).
Hollenberg NK, Joseph Izzo, Sica DA, White WB, Mansoor GA. Vascular disease and the renin-angiotensin system in the patient with hypertension: panel discussion and questions from the audience.. Blood Press Monit. ; 5 Sup.
Joseph Izzo. Systolic hypertension, arterial stiffness, and vascular damage: role of the renin-angiotensin system.. Blood Press Monit. ; 5 Sup.
Shykoff BE, Hawari FI, Izzo JL. Diameter, pressure and compliance relationships in dorsal hand veins.. Vasc Med. ; 6(2).
O'Donovan RM, Gutierrez OH, Izzo JL. Preservation of renal function by percutaneous renal angioplasty in high-risk elderly patients: short-term outcome.. Nephron. ; 60(2).
Joseph Izzo. Angiotensin converting enzyme inhibition. 1983.
Joseph Izzo, Black, H.R., Taubert, K.. Hypertension Primer..
Professional Memberships:
United States Pharmacopeia; USP Counsel of Experts, Cardiovascular and Renal Drugs Expert Committee (2000–2005)
American Society of Hypertension; Specialist Committee (1999–2001)
American Society of Hypertension; Professional Education Committee (1998–2004)
American Heart Association; Continuing Education Committee (National Committee) (1997–2000)
American College of Physicians; Councilor for Upstate Region (New York State Chapter) (1996–2000)
United States Pharmacopeia; USP Revisions Panel for Cardiorenal Drugs, 1995-2000 (1995–2000)
American Society for Clinical Pharmacology and Therapeutics (1990–1997)
American Society of Nephrology; Member, 1979-2002
Scientific Program Abstract Grader, 1984-86
Chairman, Hypertension Section, 1987
American Federation for Biomedical Research, Member, 1980-2000
Inter-American Society for Hypertension, Member, 1980-present
American Assoc. for the Advancement of Science, Member, 1981-84
International Society of Nephrology, Member, 1982-1993
New York Academy of Sciences, Member, 1982-84
Internationl Society for Hypertension, Member, 1984-present (1979–2002)
Presentations:
"Estrogen may influence blood pressure regulation" Thirteenth Scientific Meeting of the American Society of Hypertension, American Society of Hypertension (1998)
"Normalization of hypertensive responses during ambulatory surgical stress by perioperative music" Thirteenth Scientific Meeting of the American Society of Hypertension (1998)
Service Activities:
Faculty Senate; Member (2001)
Biochemistry, School of Medicine & Biomedical Sciences Sample Committee; Member (1999)
Biochemistry, School of Medicine & Biomedical Sciences Sample Committee; Member (1999)
Biochemistry, School of Medicine & Biomedical Sciences Sample Committee; Chair (1999)
School of Medicine & Biomedical Sciences Faculty Council; Alternate Member (1998–2002)
School of Medicine & Biomedical Sciences Faculty Council; Member (1989)
Visiting Professor; SUNY-Brooklyn (Endocrinology), 12/01; Visiting Professor (2001)
Visiting Professor; Mount Sinai School of Medicine (Hypertension), 2/01; Visiting Professor (2001)
Visting Professorship; University of California, San Francisco (Cardiology) 12/00; Visiting Professor (2000)
Visiting Professor; Long Island Jewish Medical Center (General Medicine), 11/00; Visiting Professor (2000)
New Service Activity; Boy Scouts of America Merit Badge Counselor; Volunteer (2000)
Editorial Board; Reviews in Crdiovascular Medicine; Editorial Board Member (1999–2001)
Editorial Board; Journal of Clinical Hypertension; Editorial Board Member (1999)
New Service Activity; Fellow, Council on Geriatric Cardiology; Member (1994)
Clinical Service; Hypertension Copnsultations (weekly, 1/2 day); Other (1990)
Clinical Service; Attending Physician, General Medicine, 2 months per year; Volunteer (1988)
Clinical Specialties:
Clinical Offices:
Insurance Accepted:
Contact Information
Erie County Medical Center 462 Grider Street Buffalo, NY 14215 Phone: (716) 898-5234 Email: jizzo@buffalo.edu
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