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James                          Olson

James R. Olson PhD

Department of Pharmacology and Toxicology

Professor

Specialty/Research Focus

Toxicology and Xenobiotics

 
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Professional Summary:

Assessing the Health Risks of Exposures to Organophosphate (OP) Pesticides
• Characterization of the in vitro and in vivo metabolism and disposition of OP pesticides in animal models and humans.
• Identify new biomarkers of susceptibility to OPs by investigating the function of genetic variants in key enzymes (CYP2B6, CYP2C19, PON1) which regulate OP metabolic activation and detoxification.
• Investigate the relationship between biomarkers of exposure, effect and susceptibility in human populations with environmental and occupational exposures to pesticides.
• Utilize enzyme-specific physiologically based pharmacokinetic /pharmacodynamic (PBPK/PD) models to better assess human exposure, target tissue dose and subsequent effects of OPs.


Assessing the Biological and Toxicological Effects of Exposures to Persistent Halogenated Aromatic Hydrocarbons, Including Dioxins, Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs).
• Assessing Human Exposures to dioxins, PBDEs, and PCBs
• Characterize the metabolism and disposition of dioxins, PBDEs, and PCBs in humans.
• Utilize toxicogenomic approaches to understand the relationship between exposures to dioxins and/or PCBs that are ligands for the Ah receptor and mechanisms for their adverse health effects.

Education and Training:
  • PhD, Pharmacology-Toxicology, Medical College of Wisconsin (1978)
  • MS, Pharmacology, Medical College of Wisconsin (1976)
  • BA, Chemistry, Illinois Wesleyan University (1974)
Employment:
  • Director, University at Buffalo (2010-present)
  • Research Professor, University at Buffalo (2010-present)
  • Professor, State University of New York at Buffalo (1994-present)
  • Associate Director, Toxicology Research Center, State University of New York at Buffalo (1984-present)
  • Clinical Professor, State University of New York at Buffalo (1994–2010)
  • Associate Professor, State University of New York at Buffalo (1986–1994)
  • Assistant Professor, University at Buffalo (1980–1986)
Awards and Honors:
  • UB Distinguished Professor (2012)
  • Sustained Achievement Award (2007)
  • Visionary Innovator (2005)

Research Expertise:
  • Toxicology and Environmental Health: Assessing the Health Risks of Exposures to Organophosphate (OP) Pesticides • Characterization of the in vitro and in vivo metabolism and disposition of OP pesticides in animal models and humans. • Identify new biomarkers of susceptibility to OPs by investigating the function of genetic variants in key enzymes (CYP2B6, CYP2C19, PON1) which regulate OP metabolic activation and detoxification. • Investigate the relationship between biomarkers of exposure, effect and susceptibility in human populations with environmental and occupational exposures to pesticides. • Utilize enzyme-specific physiologically based pharmacokinetic /pharmacodynamic (PBPK/PD) models to better assess human exposure, target tissue dose and subsequent effects of OPs. Assessing the Biological and Toxicological Effects of Exposures to Persistent Halogenated Aromatic Hydrocarbons, Including Dioxins, Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs). • Assessing Human Exposures to dioxins, PBDEs, and PCBs • Characterize the metabolism and disposition of dioxins, PBDEs, and PCBs in humans. • Utilize toxicogenomic approaches to understand the relationship between exposures to dioxins and/or PCBs that are ligands for the Ah receptor and mechanisms for their adverse health effects. • Characterizing the adverse effects of dioxin on lung development and the role of the AhR pathway in the developing lung.
Grants and Sponsored Research:
  • April 2012–March 2014
    Bioactivation of PBDEs by Human Cytochrome P-450
    NIEHS
    Role: Co-Principal Investigator
    $433,483
  • February 2012–January 2014
    The Impact of Genetic Variability on Human Susceptibility to Chlorpyrifos, NRSA Predoctoral Fellowship on behalf of Alice Crane, MD/PhD student
    NIEHS
    Role: Co-Investigator
    $64,438
  • June 2008–May 2013
    Biomarkers of Organophosphorus Pesticide-Induced Neurotoxicity
    NIEHS
    Role: Co-Investigator
    $777,129
  • September 2007–August 2012
    CYP-Specific PBPK/PD Models to Interpret Biomarkers for Organophosphate Pesticides
    US EPA
    Role: Principal Investigator
    $749,722
  • July 2009–June 2012
    Assessing Vulnerability of the Adolescent Brain to Organophosphorus Pesticides
    NIEHS
    Role: Co-Investigator
    $50,674
  • May 2009–April 2012
    Biomarkers of Organophosphorus Pesticide-Induced Neurotoxicity: Research Supplement to Promote Diversity in Health-Related Research on behalf ofCorie Ellison, Ph.D. Candidate, University at Buffalo, James Olson, Major Advisor
    NIEHS
    Role: Co-Investigator
    $187,458
  • September 2007–August 2010
    Interpretation of Biomarkers Using Physiologically Based PharmacokineticModeling Environmental Protection Agency
    EPA
    Role: Principal Investigator
    $749,280
  • December 2006–November 2008
    Dietary Isothiocyanates in Cancer Prevention: Effects on Estrogen
    NCI
    Role: Co-Investigator
  • March 2007–February 2008
    Research Reagents for Human Serum Paraoxonase 1
    NYSTAR Technology Transfer Incentive Program
    Role: Co-Investigator
  • October 2003–September 2007
    University-Community Consortium for Anniston Environmental Health Research
    ATSDR/CDC
    Role: Principal Investigator
  • June 2004–March 2007
    Identification of functional peptide ligands for the AhR
    NIEHS
    Role: Principal Investigator
  • February 2003–December 2006
    Biomarkers of Human Exposure to Pesticides Utilizing a New PBPK/PD Model and Kinetic Data on Pesticide Metabolism in Humans
    U.S. EPA
    Role: Principal Investigator
See All (12 Total) >

Evaluative Studies and Case Reports:
Journal Articles:
See All (100 Total) >

Professional Memberships:
  • American Society for Pharmacology and Experimental Therapeutics (1990)
  • Society of Toxicology (1984)
Presentations:
  • "Predictors of human serum polychlorinated biphenyls (pcbs) concentrations in the Anniston Community Health Survey" 30th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - Dioxin 2010 (2010)
  • "Soil-serum PCB associations in the Anniston Community Health Survey" 30th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - Dioxin 2010 (2010)
  • "Spatial distribution and determinants of PCB contamination in residential soil in Anniston, Alabama." 30th International Symposium on Halogenated Persistent Organic Pollutants (POPs) - Dioxin 2010 (2010)
  • "Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers" Society of Toxicology, Society of Toxicology (2010)
  • "Biomarkers of organophosphorus pesticide-induced neurotoxicity" Society of Toxicology (2010)
  • "Developing a monoclonal antibody based capture assay to quantify cytosolic AHR." Society of Toxicology (2010)
  • "Exposure Estimates and PBPK Modeling of Chlorpyrifos in Rats and Humans" Society of Toxicology (2010)
  • "Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in human blood following in vitro and in vivo exposure to chlorpyrifos" Society of Toxicology (2010)
  • "Oxidative DNA adducts in the livers of female Srague-Dawley rats chronically exposed to polyhalogenated aromatic hydrocarbons (PHAHs)." Society of Toxicology (2010)
  • "Strain and dose-related effects of subchronic chlorpyrifos (CPF) exposure on biomarkers of exposure and oxidative stress in rats." Society of Toxicology (2010)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

Office - 13 Cary Hall
102 Farber Hall
3435 Main St
Buffalo, NY 14214
Phone: (716) 829-2319
Fax: (716) 829-2801
Email: jolson@buffalo.edu


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