Jun Xia PhD
Jun Xia
PhD
Professional Summary:
The main focus of my research is to develop novel optical and ultrasonic imaging techniques to meet needs in cancer and neurological research. In my lab, students will have the opportunities to be trained in optical and ultrasonic engineering, be involved with preclinical and clinical imaging studies, and be collaborating with chemists, physicians and neurologists in Western New York and Ontario Canada.
Education and Training:
- PhD, Mechanical Engineering, University of Toronto (2010)
- BS, Applied Physics, University of Science and Technology of China (2004)
Employment:
- Professor, Biomedical Engineering, University at Buffalo (2024-present)
- Associate Professor, Biomedical Engineering, University at Buffalo School of Engineering and Applied Sciences (2020–2024)
- Assistant Professor, University at Buffalo School of Engineering and Applied Sciences (2014–2020)
- Post Doctoral Fellow, Biomedical Engineering, Washington University in St. Louis School of Engineering and Applied Sciences (2010–2014)
Grants and Sponsored Research:
- December 2023–November 2027
mHealth Technologies for Accessing Blood Perfusion of Chronic Wounds
NIH
Role: Co-Investigator
$2,687,634 - September 2022–August 2025
Qualcomm University Innovation Center for Research in Medical Imaging and Sensing Technology
Qualcomm Inc.
Role: Principal Investigator
$990,000 - May 2021–February 2025
Development of photoacoustic tomography for non-invasive, label-free imaging of tissue perfusion in chronic wounds
NIH
Role: Principal Investigator
$1,640,000 - May 2020–December 2024
Multiparametric photoacoustic and ultrasonic imaging of the breast in cranial-caudal view
NIH
Role: Principal Investigator
$1,420,000 - July 2017–January 2021
Breast cancer screening through the combination of light and ultrasound
Susan G. Komen Foundation
Role: Principal Investigator
$450,000 - September 2015–August 2017
Potentiometric photoacoustic imaging of brain activity enabled by near infrared to visible light converting nanoparticles
NIH
Role: Principal Investigator
$447,197 - February 2016–March 2017
Development of a Multisensory System for Continuous Monitoring of Blood Glucose Level
University at Buffalo Innovative Micro-Programs Accelerating Collaboration in Themes (IMPACT)
Role: Principal Investigator
$35,000 - September 2015–October 2016
Brain Network: Nanomaterials Enabled Functional Imaging
The Research Foundation for SUNY
Role: Co-Investigator
$450,000
Journal Articles:
- Kilian HI, Kang H, Nyayapathi N, Fukuda T, Adluru E, Zhang H, Quinn B, Xia J, Choi HS, Lovell JF. (2020) Facile formulation of a long-wavelength cyanine for optical imaging in the second near-infrared window. Biomater Sci (Aug), 8(15): 4199-4205.
- Chitgupi U, Nyayapathi N, Kim J, Wang D, Sun B, Li C, Carter K, Huang WC, Kim C, Xia J, Lovell JF. (2019) Surfactant-Stripped Micelles for NIR-II Photoacoustic Imaging through 12 cm of Breast Tissue and Whole Human Breasts. Adv Mater (Oct), 31(40): 1902279-1902279.
- Moukheiber D, Chitgupi U, Carter KA, Luo D, Sun B, Goel S, Ferreira CA, Engle JW, Wang D, Geng J, Zhang Y, Xia J, Cai W, Lovell JF. (2019) Surfactant-Stripped Pheophytin Micelles for Multimodal Tumor Imaging and Photodynamic Therapy. ACS Appl Bio Mater (Jan), 2(1): 544-554.
- Miranda D, Huang H, Kang H, Zhan Y, Wang D, Zhou Y, Geng J, Kilian HI, Stiles W, Razi A, Ortega J, Xia J, Choi HS, Lovell JF. (2019) Highly-Soluble Cyanine J-aggregates Entrapped by Liposomes for In Vivo Optical Imaging around 930 nm. Theranostics (Jan), 9(2): 381-390.
- Wang D, Lee DH, Huang H, Vu T, Lim RSA, Nyayapathi N, Chitgupi U, Liu M, Geng J, Xia J, Lovell JF. (2018) Ingestible roasted barley for contrast-enhanced photoacoustic imaging in animal and human subjects. Biomaterials (Aug), 175: 72-81.
- Wang Y, Lim RSA, Zhang H, Nyayapathi N, Oh KW, Xia J. (2018) Optimizing the light delivery of linear-array-based photoacoustic systems by double acoustic reflectors. Sci Rep (Aug), 8(1): 13004-13004.
- Wang Y, Wang D, Hubbell R, Xia J. (2017) Second generation slit-based photoacoustic tomography system for vascular imaging in human. J Biophotonics (Jun), 10(6-7): 799-804.
- Yeh C, Li L, Zhu L, Xia J, Li C, Chen W, Garcia-Uribe A, Maslov KI, Wang LV. (2017) Dry coupling for whole-body small-animal photoacoustic computed tomography. J Biomed Opt (Apr), 22(4): 41017-41017.
- Zhang Y, Hong H, Sun B, Carter K, Qin Y, Wei W, Wang D, Jeon M, Geng J, Nickles RJ, Chen G, Prasad PN, Kim C, Xia J, Cai W, Lovell JF. (2017) Surfactant-stripped naphthalocyanines for multimodal tumor theranostics with upconversion guidance cream. Nanoscale (Mar), 9(10): 3391-3398.
- Wang D, Wang Y, Wang W, Luo D, Chitgupi U, Geng J, Zhou Y, Wang L, Lovell JF, Xia J. (2017) Deep tissue photoacoustic computed tomography with a fast and compact laser system. Biomed Opt Express (Jan), 8(1): 112-123.
- Zhang Y, Wang D, Goel S, Sun B, Chitgupi U, Geng J, Sun H, Barnhart TE, Cai W, Xia J, Lovell JF. (2016) Surfactant-Stripped Frozen Pheophytin Micelles for Multimodal Gut Imaging. Adv Mater (Oct), 28(38): 8524-8530.
- Liu B, C Li, G Chen, B Liu, X Deng, Y Wei, J Xia, B Xing, Pa Ma, and J Lin. (2016) Synthesis and Optimization of MoS2@ Fe3O4‐ICG/Pt (IV) Nanoflowers for MR/IR/PA Bioimaging and Combined PTT/PDT/Chemotherapy Triggered by 808 nm Laser. Advanced Science (Jul), 4: 4884-4894.
- L. Lei, J. Xia, G. Li, A. Garcia-Uribe, Q. Sheng, M.A. Anastasio, and L.V. Wang. (2016) Label-free photoacoustic tomography of whole mouse brain structures ex vivo. Neurophotonics (Jul), 3(3): 1-8.
- Huang H, Wang D, Zhang Y, Zhou Y, Geng J, Chitgupi U, Cook TR, Xia J, Lovell JF. (2016) Axial PEGylation of Tin Octabutoxy Naphthalocyanine Extends Blood Circulation for Photoacoustic Vascular Imaging. Bioconjug Chem (Jun).
- Wang D, Wang Y, Zhou Y, Lovell JF, Xia J. (2016) Coherent-weighted three-dimensional image reconstruction in linear-array-based photoacoustic tomography. Biomed Opt Express (May), 7(5): 1957-1965.
- Wan H. Zhou Y. Ying L. Meng J. Song L. Xia J. . (2016) Enabling high-speed wide-field dynamic imaging in multifocal photoacoustic computed microscopy: a simulation study. Applied Optics (Apr), 55(14): 3724-3729.
- Zhou Y, Wang D, Zhang Y, Chitgupi U, Geng J, Wang Y, Zhang Y, Cook TR, Xia J, Lovell JF. (2016) A Phosphorus Phthalocyanine Formulation with Intense Absorbance at 1000 nm for Deep Optical Imaging. Theranostics (Mar), 6(5): 688-697.
- Xia J. (2016) Multiscale Functional and Molecular Photoacoustic Tomography. Ultrasonic Imaging (Jan), 38(1): 44-62.
- Wang D. Wu Y. Xia J. (2016) Review on photoacoustic tomography of the brain using nanoprobes. Neurophotonics (Jan), 3(1): 01090-01090.
- Wang Y, Wang D, Zhang Y, Geng J, Lovell JF, Xia J. (2016) Slit-enabled linear-array photoacoustic tomography with near isotropic spatial resolution in three dimensions. Opt Lett (Jan), 41(1): 127-130.
- Li G, Li L, Zhu L, Xia J, Wang LV. (2015) Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array. J Biomed Opt (Jun), 20(6): 066010-066010.
- Danielli A, Maslov K, Favazza CP, Xia J, Wang LV. (2015) Nonlinear photoacoustic spectroscopy of hemoglobin. Appl Phys Lett (May), 106(20): 203701-203701.
- Yao J, Xia J, Wang LV. (2015) Multiscale Functional and Molecular Photoacoustic Tomography. Ultrason Imaging (May).
- Cash KJ, Li C, Xia J, Wang LV, Clark HA. (2015) Optical drug monitoring: photoacoustic imaging of nanosensors to monitor therapeutic lithium in vivo. ACS Nano (Feb), 9(2): 1692-1698.
- Li G, Xia J, Wang K, Maslov K, Anastasio MA, Wang LV. (2015) Tripling the detection view of high-frequency linear-array-based photoacoustic computed tomography by using two planar acoustic reflectors. Quant Imaging Med Surg (Feb), 5(1): 57-62.
- Wang L, Li G, Xia J, Wang LV. (2015) Ultrasonic-heating-encoded photoacoustic tomography with virtually augmented detection view. Optica (Jan), 2(4): 307-312.
- Lin L, Xia J, Wong TT, Li L, Wang LV. (2015) In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography. J Biomed Opt (Jan), 20(1): 016019-016019.
- Xia J, Kim C, Lovell JF. (2015) Opportunities for Photoacoustic-Guided Drug Delivery. Curr Drug Targets (Jan), 16(6): 571-581.
- Xia J, Yao J., Wang L.V. (2014) PHOTOACOUSTIC TOMOGRAPHY: PRINCIPLES AND ADVANCES. Progress in Electromagnetics Research (May).
- Wang K, Xia J, Li C, Wang LV, Anastasio MA. (2014) Fast spatiotemporal image reconstruction based on low-rank matrix estimation for dynamic photoacoustic computed tomography. J Biomed Opt (May), 19(5): 056007-056007.
- Xia J, Wang LV. (2014) Small-animal whole-body photoacoustic tomography: a review. IEEE Trans Biomed Eng (May), 61(5): 1380-1389.
- Yuan H, Wilson CM, Xia J, Doyle SL, Li S, Fales AM, Liu Y, Ozaki E, Mulfaul K, Hanna G, Palmer GM, Wang LV, Grant GA, Vo-Dinh T. (2014) Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor. Nanoscale (Apr), 6(8): 4078-4082.
- Krumholz A, Shcherbakova DM, Xia J, Wang LV, Verkhusha VV. (2014) Multicontrast photoacoustic in vivo imaging using near-infrared fluorescent proteins. Sci Rep (Feb), 4: 3939-3939.
- Xia J, Chen W, Maslov K, Anastasio MA, Wang LV. (2014) Retrospective respiration-gated whole-body photoacoustic computed tomography of mice. J Biomed Opt (Jan), 19(1): 16003-16003.
- Nasiriavanaki M, Xia J, Wan H, Bauer AQ, Culver JP, Wang LV. (2014) High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain. Proc Natl Acad Sci U S A (Jan), 111(1): 21-26.
- Xia J, Li G, Wang L, Nasiriavanaki M, Maslov K, Engelbach JA, Garbow JR, Wang LV. (2013) Wide-field two-dimensional multifocal optical-resolution photoacoustic-computed microscopy. Opt Lett (Dec), 38(24): 5236-5239.
- Wang L, Xia J, Yao J, Maslov KI, Wang LV. (2013) Ultrasonically encoded photoacoustic flowgraphy in biological tissue. Phys Rev Lett (Nov), 111(20): 204301-204301.
- Huang B, Xia J, Maslov K, Wang LV. (2013) Improving limited-view photoacoustic tomography with an acoustic reflector. J Biomed Opt (Nov), 18(11): 110505-110505.
- Wang Y, Xia J, Wang LV. (2013) Deep-tissue photoacoustic tomography of Förster resonance energy transfer. J Biomed Opt (Oct), 18(10): 101316-101316.
- Xia J, Huang C, Maslov K, Anastasio MA, Wang LV. (2013) Enhancement of photoacoustic tomography by ultrasonic computed tomography based on optical excitation of elements of a full-ring transducer array. Opt Lett (Aug), 38(16): 3140-3143.
- Xia J, Danielli A, Liu Y, Wang L, Maslov K, Wang LV. (2013) Calibration-free quantification of absolute oxygen saturation based on the dynamics of photoacoustic signals. Opt Lett (Aug), 38(15): 2800-2803.
- Wu L, Cai X, Nelson K, Xing W, Xia J, Zhang R, Stacy AJ, Luderer M, Lanza GM, Wang LV, Shen B, Pan D. (2013) A Green Synthesis of Carbon Nanoparticle from Honey for Real-Time Photoacoustic Imaging. Nano Res (Jan), 6(5): 312-325.
- Yao J, Xia J, Maslov KI, Nasiriavanaki M, Tsytsarev V, Demchenko AV, Wang LV. (2013) Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo. Neuroimage (Jan), 64: 257-266.
- Xia J, Mandelis, A. (2010) Direct-search deep level photothermal spectroscopy: An enhanced reliability method for overlapped semiconductor defect state characterization. Applied Physics Letters (Jun), 96(26).
- Xia J, Mandelis, A. (2009) Radiative defect state identification in semi-insulating GaAs using photo-carrier Radiometry. Semiconductor Science and Technology (Dec).
- Xia J, Mandelis, A. (2009) Broadening effects and ergodicity in deep level photothermal spectroscopy of defect states in semi-insulating GaAs: A combined temperature-, pulse-rate-, and time-domain study of defect state kinetics. Journal of Applied Physics (May), 105(10).
- Xia J, Mandelis, A. (2008) Deep level photothermal spectroscopy: Physical principles and applications to semi-insulating GaAs band-gap multiple trap states. Journal of Applied Physics (Feb), 103: 43704.
- Xia J, Mandelis, A. (2007) Noncontact deep level photo-thermal spectroscopy: Technique and application to semi-insulating GaAs Wafers. Applied physics letters (Feb), 90(6): 62119.
Professional Memberships:
- IEEE; Member
- OSA; Member
- SPIE; Member
Service Activities:
- Clinical Translational Imaging Science – CTIS; Reviewer (2021)
- Imaging Technology Development – ITD; Reviewer (2019–2021)
- Frontiers in Photonics: Biophotonics; Associate Editor
- Nanomaterials; Topical Editor