Kristina Seiffert MD

Kristina Seiffert

Kristina Seiffert
MD

Research Assistant Professor

Department of Dermatology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Autoimmunity; Dermatology; Immunology; Molecular Basis of Disease; Neuroimmunology

Contact Information
6085 Clinical and Translational Research Center
Buffalo, New York 14203
Phone: (716) 842-2118
krs2002@buffalo.edu



Professional Summary:

As a physician with clinical expertise in dermatology and a bench scientist with over 20 years of experience in cutaneous immunology, my research focuses on autoimmune disorders and neuroimmunology of the skin.

I am particularly interested in the blistering autoimmune skin disease Pemphigus vulgaris (PV), which, while rare, serves as an excellent model to investigate the basic aspects of autoimmune disease in general. The work in our laboratory is patient-based, and we have an unparalleled collection of blood samples and clinical information from over 400 individuals affected by PV enrolled in our IRB-approved studies focusing on mechanisms of autoimmunity (T effector and regulatory cells, immunoglobulin subtypes, auto-antigen and auto-antibody profiles) as well as clinical expression of disease. We have also applied cutting-edge atomic force microscopy technology to the investigation of antibody effects in the tissue level in PV, and are using large throughput autoantibody array as well as cytometry by time of flight (CyTOF) methodology.

Another main interest of mine is investigating the role of stress hormones and neural transmitters in skin diseases, in particular the effect of adrenaline on Langerhans cells (resident dendritic cells within the epidermis). It has long been postulated that stress can affect certain skin conditions, but only recent experimental evidence has established a role of the neuroendocrine system in cutaneous inflammation. Exploring the role of stress hormones and neural transmitters promises to affect greatly the way we view and treat many skin diseases including, but not limited to auto-inflammatory and auto-immune diseases.

As a research assistant professor in the department of dermatology I oversee the work of postdoctoral fellows, MD/PhD students and medical students involved in the day-to-day operations of our basic science laboratory. I have also actively participated in dermatology resident teaching through regularly scheduled basic science journal clubs and by supervising resident research rotations in the laboratory.

Education and Training:

  • Fellowship, Postdoctoral Research Fellow, Weill Medical College of Cornell University (2005)
  • Residency, Dermatology Residency, Free University of Berlin (1998)
  • Other, Dr. med. (medical research doctorate) degree, Free University of Berlin Medical School (1997)
  • MD, Free University of Berlin (1996)

Employment:

  • Research Assistant Professor, Dermatology, University at Buffalo, School of Medicine and Biomedical Sciences Jacobs School of Medicine & Biomedical Sciences (2011-present)
  • Research Associate, Dermatology, Michigan State University College of Human Medicine (2005–2011)
  • Research Fellow, Dermatology, Cornell University Weill Medical College (1998–2005)
  • Research Fellow, Dermatology, Free University of Berlin University Medical Center Benjamin Franklin (1996–1998)
  • Resident, Dermatology, Free University of Berlin University Medical Center Benjamin Franklin (1996–1998)

Awards and Honors:

  • Induction into the Gold Humanism Honor Society (2024)
  • Louis Sklarow Memorial Trust Award (2015)
  • Dermatology Foundation Research Fellowship (2000)
  • Travel Grant- European Society for Dermatological Research (1998)

Research Expertise:

  • Mechanisms of Cutaneous Autoimmunity and Neuroimmunology of the Skin

Grants and Sponsored Research:

  • July 2015–June 2016
    Dr. Louis Sklarow Memorial Trust
    Role: Principal Investigator
    $9,370

Journal Articles:

See all (50 more)

Books and Book Chapters:

  • Seiffert, K. (2009) Regulation of Cutaneous Immunity by Catecholamines. In: Regulation of Cutaneous Immunity by Catecholamines. Springer, 65-74.
  • Seiffert K. (2008) Behavioral Medicine-Psychobiology, Psychopathology and Clinical Use. In: Atopische Dermatitis (Atopic Dermatitis). Verhaltensmedizin
  • Seiffert K. (2004) Haut (Skin). In: Intensivkurs: Allgemeine und Spezielle Pathologie. Elsevier (editors: K.J. Buehling, J. Lepenies, K. Witt), 379-392.

Professional Memberships:

  • International Investigative Dermatology (2010–present)
  • Science Alliance (New York Academy of Sciences) (2004–2011)
  • Society for Investigative Dermatology (2002–present)

Presentations:

  • "Desmosomal cadherin tension loss in Pemphigus vulgaris mediated by the inhibition of active RhoA at cell-cell adhesion." Alpine Desmosome Disease Meeting 2024 (2024)
  • "Anti-thyroid peroxidase antibodies target a cytoplasmic protein in keratinocytes and may contribute to blister formation in Pemphigus vulgaris" International Pemphigus& Pemphigoid Foundation scientific seminar on autoimmune bullous disease (2021)
  • "HLA Drives Both Activation and Protection of the Autoimmune Response in Pemphigus" 4th Scientific Conference of the International Pemphigus & Pemphigoid Foundation (2017)
  • "How HLA Shapes (Auto)Immune Responses in Health and Disease: A Blistering Tale" Clinical and Translational Research Center Seminar Series (2017)
  • "IL-13 receptor alpha 1 downregulation as a protective mechanism and therapeutic target in Pemphigus" Society for Investigative Dermatology Annual Meeting; Society for Investigative Dermatology (2015)
  • "Novel Multiplex Autoantigen Arrays for Biomarker Discovery in Skin autoimmunity" Clinical and Translational Research Colliquium; University at Buffalo Clinical and Translational Research Center; Translational Pilot Program (2013)
  • "Novel Autoantigen Microarrays Identify Desmoglein and Non-Desmoglein Targets in Pempigus Vulgaris" International J.C. Bystryn Pemphigus & Pemphigoid Meeting; NIH (2010)
  • "Stress and the Skin" Grand Rounds; Division of Dermatology and Cutaneous Sciences, Michigan State University; Division of Dermatology and Cutaneous Sciences (2009)
  • "Catecholamines and Langerhans Cells" Weill Cornell Symposium on the Science of Dermatology; Weill Cornell Medical College; Weill Cornell (2006)
  • "Identification of two distinct CD8+T cell populations associated with remittent disease in Pemphigus" Society for Investigative Dermatology Annual Meeting; Society for Investigative Dermatology; Society for Investigative Dermatology (2006)
  • "Purinergic receptor signaling and cutaneous inflammation" Grand Rounds; New York Hospital , Cornell Medical Center (2005)
  • "Regulation of Cutaneous Immunity by Catecholamines" Skin Biology Club Meeting; New York Academy of Sciences; Skin Biology Club (2002)
  • "Regulation of Cutaneous Immunity by Catecholamines" Joint Meeting of the Experimental Contact Dermatitis Research Group and the American Contact Dermatitis Society; ECDRG & ACDs; ECDRG & ACDS (2002)
  • "How Stress Affects the Skin: the Adrenergic System and Cutaneous Immunity" Grand Rounds, New York Hospital/Cornell Medical Center; ; New York Hospital/Cornell Medical Center (2001)
  • "Expression of Neuropeptide Receptors by Human Sebocytes and Stimulatory effect of their Agonists on Cytokine Production" 3rd Teupitz Colloquium (2000)
  • "Epinephrine and Norepinephrine inhibit the antigen presenting capability of epidermal Langerhans cells." Society of Investigative Dermatology Annual Meeting; Society of Investigative Dermatology; Society of Investigative Dermatology (2000)
  • "5-alpha reductase inhibitors exhibit distinct effects on human sebocytes and keratinocytes in vitro" International Investigative Dermatology Meeting - Joint Meeting of the European, Japanese, and the American Society of Investigative Dermatology; ; International Investigative Dermatology (1998)
  • "Psychophysiological reaction patterns of patients with atopic dermatitis" 6th International Congress of Dermatology and Psychiatry (1995)
See all (8 more)

Service Activities:

  • Biomolecules - Special Issue “Molecular Insights into Treatment and Prognosis of Autoimmune Bullous Diseases; Editor (2024–present)
  • Journal of Medicine and Life; Ad-hoc reviewer (2023–present)
  • Photodermatology, Photoimmunology and Photomedicine; Ad-hoc reviewer (2022–present)
  • Pennsylvania State University 2022 KL2 Early-Stage Investigator Training Program; Scientific Research Study Section Membership (2022)
  • Oxidative Medicine and Cellular Longevity; Ad-hoc reviewer (2020–present)
  • Yale Journal of Biology and Medicine; Ad-hoc reviewer (2019)
  • JDDG - Journal of the German Society of Dermatology; Ad-hoc reviewer (2019–present)
  • International Journal of Dermatology; Ad-hoc reviewer (2019–present)
  • Journal of the European Academy of Dermatology and Venereology; Ad-hoc reviewer (2019–present)
  • Experimental Dermatology; Ad-hoc reviewer (2019–present)
  • E-Rare Joint Transnational Call 2018, Transnational research projects on hypothesis driven use of multi-omic integrated approaches for rare diseases; ZonMw (The Netherlands Organization for Health Research and Development); Scientific Research Study Section Membership (2018)
  • Frontiers Immunology; Ad-hoc reviewer (2018–present)
  • Frontiers in Immunology, Immunological Tolerance and Regulation; Editorial Board Member (2018–present)
  • British Journal of Dermatology; Ad-hoc reviewer (2015–present)
  • ; Faculty Council Member (2012–2017)
  • Archives of Dermatologic Research; Ad-hoc Reviewer (2008–present)
  • Hormone and Metabolic Research; Ad-hoc Reviewer (2005–present)
  • Journal of Investigative Dermatology; Ad-hoc Reviewer (2005–present)

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Contact Information

6085 Clinical and Translational Research Center
Buffalo, New York 14203
Phone: (716) 842-2118
krs2002@buffalo.edu