Lin Liu MD, PhD
Lin Liu
MD, PhD
Clinical Assistant Professor
Department of Pathology and Anatomical Sciences
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Surgical Pathology
Professional Summary:
I am interested in all aspects in general surgical pathology with major focus on medical renal and genitourinary pathology. I also have special interest in immunology and molecular pathology. Due to my previous long years research training, I would like to continue the endeavor in research directed to address clinical related questions and disease mechanisms.
Education and Training:
- Fellow, Surgical Pathology, Pennsylvania Hospital, Penn Medicine (2015)
- Residency, Pathology, Univeristy of Pittsburgh Medical Center (2012)
- Senior research Associate, Immunology, University of Pittsburgh (2008)
- Postdoctoral Fellow, Immunology, Yale University School of Medicine (2003)
- PhD, Biochemistry and Biophysics, Univeristy of Pennsylvania (1999)
- Physician, Internal Medicine, China-Japan Friendship Hospital (1994)
- MD, Beijing Medical University (Peking University Health Science Center) (1992)
Awards and Honors:
- NIH Training Grant (2005)
- NIH Training Grant (2003)
- Howard Hughes Institute fellowship (2001)
- Full scholarship from University of Pennsylvania Gratuate Biological Studies (1999)
Journal Articles:
- Lu B, Chen L, Liu L, Zhu Y, Wu C, Jing J, Zhang X. USCAP 2012 poster) Lu B, Chen L, Liu L, Zhu Y, Wu C, Jiang J, Zhang X. T-cell-mediated tumor immune surveillance and expression of B7 co-inhibitory molecules in cancers of the upper gastrointestinal tract. Immunol Res.. 2011; 50(2-3).
- Zhu Y, Ju S, Chen E, Dai S, Li C, Morel P, Liu L, Zhang X, Lu B. T-bet and eomesodermin are required for T cell-mediated antitumor immune responses. J Immunol.. 2010; 15(185).
- Ju S, Zhu Y, Liu L, Dai S, Li C, Chen E, He Y, Zhang X, Lu B. Gadd45b and Gadd45g are important for anti-tumor immune responses. Eur J Immunol. 2009; 39(11).
- Gonzalez-Garcia I, Zhao, Y, Ju, S, Gu, Q, Liu L, Kolls, JK, Lu, B. IL-17 signaling-independent central nervous system autoimmunity is negatively regulated by TGF-beta. J Immunol.. 2006; 1(182).
- Liu L. Gadd45 beta and Gadd45 gamma are critical for regulating autoimmunity. J Exp Med.. 2005; 21(10).
- N. Barlev, Liu L, NH. Chehab, T. Halazonetis, S.L. Berger. Acetylation of p53 at 320 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol. Cell. 2001; 8(6).
- Liu L, Scolnick DM, Trievel RC, Zhang HB, Marmorstein R, Halazonetis TD, Berger SL. p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol. 1999; 19(2).
- Liu L*, Wang L*, Berger SL (*these authors contributed equally to this work). Critical residues for histone acetylation by GCN5, functioning in ADA and SAGA complexes, are also required for transcriptional function in vivo. Genes Dev. 1998; 12(5).
- Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL. Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku/DNA-PK complex. Mol Cell Biol. 1998; 18(3).
- Gregory PD, Schmid A, Zavari M, Liu L, Berger SL, Hörz W,. Absence of Gcn5 HAT activity defines a novel state in the opening of chromatin at the PHO5 promoter in yeast. Mol Cell. 1998; 1(4).
Abstracts:
- Liu L, Randhawa P. The Banff Schema for Renal Allograft Pathology: Revisiting Scoring Paradigms for Inflammation and Tubulit. USCAP 2012. 2012.