University at Buffalo - The State University of New York
Skip to Content
Laurie                         Sadler

Laurie S. Sadler MD, FACMG

Department of Pediatrics

Clinical Associate Professor

Specialty/Research Focus

Children and Adults; Clinical Genetics; Dysmorphology; Pediatric Genetics; Pediatrics

 
Professional Summary:

I specialize in the evaluation of children and adults with birth defects, developmental disability, autism and genetic disorders and/or syndromes. My goal as a clinical geneticist/dymorphologist is to make specific overall diagnoses in order to provide patients and their families with information regarding prognosis and recurrence risks, i.e., the likelihood that a trait or disorder present in one family member will occur again in other family members. In addition, I help coordinate patient care in conjunction with patients’ primary care physicians and other specialists. I also work closely with genetic counselors who evaluate patients for a variety of concerns and help to coordinate genetic diagnostic testing as indicated.

As a UBMD physician working at the Women and Children‘s Hospital of Buffalo, I direct the Williams Syndrome Clinic and serve as the clinical director at the Craniofacial Center of Western New York. The Craniofacial Center provides comprehensive, interdisciplinary evaluation and management of individuals from birth through adulthood with congenital and acquired craniofacial abnormalities. Common diagnoses include clefts of the lip and/or palate, craniosynostosis and ear anomalies. We hold monthly conferences that focus both on teaching and communication amongst providers in an effort to optimize patient care.

My particular interest in the care of individuals with Williams Syndrome led me to start a multidisciplinary Williams Syndrome clinic in 1994. This is one of only twelve such clinics in the country. The clinic is held monthly, and it is organized by patient age groups; the format allows families to interact and share their experiences. Geneticists, genetic counselors, cardiologists, pediatric psychiatrists and pediatric dentists contribute their expertise at these clinics, and every patient sees a provider from each of these specialties. Additional evaluations for our Williams Syndrome patients are provided by other specialists such as ophthalmologists, nephrologists and neuropsychologists, depending on individual patient needs. I have coordinated a number of research studies in this patient population, and I have published extensively in this field.

As a UB faculty member, I also teach residents and medical students during their month-long genetics elective.

Education and Training:
  • Postdoctoral Fellow, Dysmorphology/Clinical Genetics, University at Buffalo (1992)
  • Residency, Pediatrics, University at Buffalo (1989)
  • Internship, Pediatrics, University at Buffalo (1987)
  • MD, Medicine, University at Buffalo, summa cum laude (1986)
  • BAMFA, Psychology and Speech and Hearing Sciences, University of Michigan (1981)
Employment:
  • Clinical Associate Professor, Pediatrics, University at Buffalo (2001-present)
  • Director, Williams Syndrome Clinic, Women and Children‘s Hospital of Buffalo (1994-present)
  • Clinical Director, Craniofacial Center of Western New York, Women and Children‘s Hospital of Buffalo (1992-present)
  • Associate Clinical Director, Division of Genetics, Pediatrics, Women and Children‘s Hospital of Buffalo (1992-present)
  • Attending Physician, Division of Genetics, UBMD Pediatrics, Women and Children's Hospital of Buffalo (1992-present)
  • Clinical Assistant Professor, Pediatrics, University at Buffalo (1992–2001)
Awards and Honors:
  • Alpha Omega Alpha Honor Medical Society

Research Expertise:
  • Craniofacial
  • Dysmorphology
  • Williams Syndrome: Diagnosis, evaluation, treatment, and family support
Grants and Sponsored Research:
  • January 2003–January 2006
    Anxiety and Mood Disorders in Williams syndrome patients and their families.
    Role: Co-Investigator

Journal Articles:
See all (1 more)
Books and Book Chapters:
  • Sadler LS, Stapleton FB. "Disorders of Porphyrin, Purine, and Pyrimidine Metabolism". Current Pediatric Therapy 15. 1996.
  • Robinson LK, Sadler LS. "Drug Induced Anomalies". Essentials of Pharmacology. 1995.
  • Robinson LK, Sadler LS. "Genetic Diagnosis: The Dysmorphology Examination". Craniofacial Anomalies: An Interdisciplinary Approach. 1991.
Abstracts:
  • Robinson LK, Sadler L, Gollin YG. New Craniofacial Syndrome. Proc Greenwood Genet Ctr. 1998; 17.

Professional Memberships:
  • American Cleft Palate-Craniofacial Association
  • Williams Syndrome Association
  • David W. Smith Society
  • American College of Medical Genetics: Fellow (FACMG)
Presentations:
  • "KIF5C Mutations Cause Severe Intellectual Disability with or without Cortical Brain Malformations" 36th Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (2015)
  • "The Diagnostic Odyssey: Changing Genetic Technologies" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (2014)
  • "Uniparental Isodisomy for Chromosome 1 in a Patient with Noonan Syndrome Phenotype" 34th Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (2013)
  • "Beyond Morphology: The Importance of Behavioral Phenotypes" Pediatric Grand Rounds, Women and Children's Hospital of Buffalo (2012)
  • "22q11 Deletion: Knowing What to Look for" Pediatric Grand Rounds, Women and Children's Hospital of Buffalo (2011)
  • "Carotid Arterial Dissection in an Adult with Williams Syndrome" 32nd Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (2011)
  • "Duplication and Deletion in a Single Family" 30th Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (2009)
  • "Chromosomal Microarray Analysis: Taking a Second Look" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (2008)
  • "Normal Morphology and Autistic Spectrum Disorder in Mosaic Monosomy 21" 15th Annual Clinical Genetics Meeting, American College of Medical Genetics (2008)
  • "Mood and Anxiety Disorders in Patients with Williams Syndrome and Their Families" Annual Meeting, American Academy of Child and Adolescent Psychiatry (2005)
  • "Mood and Anxiety Disorders in Patients with Williams Syndrome and Their Families" 26th Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (2005)
  • "Mood and Anxiety Disorders in Patients with Williams Syndrome and Their Families" Annual Convention, American Medical Student Association (2005)
  • "Severe Mandibuloacral Dysplasia" 23rd Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (2002)
  • "Gender Differences in Cardivascular Disease in Williams Syndrome" 21st Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (2000)
  • "Community Integration in Williams Syndrome" 8th International Professional Conference on Williams Syndrome, Williams Syndrome Association (2000)
  • "Carotid Ultrasound Examination in the Williams Syndrome" 17th Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (1996)
  • "Carotid Ultrasound Examination in the Williams Syndrome" 7th International Professional Conference on Williams Syndrome, Williams Syndrome Association (1996)
  • "Subnormal Binocular Vision in the Williams Syndrome" 45th Annual Meeting, American Society of Human Genetics (1995)
  • "Fetus-in-fetu: An Included Heteropagus Conjoined Twin" 16th Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (1995)
  • "Subnormal Binocular Vision in the Williams Syndrome" Eastern Regional Orthoptic Meeting, American Association of Certified Orthoptists (1995)
  • "Anencephaly and Laterality: A Preliminary Report" 15th Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (1994)
  • "Collagen Analysis in a Case of the Hallerman-Streiff Syndrome: Insight into Possible Pathogenesis" 15th Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (1994)
  • "The Body Stalk Anomaly: Report of a Case, Review of the Literature, Speculation on Development Pathogenesis" 14th Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (1993)
  • "Ear Length in African-American Newborns with and without the Down Syndrome" 13th Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (1992)
  • "The Chorioretinal Dysplasia-microcephaly-mental Retardation Syndrome: Report of an American Family" 13th Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (1992)
  • "Distal Digital Hypoplasia in the Fetal Alcohol Syndrome" 5th Annual Conference, Organization of Teratogen Information Services (1992)
  • "Further Evidence of the Mesodermal Pathogenesis of the Diabetic Embryopathy" 12th Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (1991)
  • "Laterality Defects and Myelodysplasia: Implications for Body Asymmetry" 12th Annual David W. Smith Workshop on Malformations and Morphogenesis, David W. Smith Society (1991)
See all (18 more)
Service Activities:
  • University at Buffalo: Faculty Senate; Member (2013–present)
  • University at Buffalo School of Medicine and Biomedical Sciences: Search Committee for Chairman of Psychiatry; Committee Member (2004)
  • University at Buffalo School of Medicine and Biomedical Sciences: Faculty Council; Member (1993–1995)
  • University at Buffalo School of Medicine and Biomedical Sciences: Incoming Residents Orientation Committee; Committee Member (1991–1993)
  • University at Buffalo Jacobs School of Medicine and Biomedical Sciences: Resident Recruitment Committee; Committee Member
  • University Pediatric Associates, Inc.: Benefits Committee; Committee Member
  • Western New York and National Williams Syndrome Association and Member Families; Advisor

School News:
In the Media:

Clinical Specialties:
Clinical Offices:
Insurance Accepted:


Contact Information

UBMD Pediatrics
Division of Genetics
1001 Main Street
Buffalo, NY 14203
Phone: (716) 323-0040
Fax: (716) 323-0292
Email: lssadler@buffalo.edu

Patient Care

Looking for a doctor? This faculty member is affiliated with UBMD, the group comprised of practicing physicians who are also professors in the UB Jacobs School of Medicine and Biomedical Sciences.

View this faculty on UBMD

Log in to Update Your Profile