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Manoj                          Mammen

Manoj J. Mammen MD

Department of Medicine

Assistant Professor

Specialty/Research Focus

Bioinformatics; Critical Care Medicine; Internal Medicine; Pulmonary; Pulmonary & Critical Care Medicine; Pulmonary Disease

 
Professional Summary:

I am engaged in clinical, teaching and research responsibilities related to the evaluation and treatment of patients with pulmonary disease or patients who are critically ill. My inpatient practice is primarily located at the medical intensive care unit (MICU) at the Buffalo General Medical Center (BGMC). The MICU provides ongoing medical care to patients who are critically ill and require significant life support therapies to sustain life or vital bodily functioning.

I also evaluate patients with pulmonary disorders including shortness of breath, lung masses, abnormal chest imaging, abnormal pulmonary function tests, chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease, pulmonary hypertension and lung cancer, at the lung and heart outpatient clinic located in BGMC. The pulmonary team to which I belong also provides inpatient pulmonary consultation at both BGMC and Roswell Park Cancer Institute.

I am specifically interested in asthma, COPD and lung cancer. I am investigating the pathophysiology of lung inflammation.

Recently I am engaged in the study of the human airways microbiome and metagenome. The human microbiome is the the collection of all the microbial organisms in a human body, and the corresponding metagenome is the collection of the genes, and gene products of the microbes. Due the potential impact of the microbiome on human health and disease, I am interested in studying the putative effects the interaction with human hosts, specifically innate immunity interaction with the metagenome in lung disease.

Additionally, I collaborate with the Division of Allergy and Immunology and the Institute of Laser, Photonics and Biophotonics to elucidate immune cell function in airway diseases such as asthma and COPD. Our research focuses on the development of therapeutics aimed at novel targets identified as important in the molecular basis of pulmonary disease; efficacious laboratory results will generate more effective treatment plans for patients.

I am actively involved in teaching medical students, residents and fellows about the appropriate care of the critically ill patient, as these trainees rotate in the MICU.

Education and Training:
  • MS, Genetics, Genomics and Bioinformatics, University at Buffalo (2016)
  • Fellowship, Pulmonary & Critical Care Medicine, Baylor College of Medicine (2010)
  • Residency, Internal Medicine, Baylor College of Medicine (2007)
  • MD, Medicine, Rutgers New Jersey Medical School (2004)
  • BA, Molecular Biology & Biochemistry/Computer Science, Rutgers University (1999)
Employment:
  • Adjunct Assistant Professor, Biomedical Informatics, University at Buffalo (2014-present)
  • Assistant Professor, Medicine, University at Buffalo (2010-present)
  • Medical Director, Western New York Lung Cancer Screening Program, Medicine, Kaleida Health (2013–2016)
  • Computer Consultant, Computer Science, NCS technologies (1999–2000)
Awards and Honors:
  • Empire Clinical Research Investigator Program Fellow (2014)
  • Gold Humanism Honor Society (2004)
  • Rutgers Presidential Scholarship (1995)
  • Robert C. Byrd Federal Scholarship (1995)

Research Expertise:
  • Biomedical Informatics
  • Nanoparticle based therapeutics in airway disease
  • Proteomics in COPD
  • RNAi therapeutics
  • Systems biology of lung inflammation
Research Centers:
  • Clinical and Translational Research Center (CTRC)
  • Center of Excellence in Bioinformatics and Life Sciences
UB 2020 Strategic Strengths:
  • Molecular Recognition in Biological Systems and Bioinformatics
  • Integrated Nanostructured Systems
  • Information and Computing Technology
  • Health and Wellness Across the Lifespan

Evaluative Studies and Case Reports:
  • Mammen MJ, Velamuri S. A Clinical Misnomer of Multiple Pulmonary Nodules. Chest. 2009; 136.
  • Cantu JA, Akkanti B, Mammen MJ, Raizen Y, Guntupalli KK. Adult Pulmonary Blastoma: A Tale of Two Histologies. Chest. 2009; 136(4).
Journal Articles:
See all (1 more)
Abstracts:
  • Mammen MJ, Tu, Chengjian, Qu, Jun, Sethi S. Pathway Analysis Of Bronchoalveolar Lavage Fluid Proteome Of Individuals With COPD Compared To Healthy Controls. American Journal of Respiratory and Critical Care Medicine. 2013; 187.
  • Mammen MJ, Qu J, Sethi S. Comprehensive Proteomic Profiling Of Bronchoalveolar Lavage Fluid Of Individuals With COPD Compared To Healthy Controls. American Journal of Respiratory and Critical Care Medicine. 2012; 185.
  • Hesselbacher, S., Xu, C., Tsai, C.L., Schabath, M., Mammen MJ, Perusich, S., Coxson, H.O., Krowchuk, N.M., Corry, D., Kheradmand, F.. Clinical And Immunologic Phenotypes Dictate Physiologic Outcome In COPD: Results From The LES-COPD Study. American Journal of Respiratory and Critical Care Medicine. 2011; 183.
  • Mammen M, Atmar, R, Bandi, V, Greenlee, K, Kheradmand, F. Proteomic Analysis Of Bronchoalveolar Lavage of Patients with COPD and COPD exacerbation. American journal of Respiratory and Critical Care Medicine. 2010; 181(A1010).
  • Shander A, Qin F, Mammen MJ, Chuy J, Dardik H. Treatment of Experimental Acute Severe Anemia with Recombinant Human Erythropoietin. Anesthesiology. 2000; 93(3).
  • Qin F, Shander A, Mammen MJ, Chuy J, Dardik H. Treatment of Experimental Acute Severe Anemia with Parental Iron. Critical Care Medicine. 1999; 27(12).
Books and Book Chapters:
  • Mahajan SD, You Y, Aalinkeel R, Reynolds JL, Nair, Bindukumar B, Mammen MJ, Ignatowski TA, Cheng, Chong, Schwartz SA. Biodegradable Nanoparticle-Based Antiretroviral Therapy across the Blood-Brain Barrier. Handbook of Clinical Nanomedicine Nanoparticles, Imaging, Therapy, and Clinical Applications. 2016.
  • Mahajan SD, Aalinkeel R, Reynolds JL, Nair BB, Mammen MJ, Dai L, Prasad PN, Schwartz SA. Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases. Nanotherapeutic Approach to Targeting HIV-1 in the CNS: Role of Tight Junction Permeability and Blood. 2015.
  • Hirshkowitz, M, Mammen M,. Emergent sleep events related to medical treatment. Acute and Emergents in Sleep Disorders. 2010; 27.

Professional Memberships:
  • New York State Thoracic Society (2011–present)
  • Society of Critical Care Medicine (2009–present)
  • American Thoracic Society (2007–present)
  • American College of Chest Physicians (2007–present)
  • American College of Physicians (2004–present)
  • American Medical Association (2000–present)
Presentations:
  • "Approach to Dyspnea" UB IM residency conference, University at Buffalo (2016)
  • "The Airways Microbiome" City-Wide Grand Rounds, University at Buffalo (2016)
  • "Updates on Lung Cancer Screening Guidelines" NEW HOPE IN THE FIGHT AGAINST LUNG CANCER, American Lung Association of the Northeast (2016)
  • "Pulmonary Exam" CPM II, University at Buffalo, Medical Students (2015)
  • "Approach to CXR" UB IM residency conference, University at Buffalo (2015)
  • "Approach to Dyspnea" UB IM residency conference, University at Buffalo (2015)
  • "Interstitial Lung Disease" Core Didactic Conference, University at Buffalo, Internal Medicine (2014)
  • "Pulmonary Exam" CPM II, University at Buffalo, Medical Students (2013)
  • "Pulmonary Exam" CPM II, University at Buffalo, Medical Students (2012)
  • "Approach to SOB and Interstitial Lung Disease" Grand Rounds, University at Buffalo, Internal Medicine (2012)
  • "Proteomic analysis of bronchoalveolar lavage of patients with COPD and COPD exacerbations" ATS International Conference, American Thoracic Society, Oral Mini-Symposium (2010)
  • "Nonsleepy OSA" Research Symposium, Baylor College of Medicine, Internal Medicine (2010)
  • "A Clinical Misnomer of Multiple Pulmonary Nodules" ACCP Conference, American College of Chest Physicians, Clinical Case (2009)
  • "A case of Pulmonary Blastoma" Citywide Conference, Baylor College of Medicine, Pulmonary (2008)
  • "A case of Asthma in Pregnancy" Citywide Conference, Baylor College of Medicine, Pulmonary (2008)
  • "A case of Benign Metastazing Leiyomyomata" Citywide Conference, Baylor College of Medicine, Pulmonary (2007)
  • "A case of Cardiac Amyloidosis in an African American male: Transthyretin in the Heart" Grand Rounds, Baylor College of Medicine, Internal Medicine (2007)
  • "A case of Cardiac Amyloidosis in an African American male: Transthyretin in the Heart" Research Symposium, Baylor College of Medicine, Internal Medicine (2007)
  • "Healthcare utilization of sleep apnea patients at the VHA" Research Symposium, Baylor College of Medicine, Internal Medicine (2007)
See all (9 more)
Service Activities:
  • School of Medicine & Biomedical Sciences Faculty Council; Alternate Member (2014)
  • New York State Thoracic Society Poster Session Moderator; Moderator (2017–present)
  • New York State Thoracic Society Informatics Committee; Chairman (2016–present)
  • PLoS One journal reviewer; Reviewer (2016–present)
  • UBMD EMR committee; Committee Member (2014–present)
  • Annals of Internal Medicine manuscript reviewer; Reviewer (2014–present)
  • Journal of Neurological Sciences reviewer; Peer Reviewer (2014–present)
  • Journal of Inflammation; Peer Reviewer (2013–present)
  • The American Journal of the Medical Sciences/Manuscript Reviewer; Peer Reviewer (2013–present)
  • American Lung Association, WNY Leadership Board; Board Member (2013–present)
  • Buffalo General Medical Center Patient Safety Committee; Member (2012–present)
  • American Thoracic Society Clinical Program committee; Member (2012–present)
  • Independent Health, Palliative Care Taskforce; Advisory Committee (2012–2013)
  • Independent Health, COPD program clinical advisory group; Advisory Committee (2011–2012)
  • New York State Thoracic Society, Executive Board; Member (2011–present)
  • Kaleida Health EMR workgroup; Member (2011–present)

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Contact Information

Buffalo General Medical Center
100 High Street, B-8
Buffalo, NY 14203
Phone: (716) 859-2271
Fax: 7168591491
Email: mammen@buffalo.edu

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