I am engaged in clinical, teaching and research responsibilities related to the evaluation and treatment of patients with pulmonary disease or patients who are critically ill. My inpatient practice situated at the medical intensive care unit at the Buffalo General Medical Center positions me to provide ongoing medical care to patients who are critically ill and require significant life support therapies to sustain life or vital bodily functioning. I am specifically interested in ARDS, asthma, chronic obstructive pulmonary disease, interstitial lung disease, pleural disease, pulmonary hypertension and lung cancer, but deal with a variety of lung disease.
I also evaluate patients with pulmonary disorders at the UBMD practice location at Conventus. As a member of the UBMD pulmonary division, I provide inpatient pulmonary consultation at both BGMC and Roswell Park Cancer Institute.
I am actively involved in teaching medical students, residents, and fellows about the appropriate care of the patient with either pulmonary disease and critical illness.
Education and Training:
MS, Genetics, Genomics and Bioinformatics, State University of New York at Buffalo (2016)
Fellowship, Pulmonary & Critical Care Medicine, Baylor College of Medicine (2010)
Residency, Internal Medicine, Baylor College of Medicine (2007)
MD, Medicine, Rutgers New Jersey Medical School (2004)
BA, Molecular Biology & Biochemistry/Computer Science, Rutgers University (1999)
Employment:
Associate Professor, Medicine, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2020-present)
Section Chief of UB Pulmonary at Buffalo General Medical Center, Medicine, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2020-present)
Adjunct Assistant Professor, Biomedical Informatics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2014-present)
Assistant Professor, Medicine, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2010–2020)
Medical Director, Western New York Lung Cancer Screening Program, Kaleida Health (2013–2016)
Student Family Healthcare Center (SFHCC) director, Rutgers New Jersey Medical School (2002–2004)
Computer Consultant, NCS technologies (1999–2000)
Awards and Honors:
Empire Clinical Research Investigator Program Fellow in Center for Nanomedicine (2014)
Gold Humanism Honor Society (2004)
Thesis with Honors, Rutgers University (1999)
Robert C. Byrd Federal Scholarship (1995)
Rutgers Presidential Scholarship (1995)
Research Expertise:
Biomedical Informatics
COVID19: Co-author of two clinical practice guidelines, ICU and pulmonary clinician who treats patients with COVID19 and teaches medical students, residents, and fellows on COVID19 management.
Critical Care Medicine
Data Science
Microbiome
Pulmonary medicine
Research Centers:
Center of Excellence in Bioinformatics and Life Sciences
Clinical and Translational Research Center (CTRC)
UB 2020 Strategic Strengths:
Extreme Events: Mitigation and Response
Health and Wellness Across the Lifespan
Information and Computing Technology
Integrated Nanostructured Systems
Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
October 2020–August 2022 The Network Biology of Pathogen-Host Interactions Driving Exacerbation in Chronic Obstructive Pulmonary Disease (COPD) Department of Defense, U.S. Army Medical Research and Materiel Command, Congressionally Directed Medical Research Programs Role: Co-Investigator $1,057,527
July 2018–June 2019 UB CAT: Circuit Clinical Data Collection and Analytics Systems, phase II UB CAT Role: Principal Investigator $197,563
July 2016–June 2019 UB Genome, Environment, and Microbiome Community of Excellence (GEM) pilot study grant:The Airway Microbiome and Lung cancer in a COPD cohort University at Buffalo Role: Principal Investigator $20,000
May 2018–April 2019 CTSI Pilot Study: Linking New York State Databases to Identify Risk Factors and Gaps in care for rural and urban health disparities in lung cancer CTSI Role: Co-Investigator $50,000
November 2017–October 2018 UB CAT: Circuit Clinical Data Collection and Analytics Systems UB CAT Role: Principal Investigator $486,184
October 2016–October 2017 AstraZeneca AB, D6571C00001 Role: Co-Investigator $8,000
July 2016–July 2017 Epigenetics profiling of Exacerbation Susceptibility in Chronic Obstructive Pulmonary Disease CTSA UB UR Collaborative Genomics Pilot Program Award Role: Co-Investigator $75,000
January 2014–December 2016 Empire Clinical Research Investigator Program: Center for Nanomedicine Fellow Role: Co-Investigator $292,000
April 2014–June 2016 A Phase I Double-Blind, Randomized, Placebo-Controlled, Multicenter Study Evaluating the Safety, Tolerability, and Pharmokinetics of GS-5745 in Subjects Gilead Role: Co-Principal Investigator $22,260
Journal Articles:
Alhazzani W, Evans L, Alshamsi F, Møller MH, Ostermann M, Prescott HC, Arabi YM, Loeb M, Ng Gong M, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Machado F, Wunsch H, Crowther M, Cecconi M, Koh Y, Burry L, Chertow DS, Szczeklik W, Belley-Cote E, Greco M, Bala M, Zarychanski R, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Nainan Myatra S, Arrington A, Kleinpell R, Citerio G, Lewis K, Bridges E, Memish ZA, Hammond N, Hayden FG, Alshahrani M, Al Duhailib Z, Martin GS, Kaplan LJ, Coopersmith CM, Antonelli M, Rhodes A. (2021) Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update. Crit Care Med (Jan)
Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Aboodi M, Wunsch H, Cecconi M, Koh Y, Chertow DS, Maitland K, Alshamsi F, Belley-Cote E, Greco M, Laundy M, Morgan JS, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Alexander PE, Arrington A, Centofanti JE, Citerio G, Baw B, Memish ZA, Hammond N, Hayden FG, Evans L, Rhodes A. (2020) Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19). Critical care medicine (Jun), 48(6): e440-e469. doi:10.1097/CCM.0000000000004363
Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Aboodi M, Wunsch H, Cecconi M, Koh Y, Chertow DS, Maitland K, Alshamsi F, Belley-Cote E, Greco M, Laundy M, Morgan JS, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Alexander PE, Arrington A, Centofanti JE, Citerio G, Baw B, Memish ZA, Hammond N, Hayden FG, Evans L, Rhodes A. (2020) Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Med (Mar).
Manoj J Mammen, Jamil Ali, Amita Aurora, Umesh C Sharma, Ravikumar Aalinkeel, Supriya D Mahajan, Mark Sands, Stanley A Schwartz. (2021) IL-17 Is a Key Regulator of Mucin-Galectin-3 Interactions in Asthma. International Journal of Cell Biology (Jun), 2021 doi:https://doi.org/10.1155/2021/9997625
Chaudhuri D, Sasaki K, Karkar A, Sharif S, Lewis K, Mammen MJ, Alexander P, Ye Z, Lozano LEC, Munch MW, Perner A, Du B, Mbuagbaw L, Alhazzani W, Pastores SM, Marshall J, Lamontagne F, Annane D, Meduri GU, Rochwerg B. (2021) Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysis. Intensive care medicine (Apr) doi:10.1007/s00134-021-06394-2
Self WH, Stewart TG, Wheeler AP, Atrouni WE, Bistran-Hall AJ, Casey JD, Cataldo VD, Chappell JD, Cohn CS, Collins JB, Denison MR, de Wit M, Dixon SL, Duggal A, Edwards TL, Fontaine MJ, Ginde AA, Harkins MS, Harrington T, Harris ES, Hoda D, Ipe TS, Jaiswal SJ, Johnson NJ, Jones AE, Laguio-Vila M, Lindsell CJ, Mallada J, Mammen MJ, Metcalf RA, Middleton EA, Mucha S, O‘Neal HR, Pannu SR, Pulley JM, Qiao X, Raval JS, Rhoads JP, Schrager H, Shanholtz C, Shapiro NI, Schrantz SJ, Thomsen I, Vermillion KK, Bernard GR, Rice TW. (2021) Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults. Trials (Mar).
Morris MC, Richman S, Lyman CA, Qu J, Mammen MJ, Sethi S, Broderick, G. (2020) Hacking the Immune Response to Infection in Chronic Obstructive Pulmonary Disease. 20th IEEE International Conference on Bioinformatics and Bioengineering (IEEE BIBE 2020) (Oct).
Mammen MJ, Sethi S. (2017) Microbiome in Chronic Lung Disease. Barcelona Respiratory Reviews (Jan), 3: 102-120.
Parikh, NU, Magnum, C, Aalinkeel R, Reynolds JL, Sykes DE, Mammen MJ, Sykes DE, Mahajan SD. (2016) Galectin-1 reduces neuroinflammation via modulation of the nitric oxide-arginase network in microglia: implications for a neuroprotective role in HIV associated neurocognitive disorders. Journal Of Neuroimmune Pharmacology, (Jan).
Mahajan SD, You Y, Aalinkeel R, Reynolds JL, Nair, Bindukumar B, Mammen MJ, Ignatowski TA, Cheng, Chong, Schwartz SA. (2016) Biodegradable Nanoparticle-Based Antiretroviral Therapy across the Blood-Brain Barrier.
Mahajan SD, Aalinkeel R, Reynolds JL, Nair BB, Mammen MJ, Dai L, Prasad PN, Schwartz SA. (2015) Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases. Elsevier.
Hirshkowitz, M, Mammen M,. (2010) Emergent sleep events related to medical treatment. Oxford University Press.
Abstracts:
JM Wells, SP Bhatt, TF Carr, GJ Criner, DMG Halpin, MK Han, R Jain, MG Kaye, M Kraft, DA Lipson, D Mapel, MJ Mammen, C McEvoy, D Midwinter, D Singh, R Wise, MT Dransfield. (2021) An Analysis of the IMPACT Trial Assessing Single-Inhaler Therapy with Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Versus FF/VI and UMEC/VI Using a Composite Adverse Event Outcome in Patients with COPD. American Thoracic Society, (May) A2240-A2240
MJ Mammen, TF Carr, GJ Criner, MT Dransfield, DMG Halpin, MK Han, RG Jain, V Kaul, MG Kaye, M Kraft, D Mapel, D Midwinter, PD Scanlon, D Singh, JM Wells, R Wise, DA Lipson. (2021) All-Cause Mortality by Subgroup in Patients with Chronic Obstructive Pulmonary Disease: Post Hoc Analysis of the IMPACT Trial. American Thoracic Society, (May) A2241-A2241
DW Mapel, M Bogart, GJ Criner, MT Dransfield, N Gaeckle, M Gotfried, DMG Halpin, MK Han, R Jain, V Kaul, MJ Mammen, D Midwinter, D Singh, R Wise, DA Lipson. (2021) Reduction in Emergency Department (ED) Visits in Patients with Chronic Obstructive Pulmonary Disease (COPD): Analysis of the IMPACT Trial. American Thoracic Society, (May) A2242-A2242
MJ Mammen, TF Carr, GJ Criner, MT Dransfield, DMG Halpin, MK Han, B Hartley, R Jain, V Kaul, MG Kaye, M Kraft, D Mapel, D Midwinter, PD Scanlon, D Singh, JMM Wells, R Wise, DA Lipson. (2021) Risk of All-Cause Mortality During and After Severe Exacerbations in Patients with Chronic Obstructive Pulmonary Disease (COPD): Post Hoc Analysis of the IMPACT Trial. American Thoracic Society, (May) A2243-A2243
Bhardwaj A, Savant AC, Tetewsky S, McCray W, Mammen MJ, Khan S, Manion C, Tse ., Liu T, Lee R, Curtis AB, Pershad A, Elkins PL, Corbelli J. (2018) Superior Survival With Direct Oral Anticoagulants Compared to Warfarin in Patients With Atrial Fibrillation and Underlying Cancer: Veterans Affairs Database Study. Circulation, (Nov)
Castner J, Jungquist C, Mammen MJ, Pender J J, Licata O, Wilding G, Sethi S. (2018) Developing Multivariable Prediction Models of Asthma Control Components Using Fitness Tracker Sleep Patterns in Women. American Journal of Respiratory Critical Care Medicine, (May)
Mammen MJ, Waldron N, Valiyaparambil S, Wrona C, Sethi S. (2018) Distinct Airway Microbiome Patterns Associated with Frequent Exacerbator Phenotype in COPD. American Journal of Respiratory and Critical Care Medicine, (May)
Mammen MJ, Buck M, Sun Y, Waldron N, Valiyaparambil S, Wrona C, Sethi S. (2018) Distinct Airway Microbiome Patterns Associated with Lung Cancer Development in a COPD Cohort. American Journal of Respiratory and Critical Care Medicine, (May)
Mammen MJ, Tsompana M, Buck M, Biswal S, Criner GJ, Sethi S. (2017) Effect Of Sulforaphane Treatment On The Airway Microbiome In COPD. American Journal of Respiratory and Critical Care Medicine, (May)
Parikh NU, Aalinkeel R, Reynolds JL, Quaye E, Cwiklinski K, Sykes DE, Mammen MJ, Sharijkova, A, Khmaladze A, Schwartz SA, Mahajan SD. (2017) Methamphetamine (METH) and HIV-tat mediated oxidative stress contributes to Mitochondrial dysfunction in microglia. JOURNAL OF NEUROIMMUNE PHARMACOLOGY, (Apr)
Parikh NU, Mammen MJ, Cumella JC, Rockoff JB, Schwartz SA. (2017) Impact of Lung Flute Therapy on Asthma: A Pilot Study. Journal of Allergy and Clinical Immunology, (Feb)
Aalinkeel R, Abou-Jaoude E, Parikh, N, Reynolds JL, Sykes DE, Mammen MJ, Mahajan SD, Schwartz SA. (2016) Galectin-3 in prostate cancer proliferation and metastasis. European Journal of Immunology, (Aug)
Parikh NU, Mahajan SD, Aalinkeel R, Reynolds JL, Nair BN, Sykes DE, Mammen MJ, Schwartz SA. (2015) Galectin-1 is Neuroprotectice and Reverses Methamphetamine Induced Blood Brain Barrier Breakdown. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, (May)
Mammen MJ, Tu, Chengjian, Qu, Jun, Sethi S. (2013) Pathway Analysis Of Bronchoalveolar Lavage Fluid Proteome Of Individuals With COPD Compared To Healthy Controls. American Journal of Respiratory and Critical Care Medicine, (May) A1109
Mammen MJ, Qu J, Sethi S. (2012) Comprehensive Proteomic Profiling Of Bronchoalveolar Lavage Fluid Of Individuals With COPD Compared To Healthy Controls. American Journal of Respiratory and Critical Care Medicine, (May) A3747
Hesselbacher, S., Xu, C., Tsai, C.L., Schabath, M., Mammen MJ, Perusich, S., Coxson, H.O., Krowchuk, N.M., Corry, D., Kheradmand, F. (2011) Clinical And Immunologic Phenotypes Dictate Physiologic Outcome In COPD: Results From The LES-COPD Study. American Journal of Respiratory and Critical Care Medicine, (May) A1016
Mammen M, Atmar, R, Bandi, V, Greenlee, K, Kheradmand, F. (2010) Proteomic Analysis Of Bronchoalveolar Lavage of Patients with COPD and COPD exacerbation. American journal of Respiratory and Critical Care Medicine, (May)
Shander A, Qin F, Mammen MJ, Chuy J, Dardik H. (2000) Treatment of Experimental Acute Severe Anemia with Recombinant Human Erythropoietin. Anesthesiology, (Jan) A495
Qin F, Shander A, Mammen MJ, Chuy J, Dardik H. (1999) Treatment of Experimental Acute Severe Anemia with Parental Iron. Critical Care Medicine, (Dec)
American College of Chest Physicians (2007–present)
American Thoracic Society (2007–present)
American College of Physicians (2004–present)
American Medical Association (2000–present)
American Associations of Physicians of Indian Origin (2000–present)
Presentations:
"The tip of the spear, the NYC/NJ COVID-19 experience." COVID-19 Symposium; American Thoracic Society (2020)
"Detecting Respiratory Compromise in the PACU" American Academy of Nursing Policy Conference; American Academy of Nursing Policy (2018)
"How to Assess for Respiratory Compromise When your patient is on Supplemental Oxygen" American Society of Pain Management Nurses Annual Conference; American Society of Pain Management Nurses (2018)
"Occupational Lung Disease" Respiratory and Lung Module; University at Buffalo (2018)
"Distinct Airway Microbiome Patterns Associated with Frequent Exacerbator Phenotype in COPD" American Thoracic Society International Conference; American Thoracic Society (2018)
"Distinct Airway Microbiome Patterns Associated with Lung Cancer Development in a COPD Cohort" American Thoracic Society international Conference; American Thoracic Society (2018)
"Pulmonary Diagnostic Testing" UB Internal Medicine Residency Lecture (2017)
"Pulmonary Exam" CPM II (2017)
"Approach to Shortness of Breath" UB Internal Medicine Residency Lecture (2017)
"Update in Lung Cancer Screening" University at Buffalo Family Medicine Grand Rounds; University at Buffalo; Family Medicine (2017)
"Pulmonary Diagnostic Testing" UB Internal Medicine Residency Lecture (2016)
"Pulmonary Exam" CPM II (2016)
"Approach to Dyspnea" UB IM residency conference; University at Buffalo (2016)
"Why are Patients with Pneumonia Readmitted?" American Thoracic Society International Conference; American Thoracic Society (2016)
"The Airways Microbiome" City-Wide Grand Rounds; University at Buffalo (2016)
"Updates on Lung Cancer Screening Guidelines" American Lung Association: NEW HOPE IN THE FIGHT AGAINST LUNG CANCER; American Lung Association of the Northeast; NEW HOPE IN THE FIGHT AGAINST LUNG CANCER (2016)
"Pulmonary Exam" CPM II; University at Buffalo; Medical Students (2015)
"Approach to CXR" UB IM residency conference; University at Buffalo (2015)
"Approach to Dyspnea" UB IM residency conference; University at Buffalo (2015)
"An Update on Lung Cancer Screening: Lung Nodule Management" UBMD Primary Care Update (2015)
"Interstitial Lung Disease" Core Didactic Conference; University at Buffalo; Internal Medicine (2014)
"Pulmonary Exam" CPM II; University at Buffalo; Medical Students (2013)
"A Systems Biology approach to COPD" URMC Pulmonary Conference; University at Rochester; Pulmonary and Critical Care Medicine (2013)
"Pulmonary Exam" CPM II; University at Buffalo; Medical Students (2012)
"Approach to SOB and Interstitial Lung Disease" Grand Rounds; University at Buffalo; Internal Medicine (2012)
"Proteomic analysis of bronchoalveolar lavage of patients with COPD and COPD exacerbations" ATS International Conference; American Thoracic Society; Oral Mini-Symposium (2010)
"Nonsleepy OSA" Research Symposium; Baylor College of Medicine; Internal Medicine (2010)
"A Clinical Misnomer of Multiple Pulmonary Nodules" ACCP Conference; American College of Chest Physicians; Clinical Case (2009)
"A case of Pulmonary Blastoma" Citywide Conference; Baylor College of Medicine; Pulmonary (2008)
"A case of Asthma in Pregnancy" Citywide Conference; Baylor College of Medicine; Pulmonary (2008)
"A case of Benign Metastazing Leiyomyomata" Citywide Conference; Baylor College of Medicine; Pulmonary (2007)
"A case of Cardiac Amyloidosis in an African American male: Transthyretin in the Heart" Grand Rounds; Baylor College of Medicine; Internal Medicine (2007)
"A case of Cardiac Amyloidosis in an African American male: Transthyretin in the Heart" Research Symposium; Baylor College of Medicine; Internal Medicine (2007)
"Healthcare utilization of sleep apnea patients at the VHA" Research Symposium; Baylor College of Medicine; Internal Medicine (2007)
The BMJ- British Medical Journal British Medical Journal peer-reviewer; Peer Reviewer (2020–present)
Pharmaceuticals and Therapeutics @ Kaleida Health; Committee Member (2020–present)
CHEST journal; Peer Reviewer (2020–present)
American Thoracic Society Health Policy Committee member; Committee Member (2017–present)
New York State Thoracic Society Poster Session Moderator; Moderator (2017–present)
American Thoracic Society Chapter Council Representative NYS representative to ATS, the NYS CCR representative; Councilor (2017–present)
BMC Medical Informatics and Decision Making reviewer; Reviewer (2016–present)
New York State Thoracic Society Informatics Committee; Chairman (2016–present)
PLoS One journal reviewer; Reviewer (2016–present)
UBMD EMR committee; Committee Member (2014–2019)
Faculty Council; Alternate Member (2014–2020)
Journal of Neurological Sciences reviewer; Peer Reviewer (2014–present)
Annals of Internal Medicine manuscript reviewer; Peer Reviewer (2014–present)
Journal of Inflammation; Peer Reviewer (2013–present)
The American Journal of the Medical Sciences/Manuscript Reviewer; Peer Reviewer (2013–present)
American Lung Association, WNY Leadership Board; Board Member (2013–2018)
Buffalo General Medical Center Patient Safety Committee; Member (2012–2014)
American Thoracic Society Clinical Program committee; Member (2012–2013)
Independent Health, Palliative Care Taskforce; Advisory Committee (2012–2013)
Independent Health, COPD program clinical advisory group; Advisory Committee (2011–2012)
New York State Thoracic Society, Executive Board; Member (2011–present)
Kaleida Health EMR workgroup; Member (2011–present)
Student Family Health Care Center Co-Director The Student Family Health Care Center established after 1967 to meet the needs of the medically underserved, this student-run clinic offers free, quality health care to the Newark community.; Co-Director (2002–2004)