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Mark                           Hicar

Mark D. Hicar MD, PhD

Department of Pediatrics

Assistant Professor

Specialty/Research Focus

Pediatric Infectious Diseases; Pediatrics

 
Professional Summary:

My lab currently focuses B cell responses during inflammation with current main projects focusing on HIV and Kawasaki disease.

Currently, the HIV field is in desperate need for greater knowledge regarding the mechanisms involved in induction of neutralizing antibodies and mucosal immune responses against HIV. I have characterized a collection of human antibodies that target structural epitopes on the Envelope protein of HIV. Current work is being pursued to define the targets of these antibodies and to assess if they can recognize cutting edge HIV vaccine candidates. Designing improved immunogens that elicit enhanced antibody activity from vaccination is the overall goal of my HIV research.

Kawasaki Disease (KD) is an inflammatory disorder of children that can lead to dire consequences. KD is the leading cause of acquired heart disease in children and primarily affects children under 5 years of age. However, the cause remains unknown. Some groups have shown indications that B cell responses target a specific entity. My work focuses on characterizing how KD presents in Western New York and explores a role for specific B cell responses in the pathogenesis of this mysterious disease.

In my career I hope to become an accomplished physician-scientist who significantly impacts both the fields of lymphocyte development and HIV infection. Mucosal immune responses are of particular interest since they are so vital in the first line of defense in HIV and most other viral infections.

Education and Training:
  • Fellowship, Pediatric Infectious Diseases, Vanderbilt University School of Medicine (2009)
  • Residency, Pediatrics, Vanderbilt University School of Medicine (2005)
  • Internship, Pediatrics, Vanderbilt University School of Medicine (2003)
  • MD, Medicine, Ohio State University College of Medicine (2002)
  • PhD, Molecular Virology, Immunology and Medical Genetics, Ohio State University College of Medicine (2002)
  • BA, Biology, University of Chicago (1993)
Employment:
  • Assistant Professor, Pediatrics, University at Buffalo (2017-present)
  • Fellowship Program Director, Infectious Diseases, Pediatrics, University at Buffalo (2016-present)
  • Attending Physician, Division of Infectious Diseases, UBMD Pediatrics, Women and Children‘s Hospital of Buffalo (2012-present)
  • Assistant Professor, Microbiology and Immunology, University at Buffalo (2012-present)
  • Research Assistant Professor, Pediatrics, University at Buffalo (2015–2017)
  • Assistant Professor, Pediatrics, University at Buffalo (2012–2015)
  • Clinical Instructor, Pediatric Infectious Diseases, Vanderbilt University, School of Medicine (2009–2012)
  • Clinical Instructor, Pediatrics, Vanderbuilt University, School of Medicine (2006–2007)
Awards and Honors:
  • Human Antibodies International Journal: 14th Annual International Conference on Human Antibodies and Hybridomas (Invited Speaker) (2008)
  • Pediatric Academic Societies: Travel Award (2008)
  • Keystone Conference: HIV Pathogenesis Travel Award (2008)
  • American Association of Immunologists: Travel Award (2007)
  • Vanderbilt Pediatric House Staff: David Karzon Research Award (2005)
  • Ohio State University: Landacre Day - 1st Place Poster Presentation (1998)
  • Ohio State University: Medical Microbiology and Immunology Teaching Assistantship (1997)
  • Ohio State University: Molecular Life Sciences Fellowship (1996)
  • Ohio State University: Roessler Fellowship (1996)
  • Phi Beta Kappa Honor Society (1989)
  • University of Chicago: National Merit Scholar (1989)
  • Infectious Diseases Society of America (IDSA), ERF/NFID: Wyeth Young Investigator Award in Vaccine Development (2009-2011)
  • Pediatric Infectious Diseases Society and St. Jude Fellowship in Basic Research (2006-2009)
  • National Institutes of Health: Loan Repayment Award (2006-2012)
  • Ohio State University: Medical Scientist Fellowship (1998-2002)

Grants and Sponsored Research:
  • February 2016–January 2021
    The Role of Non-Broadly Neutralizing Antibodies Targeting gp41 Structural Epitopes in Long-Term Nonprogression of HIV Infection
    National Institute of Allergy and Infectious Diseases
    Role: Principal Investigator
    $1,900,000
  • January 2016–December 2017
    A His-Tag Binding Membrane System for Generating Neutralizing GP41 MPER Antibodies
    National Institutes of Health
    Role: Co-Investigator
    $250,000
  • May 2016–April 2017
    Antibody and B-Cell Characterization During Acute Kawasaki Disease
    Wildermuth Research Foundation
    Role: Principal Investigator
    $25,000
  • May 2014–April 2015
    Identifying Targets of Antibodies Cloned from Children Presenting with Acute Kawasaki Disease (KD)
    Wildermuth Research Foundation
    Role: Principal Investigator
    $23,000
  • August 2009–August 2014
    Antibodies Recognizing Quaternary Differences in HIV Envelope Glycoproteins
    National Institutes of Health
    Role: Principal Investigator
    $591,500
  • July 2012–July 2014
    Antibodies Recognizing Quaternary Differences in HIV Envelope Glycoproteins (K08)
    National Institute of Allergy and Infectious Disease
    Role: Principal Investigator
    $283,925
  • January 2013–December 2013
    CMV Pilot Grant Proposal
    Stone Goode Trust
    Role: Principal Investigator
    $42,000
  • June 2006–June 2013
    NIH Loan Repayment Program
    National Institutes of Health
    Role: Principal Investigator
    $146,411
  • January 2009–January 2011
    Trimer-Specific Antibodies Influence HIV Envelope Diversity
    IDSA ERF/NFID
    Role: Principal Investigator
    $60,000
  • July 2006–June 2009
    Role of Antibody Repertoire Restriction in HIV-1 Neutralization
    Pediatric Infectious Diseases Society/St. Jude Children‘s Research Hospital Fellowship Program in Basic Research
    Role: Principal Investigator
    $270,000

Journal Articles:
See all (3 more)

Professional Memberships:
  • Pediatric Infectious Diseases Society
  • Infectious Diseases Society of America
  • American Academy of Pediatrics
  • Society for Pediatric Research
  • Buffalo Pediatric Society
Presentations:
  • "B Cell Subsets Support an Infectious Disease Etiology of Kawasaki Disease" Annual Meeting, Pediatric Academic Societies (2017)
  • "Influence of Distance to Treatment Center on Rates of Kawasaki Disease in Western New York" Annual Meeting, Pediatric Academic Societies (2017)
  • "Monoclonal Antibodies to Structural gp41 Epitopes" HIV Broadly Neutralizing Monoclonal Antibodies Working Group, University at Buffalo (2017)
  • "Roundtable on Resident Career Paths" Pediatric Resident Lecture, Women and Children's Hospital of Buffalo (2017)
  • "Antibodies Targeting Structural Epitopes on gp41 as a Potential Inherent Resistance Mechanism to HIV Fusion Inhibitors" World AIDS Day Meeting, University of Rochester Center for AIDS Research (2016)
  • "Steroid Use in Early Kawasaki Disease" Infectious Diseases Journal Club, University at Buffalo (2016)
  • "Common Pediatric Exanthems" Pediatric Resident Lecture Series, Women and Children's Hospital of Buffalo (2016)
  • "Diarrheal Illness" Pediatric Resident Lecture Series, Women and Children's Hospital of Buffalo (2016)
  • "Encephalitis and Meningitis" Pediatric Resident Lecture Series, Women and Children's Hospital of Buffalo (2016)
  • "Studying Humoral Immunity in HIV and Kawasaki Disease" Research Seminar Series, University at Buffalo Clinical and Translational Research Center (2016)
  • "Endemic Measles Has Officially Been Eradicated from the Americas" Online Article, Self Magazine (2016)
  • "Zika Virus Biology and Testing" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (2016)
  • "Why Can It Take So Long to Get a Lyme Disease Diagnosis?" Online Article, Self Magazine (2016)
  • "IL-21 Levels Do Not Distinguish Children Presenting with Kawasaki Disease from Other Febrile Children" Annual Meeting, Pediatric Academic Societies (2016)
  • "Influenza, Respiratory Infections and Diarrheal Illness" Infectious Disease Epidemiology Course, Daemen College (2016)
  • "Kawasaki Cases in Western New York" Research Scholars Day, University at Buffalo (2016)
  • "Schumer Urges Approval of Funding to Prevent Zika" News Article, Buffalo News (2016)
  • "Zika Emergency Funding" Press Conference with Senator Charles Schumer, WBFO (2016)
  • "Zika Funding" Newspaper Article, Buffalo News (2016)
  • "Bartonella, Capnocytophaga" Infectious Diseases Case Conference, University at Buffalo (2016)
  • "IL-21 Levels Do Not Distinguish Children Presenting with Kawasaki Disease from Other Febrile Children" Annual Conference, Eastern Society for Pediatric Research (2016)
  • "MRSA Rhabdomyolisis" Infectious Diseases Case Conference, University at Buffalo (2016)
  • "Coxsackivirus Pleurodynia" Infectious Diseases Case Conference, University at Buffalo (2015)
  • "Update on Kawasaki Research" Infectious Diseases Case Conference, University at Buffalo (2015)
  • "Evaluation of B Cell Populations as Correlative Markers in Kawasaki Disease" ID Week, Infectious Disease Society of America (2015)
  • "Highlights of ID Week" Infectious Diseases Case Conference, University at Buffalo (2015)
  • "Antibodies Targeting Structural Epitopes on gp41 as a Potential Inherent Resistance Mechanism to HIV Fusion Inhibitors" Annual Meeting, Pediatric Academic Societies (2015)
  • "Cardiac Related Infections" Pediatric Resident Lecture Series, Women and Children's Hospital of Buffalo (2015)
  • "Coxsackie Presenting Like Kawasaki with Cholangitis" Infectious Diseases Case Conference, University at Buffalo (2015)
  • "Eikenella Knee Septic Arthritis After Self-Bite" Infectious Diseases Case Conference, University at Buffalo (2015)
  • "Infectious Diseases Update" Pediatric Grand Rounds, Women and Children's Hospital of Buffalo (2015)
  • "Muscle, Bone and Joint Infections" Pediatric Resident Lecture Series, Women and Children‘s Hospital of Buffalo (2015)
  • "Paragonimus Westermani Infection Masking as Recalcitrant Multi-Drug Resistant Tuberculosis" Annual Meeting, Pediatric Academic Societies (2015)
  • "Anti-Trimer Antibodies: Marker of HIV Non-Progression" Dr. Daniel Schwartz's Lab Meeting, University at Buffalo (2015)
  • "Antibodies Targeting Structural Epitopes on gp41 as a Potential Inherent Resistance Mechanism to HIV Fusion Inhibitors" Annual Conference, Eastern Society for Pediatric Research (2015)
  • "Bactrim vs. Clindamycin in Cellulitis/Abscess" Infectious Diseases Journal Club, University at Buffalo (2015)
  • "Paragonimus Westermani Infection Masking as Recalcitrant Multi-Drug Resistant Tuberculosis" Annual Conference, Eastern Society for Pediatric Research (2015)
  • "Measles Lessons: UB Medical Faculty Tweak How They Teach" News Release, University at Buffalo (2015)
  • "Development of a Next-Generation Sequencing Protocol to Investigate Antibody Repertoire of Kawasaki Disease Patients" Medical Student Research Forum, University at Buffalo (2015)
  • "Antibodies to Conformational Epitopes Interfere with T20 Fusion Inhibition" ID Week, Infectious Disease Society of America (2014)
  • "Infectious Diseases Update" Pediatric Grand Rounds, Women and Children's Hospital of Buffalo (2014)
  • "Viral Isolates" Pediatric Grand Rounds, Women and Children's Hospital of Buffalo (2014)
  • "Cat Scratch Encephalopathy" Infectious Diseases Case Conference, University at Buffalo (2014)
  • "Development of Anti-HIV Antibody Production and Functional Assay Screening" Medical Student Research Forum, University at Buffalo (2014)
  • "Characterization of an Immunodominant Quaternary Epitope Reveals Differential Antigenic Presentation of HIV Envelope Trimers" Biotechnology Conference: Harnessing Immunity to Prevent and Treat Disease, Cold Spring Harbor Laboratory (2013)
  • "Congenital Infections" Pediatric Resident Lecture Series, Women and Children's Hospital of Buffalo (2013)
  • "Kawasaki Disease" Pediatric Resident Lecture Series, Women and Children's Hospital of Buffalo (2013)
  • "Osteomyelitis" Pediatric Resident Lecture Series, Women and Children's Hospital of Buffalo (2013)
  • "Primary Tuberculosis Meningitis" QA Conference, Women and Children‘s Hospital of Buffalo (2013)
  • "An Update on Potential Respiratory Virus Battleships" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (2013)
  • "Revised AAP Acute Otitis Media Guidelines" Pediatric Grand Rounds, Women and Children's Hospital of Buffalo (2013)
  • "Immune Mechanisms Affecting Antibody Responses in CMV" Pediatric Research Conference, Women and Children's Hospital of Buffalo (2013)
  • "Chronic Osteomyelitis with Secondary Neutropenia and Appendicitis" QA Conference, Women and Children's Hospital of Buffalo (2013)
  • "HIV Cure in Infant" News Interview, Channel 7 (2013)
  • "HIV Cure in Infant" In the News, University at Buffalo (2013)
  • "Liver and Spleen Cat-Scratch Disease" Infectious Diseases Case Conference, University at Buffalo (2013)
  • "Orbital Pseudotumor" Infectious Diseases Case Conference, University at Buffalo (2013)
  • "Systemic JIA Rash" Infectious Diseases Case Conference, University at Buffalo (2013)
  • "Update on Kawasaki Disease" Pediatric Grand Rounds, Women and Children's Hospital of Buffalo (2013)
  • "Contaminated Methylprednisone" Infectious Diseases Journal Review, University at Buffalo (2012)
  • "E. Faecium Bact/abd Abscess" Infectious Diseases Case Conference, University at Buffalo (2012)
  • "IV Infiltrate" Infectious Diseases Case Conference, University at Buffalo (2012)
  • "LCMV Retinitis" Infectious Diseases Case Conference, University at Buffalo (2012)
  • "Strep Urinary Antigen Tests" Infectious Diseases Case Conference, University at Buffalo (2012)
  • "Fungal Methylpred" Infectious Diseases Journal Club Conference, University at Buffalo (2012)
  • "S. aureus in Pharyngeal Abscesses" Infectious Diseases Journal Club Conference, University at Buffalo (2012)
  • "Common Pediatric Exanthems" Pediatric Resident Lecture Series, Women and Children's Hospital of Buffalo (2012)
  • "Diarrheal Illness" Pediatric Resident Lecture Series, Women and Children's Hospital of Buffalo (2012)
  • "Encephalitis and Meningitis" Pediatric Resident Lecture Series, Women and Children's Hospital of Buffalo (2012)
  • "HIV Envelope Trimerization Strategy Influences Differential Presentation of Highly Immunogenic Complex Quaternary Epitopes Identified Using HIV Virus-like Particles" ID Week, Infectious Diseases Society of America/Pediatric Infectious Diseases Society (2012)
  • "B Cell Responses in Kawasaki Disease" Pediatric Infectious Diseases Proposal Review, Women and Children's Hospital of Buffalo (2012)
  • "Fungal Infections" Pediatric ID Fellow Didactic Lecture Series, Vanderbuilt Children's Hospital (2012)
  • "The Natural Trimer-specific Antibody Response Against HIV-1" Seminar, University of Minnesota Center for Infectious Diseases and Microbiology Translational Research (2012)
  • "Common Pediatric Infections" VMS III Lecture Didactic Lecture Series, Vanderbuilt Children's Hospital (2011)
  • "Common Pediatric Infections" VMS III Lecture Didactic Lecture Series, Vanderbuilt Children's Hospital (2011)
  • "The Natural Trimer-specific Antibody Response Against HIV-1" Department of Pediatrics, University of Oklahoma Health Sciences Center (2011)
  • "The Natural Trimer-specific Antibody Response Against HIV-1" Department of Pediatrics, Wake Forest University (2011)
  • "The Natural Trimer-specific Antibody Response Against HIV-1" Department of Pediatrics, University at Buffalo (2011)
  • "Common Pediatric Infections" VMS III Lecture Didactic Lecture Series, Vanderbuilt Children's Hospital (2011)
  • "The Natural Trimer-specific Antibody Response Against HIV-1" Department of Pediatrics, University of Chicago (2011)
  • "Fungal Infections" Pediatric ID Fellow Didactic Lecture Series, Vanderbuilt Children's Hospital (2011)
  • "The Natural Trimer-specific Antibody Response Against HIV-1" Department of Pediatrics Infection and Immunity: Data Forum, University of Cincinnati (2011)
  • "Common Pediatric Infections" VMS III Lecture Didactic Lecture Series, Vanderbuilt Children's Hospital (2011)
  • "Fungal Infections" Pediatric Resident Didactic Lecture Series, Vanderbuilt Children's Hospital (2011)
  • "The Natural Trimer-specific Antibody Response Against HIV-1" , Saban Research Institute of University of Southern California/Children‘s Hospital of Los Angeles (2010)
  • "The Natural Trimer-specific Antibody Response Against HIV-1" Microbiology and Immunology Special Seminar, Vanderbuilt University (2010)
  • "The Natural Trimer-specific Antibody Response Against HIV-1" Southwestern Medical Center, University of Texas (2010)
  • "Cloning of Quaternary Specific Antibodies" AIDS Vaccine 2010, Global HIV Vaccine Enterprise/Center for AIDS Research at Emory University (2010)
  • "HIV Vaccines: An Antibody Perspective" Translational Research Seminar, University of Minnesota, Center for Infectious Diseases and Microbiology (2010)
  • "Effect of Mutation on Trimer Specificity of Anti-HIV Antibodies" Microbial Research Conference, St. Jude Children‘s Hospital/Pediatric Infectious Diseases Society (2010)
  • "Clonal Analysis of the Human B Cell Response to HIV" Rheumatology Grand Rounds, Vanderbuilt University (2009)
  • "Mycoplasma Encephalitis" Pediatric Chief's Case Discussant, Vanderbuilt Children's Hospital (2009)
  • "Novel Method to Generate Anti-HIV Human Monoclonal Antibodies" Microbial Research Conference, St. Jude Children‘s Hospital/Pediatric Infectious Diseases Society (2009)
  • "Novel Method to Generate Anti-HIV Human Monoclonal Antibodies" Adult ID Grand Rounds, Vanderbuilt University (2009)
  • "Pediatric ID Emergencies" Pediatric ED Resident Educational Conference, Vanderbuilt Children's Hospital (2009)
  • "Antibody-mediated Neutralization of HIV-1" Pediatric Infectious Diseases Lecture Series, Vanderbuilt University (2008)
  • "Novel Method to Generate Anti-HIV Human Monoclonal Antibodies" 14th Annual International Conference on Human Antibodies and Hybridomas, International Journal Human Antibodies (2008)
  • "Chronic Granulomatous Disease" Pediatric Chief's Case Discussant, Vanderbuilt Children's Hospital (2008)
  • "Novel Method to Generate Anti-HIV Human Monoclonal Antibodies" Annual Meeting, Pediatric Academic Societies/Society for Pediatric Research (2008)
  • "Novel Method to Generate Anti-HIV Human Monoclonal Antibodies" Research in Progress Seminar, Vanderbuilt University, Microbiology and Immunology Department (2008)
  • "Novel Method to Generate Anti-HIV Human Monoclonal Antibodies" Microbial Research Conference, St. Jude Children's Hospital/Pediatric Infectious Diseases Society (2008)
  • "Novel Method to Generate Anti-HIV Human Monoclonal Antibodies" HIV Pathogenesis Keystone Conference, Keystone Symposia on Molecular and Cellular Biology (2008)
  • "Cat-Scratch Fever" Pediatric Chief's Case Discussant, Vanderbuilt Children's Hospital (2007)
  • "Acute Hematogenous Osteomyelitis" Pediatric Chief's Case Discussant, Vanderbuilt Children's Hospital (2006)
  • "Acute Rheumatic Fever" Pediatric Chief's Case Discussant, Vanderbuilt Children's Hospital (2005)
  • "Developmental Immunity of HIV" Pediatric Grand Rounds, Vanderbuilt Children's Hospital (2005)
  • "Binding of Antibodies Generated in Human gp120 HIV Vaccine Trials to Particle-associated gp120 Trimers" Annual Meeting, Pediatric Academic Societies/Society for Pediatric Research (2004)
  • "The Characterization of Human KRC and Analysis of the Developmental Role of KRC in teh Thymus and Neural Tissue" Dissertation Defense, Ohio State University (2002)
  • "Developmental Expression of the Recognition Signal Sequence Binding Protein KRC is Consistent with Involvement in Regulating V(D)J Recombination" 15th Annual National Medical Scientist Training Programs, National Institute of General Medical Sciences (NIGMS) (2000)
  • "Developmental Expression of the Recognition Signal Sequence Binding Protein KRC is Consistent with Involvement in Regulating V(D)J Recombination" Immunology 2000, Federation of American Societies for Experimental Biology (FASEB)/American Association of Immunologists (AAI) (2000)
  • "Expression of KRC is Consistent with a Role in V(D)J Recombination" MVIMG Student Colloquium, Ohio State University (2000)
  • "Developmental Expression of KRC" Comprehensive Cancer Center Retreat, Ohio State University (2000)
  • "Developmental Expression of the Recognition Signal Sequence Binding Protein KRC is Consistent with Involvement in Regulating V(D)J Recombination" Keystone T-cell Development Conference, Keystone Symposia on Molecular and Cellular Biology (2000)
  • "Characterization of Human KRC Gene" Bennett Day, Ohio State University (1998)
  • "Characterization of Human KRC Gene" Landacre Day, Ohio State University (1998)
  • "The Human KRC Gene and Its Products" Graduate Research Forum, Ohio State University (1998)
  • "The Human KRC Gene" Stone Labs Meeting, Ohio State University (1997)
  • "Health Care in Romania: Is It True What They Say?" International Health Luncheon Series, Children's Hospital (1995)
See all (108 more)
Service Activities:
  • Journal of the Pediatric Infectious Diseases Society; Ad Hoc Reviewer (2017–present)
  • Pediatric Academic Societies: Meeting Abstracts; Reviewer (2017–present)
  • University at Buffalo Jacobs School of Medicine and Biomedical Sciences: Search Committee for Infectious Diseases Physician; Committee Member (2016–present)
  • University at Buffalo: Faculty Senate; Member (2016–present)
  • Society for Pediatric Research: Communications Committee; Committee Member (2015–present)
  • University at Buffalo Jacobs School of Medicine and Biomedical Sciences: CME for the Division of Pediatric Infectious Diseases; Director (2015–present)
  • Pediatrics Journal; Reviewer (2015–present)
  • University at Buffalo Jacobs School of Medicine and Biomedical Sciences: Emergency Medicine Fellowship Scholarly Oversight Committee; Committee Member (2015–present)
  • Research and Reports in Biology; Reviewer (2014–present)
  • University at Buffalo Jacobs School of Medicine and Biomedical Sciences: Pediatric Research Conference; Founder and Coordinator (2013–present)
  • University at Buffalo Jacobs School of Medicine and Biomedical Sciences: Go Live Computer Order Set Developer (Division of Infectious Diseases) (2013)
  • Heck Foundation; Grant Reviewer (2012–present)
  • Pediatric Infectious Disease Journal; Reviewer (2012–present)
  • Pediatric Infectious Disease Journal; Reviewer (2011–2012)
  • Vanderbuilt University: Pediatric Residency Applications; Interviewer (2010–2011)
  • Vanderbuilt University: Global Health Intersession; Group Leader (2010)
  • Vanderbuilt University: Pediatric Infectious Disease Division Research Retreat Committee; Chair (2008)
  • Vanderbuilt University: Pediatric Infectious Disease Division Head Search Committee; Committee Member (2007)

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Contact Information

UBMD Pediatrics
Division of Infectious Diseases
1001 Main Street
Buffalo, NY 14203
Phone: (716) 323-0150
Fax: (716) 323-0296
Email: markhica@buffalo.edu

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