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Timothy                        Murphy

Timothy F. Murphy MD

Department of Medicine

SUNY Distinguished Professor; Senior Associate Dean for Clinical and Translational Research

Specialty/Research Focus

Infectious Disease

 
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Professional Summary:

Research in my laboratory focuses on nontypeable Haemophilus influenzae and Moraxella catarrhalis, important pathogens in otitis media and lower respiratory tract infections in adults with chronic obstructive pulmonary disease (COPD). A goal of work is to develop vaccine to prevent these infections. To that end, outer membrane proteins have been identified and are being evaluated as potential vaccine antigens.

A COPD Study Clinic supported by a grant from the Department of Veteran Affairs has been running continuously since 1994. This prospective study follows adults with COPD during monthly clinic visits during which sputum and serum samples are collected. Bacterial isolates are recovered from sputum and are subjected to molecular typing. These studies are elucidating the dynamics of respiratory tract bacterial colonization. In addition, serum and sputum samples are being studied to learn about systemic and mucosal immune responses to bacterial pathogens.

Education and Training:
  • Fellowship, Infectious Diseases, Tufts University (1981)
  • Residency, Medicine, New York Hospital Cornell Medical Center (1979)
  • MD, Tufts University (1976)
Employment:
  • Director, Clinical and Translational Research Center, University at Buffalo (2012-present)
  • SUNY Distinguished Profesor, University at Buffalo (2011-present)
  • Senior Associate Dean for Clinical and Translational Research, University at Buffalo (2009-present)
  • Professor, Department of Medicine, University at Buffalo (1992-present)
  • UB Distinguished Professor, University at Buffalo (2004–2011)
  • Chief, University at Buffalo (1993–2009)
  • Chief, Infectious Diseases, VA WNY Healthcare System (1990–2009)
  • Consultant, Erie County Medical Center (1990–2000)
  • Consultant, Buffalo General Hospital (1981–2000)
  • Visiting Professor, University of Canberra, Australia, Faculty of Applied Science, Australia (1995–1996)
  • Adjunct Associate Professor, University at Buffalo (1987–1994)
  • Associate Professor, University at Buffalo (1987–1992)
  • Chief, Infectious Diseases, Erie County Medical Center (1988–1990)
  • Internist, Erie County Medical Center (1981–1990)
  • Assistant Professor, University at Buffalo (1981–1987)
See All (15 Total) >
Awards and Honors:
  • SUNY Distinguished Professor (2011)
  • Visionary Innovator Award, University at Buffalo (2009)
  • Empire Clinical Research Investigator Program Award (2008)
  • Top 5% Reviewers, Journal of Infectious Diseases (2005)
  • UB Distinguished Professor (2004)
  • Outstanding Inventor Award, State University of New York (2002)
  • Who's Who in the World (2000)
  • Stockton Kimball Ward, University at Buffalo School of Medicine (2000)
  • Niagara Frontier Inventor of the Year (1998)
  • Niagara Frontier Inventor of the Year, semi-finalist (1996)
  • American Society for Clinical Investigation (1995)
  • Senior International Fellowship, Fogarty Center, NIH (1995)
  • Eastern Regional Young Investigator Award (1994)
  • Niagara Frontier Inventor of the Year (1992)
  • American Men and Women of Science (1991)
  • Who's Who in Science and Engineering (1990)
  • Sinsheimer Scholar Award (1982)
  • Teaching Excellence Citation, Tufts University School of Medicine (1980)
  • Alpha Omega Alpha, Tufts University School of Medicine (1975)

Research Expertise:
  • Bacterial infection in chronic obstructive pulmonary disease (COPD)
  • Haemophilus influenzae pathogenesis
  • Microbial pathogenesis within the respiratory tract
  • Moraxella catarrhalis pathogenesis
  • Vaccine development
Grants and Sponsored Research:
  • September 2014–August 2018
    Persistent H.influenza in COPD: virulence, vaccines, and antibiotic resistance
    NIAID
    Role: Principal Investigator
    $2,456,267
  • July 2012–June 2017
    Moraxella catarrhalis: virulence-based prevention
    NIDC
    Role: Principal Investigator
    $1,605,805
  • September 2011–August 2016
    Research in Infectious Diseases, Microbiology and Immunology for Medical Students. T35 Training grant.
    NIH, National Institute of Allergy and Infectious Diseases
    Role: Co-Principal Investigator
    $177,065
  • December 2013–November 2015
    Selective eradication of nasopharyngeal colonization to prevent otitis media
    NIDCD
    Role: Principal Investigator
    $448,061
  • January 1993–March 2014
    Bacterial infection in COPD
    Department of Veterans Affairs/Merit Review
    Role: Co-Investigator
    $750,000
  • January 2007–December 2012
    Pathogenesis of Haemophilus influenza Infections in COPD
    NIH
    Role: Principal Investigator
    $1,225,125
  • January 1983–December 2012
    Development of a vaccine for nontypeable H. influenzae and Pathogenesis of nontypeable Haemophilus influenzae(2RO1AI019641)
    NIH
    Role: Principal Investigator
    $1,250,000
  • January 1987–June 2012
    Development of a vaccine for Moraxella catarrhalis (RO1AI28304)Pathogenesis of Moraxella catarrhalis in chronic obstructive pulmonary disease (2R56AI1028304)
    NIH
    Role: Principal Investigator
    $1,250,000
  • May 2007–December 2007
    Genotyping Analysis of Streptococcus pneumoniae strains isolated from the PERSPECTIVE study.
    Sanofi-Aventis Pharmaceuticals
    Role: Principal Investigator
    $60,000
  • September 2002–August 2007
    Development of a vaccine for H. influenzae
    NIH
    Role: Principal Investigator
    $1,200,000
See All (10 Total) >
Patents:
  • Methods for Stimulating Immune Response against Moraxella catarrhalis (2010)
  • Vaccine for nontypeable Haemophilus influenzae infection (2008)
  • Method for detecting bacterial exacerbations of chronic lung disease (2004)
  • Peptide expression and delivery system (2000)
  • Gene encoding outer membrane protein B1 of Moraxella catarrhalis (1999)
  • Vaccine for Branhamella catarrhalis (1999)
  • Vaccine for Branhamella catarrhalis (1998)
  • Vaccine for Branhamella catarrhalis (1998)
  • Vaccine for Moraxella catarrhalis (1997)
  • Method for detecting Branhamella catarrhalis (1996)
  • Method for purifying an outer membrane protein of Haemophilus influenzae (1994)
  • DNA probe for the identification of Haemophilus influenzae (1992)

Evaluative Studies and Case Reports:
Journal Articles:
See All (129 Total) >

Professional Memberships:
  • American Society for Microbiology, Councilor at Large; Microbial pathogenesis (1996–1998)
  • American Federation for Medical Research, Institutional Representative (1988–1993)
  • American Association for the Advancement of Science
  • American Society for Clinical Investigation
  • Western New York American Society for Microbiology
  • American College of Physicians, Fellow
  • Infectious Diseases Society of America, Fellow
  • Alpha Omega Alpha Honor Medical Society
  • Buffalo Collegium of Immunology
Presentations:
  • "IgA proteases of nontypeable Haemophilus influenzae. Characterization of "new" putative virulence factors" Acute Respiratory Tract Infection Panel Meeting, US Japan Cooperative Medical Science Program (2009)
  • "Haemophilus influenzae in COPD: a uniquely adapted human pathogen" Center for Genomic Sciences, Allegheny General Hospital (2008)
  • "Clinical implications of nasopharyngeal bacterial colonization" Symposium International Congress of Infectious Diseases (2008)
  • "Mechanisms of recurrent bacterial infection in chronic obstructive pulmonary disease: a model of microbial evasion" Symposium General Meeting of the American Society for Microbiology (2008)
  • "Streptococcus pneumoniae in community acquired pneumonia: the case against placebo-controlled trials" 4th International Symposium on Resistant Gram-positive Infections (2008)
  • "Haemophilus influenzae and Moraxella catarrhalis in COPD: Pathogenesis and immunity" HinMax 2008-1st International Workshop on Haemophilus influenzae and Moraxella catarrhalis (2008)
  • "Mining the Moraxella catarrhalis genome: identification of potential vaccine antigens expressed during human infection" HinMax 2008-1st International Workshop on Haemophilus influenzae and Moraxella catarrhalis (2008)
  • "Upper and lower respiratory tract infections caused by Haemophilus influenzae and Moraxella catarrhalis" First Global Master Class on Childhood Bacterial Respiratory Diseases (2008)
  • "Bacterial infection in COPD" Grand Rounds, Erie County Medical Center (2008)
  • "Mining the Moraxella catarrhalis genome: Identification of potential vaccine antigens expressed during human infection" US Japan Cooperative Medical Science Program Acute Respiratory Tract Infection Panel Meeting (2008)
  • "Community acquired pneumonia and placebo controlled trials: Review of the literature and discussion of feasibility and potential value" Workshop on Community-acquired Pneumonia sponsored by the Infectious Diseases Society of America and FDA (2008)
  • "Pathogenesis of Haemophilus influenzae Infection, an Exclusively Human Pathogen" University of Rochester Department of Microbiology (2007)
  • "Bacterial infection in chronic obstructive pulmonary disease" University of Rochester Division of Infectious Diseases (2007)
  • "Pathogenesis of Haemophilus influenzae Infection, an Exclusively Human Pathogen" University of Texas at Austin Section of Molecular Genetics and Microbiology (2007)
  • "Bacterial Infection of the Respiratory Tract. New Observations Using New Methods" Wakayama University Department of Otolaryngology (2007)
  • "Pathogenesis of Haemophilus influenzae Infection, the Resurrection of IgA Protease" US Japan Cooperative Medical Science Program Acute Respiratory Tract Infection Panel Meeting (2007)
  • "Respiratory Tract Infections: A View Through the Molecular Looking Glass" Annual Meeting of the University at Buffalo School of Dental Medicine Alumni Association (2006)
  • "Bacterial Infection in Chronic Obstructive Pulmonary Disease: Is there a Role for Antibiotics and Vaccines?" Grand Rounds, Montefiore Medical Center (2006)
  • "Respiratory Tract Infections: A View Through the Molecular Looking Glass" University at Buffalo Academy on the Road Harrington Lecture (2006)
  • "Virulence Factors of Haemophilus influenzae in Chronic Obstructive Pulmonary Disease: A Genomics Approach" US Japan Cooperative Medical Science Program Acute Respiratory Tract Infection Panel Meeting (2006)
  • "Nontypeable Haemophilus influenzae in Adults with Chronic Obstructive Pulmonary Disease, a Persistent Pathogen" Symposium at 45th Interscience Conference on Antimicrobial Agents and Chemotherapy of the American Society for Microbiology (2005)
  • "Vaccine Development for Nontypeable Haemophilus influenzae: Feasibility of Prevention of Infection by a Persistent Pathogen" American Society for Microbiology Conference on Pasteurellaceae 2005 (2005)
  • "Bacterial Infection in Chronic Lung Disease: What You See Depends on How You Look!" UB This Summer Lecture Series (2005)
  • "An Ounce of Prevention: Vaccines Current and Future" Symposium American Thoracic Society International Conference (2005)
  • "Community Acquired Pneumonia" Grand Rounds. Erie County Medical Center (2005)
  • "Recent Developments in Vaccines" 27th Annual International Conference on Pediatric/Adult Allergy and Immunology (2004)
  • "Bacterial Infection in COPD: Beyond Sputum Cultures" University of Iowa, Department of Microbiology (2004)
  • "Update of Vaccines for Moraxella catarrhalis" NIH Workshop on Vaccines for Otitis Media: Overcoming Obstacles to Progress (2004)
  • "Development of a Vaccine for Moraxella catarrhalis" Department of Medicine Research Conference. University at Buffalo, SUNY (2004)
  • "Antibiotics for Upper Respiratory Tract Infections: When and When Not to Use Them" Upstate District Meeting of the American College of Physicians (2004)
  • "Persistent Colonization of the Respiratory Tract by Haemophilus influenzae in Chronic Obstructive Pulmonary Disease in Spite of Negative Sputum Cultures" 8th Annual Meeting of the Acute Respiratory Infection Panel of the U.S.-Japan Cooperative Medical Science Program (2004)
See All (31 Total) >
Service Activities:
  • Park School English Class/Scientific Writing; Contributor (2008)
  • Academic Medicine Services; Treasurer (2007)
  • Medical Research Board, Oishei Foundation Buffalo NY; Board Member (2007)
  • Infectious Diseases Festival for Junior Health Fellows; Buffalo VA Infectious Diseases Laboratories; Organizing Committee Member (2006)
  • American College of Physicians - American Society of Internal Medicine; Committee Member (2006)
  • Editorial Advisory Board, Journal of Infectious Diseases; Editorial Board Member (2006)
  • Niagara Frontier Inventor of the Year; Judge (2006)
  • Biosafety Committee, Buffalo VA Medical Center; Chair (2004–2009)
  • Infectious Diseases Society of America Committee on Acute Exacerbations of Chronic Obstructive Pulmonary Disease; with American Thoracic Society; Chair (2004–2005)
  • NIH Worship on Vaccines for Otitis Media; Organizing Committee Member (2004)
  • Leadership Council, American College of Physicians; Member (2004)
  • Eight International Symposium on Recent Advances in Otitis Media; Advisory Board (2003)
  • Eight International Symposium on Recent Advances in Otitis Media; Vaccine Panel; Panel Member (2003)
  • Infectious Diseases Society of America, Publications; Chair (2001–2004)
  • National Board of Medical Examiners; United States Medical Licensing Examination; Committee Member (2000–2003)
  • 4th Extraordinary International Symposium on Recent Advances in Otitis Media; Sendai, Japan; Advisor (2000–2001)
  • Infectious Diseases Society of America, Publications; Committee Member (1999–2004)
  • Infectious Diseases Medical Research Advisory Group; Department of Veterans Affairs; Advisory Committee (1999–2003)
  • Research Leadership Advisory Council; Member (1998–2009)
  • 7th International Symposium on Recent Advances in Otitis Media; Advisor (1998–1999)
  • American College of Physicians - American Society of Internal Medicine; Committee Member (1998)
  • NIAID-sponsored Symposium on CAP in adult and elderly populations; Co-Chair (1998)
  • US/Japan Co-operative Medical Science Program at NIH; Panel Member (1998)
  • American Society for Microbiology; Councilor (1996–1998)
  • NIH Bacteriology Mycology 2 Study Section; Chair (1992–1994)
  • Budget, Space and Equipment Subcommittee; Buffalo VAMC; Committee Member (1991–1994)
  • Research and Development Committee; Buffalo VAMC; Committee Member (1990–1993)
  • American Federation for Clinical Research; University Representative (1988–1993)
  • Infection Control Committee, Erie County Medical Center; Committee Member (1981–1987)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

Clinical and Translational Research Center
875 Ellicott St.
Room 6091
Buffalo, NY 14203
Phone: (716) 881-8911
Fax: (716) 854-1397
Email: murphyt@buffalo.edu


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