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Noreen                         Williams

Noreen Williams PhD

Department of Microbiology and Immunology

Professor

Specialty/Research Focus

Gene Expression; Infectious Disease; Microbial Pathogenesis; Microbiology; Molecular and Cellular Biology; Molecular Basis of Disease; Protein Function and Structure; Regulation of metabolism; RNA; Transcription and Translation

 
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Professional Summary:

Regulation of Gene Expression in Trypanosomes

Our laboratory uses molecular biological and biochemical approaches to study a group of parasitic protozoans that cause disease in humans and domestic animals in much of the tropical world. The major project focuses on Trypanosoma brucei, the causative agent of African sleeping sickness, which is transmitted by the tse-tse fly. Other projects focus on Trypanosoma cruzi, which causes Chagas disease in South and Central America and is transmitted by the reduviid bug. Treatment for these diseases is severely limited due to increasing drug resistance and issues of drug toxicity or lack of available drugs. The goal of our work is to discover and exploit critical events that occur in the parasite life cycle that may be used to prevent growth or transmission of the parasite.

The major project in the laboratory examines the ribosome, the complex molecular machine that drives protein synthesis. While many features of the ribosome and its assembly pathway are conserved in the parasites we study, we have identified a number of features in this pathway that are very different from the pathway in the human host. Our laboratory discovered a pair of trypanosome-specific RNA binding proteins, P34 and P37, which are essential to the formation of ribosomes only in these parasites. We have shown that these proteins interact with 5S rRNA and ribosomal protein L5 in a unique pre-ribosomal complex that is essential for ribosomal biogenesis and survival of the trypanosomes. Perhaps due to the presence of the trypanosome-specific proteins, P34 and P37, the normally conserved L5 protein also possesses unusual structural and functional characteristics. In addition, we have shown that P34 and P37 are required for the export of the large ribosomal subunit from the nucleus to the cytoplasm where it assembles into the fully functional ribosome required for protein synthesis.

The multiple roles of these trypanosome-specific proteins in the normally highly conserved pathway of ribosomal biogenesis is a surprising finding and may suggest that the interaction of these proteins with other components of the ribosomal assembly pathway can be developed as targets for chemotherapy. We have developed a fluorescence resonance energy transfer assay that allows us to study these interactions more closely. This method also allows us to develop a high throughput screen for small molecules that disrupt the complex in trypanosomes and do not harm the human host. Since little is known about the ribosome in trypanosomes, we are current collaborating in a project to examine the structure of the ribosome and intermediates in the pathway of assembly using cryo-EM. These experiments will provide important information about the unique features of the structure and function of the trypanosome ribosome. These studies will increase our understanding of the basic biology of the ribosome and further our discovery of potential drug targets.

More recently we have begun work characterizing this complex in the related parasite, T. cruzi with the idea that we may be able to use a similar approach to develop chemotherapeutic targets that would apply to the two related parasites, T. brucei and T. cruzi . In addition, we continue in a long standing collaboration with Dr. Beatriz Garat at the Universidad de la Républica in Uruguay, examining both DNA and RNA binding proteins which regulate gene expression in Trypanosoma cruzi.

Education and Training:
  • Postdoctoral Fellow, Biological Sciences, Johns Hopkins University/McCollum Pratt Institute (1987)
  • Postdoctoral Fellow, Biological Chemistry, Johns Hopkins School of Medicine (1984)
  • PhD, Biochem/Mol. Biol., New York University (1981)
  • BS, University of Maine (1977)
Employment:
  • Vice Chair, Microbiology and Immunology, University at Buffalo (2013-present)
  • Professor, Microbiology and Immunology, Unviersity at Buffalo (2002-present)
  • Associate Professor, Microbiology and Immunology, University at Buffalo (1998–2002)
  • Assistant Professor, University at Buffalo (1992–1997)
  • Assistant Professor, USUHS (1987–1992)
Awards and Honors:
  • Ellison Foundation Visiting Scholar (2003)
  • National Research Council Award (1987)
  • National Research Service Award (1984)
  • Summer Fellowship, New York University (1981)
  • Summer Fellowship, New York University (1980)

Research Centers:
  • Witebsky Center for Microbial Pathogenesis and Immunology
UB 2020 Strategic Strengths:
  • Molecular Recognition in Biological Systems and Bioinformatics
  • Extreme Events: Mitigation and Response
Grants and Sponsored Research:
  • May 2014–May 2019
    Ribosome biogenesis in trypanosomes
    NIH
    Role: Principal Investigator
  • July 1999–June 2015
    Training in Microbial Pathogenesis
    National Institute of Allergy and Infectious Diseases
    Role: Co-Investigator
  • April 2010–April 2015
    A novel preribosomal complex in trypanosomes supplement for underrepresented minorities
    NIH
    Role: Principal Investigator
  • April 2010–March 2015
    A novel preribosomal complex in trypanosomes
    NIH
    Role: Principal Investigator
  • July 2010–June 2013
    Ribosomal biogenesis at a chemotherapeutic target for T. cruzi
    American Heart Association
    Role: Principal Investigator
  • April 2004–March 2011
    Trypanosome RNA binding proteins
    NIH
    Role: Co-Investigator
  • March 2002–February 2007
    Biogenesis of the T. brucei Mitochondrial ATP Synthase
    NIH
    Role: Principal Investigator
    $1,537,920
  • September 2001–August 2006
    Training-Infectious Disease, Microbiology, and Immunology for Medical Students
    State University of New York at Buffalo
    Role: Consultant
    $213,900
  • July 2001–June 2004
    Single-stranded Binding Proteins in Trypanosoma cruzi
    NIH/Fogarty FIRCA
    Role: Principal Investigator
    $118,108
  • April 1999–March 2004
    Developmental Regulation of DNA/RNA Binding Proteins
    NIH
    Role: Principal Investigator
    $885,006
  • July 2001–June 2002
    UB Graduate Group Award
    Buffalo DNA Replication Graduate Group
    Role: Co-Principal Investigator
    $3,000
  • June 1996–May 2002
    Training Program in Peridontal Disease
    National Institute for Dental & Craniofacial Research
    Role: Consultant
    $1,165,033
  • December 1992–November 1999
    Control and Development of Parasite Energy Metabolism
    NIH
    Role: Principal Investigator
    $740,665
  • January 1994–January 1999
    Markey Foundation Award
    Markey Foundation Award
    Role: Contributor
    $1,000,000
  • May 1995–April 1996
    Characterization of a Novel DNA Polymerase from Trypanosoma brucei
    UB Multidisciplinary Pilot Project Program
    Role: Principal Investigator
    $20,000
  • August 1992–August 1995
    Energy Matabolism of Trypanosoma brucei
    Research Competition Award, UB Intramural
    Role: Principal Investigator
    $50,000
  • September 1989–January 1993
    Structure, Function, and Developmental Regulation of T. brucei
    National Science Foundation
    Role: Principal Investigator
    $215,000
  • April 1988–September 1991
    H+-ATPase from T. brucei: Isolation and Characterization
    USUHS
    Role: Principal Investigator
    $103,750
  • October 1987–March 1988
    H+-ATPase: Structure and Function of the Active Site
    USUHS
    Role: Principal Investigator
    $13,500
See All (19 Total) >

Journal Articles:
See All (40 Total) >
Abstracts:
  • Umaer, K and Williams N. Kinetoplast specific RNA-protein interactions in Trypanosoma cruzi ribosome biogenesis. Woods Hole Molecular Parasitology meeting. 2014.
  • Kamina, A and Williams N. Mutagenesis analysis of a pre-ribosomal complex in Trypanosoma brucei. Woods Hole Molecular Parasitology Meeting. 2013.
  • Umaer, K, Ciganda, M. and Williams N. Functional analysis of ribosomal protein L5 in Trypanosoma brucei. Woods Hole Molecular Parasitology Meeting. 2013.
  • Umaer, K and Williams N. Characterization of a preribosomal particle in Trypanosoma brucei and Trypanosoma cruzi. Woods Hole Molecular Parasitology Meeting. 2012.
  • Wang, L and Williams N. Dissecting molecular interactions in a novel preribosomal particel in T. brucei. Woods Hole Molecular Parasitology Meeting. 2011.
  • Wang, L and Williams N. Dissecting molecular interactions in a novel preribosomal particle. Kinetoplastid Molecular Cell Biology Meeting. 2011.
  • Ciganda, M and Williams N. Characterization of two 5S rRNA-binding proteins in Trypanosoma brucei and their role in ribosome biogenesis. Woods Hole Molecular Parasitology Meeting. 2010.
  • Wang, L and Williams N. The role of trypanosome-specific proteins P34 and P37 in ribosomal biogenesis. Woods Hole Molecular Parasitology Meeting. 2010.
  • Ciganda, M. Hellman, K, and Williams N. Two RNA-binding proteins involved in ribosome biogenesis in Trypanosoma brucei. Kinetoplastid Molecular Cell Biology Meeting. 2007.
  • Li, J., William Ruyechan, Noreen Williams. Differential regulation of two homologous nucleic acid binding proteins in T. brucei, p34 and p37. 2nd Internatioinal Conference on proteins that Bind RNA, Austin/Lake Travis, Texas. 2001.
  • Li, J., William Ruyechan, Noreen Williams. Differential regulation of two homologous RNA binding proteins in T. brucei, p34 and p37. RNA Society Meeting, Banff, Alberta. 2001.
  • Hellman, K., William Ruyechan, Noreen Williams. Characterization of the RNA binding properties and protein-protein interactions of p34 and p37 from Trypanosoma brucei. RNA Society Meeting, Banff, Alberta. 2001.
  • Pitula, J., William Ruyechan, Noreen Williams. Two families of RNA binding proteins from Trypanosoma brucei associate in a complex which contains 5S rRNA. RNA Society Meeting, Madison Wisconsin. 2000.
  • Li, J., William Ruyechan, Noreen Williams. Differential regulation of two homologous RNA binding proteins in Trypanosoma brucei, p34 and p37. RNA Society Meeting, Madison, Wisconsin. 2000.
  • Pitula, J., William Ruyechan, Noreen Williams. Two novel RNA binding proteins from Trypanosoma brucei. RNA Society Meeting, Edinburgh, Scotland. 1999.
  • Brown, S.V., Noreen Williams. Regulation of the Trypanosoma brucei ATP synthase beta subunit. FASEB J.. 1997; 11.
  • Zhang, J., William Ruyechan, Noreen Williams. Characterization of Trypanosoma brucei Single-Strand Nucleic Acid Binding Proteins p34 and p37. Global Meeting on Parasitic Disease, New Delhi, India. 1996.
  • Brown, S.V., Chi, T.B., Tanaka, M., Noreen Williams. The Mitochondrial ATP Synthase of Trypanosoma brucei: Regulation and Genetic Mapping. Biophys. J.. 1995; 68.
  • Sondej, M., Noreen Williams. Regulation of the Mannose Phosphotransferase System in Escherichia coli. 95th ASM General Meeting. 1995.
  • Noreen Williams. Regulation and Characterization of the Trypanosoma brucei ATP Synthase. International Congress of Protozoology Reports, Berlin, Germany. 1993.
  • William Ruyechan, Noreen Williams. DNA binding Proteins of Trypanosoma brucei. International Congress of Protozoology, Berlin, Ge rmany. 1993.
  • Sondej, M., Noreen Williams. The Escherichia coli Pel Protein: Its Role in lambda Phage Penetration and Mannose Transport. 93rd ASM General Meeting. 1993.
  • Noreen Williams, Frank, P.H.. Developmental Regulation and Characterization of the Trypanosoma brucei ATP Synthase. Biophys. J.. 1992; 61.
  • Noreen Williams, Frank, P.H.. The mitochondrial ATP synthase of Trypanosoma brucei. Biophys. J.. 1990; 57.
  • Noreen Williams, Frank, P.H.. The mitochondrial ATP synthase from Trypanosoma brucei. 6th EBEC Meetings Short Reports, Noordwijkerhout, The Netherlands. 1990.
  • Noreen Williams, Fox, D.K., Roseman, S.. The E. coli mannose phosphotransferase system (PTS): Molecular cloning and identification pf products of the ptsM locus. Fed. Proc.. 1986; 45.
  • Pedersen, P.L., Noreen Williams, Hullihen, J.. Relationship of ligand binding properties of ATP synthase (F1) of rat liver to the enzyme structure and mechanism. 4th EBEC Meeting Short Reports, Prague, Czechoslovakia. 1986.
  • Noreen Williams, Pedersen, P.L.. Magnesium binding to the purified F1-ATPase of rat liver mitochondria -Implications for function. Biophysical J.. 1985; 47.
  • Kaplan, R.S., Noreen Williams, Hullihen, J., McEnery, M., Nakashima, R.A., Paggi, M., Pedersen, P.L.. Anion transport, ATP synthesis, and ATP export in liver mitochondria-Recent progress on molecular components catalyzing these processes. Short Reports of the Third EBEC Meeting, Hanover, Germany. 1984; A.
  • Noreen Williams, Pedersen, P.L.. Structure of the H+-ATPase of liver mitochondria: Interaction of the gamma subunit with both the alpha and beta subunits. Biophysical J.. 1983; 41.
  • Coleman, P.S., Noreen Williams. Probing the mechanism of the rat liver F1-ATPase by benzoyl ATP. Biophysical J.. 1982; 37.
  • Noreen Williams, Coleman, P.S.. Photoaffinity labelling of specific subunits of mitochondrial F1-ATPase by benzoylbenzoic ATP. Fed. Proc.. 1981; 40.
  • Noreen Williams, Coleman, P.S.. Benzophenone derivatives of adenine nucleotides as new photoaffinity probes for the F1-ATPase binding site studies. Fed. Proc.. 1980; 39.
See All (33 Total) >
Books and Book Chapters:
  • Noreen Williams, Hullihen, J., Pedersen, P.L.. Mitochondrial ATP synthase: Role of metal binding in structure and function. Ion Pumps: Structure, Function and Regulation. 1988.

Professional Memberships:
  • NIH Tropical Medicine and Parasitology Study Section; member, ad hoc 2000 (2000)
  • The RNA Society; member (1999)
  • NIH International and Cooperative Projects Study Section; Chair 2000-2001, Member 1996-2001, ad hoc Member 2001-2002 Chair Special Study Section 2002 (1996–2002)
  • American Society for Tropical Health and Hygiene; member (1993)
  • Editorial Board, Journal of Bioenergetics and Biomembranes; member (1991)
  • American Association for the Advancement of Science; Member (1990)
  • American Society for Microbiology; member; president of Western New York branch ASM, 1995-1997 (1986)
  • American Society for Biochemistry and Molecular Biology; member (1986)
  • Biophysical Society (The Bioenergetics Subgroup_; member (1980–1998)
  • New York Academy of Science; member (1978)
Presentations:
  • "FRET analysis of a preribosomal particle in T. brucei" Woods Hole Meeting on Molecular Parasitology (2012)
  • "Trypanosoma brucei ribosomal biogenesis pathway: conserved and not conserved" Columbia University, Columbia University (2012)
  • "Molecular interactions in a preribosomal particle in T. brucei" Woods Hole Meeting on Molecular Parasitology (2011)
  • "A novel preribosomal particle in Trypanosoma brucei" Woods Hole Meeting on Molecular Parasitology (2009)
  • "Trypanosoma brucei RNA binding proteins, p34 and p37, are essential components of the ribosomal biogenesis pathway" Woods Hole Meeting on Molecular Parasitology (2008)
  • "Novel Approaches" Woods Hole Meeting on Molecular Parasitology (2007)
  • "Multitasking RNA Binding Proteins in Trypanosoma brucei: How Do They Do It All ?" Drexel University School of Medicine (2006)
  • "T. brucei RNA binding proteins, p34 and p37, regulate the cellular localization of NOPP44/46" Woods Hole Meeting on Molecular Parasitology (2006)
  • "Biochemistry" Woods Hole Meeting on Molecular Parasitology (2005)
  • "Developmental regulation of the Trypanosoma brucei ATP synthase is mediated by subunit transcript levels" Woods Hole Meeting on Molecular Parasitology (2005)
  • "Intertwined studies of function and developmental regulation of two trypanosome RNA binding proteins" University of South Alabama (2005)
  • "Function and developmental regulation of two RNA binding proteins" Universidad de la Républica, Universidad de la Républica, Dept. of Biochemistry, Montevideo, Uruguay (2004)
  • "Function and developmental regulation of two RNA binding proteins" Instituto de Biologia Molecular do Parana, Instituto de Biologia Molecular do Parana, Instituto de Biologia Molecular do Parana (2004)
  • "Post- transcriptional regulation of two closely related RNA binding proteins by their 3’ untranslated regions in Trypanosoma brucei" Woods Hole Meeting on Molecular Parasitology (2004)
  • "RNA Editing and Splicing" Woods Hole Meeting on Molecular Parasitology, RNA Editing and Splicing (2004)
  • "Intertwined studies of function and developmental regulation of two trypanosome RNA binding proteins" West Virginia University, Dept of Biochemistry and Molecular Pharmacology, West Virginia University (2003)
  • "Intertwined studies of function and developmental regulation of two trypanosome RNA binding proteins" Ellison Visiting Scholar Seminar Series, Marine Biological Laboratory, Global Infectious Diseases Laboratory (2003)
  • "A study of two novel RNA binding proteins in trypanosome ribosomal biogenesis" Woods Hole Meeting on Molecular Parasitology (2003)
  • "The 3'UTR regulates developmental expression of p34 and p37 in Trypanosoma brucei" Woods Hole Meeting on Molecular Parasitology (2003)
  • "Analysis of the role of two RNA binding proteins in ribosome biogenesis in trypansomes" Ribosome 2003, RNA Society (2003)
  • "Post-transcriptional Regulation of p34 and p37 in Trypanosoma brucei" Tetra-state Trypanosome Meeting, Rockefeller University, Rockefeller University (2003)
  • "Protein-protein and protein -RNA interactions of T. brucei p34 and p37" Tetra-state Trypanosome Meeting, Rockefeller University, Rockefeller University (2003)
  • "Translational and posttranslational regulation of T. brucei RNA binding proteins p34 and p37" Tetra-State Trypanosome Meeting, Rockefeller University, Rocekfeller University (2003)
  • "Intertwined studies of function and developmental regulation of two trypanosome RNA binding proteins" New York State Department of Health, Wadsworth Center, Axelrod Institute for Public Health (2003)
  • "RNAi and RNA Stability" Woods Hole Meeting on Molecular Parasitology, RNAi and RNA Stability (2003)
  • "Intertwined studies of function and developmental regulation of two trypanosome RNA binding proteins" University of Vermont, University of Vermont, Dept of Microbiology and Molecular Genetics (2002)
  • "Functional Analysis of two RNA binding proteins, p34 and p37, from T. brucei" Woods Hole Meeting on Molecular Parasitology (2002)
  • "Function and Regulation of Two 5S rRNA Binding Proteins from Trypanosoma brucei, p34 and p37" Universidad de la Républica, Montevideo, Uruguay, Universidad de la Républica, Dept. of Biochemistry (2002)
  • "Differential regulation of two homologous RNA binding proteins in T. brucei, p34 and p37" Woods Hole Meeting on Molecular Parasitology (2001)
  • "Genetic regulation of the Trypanosoma brucei mitochondrial ATP synthase" Woods Hole Meeting on Molecular Parasitology (2000)
  • "Two families of developmentally regulated RNA binding proteins from Trypanosoma brucei associate in a complex which contains 5S rRNA" Woods Hole Meeting on Molecular Parasitology (2000)
  • "Tropical parasites: Microbes on the move" Buffalo Museum of Science (2000)
  • "Two Trypanosoma brucei RNA binding proteins in search of a target" UMDNJ (2000)
  • "Two novel RNA binding proteins from Trypanosoma brucei" Woods Hole Meeting on Molecular Parasitology (1999)
  • "Developmental regulation of two RNA binding proteins in Trypanosoma brucei" Rockefeller University (1998)
  • "Life cycle regulation of two RNA binding proteins in Trypanosoma brucei" University at Buffalo, Dept. of Biology (1997)
  • "Mitochondrial DNA polymerases in T. brucei" Buffalo DNA Replication Graduate Group (1997)
  • "Characterization of Trypanosoma brucei single-strand nucleic acid binding proteins p34 and p37" Global Meeting on Parasitology (1996)
  • "Pathways, targets, and resistance, I." Woods Hole Meeting on Molecular Parasitology (1995)
  • "The mitochondrial ATP synthase of Trypanosoma brucei: Regulation and genetic mapping" Biophysical Society (1995)
  • "ATP synthesis: How a parasite regulates a complex enzyme" University at Buffalo, Dept. of Microbiology (1994)
  • "ATP synthesis: How a parasite regulates a complex enzyme" University at Buffalo, Dept. of Biophysics (1994)
  • "Making ATP: How a parasite regulates a complex enzyme" University at Buffalo, Center for Advanced Molecular Biology and Immunology (1994)
  • "Regulation and characterization of the Trypanosoma brucei ATP synthase" International Congress on Protozoology (1993)
  • "Characterization and developmental regulation of the mitochondrial ATP synthase of Trypanosoma brucei" University of Buffalo, Dept. of Biochemistry (1991)
  • "Developmental regulation of the Trypanosoma brucei ATP synthase" University of Pennsylvania Medical Center Hershey, Cell Biology (1990)
  • "Regulation of the mitochondrial ATP synthase of Trypanosoma brucei" USUHS, Dept. of Microbiology (1990)
  • "The mitochondrial ATP synthase of Trypanosoma brucei" Biophysical Society (1990)
  • "The mitochondrial ATP synthase of Trypanosoma brucei" University of New Mexico, Dept. of Biochemistry (1990)
  • "The mitochondrial ATP synthase of Trypanosoma brucei" NIH Parasitology Section (1989)
See All (50 Total) >
Service Activities:
  • School of Medicine & Biomedical Sciences Unqualified Promotions; Chair (2013–2014)
  • School of Medicine & Biomedical Sciences Unqualified Promotions; Member (2012–2015)
  • Microbiology and Immunology, School of Medicine & Biomedical Sciences Graduate Affairs; Member (2012)
  • Microbiology and Immunology, School of Medicine & Biomedical Sciences Appointment and Promotions; Chair (2008)
  • School of Medicine & Biomedical Sciences Unqualified Promotions; Member (2006–2009)
  • Microbiology and Immunology, School of Medicine & Biomedical Sciences IFR; Member (2006–2011)
  • Microbiology and Immunology, School of Medicine & Biomedical Sciences Graduate Affairs; Chair (2006–2008)
  • School of Medicine & Biomedical Sciences Executive Commitee; Member (2004–2005)
  • School of Medicine & Biomedical Sciences Faculty Council Steering Committee; Member (2004–2005)
  • School of Medicine & Biomedical Sciences Unqualified Promotions; Member (2003–2006)
  • School of Medicine & Biomedical Sciences Faculty Council; Member (2003–2005)
  • School of Medicine & Biomedical Sciences Apppointment, Promotions,Tenure & Privileges; Member (2003)
  • Microbiology and Immunology, School of Medicine & Biomedical Sciences Graduate Affairs (2002–2010)
  • School of Medicine & Biomedical Sciences Unqualified Promotions; Member (1998–2001)
  • School of Medicine & Biomedical Sciences Election & Bylaws; Member (1995–2000)
  • School of Medicine & Biomedical Sciences Admissions Committee; Member (1992–1993)
  • Organizer International Molecular Parasitology Meeting; Organizing Committee Member (2010–2013)
  • Review Panel for Interdisciplinary Research and Creative Activity Fund; University at Buffalo; Member (2008)
  • NIH Infectious Disease Physician Scientist Program; Advisor (2003–2006)
  • NIH Biomedical Summer Undergraduate Research Experience; Member (2001–2005)
  • Annual Buffalo RNA Graduate Group Spring Forum; Organizing Committee Member (2001–2002)
  • Mock Study Section Review Panel; sponsored by the Office of the Vice President for Research,University at Buffalo; Panel Member (2001)
  • Witebsky Center for Microbial Pathogenesis and Immunology; Ex-officio member of all Witebsky Center Committees; Member Microbial Pathogenesis Training Grant Committee 1998-present; Member organizing committee Fall Immunology Meeting; Director (2000–2002)
  • Provost's Associate Professor Advisory Board; University at Buffalo; Member (2000–2002)
  • RNA Graduate Group; Co-Founder (2000–2002)
  • Buffalo Museum of Science Microbiology Presentations in association with Mi; UB Liason and Presenter; Organizing Committee Member (2000)
  • Inquiry Program West Seneca Schools, Microbiology Program, 6th grade; organizer; Other (1999)
  • Wellcome Trust Fund; Reviewer (1999)
  • Divine Child School, Microbiology Program; Presentor (1998–2000)
  • Review Panel for Conferences in the Disciplines; University at Buffalo; Member (1998–1999)
  • National Heart Blood and Lung Minority Undergraduate Research Program; summer 1997, 1998, 1999, 2000, 2001; Student Mentor (1997–2001)
  • Williamsville High School; Student Mentor (1997–1998)
  • Upward Bound; seminar speaker; Advisory Board (1997)
  • Upward Bound Microbiology Session; Summer 1996, 1997; Organizing Committee Member (1996–1997)
  • Program Committee, Taking Our Daughters to Work at UB; University at Buffalo; Co-Chair (1996–1999)
  • Upward Bound Science Fair; Judge (1996)
  • DNA Replication Graduate Group; Co-Founder (1995–2004)
  • Minority High School Student Research Apprentice Program; Student Mentor (1994)
  • Advisory Board for Upward Bound Math and Science Regional Center; Member (1994–1998)
  • Howard Hughes Undergraduate Biological Sciences Program; Student Mentor (1994–1997)
  • Medical School Research Day; University at Buffalo; Judge (1993)
  • CAMBI Summer Mentorship Program; Student Mentor (1992)
  • Advanced Techniques Course, Center for Advanced Molecular Biology and Immun; Director (1992)
  • Faculty Advisorto First Year Medical Students; Uniformed Services University; Advisor (1989–1990)
  • Thomas Jefferson High School for Science and Technology mentorship program; mentor; Student Mentor (1988–1990)
  • Advance Member; Uniformed Services University--(self-evaluation retreat); Member (1988)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

253 Biomedical Research Building
Buffalo, NY 14214
Phone: (716) 829-2279
Email: nw1@buffalo.edu


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