Paola Ghione MD
Paola Ghione
MD
Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Cell growth, differentiation and development; Gene Expression; Hematology - Clinical Pathology; Immunology; Molecular and Cellular Biology; Oncology
Professional Summary:
I am a hematologist specialized in the care of Lymphoma. I take care of people with Hodgkin and non-Hodgkin lymphoma, cutaneous lymphomas and chronic lymphoid leukemia. My research is focused on clinical trials and correlative work to improve quality of life and survival of people with these diseases.
Education and Training:
- Fellowship, Lymphoma, Memorial Sloan Kettering Cancer Center (2020)
- Fellowship, Hematology Oncology, University of Torino (2017)
- MD, Medicine and Surgery, University of Torino, Summa Cum Laude (2011)
Employment:
- Assistant Professor of Oncology, Department of Medicine, Roswell Park Comprehensive Cancer Center Roswell Park Graduate Division (2020-present)
Awards and Honors:
- 15-ICML travel grant for 10 best abstracts (2019)
Research Expertise:
- cutaneous lymphoma
- Hodgkin lymphoma
- T cell lymphoma
Journal Articles:
- Ghione P, Faruque P, Mehta-Shah N, Seshan V, Ozkaya N, Bhaskar S, Yeung J, Spinner MA, Lunning M, Inghirami G, Moskowitz A, Galasso N, Ganesan N, van der Weyden C, Ruan J, Prince HM, Trotman J, Advani R, Dogan A, Horwitz S. (2020) T follicular helper phenotype predicts response to histone deacetylase inhibitors in relapsed/refractory peripheral T-cell lymphoma. Blood Adv (Oct), 4(19): 4640-4647.
- Ghione P, Qi S, Imber BS, Seshan V, Moskowitz A, Galasso N, Lunning M, Straus D, Sauter C, Dahi P, Dogan A, Yahalom J, Horwitz S. (2020) Modified SMILE (mSMILE) and intensity-modulated radiotherapy (IMRT) for extranodal NK-T lymphoma nasal type in a single-center population. Leuk Lymphoma (Aug)1-11.
- Bobillo S, Joffe E, Lavery JA, Sermer D, Ghione P, Noy A, Caron PC, Hamilton AM, Hamlin PA, Horwitz SM, Kumar A, Matasar MJ, Moskowitz AJ, Owens C, Palomba ML, Batlevi C, Straus DJ, von Keudell G, Zelenetz AD, Yahalom J, Dogan A, Seshan VE, Younes A. (2020) Clinical Characteristics and Outcomes of Extranodal Stage I Diffuse Large B Cell Lymphoma in The Rituximab-Era. Blood (Jul).
- Ferrero S, Rossi D, Rinaldi A, Bruscaggin A, Spina V, Eskelund CW, Evangelista A, Moia R, Kwee I, Dahl C, Di Rocco A, Stefoni V, Diop F, Favini C, Ghione P, Mahmoud AM, Schipani M, Kolstad A, Barbero D, Novero D, Paulli M, Zamò A, Jerkeman M, da Silva MG, Santoro A, Molinari A, Ferreri A, Grønbæk K, Piccin A, Cortelazzo S, Bertoni F, Ladetto M, Gaidano G. (2020) KMT2D mutations and TP53 disruptions are poor prognostic biomarkers in mantle cell lymphoma receiving high-dose therapy: a FIL study. Haematologica (Jun), 105(6): 1604-1612.
- Fiore D, Cappelli LV, Zumbo P, Phillips JM, Liu Z, Cheng S, Yoffe L, Ghione P, Di Maggio F, Dogan A, Khodos I, de Stanchina E, Casano J, Kayembe C, Tam W, Betel D, Foa' R, Cerchietti L, Rabadan R, Horwitz S, Weinstock DM, Inghirami G. (2020) A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries. Cancers (Basel) (Jun), 12(6).
- Toure A, Ghione P, Phillips S, Klute K, Leonard JP, Martin P. (2020) Lymphoma Study Titles on ClinicalTrials.gov Lack Details Necessary for Study Identification. Clin Lymphoma Myeloma Leuk (Jan), 20(2): 82-86.
- Mato AR, Roeker LE, Lamanna N, Allan JN, Leslie L, Pagel JM, Patel K, Osterborg A, Wojenski D, Kamdar M, Huntington SF, Davids MS, Brown JR, Antic D, Jacobs R, Ahn IE, Pu J, Isaac KM, Barr PM, Ujjani CS, Geyer MB, Berman E, Zelenetz AD, Malakhov N, Furman RR, Koropsak M, Bailey N, Hanson L, Perini GF, Ma S, Ryan CE, Wiestner A, Portell CA, Shadman M, Chong EA, Brander DM, Sundaram S, Seddon AN, Seymour E, Patel M, Martinez-Calle N, Munir T, Walewska R, Broom A, Walter H, El-Sharkawi D, Parry H, Wilson MR, Patten PEM, Hernández-Rivas JÃ, Miras F, Fernández Escalada N, Ghione P, Nabhan C, Lebowitz S, Bhavsar E, López-Jiménez J, Naya D, Garcia-Marco JA, SkÃ¥nland SS, Cordoba R, Eyre TA. (2020) Outcomes of COVID-19 in patients with CLL: a multicenter international experience. Blood (Jan), 136(10): 1134-1143.
- Cordeiro PG, Ghione P, Ni A, Hu Q, Ganesan N, Galasso N, Dogan A, Horwitz SM. (2020) Risk of breast implant associated anaplastic large cell lymphoma (BIA-ALCL) in a cohort of 3546 women prospectively followed long term after reconstruction with textured breast implants. J Plast Reconstr Aesthet Surg (Jan), 73(5): 841-846.
- Ghione P, Moskowitz AJ, De Paola NEK, Horwitz SM, Ruella M. (2018) Novel Immunotherapies for T Cell Lymphoma and Leukemia. Curr Hematol Malig Rep (Dec), 13(6): 494-506.
- Teater M, Dominguez PM, Redmond D, Chen Z, Ennishi D, Scott DW, Cimmino L, Ghione P, Chaudhuri J, Gascoyne RD, Aifantis I, Inghirami G, Elemento O, Melnick A, Shaknovich R. (2018) AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis. Nat Commun (Jan), 9(1): 222-222.
- Olivieri J, Mosna F, Pelosini M, Fama A, Rattotti S, Giannoccaro M, Carli G, Tisi MC, Ferrero S, Sgherza N, Mazzone AM, Marino D, Calimeri T, Loseto G, Saraceni F, Tomei G, Sica S, Perali G, Codeluppi K, Billio A, Olivieri A, Orciuolo E, Matera R, Stefani PM, Borghero C, Ghione P, Cascavilla N, Lanza F, Chiusolo P, Finotto S, Federici I, Gherlinzoni F, Centurioni R, Fanin R, Zaja F. (2018) A Comparison of the Conditioning Regimens BEAM and FEAM for Autologous Hematopoietic Stem Cell Transplantation in Lymphoma: An Observational Study on 1038 Patients From Fondazione Italiana Linfomi. Biol Blood Marrow Transplant (Jan), 24(9): 1814-1822.
- Rutherford SC, Li V, Ghione P, Chen Z, Martin P, Leonard JP. (2017) Bone marrow biopsies do not impact response assessment for follicular lymphoma patients treated on clinical trials. Br J Haematol (Oct), 179(2): 242-245.
- Martin P, Ghione P, Dreyling M. (2017) Mantle cell lymphoma - Current standards of care and future directions. Cancer Treat Rev (Jul), 58: 51-60.
- Mondello P, Steiner N, Willenbacher W, Wasle I, Zaja F, Zambello R, Visentin A, Mauro E, Ferrero S, Ghione P, Pitini V, Cuzzocrea S, Mian M. (2016) Bendamustine plus rituximab versus R-CHOP as first-line treatment for patients with indolent non-Hodgkin's lymphoma: evidence from a multicenter, retrospective study. Ann Hematol (Jun), 95(7): 1107-1114.
- Ferrero S, Pastore A, Scholz CW, Forstpointner R, Pezzutto A, Bergmann L, Trümper L, Finke J, Keller U, Ghione P, Passera R, Hiddemann W, Weigert O, Unterhalt M, Dreyling M. (2016) Radioimmunotherapy in relapsed/refractory mantle cell lymphoma patients: final results of a European MCL Network Phase II Trial. Leukemia (Apr), 30(4): 984-987.
- Culjkovic-Kraljacic B, Fernando TM, Marullo R, Calvo-Vidal N, Verma A, Yang S, Tabbò F, Gaudiano M, Zahreddine H, Goldstein RL, Patel J, Taldone T, Chiosis G, Ladetto M, Ghione P, Machiorlatti R, Elemento O, Inghirami G, Melnick A, Borden KL, Cerchietti L. (2016) Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas. Blood (Feb), 127(7): 858-868.
- Mondello P, Steiner N, Willenbacher W, Ferrero S, Ghione P, Marabese A, Pitini V, Cuzzocrea S, Mian M. (2016) Lenalidomide in Relapsed or Refractory Diffuse Large B-Cell Lymphoma: Is It a Valid Treatment Option?. Oncologist (Jan), 21(9): 1107-1112.
- Drandi D, Kubiczkova-Besse L, Ferrero S, Dani N, Passera R, Mantoan B, Gambella M, Monitillo L, Saraci E, Ghione P, Genuardi E, Barbero D, Omedè P, Barberio D, Hajek R, Vitolo U, Palumbo A, Cortelazzo S, Boccadoro M, Inghirami G, Ladetto M. (2015) Minimal Residual Disease Detection by Droplet Digital PCR in Multiple Myeloma, Mantle Cell Lymphoma, and Follicular Lymphoma: A Comparison with Real-Time PCR. J Mol Diagn (Nov), 17(6): 652-660.
- Tedeschi A, Picardi P, Ferrero S, Benevolo G, Margiotta Casaluci G, Varettoni M, Baratè C, Motta M, Gini G, Goldaniga MC, Visco C, Zaja F, Belsito Petrizi V, Ravelli E, Gentile M, Urbano MA, Franceschetti S, Ghione P, Orsucci L, Frustaci AM, Gaidano G, Vitolo U, Morra E. (2015) Bendamustine and rituximab combination is safe and effective as salvage regimen in Waldenström macroglobulinemia. Leuk Lymphoma (Mar), 56(9): 2637-2642.
- Ferrero S, Capello D, Svaldi M, Boi M, Gatti D, Drandi D, Rossi D, Barbiero S, Mantoan B, Mantella E, Zanni M, Ghione P, Larocca A, Passera R, Bertoni F, Gattei V, Forconi F, Laurenti L, Del Poeta G, Marasca R, Cortelazzo S, Gaidano G, Palumbo A, Boccadoro M, Ladetto M. (2012) Multiple myeloma shows no intra-disease clustering of immunoglobulin heavy chain genes. Haematologica (Jun), 97(6): 849-853.
Presentations:
- "Risk of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) in a cohort of 3,546 women prospectively followed after receiving textured breast implants." Lugano, 15-ICML; ; T cell lymphoma (2019)
Service Activities:
- Biomdedical Research; Member (2020–present)