Paul R. Knight III MD, PhD
Paul R. Knight III
MD, PhD
Distinguished Professor of Anesthesiology and Microbiology
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Anesthesiology
Contact Information
Patient Care
Patient Care
This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.
View this physician on UBMDEducation and Training:
- Residency, Anesthesiology, Milton S. Hershey Medical Center (1977)
- Residency, Surgery, Milton S. Hershey Medical Center (1975)
- MD, Medicine, Pennsylvania State University (1973)
- PhD, Virology and host response, Pennsylvania State University (1973)
- Fellowship, Microbiology, Pennsylvania State College of Medicine (1972)
Employment:
- SUNY Distinguished Professor, Anesthesiology, Microbiology and Immunology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2013-present)
- Associate Chair for Research, Anesthesiology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1998-present)
- UB Distinguished Professor, Anesthesiology, Microbiology and Immunology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2011–2013)
- Professor, Anesthesiology and Microbiology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1992–2011)
- Professor and Chair, Anesthesiology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1992–1998)
- Research Professor, Epidemiology, University of Michigan School of Public Health (1977–1992)
- Senior Associate Chair for Academic affairs, Anesthesiology, University of Michigan School of Medicine (1977–1992)
Grants and Sponsored Research:
- July 2012–June 2017
Anesthesiology Research Training Grant
US Department of Health, Education and Welfare
Role: Principal Investigator - March 2007–April 2012
Pathogenesis of Aspiration Pneumonitis
NIH
Role: Principal Investigator
$1,981,250 - July 2009–June 2011
Influenza Therapy by Au-nanorod 5'PPP-NSI-siRNA/cDNA targeting of bronchial cells
US Dept of Health, Education and Welfare
Role: Principal Investigator - February 2008–February 2011
Influenza and Secondary Bacterial Pneumonia
US Dept of Health, Education and Welfare
Role: Contributor - February 2006–January 2011
Lung contusion-mechanisms and interaction with aspiration
US Dept of Health, Education and Welfare
Role: Contributor - April 2001–March 2006
Brain-derived TNF and Adrenergic Responses in Neuropathic Pain
National Institutes of Health
Role: Co-Investigator
$1,370,058 - July 2001–June 2005
The Pathogenesis of Grand Negative Bacillary Pneumonia
US Dept of Health, Educatoin and Welfare
Role: Co-Investigator
Journal Articles:
- Martuscello RT, Spengler RN, Bonoiu AC, Davidson BA, Helinski J, Ding H, Mahajan S, Kumar R, Bergey EJ, Knight PR, Prasad PN, Ignatowski TA. (2012) Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms. Pain (Sep), 153(9): 1871-1882.
- El-Solh AA, Vora H, Knight PR, Porhomayon J. (2011) Diagnostic use of serum procalcitonin levels in pulmonary aspiration syndromes. Crit Care Med (Jun), 39(6): 1251-1256.
- Gerard E, Spengler RN, Bonoiu AC, Mahajan SD, Davidson BA, Ding H, Kumar R, Prasad PN, Knight PR, Ignatowski TA. (2015) Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor. Pain (Jul), 156(7): 1320-1333.
- Smit PJ, Guo WA, Davidson BA, Mullan BA, Helinski JD, Knight III PR. (2014) AGE-associate RAGE and HMGB1 in Aspiration Lung Injury. Journal of Surgical Research (Jan).
- Fernandez SF, Fung C, Helinski JD, Alluri R, Davidson BA, Knight PR. (2013) Low pH environmental stress inhibits LPS and LTA-stimulated proinflammatory cytokine production in rat alveolar macrophages. Biomed Res Int (Oct), 2013: 742184-742184.
- Marks LR, Davidson BA, Knight PR, Hakansson AP. (2013) Interkingdom signaling induces Streptococcus pneumoniae biofilm dispersion and transition from asymptomatic colonization to disease. MBio (Jul), 4(4).
- Grimm MJ, Vethanayagam RR, Almyroudis NG, Dennis CG, Khan AN, D‘Auria AC, Singel KL, Davidson BA, Knight PR, Blackwell TS, Hohl TM, Mansour MK, Vyas JM, Röhm M, Urban CF, Kelkka T, Holmdahl R, Segal BH. (2013) Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice. J Immunol (Apr), 190(8): 4175-4184.
- Lakshminrusimha S, Suresh MV, Knight PR, Gugino SF, Davidson BA, Helinski JD, Nielsen LC, Russell JA, Yu B, Zeng L, Pennathur S, Raghavendran K. (2013) Role of pulmonary artery reactivity and nitric oxide in injury and inflammation following lung contusion. Shock (Mar), 39(3): 278-285.
- Davidson BA, Vethanayagam RR, Grimm MJ, Mullan BA, Raghavendran K, Blackwell TS, Freeman ML, Ayyasamy V, Singh KK, Sporn MB, Itagaki K, Hauser CJ, Knight PR, Segal BH. (2013) NADPH Oxidase and Nrf2 Regulate Gastric Aspiration-Induced Inflammation and Acute Lung Injury. J Immunol (Jan).
- Guo WA, Davidson BA, Ottosen J, Ohtake PJ, Raghavendran K, Mullan BA, Dayton MT, Knight PR. (2012) Effect of high advanced glycation end-product diet on pulmonary inflammatory response and pulmonary function following gastric aspiration. Shock (Dec), 38(6): 677-684.
- Guo WA, Knight PR, Raghavendran K, Guo W. (2012) The receptor for advanced glycation end products and acute lung injury/acute respiratory distress syndrome. Intensive Care Med (Oct), 38(10): 1588-1598.
- Suresh MV, Yu B, Machado-Aranda D, Bender MD, Ochoa-Frongia L, Helinski JD, Davidson BA, Knight PR, Hogaboam CM, Moore BB, Raghavendran K. (2012) Role of macrophage chemoattractant protein-1 in acute inflammation after lung contusion. Am J Respir Cell Mol Biol (Jun), 46(6): 797-806.
- Raghavendran K, Nemzek J, Napolitano LM, Knight PR. (2011) Aspiration-induced lung injury. Crit Care Med (Apr), 39(4): 818-826.
- Chakravarthy KV, Davidson BA, Helinski JD, Ding H, Law WC, Yong KT, Prasad PN, Knight PR. (2011) Doxorubicin-conjugated quantum dots to target alveolar macrophages and inflammation. Nanomedicine (Feb), 7(1): 88-96.
- El Solh AA, Vora H., Knight III PR, Porhomayon J. (2011) Diagnostic utility of serum procalcitonin levels in pulmonary aspiration syndromes. Critical Care Medicine (Jan), 39: 1251-1256.
- Chakravarthy KV, Bonoiu AC, Davis WG, Ranjan P, Ding H, Hu R, Bowzard JB, Bergey EJ, Katz JM, Knight PR, Sambhara S, Prasad PN. (2010) Gold nanorod delivery of an ssRNA immune activator inhibits pandemic H1N1 influenza viral replication. Proc Natl Acad Sci U S A (Jun), 107(22): 10172-10177.
- Raghavendran K, Davidson BA, Hutson AD, Helinski JD, Nodzo SR, Notter RH, Knight PR. (2009) Predictive modeling and inflammatory biomarkers in rats with lung contusion and gastric aspiration. J Trauma (Dec), 67(6): 1182-1190.
- Raghavendran K, Notter RH, Davidson BA, Helinski JD, Kunkel SL, Knight PR. (2009) Lung contusion: inflammatory mechanisms and interaction with other injuries. Shock (Aug), 32(2): 122-130.
- Raghavendran K, Davidson BA, Huebschmann JC, Helinski JD, Hutson AD, Dayton MT, Notter RH, Knight PR. (2009) Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion. J Surg Res (Aug), 155(2): 273-282.
- Sands MF, Ohtake PJ, Mahajan SD, Takyar SS, Aalinkeel R, Fang YV, Blume JW, Mullan BA, Sykes DE, Lachina S, Knight PR, Schwartz SA. (2009) Tissue inhibitor of metalloproteinase-1 modulates allergic lung inflammation in murine asthma. Clin Immunol (Feb), 130(2): 186-198.
- Raghavendran K, Davidson BA, Knight PR, Wang Z, Helinski J, Chess PR, Notter RH. (2008) Surfactant dysfunction in lung contusion with and without superimposed gastric aspiration in a rat model. Shock (Nov), 30(5): 508-517.
- Jamesdaniel S, Ding D, Kermany MH, Davidson BA, Knight PR, Salvi R, Coling DE. (2008) Proteomic analysis of the balance between survival and cell death responses in cisplatin-mediated ototoxicity. J Proteome Res (Aug), 7(8): 3516-3524.
- Raghavendran K, Pryhuber GS, Chess PR, Davidson BA, Knight PR, Notter RH. (2008) Pharmacotherapy of acute lung injury and acute respiratory distress syndrome. Curr Med Chem (Jan), 15(19): 1911-1924.
- Russo TA, Davidson BA, Beanan JM, Olson R, Holm BA, Notter RH, Knight PR. (2007) Capsule and O-antigen from an extraintestinal isolate of Escherichia coli modulate cytokine levels in rat macrophages in vitro and in a rat model of pneumonia. Exp Lung Res (Sep), 33(7): 337-356.
- Segal BH, Davidson BA, Hutson AD, Russo TA, Holm BA, Mullan B, Habitzruther M, Holland SM, Knight PR. (2007) Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Am J Physiol Lung Cell Mol Physiol (Mar), 292(3): 760-768.
- Russo TA, Wang Z, Davidson BA, Genagon SA, Beanan JM, Olson R, Holm BA, Knight PR, Chess PR, Notter RH. (2007) Surfactant dysfunction and lung injury due to the E. coli virulence factor hemolysin in a rat pneumonia model. Am J Physiol Lung Cell Mol Physiol (Mar), 292(3): 632-643.
- Spengler RN, Sud R, Knight PR, Ignatowski TA. (2007) Antinociception mediated by alpha(2)-adrenergic activation involves increasing tumor necrosis factor alpha (TNFalpha) expression and restoring TNFalpha and alpha(2)-adrenergic inhibition of norepinephrine release. Neuropharmacology (Feb), 52(2): 576-589.
- Nader ND, McQuiller PS, Raghavendran K, Spengler RN, Knight PR. (2007) The role of alveolar macrophages in the pathogenesis of aspiration pneumonitis. Immunol Invest (Jan), 36(4): 457-471.
- Nader ND, Karamanoukian HL, Reedy RL, Salehpour F, Knight PR, Nader N. (2006) Inclusion of sevoflurane in cardioplegia reduces neutrophil activity during cardiopulmonary bypass. J Cardiothorac Vasc Anesth (Feb), 20(1): 57-62.
- Hutson AD, Davidson BA, Raghavendran K, Chess PR, Tait AR, Holm BA, Notter RH, Knight PR. (2006) Statistical prediction of the type of gastric aspiration lung injury based on early cytokine/chemokine profiles. Anesthesiology (Jan), 104(1): 73-79.
- Raghavendran K, Davidson BA, Helinski JD, Marschke CJ, Manderscheid P, Woytash JA, Notter RH, Knight PR. (2005) A rat model for isolated bilateral lung contusion from blunt chest trauma. Anesth Analg (Nov), 101(5): 1482-1489.
- Russo TA, Davidson BA, Genagon SA, Warholic NM, Macdonald U, Pawlicki PD, Beanan JM, Olson R, Holm BA, Knight PR. (2005) E. coli virulence factor hemolysin induces neutrophil apoptosis and necrosis/lysis in vitro and necrosis/lysis and lung injury in a rat pneumonia model. Am J Physiol Lung Cell Mol Physiol (Aug), 289(2): 207-216.
- Raghavendran K, Davidson BA, Woytash JA, Helinski JD, Marschke CJ, Manderscheid PA, Notter RH, Knight PR. (2005) The evolution of isolated bilateral lung contusion from blunt chest trauma in rats: cellular and cytokine responses. Shock (Aug), 24(2): 132-138.
- Nader ND, Davidson BA, Tait AR, Holm BA, Knight PR. (2005) Serine antiproteinase administration preserves innate superoxide dismutase levels after acid aspiration and hyperoxia but does not decrease lung injury. Anesth Analg (Jul), 101(1): 213-219.
- Nader ND, Davidson BA, Tait AR, Holm BA, Knight PR. (2005) Serine antiproteinase administration preserves innate superoxide dismutaselevels after acid aspiration and hyperoxia but does not decrease lung injury. Anesth Analg (Jul), 101(1): 213-219.
- Raghavendran K, Davidson BA, Mullan BA, Hutson AD, Russo TA, Manderscheid PA, Woytash JA, Holm BA, Notter RH, Knight PR. (2005) Acid and particulate-induced aspiration lung injury in mice: importance of MCP-1. Am J Physiol Lung Cell Mol Physiol (Jul), 289(1): 134-143.
- Davidson BA, Stewart CC, Russo TA, Chess PR, Knight PR. (2005) Discrimination of resident and infiltrated alveolar macrophages by flow cytometry in influenza A virus-infected mice. Exp Lung Res (Apr), 31(3): 323-339.
- Davidson BA, Knight PR, Wang Z, Chess PR, Holm BA, Russo TA, Hutson A, Notter RH. (2005) Surfactant alterations in acute inflammatory lung injury from aspiration of acid and gastric particulates. Am J Physiol Lung Cell Mol Physiol (Apr), 288(4): 699-708.
- Ignatowski TA, Sud R, Reynolds JL, Knight PR, Spengler RN. (2005) The dissipation of neuropathic pain paradoxically involves the presence of tumor necrosis factor-alpha (TNF). Neuropharmacology (Mar), 48(3): 448-460.
- Fernandez SF, Huang MH, Davidson BA, Knight PR, Izzo JL. (2005) Mechanisms of angiotensin II-mediated decreases in intraneuronal Ca2+ in calcium-loaded stellate ganglion neurons. Hypertension (Feb), 45(2): 276-282.
- Raghavendran K, Davidson BA, Chess PR, Nader ND, Notter RH, Knight PR. (2005) Acute inflammatory gastric aspiration-related lung injury. Cur Resp Med Rev (Jan), 1: 273-290.
- Knight PR, Davidson BA, Nader ND, Helinski JD, Marschke CJ, Russo TA, Hutson AD, Notter RH, Holm BA. (2004) Progressive, severe lung injury secondary to the interaction of insults in gastric aspiration. Exp Lung Res (Oct), 30(7): 535-557.
- Manderscheid PA, Bodkin RP, Davidson BA, Jensen E, Russo TA, Knight PR. (2004) Bacterial clearance and cytokine profiles in a murine model of postsurgical nosocomial pneumonia. Clin Diagn Lab Immunol (Jul), 11(4): 742-751.
- Rotta AT, Shiley KT, Davidson BA, Helinski JD, Russo TA, Knight PR. (2004) Gastric acid and particulate aspiration injury inhibits pulmonary bacterial clearance. Crit Care Med (Mar), 32(3): 747-754.
- Knight PR, Sreekumar A, Siddiqui J, Laxman B, Copeland S, Chinnaiyan A, Remick DG. (2004) Development of a sensitive microarray immunoassay and comparison with standard enzyme-linked immunoassay for cytokine analysis. Shock (Jan), 21(1): 26-30.
- Russo TA, Davidson BA, Topolnycky DM, Olson R, Morrill SA, Knight PR, Murphy PM. (2003) Human neutrophil chemotaxis is modulated by capsule and O antigen from an extraintestinal pathogenic Escherichia coli strain. Infect Immun (Nov), 71(11): 6435-6445.
- Russo TA, Davidson BA, Carlino-MacDonald UB, Helinski JD, Priore RL, Knight PR. (2003) The effects of Escherichia coli capsule, O-antigen, host neutrophils, and complement in a rat model of Gram-negative pneumonia. FEMS Microbiol Lett (Sep), 226(2): 355-361.
- Fernandez SF, Huang MH, Davidson BA, Knight PR, Izzo JL. (2003) Modulation of angiotensin II responses in sympathetic neurons by cytosolic calcium. Hypertension (Jan), 41(1): 56-63.
- Russo TA, Bartholomew LA, Davidson BA, Helinski JD, Carlino UB, Knight PR, Beers MF, Atochina EN, Notter RH, Holm BA. (2002) Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol (Sep), 283(3): 655-663.
- Covey WC, Ignatowski TA, Renauld AE, Knight PR, Nader ND, Spengler RN. (2002) Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain. Reg Anesth Pain Med (Jul), 27(4): 357-366.
- Knight PR, Bacon DR. (2002) An unexplained death: Hannah Greener and chloroform. Anesthesiology (May), 96(5): 1250-1253.
- Patel AB, Sokolowski J, Davidson BA, Knight PR, Holm BA. (2002) Halothane potentiation of hydrogen peroxide-induced inhibition of surfactant synthesis: the role of type II cell energy status. Anesth Analg (Apr), 94(4): 943-947.
- Nader ND, Ignatowski TA, Kurek CJ, Knight PR, Spengler RN. (2001) Clonidine suppresses plasma and cerebrospinal fluid concentrations of TNF-alpha during the perioperative period. Anesth Analg (Aug), 93(2): 363-369.
- Nader ND, Ignatowski TA, Knight PR, Spengler RN. (2001) Clonidine suppresses neuraxial release of TNF in perioperative period. Anesth Analog (Jan), 93: 148-154.
- Shanley TP, Davidson BA, Nader ND, Bless N, Vasi N, Ward PA, Johnson KJ, Knight PR. (2000) Role of macrophage inflammatory protein-2 in aspiration-induced lung injury. Crit Care Med (Jul), 28(7): 2437-2444.
- Knight PR, Kurek C, Davidson BA, Nader ND, Patel A, Sokolowski J, Notter RH, Holm BA. (2000) Acid aspiration increases sensitivity to increased ambient oxygen concentrations. Am J Physiol Lung Cell Mol Physiol (Jun), 278(6): 1240-1247.
- Russo TA, Davidson BA, Priore RL, Carlino UB, Helinski JD, Knight PR. (2000) Capsular polysaccharide and O-specific antigen divergently modulate pulmonary neutrophil influx in an Escherichia coli model of gram-negative pneumonitis in rats. Infect Immun (May), 68(5): 2854-2862.
- Covey WC, Ignatowski TA, Knight PR, Spengler RN. (2000) Brain-derived TNFalpha: involvement in neuroplastic changes implicated in the conscious perception of persistent pain. Brain Res (Mar), 859(1): 113-122.
- Nader ND, Knight PR, Davidson BA, Safaee SS, Steinhorn DM. (2000) Systemic perfluorocarbons suppress the acute lung inflammation after gastricacid aspiration in rats. Anesth Analg (Feb), 90(2): 356-361.
- Shanley TP, Davidson BA, Nader ND, Bless N, Vasi N, Ward PA, Johnson KJ, Knight PR. (2000) The role of macrophage inflammatory protein-2 in aspiration-induced lung injury. Critical Care Medicine (Jan), 28(7): 2437-2444.
- Ignatowski TA, Covey WC, Knight PR, Severin CM, Nickola TJ, Spengler RN. (1999) Brain-derived TNFalpha mediates neuropathic pain. Brain Res (Sep), 841(1-2): 70-77.
- Nader ND, Knight PR, Bobela I, Davidson BA, Johnson KJ, Morin F. (1999) High-dose nitric oxide inhalation increases lung injury after gastric aspiration. Anesthesiology (Sep), 91(3): 741-749.
- Davidson BA, Knight PR, Helinski JD, Nader ND, Shanley TP, Johnson KJ. (1999) The role of tumor necrosis factor-alpha in the pathogenesis of aspiration pneumonitis in rats. Anesthesiology (Aug), 91(2): 486-499.
- Nader-Djalal N, Knight PR. (1998) Volatile anesthetic effects on ischemic myocardium. Curr Opin Anaesthesiol (Aug), 11(4): 403-406.
- Nader-Djalal N, Knight PR, Thusu K, Davidson BA, Holm BA, Johnson KJ, Dandona P. (1998) Reactive oxygen species contribute to oxygen-related lung injury after acidaspiration. Anesth Analg (Jul), 87(1): 127-133.
- Nader-Djalal N, Knight PR, Bacon MF, Tait AR, Kennedy TP, Johnson KJ, Nader N. (1998) Alterations in the course of acid-induced lung injury in rats after general anesthesia: volatile anesthetics versus ketamine. Anesth Analg (Jan), 86(1): 141-146.
- Nader-Djalal N, Knight PR, Davidson BA, Johnson K, Nader N. (1997) Hyperoxia exacerbates microvascular lung injury following acid aspiration. Chest (Dec), 112(6): 1607-1614.
- Hantler CB, Wilton NC, Knight PR. (1994) Comparative effects of halothane, enflurane, and isoflurane on atrioventricular conductivity and subsidiary pacemaker function in dogs. Anesth Analg (Sep), 79(3): 455-459.
- Hantler CB, Knight PR, Wahr J, Landau S, Jones DJ. (1994) Cardiac electrophysiologic effects of diltiazem in dogs receiving either enflurane or chloralose anesthesia. Anesth Analg (Jul), 79(1): 28-34.
- Knight PR, Smith MD, Davidson BA. (1994) Effects hypoxia/reoxygenation on intracellular calcium ion homeostasis in ventricular myocytes during halothane exposure. Adv Pharmacol (Jan), 31: 109-123.
- Knight PR, Rutter T, Tait AR, Coleman E, Johnson K. (1993) Pathogenesis of gastric particulate lung injury: a comparison and interaction with acidic pneumonitis. Anesth Analg (Oct), 77(4): 754-760.
- Bleske BE, Rice TL, Warren EW, De Las Alas VR, Tait AR, Knight PR. (1993) The effect of sodium bicarbonate administration on the vasopressor effect of high-dose epinephrine during cardiopulmonary resuscitation in swine. Am J Emerg Med (Sep), 11(5): 439-443.
- Wilde DW, Davidson BA, Smith MD, Knight PR. (1993) Effects of isoflurane and enflurane on intracellular Ca2+ mobilization in isolated cardiac myocytes. Anesthesiology (Jul), 79(1): 73-82.
- Shayevitz JR, Johnson KJ, Knight PR. (1993) Halothane-oxidant interactions in the ex vivo perfused rabbit lung. Fluid conductance and eicosanoid production. Anesthesiology (Jul), 79(1): 129-138.
- Tait AR, Davidson BA, Johnson KJ, Remick DG, Knight PR. (1993) Halothane inhibits the intraalveolar recruitment of neutrophils, lymphocytes, and macrophages in response to influenza virus infection in mice. Anesth Analg (May), 76(5): 1106-1113.
- Markovic SN, Knight PR, Murasko DM. (1993) Inhibition of interferon stimulation of natural killer cell activity in mice anesthetized with halothane or isoflurane. Anesthesiology (Apr), 78(4): 700-706.
- Wilton NC, Knight PR, Ullrich K, Martin B, Gallagher KP. (1993) Transmural redistribution of myocardial blood flow during isoflurane anesthesia and its effects on regional myocardial function in a canine model of fixed coronary stenosis. Anesthesiology (Mar), 78(3): 510-523.
- Knight PR, Druskovich G, Tait AR, Johnson KJ. (1992) The role of neutrophils, oxidants, and proteases in the pathogenesis of acid pulmonary injury. Anesthesiology (Oct), 77(4): 772-778.
- Wilde DW, Knight PR, Sheth N, Williams BA. (1991) Halothane alters control of intracellular Ca2+ mobilization in single rat ventricular myocytes. Anesthesiology (Dec), 75(6): 1075-1086.
- Shayevitz JR, Varani J, Ward PA, Knight PR. (1991) Halothane and isoflurane increase pulmonary artery endothelial cell sensitivity to oxidant-mediated injury. Anesthesiology (Jun), 74(6): 1067-1077.
- Wahr JA, Gallagher KP, Tait AR, Hantler CB, Knight PR. (1991) Hemodynamic alterations and regional myocardial blood flow during supraceliac aortic occlusion in dogs with a critical coronary stenosis. J Cardiothorac Vasc Anesth (Feb), 5(1): 3-9.
- Wilde DW, Gutta R, Haney MF, Knight PR. (1991) Effects of volatile anesthetics on the intracellular Ca2+ concentration in cardiac muscle cells. Adv Exp Med Biol (Jan), 301: 125-141.
- Deutsch N, Hantler CB, Tait AR, Uprichard A, Schork MA, Knight PR. (1990) Suppression of ventricular arrhythmias by volatile anesthetics in a canine model of chronic myocardial infarction. Anesthesiology (Jun), 72(6): 1012-1021.
- Penna AM, Johnson KJ, Camilleri J, Knight PR. (1990) Alterations in influenza A virus specific immune injury in mice anesthetized with halothane or ketamine. Intervirology (Jan), 31(2-4): 188-196.
- Kennedy TP, Johnson KJ, Kunkel RG, Ward PA, Knight PR, Finch JS. (1989) Acute acid aspiration lung injury in the rat: biphasic pathogenesis. Anesth Analg (Jul), 69(1): 87-92.
- Weinberg JM, Davis JA, Shayman JA, Knight PR. (1989) Alterations of cytosolic calcium in LLC-PK1 cells induced by vasopressin and exogenous purines. Am J Physiol (May), 256(5 Pt): 967-976.
- Bedows E, Davidson BA, Williams BA, Knight PR. (1989) Characterization of a halothane-resistant strain of measles virus. Antimicrob Agents Chemother (Mar), 33(3): 400-403.
- Tait AR, Du Boulay PM, Knight PR. (1988) Alterations in the course of and histopathologic response to influenza virus infections produced by enflurane, halothane, and diethyl ether anesthesia in ferrets. Anesth Analg (Jul), 67(7): 671-676.
- Larson LO, Hantler CB, Lynch JJ, Landau SN, Buben JA, Lucchesi BR, Knight PR. (1988) Cardiac electrophysiologic interactions of bepridil, a new calcium antagonist, with enflurane, halothane, and isoflurane. J Cardiothorac Anesth (Jun), 2(3): 346-355.
- Wilton NC, Tait AR, Kling TF, Knight PR. (1988) The effect of trimethaphan-induced hypotension on canine spinal cord blood flow. Measurement at different cord levels using radiolabelled microspheres. Spine (Phila Pa 1976) (May), 13(5): 490-493.
- Wilton NC, Hantler CB, Landau SN, Larson LO, Knight PR. (1988) Effects of the volatile anesthetic agents on sinus node function and atrioventricular conduction in dogs: a comparison with chloralose anesthesia. J Cardiothorac Anesth (Apr), 2(2): 188-193.
- Tait AR, Knight PR. (1987) The effects of general anesthesia on upper respiratory tract infections in children. Anesthesiology (Dec), 67(6): 930-935.
- Tatekawa S, Traber KB, Hantler CB, Tait AR, Gallagher KP, Knight PR. (1987) Effects of isoflurane on myocardial blood flow, function, and oxygen consumption in the presence of critical coronary stenosis in dogs. Anesth Analg (Nov), 66(11): 1073-1082.
- Pollard BJ, Fletcher IR, Tait AR, Knight PR, Van der Spek AF. (1987) The effects of calcium-blocking agents on sympathetic responses to acute haemorrhagic shock in dogs. Eur J Anaesthesiol (Sep), 4(5): 369-374.
- Hantler CB, Wilton N, Learned DM, Hill AE, Knight PR. (1987) Impaired myocardial conduction in patients receiving diltiazem therapy during enflurane anesthesia. Anesthesiology (Jul), 67(1): 94-96.
- Spargo PM, Tait AR, Knight PR, Kling TF. (1987) Effect of nitroglycerine-induced hypotension on canine spinal cord blood flow. Br J Anaesth (May), 59(5): 640-647.
- Tait AR, Knight PR. (1987) Intraoperative respiratory complications in patients with upper respiratory tract infections. Can J Anaesth (May), 34(3 ( P): 300-303.
- Marks MW, Burney RE, Mackenzie JR, Knight PR. (1986) Enhanced capillary blood flow in rapidly expanded random pattern flaps. J Trauma (Oct), 26(10): 913-915.
- Bedows E, Holland TC, Knight PR. (1986) Inhibition of herpes simplex virus type 1 replication by halothane. Antimicrob Agents Chemother (May), 29(5): 941-944.
- Kling TF, Wilton N, Hensinger RN, Knight PR. (1986) The influence of trimethaphan (Arfonad)-induced hypotension with and without spine distraction on canine spinal cord blood flow. Spine (Phila Pa 1976) (Apr), 11(3): 219-224.
- Kling TF, Fergusson NV, Leach AB, Hensinger RN, Lane GA, Knight PR. (1985) The influence of induced hypotension and spine distraction on canine spinal cord blood flow. Spine (Phila Pa 1976) (Dec), 10(10): 878-883.
- Marks MW, Mackenzie JR, Burney RE, Knight PR, Anderson SH. (1985) Response of random skin flaps to rapid expansion. J Trauma (Oct), 25(10): 947-952.
- Cohen PJ, Bedows E, Brabec MJ, Knight PR. (1985) Hyperbaric pressure of 51 atmospheres is without effect on the depression of oxygen uptake in kidney tissue culture produced by halothane. Life Sci (Sep), 37(13): 1221-1224.
- Kroll DA, Knight PR. (1984) Antifibrillatory effects of volatile anesthetics in acute occlusion/reperfusion arrhythmias. Anesthesiology (Dec), 61(6): 657-661.
- Brabec MJ, Bedows E, Davidson BA, Knight PR. (1984) Effect of general anesthetics and pressure on aerobic metabolism of monkey kidney cells. Anesthesiology (Jul), 61(1): 43-47.
- Bedows E, Davidson BA, Knight PR. (1984) Effect of halothane on the replication of animal viruses. Antimicrob Agents Chemother (Jun), 25(6): 719-724.
- Bjoraker DG, Knight PR. (1984) Intravenous nitroglycerin administration during infrarenal aortic clamping. Can Anaesth Soc J (Jan), 31(1): 44-50.
- Knight PR, Lane GA, Hensinger RN, Bolles RS, Bjoraker DG. (1983) Catecholamine and renin--angiotensin response during hypotensive anesthesia induced by sodium nitroprusside or trimethaphan camsylate. Anesthesiology (Sep), 59(3): 248-253.
- Nahrwold ML, Bedows E, Davidson BA, Knight PR. (1983) Pressure reversal of halothane‘s antiviral effect. Anesthesiology (Aug), 59(2): 109-112.
- Knight PR, Bedows E, Nahrwold ML, Maassab HF, Smitka CW, Busch MT. (1983) Alterations in influenza virus pulmonary pathology induced by diethyl ether, halothane, enflurane, and pentobarbital anesthesia in mice. Anesthesiology (Mar), 58(3): 209-215.
- Hantler CB, Knight PR. (1982) Intracranial hypertension following cross-clamping of the thoracic aorta. Anesthesiology (Feb), 56(2): 146-147.
- Jones RM, Hantler CB, Knight PR. (1981) Use of pentolinium in postoperative hypertension resistant to sodium nitroprusside. Br J Anaesth (Nov), 53(11): 1151-1154.
- Hill AB, Nahrwold ML, de Rosayro AM, Knight PR, Jones RM, Bolles RE. (1981) Prevention of rigidity during fentanyl--oxygen induction of anesthesia. Anesthesiology (Oct), 55(4): 452-454.
- Graham MD, Knight PR. (1981) Atelectatic tympanic membrane reversal by nitrous oxide supplemented general anesthesia and polyethylene ventilation tube insertion. A preliminary report. Laryngoscope (Sep), 91(9 Pt): 1469-1471.
- Knight PR, Nahrwold ML, Bedows E. (1981) Inhibiting effects of enflurane and isoflurane anesthesia on measles virus replication: comparison with halothane. Antimicrob Agents Chemother (Sep), 20(3): 298-306.
- Jones RM, Knight PR. (1981) Cardiovascular and hormonal responses to electroconvulsive therapy. Modification of an exaggerated response in an hypertensive patient by beta-receptor blockade. Anaesthesia (Aug), 36(8): 795-799.
- Hill AB, Bowley CJ, Nahrwold ML, Knight PR, Kirsh MM, Denlinger JK. (1981) Intranasal administration of nitroglycerin. Anesthesiology (Apr), 54(4): 346-348.
- Jones RM, Knight PR, Hill AB, Nahrwold ML, Kirsh MM. (1981) Termination of cardiopulmonary bypass facilitated by insulin. Anaesthesia (Apr), 36(4): 394-397.
- Jones RM, Fiddian-Green R, Knight PR. (1980) Narcotic-induced choledochoduodenal sphincter spasm reversed by glucagon. Anesth Analg (Dec), 59(12): 946-947.
- Knight PR, Lane GA, Nicholls MG, Tait AR, Nahrwold ML, Hensinger RN, Cohen PJ. (1980) Hormonal and hemodynamic changes induced by pentolinium and propranolol during surgical correction of scoliosis. Anesthesiology (Aug), 53(2): 127-134.
- Knight PR, Nahrwold ML, Bedows E. (1980) Anesthetic action and virus replication: inhibition of measles virus replication in cells exposed to halothane. Antimicrob Agents Chemother (May), 17(5): 890-896.
- Knight PR, Kroll DA, Nahrwold ML, Denlinger JK, Kirsh M, Welter LO, Hill AG, Cohen PJ, Ronfeld RA. (1980) Comparison of cardiovascular responses to anesthesia and operation when intravenous lidocaine or morphine sulfate is used as adjunct to diazepam-nitrous oxide anesthesia for cardiac surgery. Anesth Analg (Feb), 59(2): 130-139.
- Knight PR, Nahrwold ML, Rosenberg A. (1978) Sialic acid release by Vibrio cholerae sialidase (neuraminidase) from the outer surface of neural cells is greatly raised by halothane. J Neurochem (Jun), 30(6): 1645-1647.
- Haspel MV, Knight PR, Duff RG, Rapp F. (1973) Activation of a latent measles virus infection in hamster cells. J Virol (Oct), 12(4): 690-695.
- Covey WC, Ignatowski TA, Renauld AE, Knight PR, Nader ND, Spengler RN. (1900) Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain. Reg Anesth Pain Med (Jan), 27(4): 357-366.
Abstracts:
- Ignatowski TA, Gerard BA, Bonoiu A, Mahajan SD, Knight III PR, Davidson BA, Bergey EJ, Prasad PN, Spengler RN. (2013) Reduction of tumor necrosis factor (TNF) in the hippocampus alleviates neuropathic pain perception. Proceedings of the 4th International Congress on Neuropathic Pain, (Jan) 29-35
- Knight PR, Davidson BA, Nahrwold ML. (1980) Human virus replication during halothane exposure. Anesthesiology, (Jan) S348