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Patricia                       Masso-Welch

Patricia A. Masso-Welch PhD

Department of Biotechnical and Clinical Laboratory Sciences

Associate Professor

Specialty/Research Focus

Apoptosis and cell death; Cell growth, differentiation and development; Cytoskeleton and cell motility; Immunology; Signal Transduction; Stem Cells

 
Professional Summary:

My independent research at The University at Buffalo focuses on targeting the mammary gland microenvironment by evaluating cellular and tissue responses during specific developmental windows of mammary gland remodeling including puberty, the period of hormonal withdrawal during estrous cycling, or post-lactational involution. My choice to focus on discrete times of development for chemopreventive intervention, rather than long-term (and often life-time) intervention, represents a unique approach of short-term exposure at critical points of mammary gland development. Our goal is to allow women to bypass the need for lifelong compliance to a chemopreventive diet or drug regimen in order to attain lifelong protection against breast cancer. Developmentally targeted dietary interventions being investigated in our lab include continuous administration of oral contraceptives, dietary exposure to conjugated linoleic acid, and ethanol.

Education and Training:
  • PhD, Immunology, University at Buffalo (1995)
  • Postdoctoral Fellow, Mammary gland biology, Roswell Park Cancer Institute (1995)
  • BS, Biology, SUNY College at Oswego, Cum Laude (1985)
  • AAS, Math/Science, Onondaga Community College (1982)
Employment:
  • Adjunct Assistant Professor, Department of Pathology and Prevention, Roswell Park Cancer Institute (2012-present)
  • Assistant Professor, Clinical Laboratory Science, SUNY at Buffalo (2004-present)
  • Non-tenure track faculty position, Pharmacology - Roswell Park, Roswell Park Cancer Institute (2001–2004)
  • Adjunct Faculty, Biological Sciences, Buffalo State College (1996)
Awards and Honors:
  • UUP Professional Development Award (2010)
  • Relay for Life, Invited Cancer Researcher Honoree (2010)
  • Bridget G. Levanthal Scholars Award 1997 (1997)
  • Travel Award, ASCB (1992)
  • New York State Fellowship (1987)
  • New York State Fellowship (1986)

Research Expertise:
  • Cell and tissue culture: The development and refinement of two- and three-dimensional tissue culture models
  • Mammary histopathology: Analysis of mammary gland gross and histologic structure, in both epithelial and stromal compartments
  • Technical communications: Scientific writing and presentation of data in oral and written scientific formats
Grants and Sponsored Research:
  • April 2013–March 2015
    Invasive breast cancer with and without DCIS: Race, risk factors and outcomes
    NIH
    Role: Co-Principal Investigator
    $165,312
  • July 2010–June 2012
    Effects of Ethanol Exposure During Involution on Post-Partum Breast Cancer
    NIAAA
    Role: Principal Investigator
    $275,000
  • June 2008–May 2011
    Life Sciences Teacher Education Summer Course
    NYS Dept. of Labor
    Role: Co-Investigator
    $360,000
  • January 2007–December 2008
    Chemopreventive Modulation of the Mammary Stromal Vascular Cell by Conjugated Linoleic Acid
    American Institute for Cancer Research
    Role: Principal Investigator
    $150,000
Patents:
  • Method for Inhibition of Angiogenesis and Vasculogenesis The present invention provides a method for inhibiting or preventing angiogenesis in animals and humans comprising the steps of administering to the animal or human an effective amount of one or more isomers of conjugated linoleic acid (“CLA”). The CLA may be administered in the form of a free fatty acid, an ester, or as a salt, in a pill, or as a component of a natural or prepared food product. (1995)

Journal Articles:
See all (8 more)

Professional Memberships:
  • American Society for Nutrition (2010–present)
  • American Association of Cancer Researchers (2000–present)
  • American Society for Cell Biology (2000–present)
Presentations:
  • "Conjugated Linoleic Acid (CLA) and Breast Cancer Chemoprevention" The IV Brazilian Congress on Milk Quality, The IV Brazilian Congress on Milk Quality, The IV Brazilian Congress on Milk Quality (2010)
  • "Breast as a Complex and Dynamic Tissue in Normal Development and Cancer: A Histological Perspective" NYS Histological Society Annual Symposium, NYS Histologic Society (2010)
  • "Role of Conjugated Linoleic Acid in Mammary Tissue Development and Breast Cancer Prevention" Special Seminar, Universidad do Estado de Santa Caterina, School of Veterinary Medicine (2009)
  • "t10,c12-CLA Stimulates Mammary Tumorigenesis in Transgenic Mice which Overexpress ErbB2 in the Mammary Epithelium" CLA Network Annual Meeting, CLA Network (2006)
  • "Conjugate Linoielic Acid (CLA): A Multipotent Chemopreventive Agent in Mammary Cancer" FASEB (2005)
  • "Protein Kinase C in Mammary Growth, Development, and Tumorigenesis" Seminar Series, W. Alton Jones Cell Science Center, PKC Working Group (1996)
  • "Characterization of Glucose Regulated Protein 170" Symposium on Cell and Molecular Biology, Fischer Winternational Symposium, Heat Shock Proteins and the Stress Response (1992)
Service Activities:
  • Faculty Senate; Alternate Member (2007–2009)
  • Outside reader; I served as an outside reader for the thesis of Dania Wahl, a masters degree candidate in the Department of Bioengineering (mentor Dr. Bob Baier).; External Reviewer (2010–2011)
  • Interactive WebCam guest lecturer; I gave an interactive webcam seminar on "Topics in Cancer Biology" with the students of Robert J. Kaiser Middle School in Monticello, NY; Guest Lecturer (2010–present)
  • Honors seminar; Guest lecturer in Cell Biology Honors Enrichment seminar, UE255. Primary instructor, Dr. Marie Janicke.; Guest Lecturer (2010–present)
  • IACUC Member; Review and advise on submitted protocols; Committee Member (2009–2011)
  • Judge; Judge for Sigma Xi Graduate Poster Competition (2009–present)
  • Judge; Judge for UB Postdoctoral Research Symposium (2009–present)
  • Judge; Judge for Annual Buffalo Conference on Immunology (2009–present)
  • Faculty Council Alternate; Serve as an Alternate for Faculty Council; Alternate Member (2007–2009)
  • Biotechnology Curriculum Committee; Serve as a Committee member to mold the Biotechnology Program curriculum; Committee Member (2007–present)
  • Biotechnology Internship Committee; Serve as a committee member to guide the Biotechnology Internship Program; Committee Member (2007–present)
  • Committe Member; I have served and continue to serve on the graduate committees for multiple students iwthin the BCLS Department.; Committee Member (2005–present)

School News:
In the Media:

Clinical Specialties:
Clinical Offices:
Insurance Accepted:


Contact Information

Cary Hall, Room 38C
3435 Main Street
Buffalo, NY 14214
Phone: 716-829-5191
Fax: 716-829-3601
Email: pmwelch@buffalo.edu


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