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Pablo                          Paez

Pablo M. Paez PhD

Department of Pharmacology and Toxicology

Assistant Professor

Specialty/Research Focus

Ion channel kinetics and structure; Molecular and Cellular Biology; Neurobiology; Neuropharmacology

 
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Professional Summary:

Our research program focuses on brain development, studying the development of the oligodendroglial and astroglial cell lineages in the central nervous system in normal, mutant and transgenic mice. The primary focus in the laboratory is on ion channels that regulate specification, migration and differentiation of these glial cells.

The oligodendrocyte generates CNS myelin, which is essential for normal nervous system function. Thus, investigating the regulatory and signaling mechanisms that control its differentiation and the production of myelin is relevant to our understanding of brain development and of adult pathologies such as multiple sclerosis. We have recently discovered that voltage-gated Ca++ channels are necessary for normal myelination acting at multiple steps during oligodendrocyte progenitor cells (OPCs) development, however nothing is known about its role in demyelination or remyelination events. Our research aims to determine if voltage-gated Ca++ channels plays a functional role in myelin repair. Using transgenic mice and new imaging techniques we are testing the hypothesis that voltage-gated Ca++ entry promotes OPC survival and proliferation in the remyelinating adult brain. Therefore, this work is relevant to developing means to induce remyelination in myelin degenerative diseases and for myelin repair in damaged nervous tissue.

Astrocytes are the most abundant cell of the human brain. They perform many functions, including biochemical support of endothelial cells that form the blood brain barrier, provision of nutrients to the nervous tissue and a role in the repair and scarring process of the brain and spinal cord following traumatic injuries. Our lab has made the novel finding of voltage-gated Ca++ channels function in astrocyte Ca++ homeostasis, and this has implications for plasticity in astrocyte development and for Ca++ regulation in general. We are testing the hypothesis that voltage-gated Ca++ entry plays a key role in astrocyte function and glial-neuronal interactions. We have generated a conditional knockout mice for voltage-gated Ca++ channels in astrocytes, these conditional knockout mice will allow the functional analysis of voltage-gated Ca++ channels in astroglia of the postnatal and adult brain. Analyzing such mice using a combination of behavioral, electrophysiological, imaging, and immunohistochemical techniques will provide new insights in our understanding of astroglial contribution to brain function.

These projects have been supported for many years by grants from the NIH and the National Multiple Sclerosis Society.

Education and Training:
  • Postdoctoral Fellow, Dev. Neuroscience, University of California at Los Angeles, David Geffen School of Medicine, Department of Psychiatry & Biobehavioral Sciences (2010)
  • PhD, Neuroscience, University of Buenos Aires, School of Pharmacy and Biochemistry (2005)
  • BS, Biochemistry, University of Buenos Aires, School of Pharmacy and Biochemistry (2000)
Employment:
  • Assistant Professor, University at Buffalo, The State University of New York (2013-present)
  • Research Associate Professor, Department of Psychiatry & Biobehavioral Sciences, University of California at Los Angeles, David Geffen School of Medicine (2010–2013)
  • Post Doctoral Fellow, Department of Psychiatry & Biobehavioral Sciences, University of California at Los Angeles, David Geffen School of Medicine (2006–2010)
  • Research Assistant, Department of Biochemical Pathology, University of Buenos Aires, School of Pharmacy and Biochemistry, Argentina (2000–2005)
  • Teaching & Research Assistant, Department of Biochemical Pathology, University of Buenos Aires, School of Pharmacy and Biochemistry, Argentina (2000–2004)
Awards and Honors:
  • International Society for Neurochemistry and European Society for Neurochemistry Travel Award (2011)
  • American Society for Neurochemistry, Young Investigator Educational Enhancement Award (2008)
  • Fine Science Tools Postdoctoral Scholars Travel Award (2008)
  • BRI/Semel Institute Neuroscience Postdoctoral Fellows Travel Award (2008)
  • UCLA Friends of the Semel Institute for Neuroscience and Human Behavior Travel Award (2007)
  • International Society for Neurochemistry and American Society for Neurochemistry Travel Award (2007)
  • National Multiple Sclerosis Society Fellowship Award (FG 1723A1/1) (2007)
  • IBRO-financed travel support, VII European Meeting on Glia Cells in Health and Disease (2005)
  • GLIA Stipend, VII European Meeting on Glia Cells in Health and Disease (2005)
  • American Society for Neurochemistry Young Investigator Educational Enhancement Award (2005)
  • Committee for Aid and Education in Neurochemistry (CAEN) of the ISN, CAEN Fellowship (2004)
  • American Society for Neurochemistry, Young Latin American Scholars Award (2003)
  • American Society for Neurochemistry, Young Investigator Educational Enhancement Award (2002)

Research Expertise:
  • Neuroscience, Neurochemistry and Molecular Biology
Grants and Sponsored Research:
  • June 2013–May 2018
    Modulation of oligodendrocyte development by voltage-operated calcium channels
    NIH, National Institute of Neurological Disorders and Stroke
    Role: Principal Investigator
    $1,742,160
  • October 2011–September 2014
    Modulation of oligodendrocyte function and myelination by the golli proteins
    National Multiple Sclerosis Society
    Role: Principal Investigator
    $471,000
  • October 2011–September 2012
    The Role of Voltage-operated Ca++ channels during oligodendrocyte development
    National Multiple Sclerosis Society
    Role: Principal Investigator
    $44,000
  • October 2009–September 2012
    Goli-mpb gene expression in the nervous system
    National Multiple Sclerosis Society
    Role: Co-Principal Investigator
    $480,000
  • April 2007–March 2010
    Golli Proteins and calcium homeostasis in oligodendroglial maturation
    National Multiple Sclerosis Society
    Role: Principal Investigator
    $150,000

Journal Articles:
See All (27 Total) >

Professional Memberships:
  • American Society for Pharmacology and Experimental Therapeutics (2013)
  • International Society for Neurochemistry (2007)
  • Society for Neuroscience (2006)
  • American Society for Neurochemistry (2001)
Presentations:
  • "Modulation of oligodendrocyte function and myelination by the golli proteins" 2nd Annual California National Multiple Sclerosis Society Research Forum, National Multiple Sclerosis Society (2011)
  • "Myelination and Remyelination" 42nd American Society for Neurochemistry Annual Meeting, American Society for Neurochemistry (2011)
  • "Molecular Regulation of Oligodendrocyte Development" 40th American Society for Neurochemistry Annual Meeting, American Society for Neurochemistry (2009)
  • "Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca++ influx" UCLA LNA Seminars, UCLA (2009)
  • "Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca++ influx" UCLA Mental Retardation Research Center Annual Retreat, UCLA (2008)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

701 Ellicott Street
Hunter James Kelly Research Institute
NYS Center of Excellence, Room B4-320
Buffalo, NY 14203
Phone: 716-881-7823
Fax: 716-881-7823
Email: ppaez@buffalo.edu


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