Cell growth, differentiation and development; Gene Expression; Immunology; Internal Medicine; Microbiology; Molecular and Cellular Biology; Molecular Basis of Disease; Molecular genetics; Nephrology
My clinical responsibilities include caring for patients coping with a wide variety of renal diseases, including but not limited to acute kidney injury (AKI), chronic kidney disease (CKD), glomerulonephritis and polycystic kidney disease. I also manage the care of patients who have resistant hypertension. I see patients at the bedside in Buffalo General Medical Center (BGMC) and in BGMC’s renal clinics.
My research focuses on finding modifiable factors to reverse or halt the progression of CKD, through modifying the contents of gut bacteria (microbiota) and studying their correlation to disease states. Studies have demonstrated that gut microbiota can influence numerous aspects of human biology, and alterations in their function and composition (dysbiosis) suggest they play a role in the pathogenesis of diverse human illnesses such as chronic inflammation, diabetes mellitus, obesity, cardiovascular diseases and recently, CKD.
I use both human and animal studies to explore the effects of gut microbiota dysbiosis on renal diseases. I have conducted clinical trials evaluating the diversities and population of gut bacteria in patients with different degrees of renal insufficiencies. I also have evaluated the role of diet on gut bacteria and inflammation, in patients with end-stage renal disease (ESRD) who are on dialysis. To confirm the findings and further explore the importance of gut microbiota on renal diseases and conditions, I am conducting animal experiments using different murine models of advanced and acute-reversible renal diseases.
In addition to my research activities, I supervise and teach renal fellows, medicine residents and medical students in the renal inpatient rotation and in the renal outpatient clinic.