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Richard                        Browne

Richard W. Browne PhD

Department of Biotechnical and Clinical Laboratory Sciences

Associate Professor

Specialty/Research Focus

Endocrinology; Endocrinology, Diabetes and Metabolism; Molecular Basis of Disease; Neurodegenerative disorders; Pathophysiology

 
Professional Summary:

Dr. Browne’s research is focused primarily on the clinical biochemistry of oxidative stress (OS) in human health and disease. Specifically, his research focuses on mechanisms of oxidative lipid damage and the antioxidant roles of high-density lipoproteins (HDL. This research includes pure biomarker method development and validation employing primarily high pressure liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) along with collaborative clinical studies of the role of oxidative stress in cancer, infertility and women’s health, and neurological disease. Current studies on-going in Dr. Browne’s laboratory include investigations of the role of HDL and PON1 in embryo morphology outcomes during in vitro fertilization (IVF), a study of the role of oxysterols in Multiple Sclerosis disease progression and investigations of the role of bioactive lipid mediators in response to air pollution.

Education and Training:
  • Fellowship, Epidemiology, NIH/NHLBI (2001)
  • PhD, Experimental Pathology, University at Buffalo, SUNY (1998)
  • MS, Medical Technology, University at Buffalo, SUNY (1994)
  • BS, Medical Technology, University at Buffalo, SUNY (1991)
Employment:
  • Medical Technology Program Director, Biotechnical and Clinical Laboratory Sciences, University at Buffalo (2014-present)
  • Associate Professor, Biotechnical and Clinical Laboratory Sciences, University at Buffalo, SUNY (2010-present)
  • Adjunct Assistant Professor, University at Buffalo, SUNY (2007-present)
  • Adjunct Research Associate Professor, Epidemiology and Environmental Health, University at Buffalo, SUNY, School of Public Health and Health Professions (2005-present)
  • Assistant Professor, Biotechnical and Clinical Laboratory Sciences, University at Buffalo, SUNY (2001–2010)

Research Expertise:
  • Research: Dr. Browne’s research is focused primarily on the clinical biochemistry of oxidative stress (OS) in human health and disease. Specifically, his research focuses on mechanisms of oxidative lipid damage and the antioxidant roles of high-density lipoproteins (HDL) and the HDL associated enzyme paraoxonase 1 (PON1). This research includes pure biomarker method development and validation along with collaborative clinical studies of the role of oxidative stress in cancer, infertility and women’s health, and neurological disease. Current studies on-going in Dr. Browne’s laboratory include investigations of the role of HDL and PON1 in embryo morphology outcomes during in vitro fertilization (IVF) and a study of the role of cholesterol, lipids and oxidative stress in Multiple Sclerosis disease progression.
Grants and Sponsored Research:
  • March 2015–February 2022
    Contract Renewal: Clinical Pharmacology Quality Assurance and Quality Control
    NIH/National Institute of Allergy and Infectious Disease
    Role: Co-Investigator
    $12,754,564
  • August 2016–January 2019
    Upstate KIDS follow up study
    NICHD
    Role: Principal Investigator
    $161,354
  • July 2016–July 2018
    Metabolomics Profiling of Biological Responses to Changes in Air Pollution Levels
    NIEHS
    Role: Co-Investigator
    $275,000
  • May 2016–May 2017
    Methylglyoxal Could Mediate The Relationship Between Infections And Diabetes: A Method Development and Feasibility Study
    UB VPR IMPACT Grant
    Role: Co-Investigator
    $35,000
  • February 2015–January 2017
    Study of Metals and Assistive Reproductive Technologies
    NIEHS
    Role: Principal Investigator
    $73,743
  • September 2015–September 2016
    Cardiovascular Protection by Phytosterols in Dyslipidemic Mother and Progeny
    NIH/NCCI-ODS
    Role: Co-Investigator
    $100,000
  • October 2012–October 2015
    Lipoprotein and Lipid Metabolism in Multiple Sclerosis Disease Progression
    National Multiple Sclerosis Society
    Role: Co-Investigator
    $704,784
  • February 2010–December 2013
    Biological Response to Change in Air Quality Pre-, Mid-, Post-Olympics
    NIH/NIEHS
    Role: Co-Investigator
    $848,133
  • October 2011–October 2013
    Effect of Vitamin D-Rich Mushrooms on Functional Performance and Quality of Life in Older Men and Women
    Mushroom Council
    Role: Co-Investigator
    $100,000
  • September 2009–September 2012
    Saliva and Serum Inflammatory Biomarkers in Periodontitis: A Study in Older Women
    NIH
    Role: Co-Investigator
    $372,016
  • August 2006–September 2012
    The Effects of Aspirin in Gestation and Reproduction (EAGR) Trial
    NIH/NICHD
    Role: Co-Investigator
    $3,230,300
  • July 2010–June 2012
    Effects of Ethanol Exposure During Involution on Post-Partum Breast Cancer
    NIAAA
    Role: Co-Investigator
    $275,000
  • March 2010–February 2012
    High Density Lipoprotein in Follicular Fluid and Fertility Outcomes
    NIA
    Role: Principal Investigator
    $275,000
  • September 2007–August 2010
    Interpretation of Biomarkers Using Physiologically Based PharmacokineticModeling Environmental Protection Agency
    EPA
    Role: Co-Investigator
    $749,280
  • August 1986–June 1989
    Metabolic Syndrome and Periodontitis in Postmenopausal Women
    NIH/NIDCR
    Role: Co-Investigator
    $317,000
See all (5 more)

Journal Articles:
See all (73 more)

Professional Memberships:
  • American Society for Clinical Laboratory Sciences (ASCLS); Regular Member (2014–present)
  • Society for Free Radical Biology and Medicine (SFRBM) (2001–present)
  • International Society for Free Radical Research (ISFRR) (2001–present)
  • American Association for Clinical Chemistry (AACC) (2000–present)
Presentations:
  • "Oxysterols in Multiple Sclerosis Disease Progression" Seminar Series, SUNY at Buffalo, Department of Oral Biology (2015)
  • "Oxysterols in Multiple Sclerosis Disease Progression" Seminar Series, University at Buffalo, Department of Oral Biology (2015)
  • "Biomarkers of Cholesterol Metabolism in Multiple Sclerosis Disease and Progression" Special Seminar Series, Wadsworth Center, Biggs Laboratory (2015)
  • "HDL Metabolism and the Human Embryo: Clinical Evaluation of Follicular Fluid Biomarkers and Reproductive Outcomes During In vitro Fertilization" Seminar Series, University at Buffalo, Department of Social and Preventive Medicine (2009)
  • "HDL Metabolism and the Human Embryo: Towards a Physiologic Model of Ovarian Granulosa Cell Lipoprotein Metabolism" Seminar Series, University at Buffalo, Department of Biochemistry (2009)
  • "Micronutrient/mineral supplementation containing high dose α-tocopherol is associated with decreased γ-tocopherol and increased circulating lipid peroxidation products" 15th Annual Meeting, Society for Free Radical Biology and Medicine (2008)
  • "Determination of analytical limits of detection: Practical consideration of laboratory techniques" 41st Annual Meeting, Society of Epidemiologic Research (2008)
  • "Oxidative stress and antioxidant defense in the clinical laboratory" Annual Scientific Meeting, American Association for Clinical Laboratory science, Upstate New york (2006)
  • "Polyunsaturated fatty acid lipid peroxidation" Seminar Series, University at Buffalo, Exercise and Nutrition Sciences (2002)
  • "The clinical assessment of oxidative stress and antioxidant defense" Fall Meeting, American Association for Clinical Chemistry, Upstate New York Section (2001)
  • "Analytical technologies for the measurement of oxidative stress" Annual Scientific Meeting, American Society for Clinical Laboratory Science, Niagara Frontier Chapter (2001)
  • "A high pressure liquid chromatography method for the direct measurement of free fatty acid hydroperoxides" International Symposium on Free Radicals in Diagnostic Medicine (1993)
  • "Determination of LHP concentration by fluorometric determination of MDA-TBA adduct" International Symposium on Free Radicals in Diagnostic Medicine (1993)
  • "Modification of lipid peroxide assay to quantify low and high concentrations in serum samples" Spring Meeting, American Association of Clinical Chemists, Upstate New York Section (1993)
See all (4 more)

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Contact Information

38 Cary Hall
3435 MainSt.
N/A
Buffalo, NY 14214
Phone: (716) 829-5181
Fax: (716) 829-3601
Email: rwbrowne@buffalo.edu


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