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Frederick                      Sachs

Frederick Sachs 

Department of Physiology and Biophysics

Specialty/Research Focus

Cardiopulmonary physiology; Cytoskeleton and cell motility; Ion channel kinetics and structure; Membrane Transport (Ion Transport); Molecular and Cellular Biology; Molecular Basis of Disease; Signal Transduction

 
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Professional Summary:

My research interests center on mechanical and electrical biophysics, from molecules to organs, and the development of new tools. And, in recent years I worked in transitional science; bringing basic science to the clinic and to industry. My basic research interests are on cell mechanics and the mechanisms by which mechanical forces are transduced into messages such as voltage and chemicals such as ATP and Ca2+. I discovered mechanosensitive ion channels in 1983. My methodology has included patch clamp, high resolution bright field light microscopy, low light fluorescence microscopy, high speed digital imaging, TIRF, digital image analysis, high voltage EM with tomography, Atomic Force Microscopy, molecular biology, natural product and recombinant protein biochemistry, NMR and microfabrication and microfluidics. We discovered the only known specific inhibitor of mechanosensitive ion channels and uncovered its remarkable mode action by using a combination of electrophysiology and chiral chemistry. We have demonstrated potential clinical applications of the peptide for cardiac arrhythmias, oncology, muscular dystrophy, and incontinence.
We have developed many scientific tools. Recently we developed a sensor chip to measure cell volume in real time, and that is now entering production with Reichert Instruments of Buffalo. We also have an Small Business Innovation Research contract to develop a microfluidic, bipolar, temperature jump chip with ALA Scientific and developed a microfabricated Atomic Force Microscopy probe that is an order of magnitude faster and more stable than any commercial probes. We have made probe operable with two independent degrees of freedom on a standard Atomic Force Microscopy. This permits us to remove all drift and coherent noise by using one axis to measure the substrate position and the other the sample position. These probes are being produced by a new company in Buffalo, kBtwist. We have used the Atomic Force Microscope combined with electrophysiology to study the dynamics of single voltage dependent ion channels. This technique provides a resolution of >0.01nm in a kHz bandwidth. I have developed other hardware including the first automated microelectrode puller, a micron sized thermometer and heater and a high speed pressure servo. Some of these devices have been patented by the University of Buffalo and some are in current production.
To analyze the reaction kinetics of single molecules, we developed and made publicly available (www.qub.buffalo.edu) a complete software package for Windows that does data acquisition and Markov likelihood analysis. The development was funded by the National Science Foundation, National Institutes of Health and Keck over the last fifteen years, and has been applied to ion channels, molecular motors and the even the sleep patterns of mice. We have taught at UB hands-on course to use the software, and the course was attended by an international group of academic scientists and students, government and industry.

Education and Training:
  • PhD, Physiology, Upstate Medical Center (1971)
  • BA, Physics, U Rochester (1962)
Employment:
  • SUNY Distinguished Professor of physiology and biophysics, SUNY at Buffalo (2002-present)
  • Professor, SUNY at Buffalo (1986-present)
  • Chemical engineering, SUNY at Buffalo (2004–2007)
  • Associate Professor, SUNY at Buffalo (1984–1986)
  • Assistant Professor, SUNY at Buffalo (1980–1984)
  • Assistant Professor, SUNY at Buffalo (1975–1980)
  • Staff Fellow, NIH (1971–1975)
  • Instructor, Organic Chemistry, Chaminade College, Chaminade College (1971)
  • Post Doctoral Fellow, Biochemistry/Biphysics, University of Hawaii, University of Hawaii (1969–1971)
  • Associate Engineer, Douglas Aircraft (1962–1964)
Awards and Honors:
  • Kenneth S. Cole Award (2013)
  • SUNY Chancellor's Research Recognition Award (2003)
  • Asian Institute of NanoScience and Technology (2003)
  • SUNY Distinguished Inventor (2002)
  • UB Distinguished Professor (2002)
  • UB MiniMed Lecture (2002)
  • Stockton-Kimball award (2001)
  • NSF Nanotechnology Review Panel (2001)
  • Fogarty Fellowship (1992)
  • Fogarty Fellowship (1991)
  • Guinness Book of Records - Smallest Thermometer (1984)
  • Outstanding Administrator of Summer Employee Prog. (1975)
  • NIH Predoctoral Traineeship
  • Rochester College Scholarship
  • NYS Science & Engineering Scholarship
  • Biophysical Society Council
  • NIH Physiology Study Section, ad hoc reviewer
  • State University of New York Chancellor’s Research Recognition Award, 2003

Research Expertise:
  • AFM
  • Digital imaging: Low light level bright field, fluorescence, EM transmission & tomography
  • Electrophysiology: Single channel recording, analysis, mechanosensitive ion channels
Grants and Sponsored Research:
  • January 2009–January 2014
    Algorithms for molecular kinetics
    NIH
    Role: Co-Principal Investigator
    $3,273,521
  • September 2004–August 2009
    Mechanoelectrical Transduction in the Myocardium
    NIH-FIRCA
    Role: Principal Investigator
    $100,000
  • September 2000–August 2005
    Mechanical transduction by cardiocytes
    NIH
    Role: Principal Investigator
    $1,634,150
  • April 2001–March 2005
    AFM of Voltage and Mechanically Gated Channels
    NIH
    Role: Principal Investigator
    $1,211,045
  • April 2000–March 2005
    Cell Mechanosensing
    Japan Science and Technology Corp.
    Role: Principal Investigator
    $400,000
  • January 2001
    Atrial Fibrillation
    Hubbard Foundation
    Role: Principal Investigator
    $10,000
See All (6 Total) >
Patents:
  • High speed gas mixing valve (2003)
  • Improved AFM scanhead (2003)
  • Microfabricated device for monitoring cell volume (2003)
  • Bubble based chip sensor technology (2002)
  • Method to make microfluidic systems & components w/out moving mech. parts (2002)
  • High speed pressure servo (2001)
  • Method to prevent arrhythmias during catheterization (2001)
  • Peptide to treat brain trauma & pathology (2001)
  • Peptide to treat diseases related to overproduction of endothelin (2001)
  • Peptide to treat gliomas of astrocytic origin (2001)
  • Cantilever for AFM Cantilever for Atomic Force Microscopy in fluids. (2000)
  • Membraneless ion channels as chem. detectors (2000)
  • Peptide to block activated ion channels A peptide to block mechanically activated ion channels. (2000)
  • Antiarrhythmic peptide Antiarrhymic peptide from venom of spider Grammostola spatulata. (1998)
  • Computer controlled micropipette Computer controlled micropipette drawing apparatus. (1989)
  • Method & apparatus for heating & controlling temp. Method and apparatus for heating and controlling the temperature of ultra small volumes. (1987)
  • Micro-thermometer (1986)
  • Microelectrodes and process for shielding same. (1984)
  • Microelectrode fabricating apparatus. (1981)
  • Multiplexor for analog and video data

Journal Articles:
  • Kerstein PC, Jacques-Fricke BT, Rengifo J, Mogen BJ, Williams JC, Gottlieb PA, Sachs F, Gomez TM. Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth. J Neurosci. 2013; 33(1).
  • Verma D, Ye N, Meng F, Sachs F, Rahimzadeh J, Hua SZ. Interplay between cytoskeletal stresses and cell adaptation under chronic flow. PLoS One. 2012; 7(9).
  • Heo J, Sachs F, Wang J, Hua SZ. Shear-induced volume decrease in MDCK cells. Cell Physiol Biochem. 2012; 30(2).
  • Gottlieb PA, Bae C, Sachs F. Gating the mechanical channel Piezo1: a comparison between whole-cell and patch recording. Channels (Austin). 2012; 6(4).
  • Gottlieb PA, Sachs F. Piezo1: properties of a cation selective mechanical channel. Channels (Austin). 2012; 6(4).
  • Sukharev S, Sachs F. Molecular force transduction by ion channels: diversity and unifying principles. J Cell Sci. 2012; 125(Pt 13).
  • Peyronnet R, Sharif-Naeini R, Folgering JH, Arhatte M, Jodar M, El Boustany C, Gallian C, Tauc M, Duranton C, Rubera I, Lesage F, Pei Y, Peters DJ, Somlo S, Sachs F, Patel A, Honoré E, Duprat F. Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels. Cell Rep. 2012; 1(3).
  • Meng F, Sachs F. Orientation-based FRET sensor for real-time imaging of cellular forces. J Cell Sci. 2012; 125(Pt 3).
  • Kowalsky GB, Beam D, Oh MJ, Sachs F, Hua SZ, Levitan I. Cholesterol depletion facilitates recovery from hypotonic cell swelling in CHO cells. Cell Physiol Biochem. 2011; 28(6).
  • Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RA, Cerbai E, Chen PS, Delmar M, Difrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, Fink M, Fischmeister R, Franz MR, Garny A, Giles WR, Hannes T, Harding SE, Hunter PJ, Iribe G, Jalife J, Johnson CR, Kass RS, Kodama I, Koren G, Lord P, Markhasin VS, Matsuoka S, McCulloch AD, Mirams GR, Morley GE, Nattel S, Noble D, Olesen SP, Panfilov AV, Trayanova NA, Ravens U, Richard S, Rosenbaum DS, Rudy Y, Sachs F, Sachse FB, Saint DA, Schotten U, Solovyova O, Taggart P, Tung L, Varró A, Volders PG, Wang K, Weiss JN, Wettwer E, White E, Wilders R, Winslow RL, Kohl P. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing. Prog Biophys Mol Biol. 2011; 107(1).
  • Rahimzadeh J, Meng F, Sachs F, Wang J, Verma D, Hua SZ. Real-time observation of flow-induced cytoskeletal stress in living cells. Am J Physiol Cell Physiol. 2011; 301(3).
  • Bae C, Sachs F, Gottlieb PA. The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. Biochemistry. 2011; 50(29).
  • Wang Y, Meng F, Sachs F. Genetically encoded force sensors for measuring mechanical forces in proteins. Commun Integr Biol. 2011; 4(4).
  • Bathany C, Beahm D, Felske JD, Sachs F, Hua SZ. High throughput assay of diffusion through Cx43 gap junction channels with a microfluidic chip. Anal Chem. 2011; 83(3).
  • Meng F, Sachs F. Visualizing dynamic cytoplasmic forces with a compliance-matched FRET sensor. J Cell Sci. 2011; 124(Pt 2).
  • Bae, C., Suchyna, T.M., Markin, V., & Sachs, F.. Modeling Ion ChannelsIn the Gigaseal. Biophysical Journal. 2011; 101.
  • Bae C, Suchyna T M, Markin V & Sachs F. Modeling Ion Channels in the Gigaseal. Biophysical Journal. 2011; 101.
  • Bathany C, Beahm D, Felske J D, Sachs F & Hua S Z. High Throughput Assay of Diffusion through Cx43 Gap Junction Channels with a Microfluidic Chip. Analytical Chemistry. 2011; 83.
  • Beyder A, Rae JL, Bernard C, Strege PR, Sachs F, Farrugia G. Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel. J Physiol. 2010; 588(Pt 24).
  • Kamaraju K, Gottlieb PA, Sachs F, Sukharev S. Effects of GsMTx4 on bacterial mechanosensitive channels in inside-out patches from giant spheroplasts. Biophys J. 2010; 99(9).
  • Gottlieb PA, Barone T, Sachs F, Plunkett R. Neurite outgrowth from PC12 cells is enhanced by an inhibitor of mechanical channels. Neurosci Lett. 2010; 481(2).
  • Hua SZ, Gottlieb PA, Heo J, Sachs F. A mechanosensitive ion channel regulating cell volume. Am J Physiol Cell Physiol. 2010; 298(6).
  • Sachs F. Stretch-activated ion channels: what are they? Physiology (Bethesda). 2010; 25(1).
  • Vandorpe DH, Xu C, Shmukler BE, Otterbein LE, Trudel M, Sachs F, Gottlieb PA, Brugnara C, Alper SL. Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One. 2010; 5(1).
  • Sharif-Naeini R, Folgering JH, Bichet D, Duprat F, Lauritzen I, Arhatte M, Jodar M, Dedman A, Chatelain FC, Schulte U, Retailleau K, Loufrani L, Patel A, Sachs F, Delmas P, Peters DJ, Honoré E. Polycystin-1 and -2 dosage regulates pressure sensing. Cell. 2009; 139(3).
  • Huang H, Wei H, Liu P, Wang W, Sachs F, Niu W. A simple automated stimulator of mechanically induced arrhythmias in the isolated rat heart. Exp Physiol. 2009; 94(10).
  • Sachs F, Brownell WE, Petrov AG. Membrane Electromechanics in Biology, with a Focus on Hearing. MRS Bull. 2009; 34(9).
  • Suchyna TM, Markin VS, Sachs F. Biophysics and structure of the patch and the gigaseal. Biophys J. 2009; 97(3).
  • Beyder A, Sachs F. Electromechanical coupling in the membranes of Shaker-transfected HEK cells. Proc Natl Acad Sci U S A. 2009; 106(16).
  • Liu X, Huang H, Wang W, Wang J, Sachs F, Niu W. Stretch-activated potassium channels in hypotonically induced blebs of atrial myocytes. J Membr Biol. 2008; 226(1-3).
  • Kockskämper J, Khafaga M, Grimm M, Elgner A, Walther S, Kockskämper A, von Lewinski D, Post H, Grossmann M, Dörge H, Gottlieb PA, Sachs F, Eschenhagen T, Schöndube FA, Pieske B. Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium. Cardiovasc Res. 2008; 79(4).
  • Spagnoli C, Beyder A, Besch S, Sachs F. Atomic force microscopy analysis of cell volume regulation. Phys Rev E Stat Nonlin Soft Matter Phys. 2008; 78(3 Pt).
  • Meng F, Suchyna TM, Sachs F. A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ. FEBS J. 2008; 275(12).
  • Kockskämper J, von Lewinski D, Khafaga M, Elgner A, Grimm M, Eschenhagen T, Gottlieb PA, Sachs F, Pieske B. The slow force response to stretch in atrial and ventricular myocardium from human heart: functional relevance and subcellular mechanisms. Prog Biophys Mol Biol. 2008; 97(2-3).
  • Pennell T, Suchyna T, Wang J, Heo J, Felske JD, Sachs F, Hua SZ. Microfluidic chip to produce temperature jumps for electrophysiology. Anal Chem. 2008; 80(7).
  • Heo J, Meng F, Sachs F, Hua SZ. Dynamic effects of Hg2+-induced changes in cell volume. Cell Biochem Biophys. 2008; 51(1).
  • Gottlieb P, Folgering J, Maroto R, Raso A, Wood TG, Kurosky A, Bowman C, Bichet D, Patel A, Sachs F, Martinac B, Hamill OP, Honoré E. Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Arch. 2008; 455(6).
  • Chemin J, Patel AJ, Duprat F, Sachs F, Lazdunski M, Honore E. Up- and down-regulation of the mechano-gated K(2P) channel TREK-1 by PIP (2) and other membrane phospholipids. Pflugers Arch. 2007; 455(1).
  • Suchyna TM, Sachs F. Mechanosensitive channel properties and membrane mechanics in mouse dystrophic myotubes. J Physiol. 2007; 581(Pt 1).
  • Spagnoli C, Beyder A, Besch SR, Sachs F. Drift-free atomic force microscopy measurements of cell height and mechanical properties. Rev Sci Instrum. 2007; 78(3).
  • Bowman CL, Gottlieb PA, Suchyna TM, Murphy YK, Sachs F. Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon. 2007; 49(2).
  • Whitehead NP, Streamer M, Lusambili LI, Sachs F, Allen DG. Streptomycin reduces stretch-induced membrane permeability in muscles from mdx mice. Neuromuscul Disord. 2006; 16(12).
  • Milescu LS, Yildiz A, Selvin PR, Sachs F. Extracting dwell time sequences from processive molecular motor data. Biophys J. 2006; 91(9).
  • Milescu LS, Yildiz A, Selvin PR, Sachs F. Maximum likelihood estimation of molecular motor kinetics from staircase dwell-time sequences. Biophys J. 2006; 91(4).
  • Beyder A, Sachs F. Microfabricated torsion levers optimized for low force and high-frequency operation in fluids. Ultramicroscopy. 2006; 106(8-9).
  • Jacques-Fricke BT, Seow Y, Gottlieb PA, Sachs F, Gomez TM. Ca2+ influx through mechanosensitive channels inhibits neurite outgrowth in opposition to other influx pathways and release from intracellular stores. J Neurosci. 2006; 26(21).
  • Honoré E, Patel AJ, Chemin J, Suchyna T, Sachs F. Desensitization of mechano-gated K2P channels. Proc Natl Acad Sci U S A. 2006; 103(18).
  • Chess PR, O'Reilly MA, Sachs F, Finkelstein JN. Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells. J Appl Physiol. 2005; 99(3).
  • Ostrow LW, Sachs F. Mechanosensation and endothelin in astrocytes--hypothetical roles in CNS pathophysiology. Brain Res Brain Res Rev. 2005; 48(3).
  • Milescu LS, Akk G, Sachs F. Maximum likelihood estimation of ion channel kinetics from macroscopic currents. Biophys J. 2005; 88(4).
  • Bao L, Sachs F, Dahl G. Connexins are mechanosensitive. Am J Physiol Cell Physiol. 2004; 287(5).
  • Gottlieb PA, Suchyna TM, Ostrow LW, Sachs F. Mechanosensitive ion channels as drug targets. Curr Drug Targets CNS Neurol Disord. 2004; 3(4).
  • Suchyna TM, Tape SE, Koeppe RE, Andersen OS, Sachs F, Gottlieb PA. Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers.. Nature. 2004; 430(6996).
  • Ostrow KL, Mammoser A, Suchyna T, Sachs F, Oswald R, Kubo S, Chino N, Gottlieb PA. cDNA sequence and in vitro folding of GsMTx4, a specific peptide inhibitor of mechanosensitive channels.. Toxicon. 2003; 42(3).
  • Niu W, Sachs F. Dynamic properties of stretch-activated K+ channels in adult rat atrial myocytes. Prog Biophys Mol Biol. 2003; 82(1-3).
  • Besch S, Snyder KV, Zhang PC, Sachs F. Adapting the Quesant Nomad atomic force microscope for biology and patch-clamp atomic force microscopy. Cell Biochem Biophys. 2003; 39(3).
  • Hua SZ, Sachs F, Yang DX, Chopra HD. Microfluidic actuation using electrochemically generated bubbles.. Anal Chem. 2002; 74(24).
  • Ding S, Sachs F. Evidence for non-independent gating of P2X2 receptors expressed in Xenopus oocytes.. BMC Neurosci. 2002; 3(1).
  • Besch SR, Suchyna T, Sachs F. High-speed pressure clamp.. Pflugers Arch. 2002; 445(1).
  • Oswald RE, Suchyna TM, McFeeters R, Gottlieb P, Sachs F. Solution structure of peptide toxins that block mechanosensitive ion channels.. J Biol Chem. 2002; 277(37).
  • Petrov AG, Sachs F. Flexoelectricity and elasticity of asymmetric biomembranes.. Phys Rev E Stat Nonlin Soft Matter Phys. 2002; 65(2 Pt).
  • Zhang PC, Keleshian AM, Sachs F. Voltage-induced membrane movement.. Nature. 2001; 413(6854).
  • Zhang PC, Keleshian AM, Sachs F. Voltage-induced membrane movement.. Nature. 2001; 413(6854).
  • Zhang PC, Keleshian AM, Sachs F. Voltage-induced membrane movement.. Nature. 2001; 413(6854).
  • Bode F, Sachs F, Franz MR. Tarantula peptide inhibits atrial fibrillation.. Nature. 2001; 409(6816).
  • Ostrow LW, Langan TJ, Sachs F. Stretch-induced endothelin-1 production by astrocytes.. J Cardiovasc Pharmacol. 2000; 36(5 Sup).
  • Ostrow LW, Langan TJ, Sachs F. Stretch-induced endothelin-1 production by astrocytes.. J Cardiovasc Pharmacol. 2000; 36(5 Sup).
  • Ostrow LW, Langan TJ, Sachs F. Stretch-induced endothelin-1 production by astrocytes.. J Cardiovasc Pharmacol. 2000; 36(5 Sup).
  • Qin F, Auerbach A, Sachs F. A direct optimization approach to hidden Markov modeling for single channel kinetics.. Biophys J. 2000; 79(4).
  • Qin F, Auerbach A, Sachs F. A direct optimization approach to hidden Markov modeling for single channel kinetics.. Biophys J. 2000; 79(4).
  • Qin F, Auerbach A, Sachs F. A direct optimization approach to hidden Markov modeling for single channel kinetics.. Biophys J. 2000; 79(4).
  • Qin F, Auerbach A, Sachs F. A direct optimization approach to hidden Markov modeling for single channel kinetics.. Biophys J. 2000; 79(4).
  • Suchyna TM, Johnson JH, Hamer K, Leykam JF, Gage DA, Clemo HF, Baumgarten CM, Sachs F. Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels.. J Gen Physiol. 2000; 115(5).
  • Niggel J, Sigurdson W, Sachs F. Mechanically induced calcium movements in astrocytes, bovine aortic endothelial cells and C6 glioma cells.. J Membr Biol. 2000; 174(2).
  • Bett GC, Sachs F. Whole-cell mechanosensitive currents in rat ventricular myocytes activated by direct stimulation.. J Membr Biol. 2000; 173(3).
  • Bett GC, Sachs F. Activation and inactivation of mechanosensitive currents in the chick heart.. J Membr Biol. 2000; 173(3).
  • Zeng T, Bett GC, Sachs F. Stretch-activated whole cell currents in adult rat cardiac myocytes.. Am J Physiol Heart Circ Physiol. 2000; 278(2).
  • Bett GC, Sachs F. Whole-cell mechanosensitive currents in rat ventricular myocytes activated by direct stimulation. J Membr Biol. 2000; 173(3).
  • Bett GC, Sachs F. Activation and Inactivation of Mechanosensitive Currents in the Chick Heart. J. Membrane Biology. 2000; 173.
  • Zeng T, Bett GC, Sachs F. Stretch-activated whole-cell currents in adult rat cardiac myocytes. American Journal of Physiology. 2000; 278.
  • Ding S, Sachs F. Inactivation of P2X2 purinoceptors by divalent cations.. J Physiol. 2000; 522 P.
  • Ding S, Sachs F. Ion permeation and block of P2X(2) purinoceptors: single channel recordings.. J Membr Biol. 1999; 172(3).
  • Sachs F. Practical limits on the maximal speed of solution exchange for patch clamp experiments.. Biophys J. 1999; 77(2).
  • Snyder KV, Kriegstein AM, Sachs F. A convenient electrode holder for glass pipettes to stabilize electrode potentials.. Pflugers Arch. 1999; 438(3).
  • Ding S, Sachs F. Single channel properties of P2X2 purinoceptors.. J Gen Physiol. 1999; 113(5).
  • Sukharev SI, Sigurdson WJ, Kung C, Sachs F. Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL.. J Gen Physiol. 1999; 113(4).
  • Akinlaja J, Sachs F. The breakdown of cell membranes by electrical and mechanical stress.. Biophys J. 1998; 75(1).
  • Luna EJ, Hitt AL, Shutt D, Wessels D, Soll D, Jay P, Hug C, Elson EL, Vesley A, Downey GP, Wang M, Block SM, Sigurdson W, Sachs F. Role of ponticulin in pseudopod dynamics, cell-cell adhesion, and mechanical stability of an amoeboid membrane skeleton.. Biol Bull. 1998; 194(3).
  • Mosbacher J, Langer M, Hörber JK, Sachs F. Voltage-dependent membrane displacements measured by atomic force microscopy.. J Gen Physiol. 1998; 111(1).
  • Sachs F. In defence of small science.. Nature. 1997; 390(6656).
  • Zhang B, Sigurdson W, Sachs F. Storing analog data in a video record.. J Neurosci Methods. 1997; 76(2).
  • Hu H, Sachs F. Stretch-activated ion channels in the heart.. J Mol Cell Cardiol. 1997; 29(6).
  • Qin F, Auerbach A, Sachs F. Maximum likelihood estimation of aggregated Markov processes.. Proc R Soc Lond B Biol Sci. 1997; 264(1380).
  • Qin F, Auerbach A, Sachs F. Maximum likelihood estimation of aggregated Markov processes.. Proc R Soc Lond B Biol Sci. 1997; 264(1380).
  • Qin F, Auerbach A, Sachs F. Maximum likelihood estimation of aggregated Markov processes.. Proc R Soc Lond B Biol Sci. 1997; 264(1380).
  • Qin F, Auerbach A, Sachs F. Maximum likelihood estimation of aggregated Markov processes.. Proc R Soc Lond B Biol Sci. 1997; 264(1380).
  • Bett GC, Sachs F. Cardiac Mechanosensitivity and Stretch Activated Ion Channels. Trends in Cardiovascular Medicine. 1997; 7.
  • Sachs F. Mechanical transduction by ion channels: how forces reach the channel. Soc Gen Physiol Ser. 1997; 52.
  • Hu H, Sachs F. Mechanically activated currents in chick heart cells.. J Membr Biol. 1996; 154(3).
  • Zabel M, Koller BS, Sachs F, Franz MR. Stretch-induced voltage changes in the isolated beating heart: importance of the timing of stretch and implications for stretch-activated ion channels.. Cardiovasc Res. 1996; 32(1).
  • Chen Y, Simasko SM, Niggel J, Sigurdson WJ, Sachs F. Ca2+ uptake in GH3 cells during hypotonic swelling: the sensory role of stretch-activated ion channels.. Am J Physiol. 1996; 270(6 Pt).
  • Qin F, Auerbach A, Sachs F. Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events.. Biophys J. 1996; 70(1).
  • Qin F, Auerbach A, Sachs F. Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events.. Biophys J. 1996; 70(1).
  • Qin F, Auerbach A, Sachs F. Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events.. Biophys J. 1996; 70(1).
  • Qin F, Auerbach A, Sachs F. Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events.. Biophys J. 1996; 70(1).
  • Sachs F. A low drift micropipette holder.. Pflugers Arch. 1995; 429(3).
  • Diamond SL, Sachs F, Sigurdson WJ. Mechanically induced calcium mobilization in cultured endothelial cells is dependent on actin and phospholipase.. Arterioscler Thromb. 1994; 14(12).
  • Sachs F, Qin F. Gated, ion-selective channels observed with patch pipettes in the absence of membranes: novel properties of a gigaseal.. Biophys J. 1993; 65(3).
  • Sachs F, Qin F. Gated, ion-selective channels observed with patch pipettes in the absence of membranes: novel properties of a gigaseal.. Biophys J. 1993; 65(3).
  • Sachs F, Qin F. Gated, ion-selective channels observed with patch pipettes in the absence of membranes: novel properties of a gigaseal.. Biophys J. 1993; 65(3).
  • Sigurdson WJ, Sachs F, Diamond SL. Mechanical perturbation of cultured human endothelial cells causes rapid increases of intracellular calcium.. Am J Physiol. 1993; 264(6 Pt).
  • Ruknudin A, Sachs F, Bustamante JO. Stretch-activated ion channels in tissue-cultured chick heart.. Am J Physiol. 1993; 264(3 Pt).
  • Bowman CL, Ding JP, Sachs F, Sokabe M. Mechanotransducing ion channels in astrocytes.. Brain Res. 1992; 584(1-2).
  • Sigurdson W, Ruknudin A, Sachs F. Calcium imaging of mechanically induced fluxes in tissue-cultured chick heart: role of stretch-activated ion channels.. Am J Physiol. 1992; 262(4 Pt).
  • Ding JP, Salvi RJ, Sachs F. Stretch-activated ion channels in guinea pig outer hair cells.. Hear Res. 1991; 56(1-2).
  • Izu YC, Sachs F. Inhibiting synthesis of extracellular matrix improves patch clamp seal formation.. Pflugers Arch. 1991; 419(2).
  • Sachs F, Sigurdson W, Ruknudin A, Bowman C. Single-channel mechanosensitive currents. Science. 1991; 253(5021).
  • Sachs F. Mechanical transduction by membrane ion channels: a mini review. Mol Cell Biochem. 1991; 104(1-2).
  • Sokabe M, Sachs F, Jing ZQ. Quantitative video microscopy of patch clamped membranes stress, strain, capacitance, and stretch channel activation.. Biophys J. 1991; 59(3).
  • Jing ZQ, Sachs F. Alignment of tomographic projections using an incomplete set of fiducial markers.. Ultramicroscopy. 1991; 35(1).
  • Bustamante JO, Ruknudin A, Sachs F. Stretch-activated channels in heart cells: relevance to cardiac hypertrophy. J Cardiovasc Pharmacol. 1991; 17 Su.
  • Ruknudin A, Song MJ, Sachs F. The ultrastructure of patch-clamped membranes: a study using high voltage electron microscopy.. J Cell Biol. 1991; 112(1).
  • Yang XC, Sachs F. Characterization of stretch-activated ion channels in Xenopus oocytes.. J Physiol. 1990; 431.
  • Sokabe M, Sachs F. The structure and dynamics of patch-clamped membranes: a study using differential interference contrast light microscopy.. J Cell Biol. 1990; 111(2).
  • Sachs F, Sokabe M. Stretch-activated ion channels and membrane mechanics. Neurosci Res Suppl. 1990; 12.
  • Gao XQ, Sachs F. Improving performance of motorized slides for micromanipulation.. J Neurosci Methods. 1989; 28(3).
  • Yang XC, Sachs F. Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions.. Science. 1989; 243(4894).
  • Sachs F. Mechanical transduction in biological systems. Crit Rev Biomed Eng. 1988; 16(2).
  • Sachs F. [Tooth structure-conserving preparation of Class V cavities]. Dtsch Zahnarztl Z. 1987; 42(12).
  • Sachs F. Baroreceptor mechanisms at the cellular level.. Fed Proc. 1987; 46(1).
  • Sachs F. Biophysics of mechanoreception. Membr Biochem. 1986; 6(2).
  • Auerbach A, Sachs F, Neil J, McGarrigle R. Temperature measurement and control of small volumes: applications for single channel recording. Methods Enzymol. 1986; 124.
  • Sachs F. [Qualitative and quantitative analysis of N2-Normal Universal]. Dtsch Zahnarztl Z. 1985; 40(9).
  • Sachs F. [McSpadden's thermoplastic root canal obturation]. Dtsch Zahnarztl Z. 1985; 40(9).
  • Guharay F, Sachs F. Mechanotransducer ion channels in chick skeletal muscle: the effects of extracellular pH.. J Physiol. 1985; 363.
  • Guharay F, Sachs F. Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle.. J Physiol. 1984; 352.
  • Auerbach A, Sachs F. Single-channel currents from acetylcholine receptors in embryonic chick muscle. Kinetic and conductance properties of gaps within bursts.. Biophys J. 1984; 45(1).
  • Auerbach A, Sachs F. Single-channel currents from acetylcholine receptors in embryonic chick muscle. Kinetic and conductance properties of gaps within bursts.. Biophys J. 1984; 45(1).
  • Auerbach A, Sachs F. Single-channel currents from acetylcholine receptors in embryonic chick muscle. Kinetic and conductance properties of gaps within bursts.. Biophys J. 1984; 45(1).
  • Auerbach A, Sachs F. Patch clamp studies of single ionic channels. Annu Rev Biophys Bioeng. 1984; 13.
  • Demjanenko V, Sachs F. Computer controlled voltage clamp.. Med Biol Eng Comput. 1983; 21(5).
  • Auerbach A, Sachs F. Flickering of a nicotinic ion channel to a subconductance state.. Biophys J. 1983; 42(1).
  • Auerbach A, Sachs F. Flickering of a nicotinic ion channel to a subconductance state.. Biophys J. 1983; 42(1).
  • Auerbach A, Sachs F. Flickering of a nicotinic ion channel to a subconductance state.. Biophys J. 1983; 42(1).
  • Sachs F, Auerbach A. Single-channel electrophysiology: use of the patch clamp. Methods Enzymol. 1983; 103.
  • Sachs F, Neil J, Barkakati N. The automated analysis of data from single ionic channels.. Pflugers Arch. 1982; 395(4).
  • Demjanenko V, Sachs F. Computer interface for electrophysiological applications: simple modifications to a commercial (Datel) single-board data-aquisition system.. Med Biol Eng Comput. 1982; 20(1).
  • Sachs F, Specht P. Fast microelectrode headstage for voltage clamp.. Med Biol Eng Comput. 1981; 19(3).
  • Sachs F, McGarrigle R. An almost completely shielded microelectrode.. J Neurosci Methods. 1980; 3(2).
  • Sachs F. Microforge modifications useful for construction of micropipettes to record the response of single ionic channels from living cells.. J Neurosci Methods. 1980; 2(3).
  • Nelson DJ, Sachs F. Single ionic channels observed in tissue-cultured muscle. Nature. 1979; 282(5741).
  • Sachs F, Lecar H. Acetylcholine-induced current fluctuations in tissue-cultured muscle cells under voltage clamp.. Biophys J. 1977; 17(2).
  • Sachs F. Electrophysiological properties of tissue cultured heart cells grown in a linear array.. J Membr Biol. 1976; 28(4).
  • Sachs F, Feinman RD. Spin-labelled human platelets.. Thromb Res. 1976; 8(1).
  • Sachs F, Latorre R. Cytoplasmic solvent structure of single barnacle muscle cells studied by electron spin resonance.. Biophys J. 1974; 14(4).
  • Sachs F, Lecar H. Acetylcholine noise in tissue culture muscle cells.. Nat New Biol. 1973; 246(155).
  • Bortoff A, Sachs F. Electrotonic spread of slow waves in circular muscle of small intestine.. Am J Physiol. 1970; 218(2).
  • Waltuch G, Sachs F. Herpes zoster in a patient with Hodgkin's disease. Treatment with idoxuridine.. Arch Intern Med. 1968; 121(5).
  • Sachs F. Biophysics of mechanoreception.. Membr Biochem. ; 6(2).
  • Sachs F, Davis H. The joint state public assistance, vocational rehabilitation cooperative programs. Expansion grants in historic perspective.. Rehabil Rec. ; 12(3).
  • Sachs F. Mechanical transduction in biological systems.. Crit Rev Biomed Eng. ; 16(2).
  • Bustamante JO, Ruknudin A, Sachs F. Stretch-activated channels in heart cells: relevance to cardiac hypertrophy.. J Cardiovasc Pharmacol. ; 17 Su.
  • Nelson DJ, Sachs F. Single ionic channels observed in tissue-cultured muscle.. Nature. ; 282(5741).
  • Sachs F, Sokabe M. Stretch-activated ion channels and membrane mechanics.. Neurosci Res Suppl. ; 12.
  • Sachs F. Mechanical transduction by membrane ion channels: a mini review.. Mol Cell Biochem. ; 104(1-2).
  • Sachs F. Stretch-sensitive ion channels: an update.. Soc Gen Physiol Ser. ; 47.
  • Yang XC, Sachs F. Mechanically sensitive, nonselective cation channels.. EXS. ; 66.
  • Sachs F. Mechanical transduction by ion channels: how forces reach the channel.. Soc Gen Physiol Ser. ; 52.
  • Sachs F, Auerbach A. Single-channel electrophysiology: use of the patch clamp.. Methods Enzymol. ; 103.
  • Sachs F, Auerbach A. Single-channel electrophysiology: use of the patch clamp.. Methods Enzymol. ; 103.
  • Sachs F, Auerbach A. Single-channel electrophysiology: use of the patch clamp.. Methods Enzymol. ; 103.
  • Sachs F, Morris CE. Mechanosensitive ion channels in nonspecialized cells.. Rev Physiol Biochem Pharmacol. ; 132.
  • Auerbach A, Sachs F, Neil J, McGarrigle R. Temperature measurement and control of small volumes: applications for single channel recording.. Methods Enzymol. ; 124.
  • Auerbach A, Sachs F, Neil J, McGarrigle R. Temperature measurement and control of small volumes: applications for single channel recording.. Methods Enzymol. ; 124.
  • Auerbach A, Sachs F, Neil J, McGarrigle R. Temperature measurement and control of small volumes: applications for single channel recording.. Methods Enzymol. ; 124.
  • Auerbach A, Sachs F. Patch clamp studies of single ionic channels.. Annu Rev Biophys Bioeng. ; 13.
  • Auerbach A, Sachs F. Patch clamp studies of single ionic channels.. Annu Rev Biophys Bioeng. ; 13.
  • Auerbach A, Sachs F. Patch clamp studies of single ionic channels.. Annu Rev Biophys Bioeng. ; 13.
  • Niu W, Sachs F. Dynamic properties of stretch-activated K+ channels in adult rat atrial myocytes.. Prog Biophys Mol Biol. ; 82(1-3).
See All (179 Total) >

Professional Memberships:
  • BBA (1997)
  • Cell Biophysics & Biochemistry; Editorial Board (1988)
  • Biophysical Journal; Editorial board (1983–1989)
  • Cellular Neurobiology; Editorial board (1983–1986)
  • Biophysical Society
  • Society of General Physiology
  • Ontario & WNY Ion Channel Interest Group
Presentations:
  • "Volume Regulation" Gordon conference (2005)
  • "Ion channels" conference (2004)
  • "Mechanical Transduction" American Society of Cell biology (2004)
  • "Cell Mechanosensing" conference (2004)
  • "Mechanical Transduction" Australian Soc. Physiology (2004)
  • "Mechanical Transduction" Australian Soc. Biophysics (2004)
  • "Mechanical Transduction" Cardiostim (2004)
  • "Mechanical Transduction" Gordon Conference (2003)
  • "Current Aspects in Basic & Clinical Electrophysiology" conference (2003)
  • "Mechanical Transduction" Nanobioscience (2002)
  • "Mechanical Transduction" Internat'l School of Condensed Matter Physics (2002)
  • "Mechanoelectric Feedback in the Heart" workshop (2002)
  • "Molecular Biophysics of Cellular Membranes" FASEB (2002)
  • "Cardiostim" Lecture (2002)
  • "Gravitaional Effects on Living Systems" Gordon Conference (2001)
  • "Physical Chemistry of Ion Channels" lecture (2000)
  • "Gordon Conference on Ion Channels, (P2X Channels)" Gordon Conference (2000)
  • "NSF Workshop on Force Transduction in Biology" workshop, NSF (2000)
  • "Int. Cong. Comparative Physiol. and Bioch." lecture (1999)
  • "FASEB symposium on mechanotransduction" lecture (1999)
  • "Biophysical Society Membrane Subgroup" lecture, Biophysical Society, Membrane Subgroup (1999)
  • "Workshop on mechanosensitivity" lecture, Society of Cell Biology (1997)
  • "Workshop on scanning probe microscopy, on AFM" lecture, Society of Cell Biology (1997)
  • "Int'l. Wksp. Mechano-Electrical Feedback & Cardiac Arryth." lecture (1997)
  • "Computaional Biology of the Heart: from structure to function" lecture, UCSD (1997)
  • ""Circulation 97"" lecture, Japanese Circulation Society (1997)
  • "Winter Brain Conference, P2X channels" lecture (1997)
See All (27 Total) >
Service Activities:
  • Keck center for computational biology administrator; Administrator (2000)
  • University Council on Research & Spon. Prog.; Member (1997)
  • Organizer of Seminars; Chairman (1995–1996)
  • Hughes Undergraduate Fellowship Advisor; Advisory Board (1995)
  • Minorities in Science; Advisory Board (1995)
  • SUNYAB NASA Fellowship Program; Member (1994)
  • Technology Transfer Consultant; Other (1991)
  • Director of Grad. Studies; Director (1989–1990)
  • Patent Policy Review board; Board Member (1989)
  • Administrator of Biophysical Sciences Mechanical Shop; Administrator (1986–1991)
  • Distinguished Scientist Seminar Series; Department Representative (1985)
  • E.C.Bar Assoc., Arbitration Board; Board Member (1985)
  • Med. Student Advisor; Advisor (1985)
  • Rep. to Med. Faculty Council from Biophysics; Department Representative (1980–1985)
  • WNY Science Fair Judge; Judge (1978)
  • Rep. to Med. Faculty Council from Pharmacology; Department Representative (1976–1978)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

301 Cary Hall
Buffalo, NY 14214
Phone: (716) 829-5161
Email: sachs@buffalo.edu


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