Stanley A. Schwartz MD, PhD
Stanley A. Schwartz
MD, PhD
UB Distinguished Professor, Medicine and Pediatrics; Division Chief, Allergy-Immunology-Rheumatology
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Allergy and Immunology
Education and Training:
- Fellowship, Clinical Immunology, Memorial Sloan-Kettering Cancer Center (1976)
- Residency, Pediatrics, Albert Einstein College of Medicine (1974)
- Internship, Pediatrics, Albert Einstein College of Medicine (1973)
- MD, Albert Einstein College of Medicine (1972)
- Postdoctoral Fellow, Biology, University of California, San Diego (1969)
- PhD, Cellular Biology, University of California, San Diego (1968)
- MS, Microbiology, Rutgers University (1965)
- AB, Biological Sciences, Rutgers College, Henry Rutgers Scholar (1963)
Employment:
- Physician, Medicine, VA of Western NY (1996-present)
- Physician, Erie County Medical Center (1996-present)
- Professor of Pediatrics, Medicine, University at Buffalo (1994-present)
- Physician, Medicine, Kaleida Health Systems (1992-present)
- Professor of Medicine, Medicine, University at Buffalo (1992-present)
- Professor of Microbiology and Immunology, Medicine, University at Buffalo (1994–2015)
- Professor of Epidemiology, The University of Michigan (1984–1992)
- Professor of Pediatrics and Microbiology & Immunology, Pediatrics, The University of Michigan, The University of Michigan (1978–1992)
- Assistant Professor, Pediatrics, Cornell University Medical College (1977–1978)
Awards and Honors:
- Stockton Kimball Award (2003)
- Sustained Academic Achievement Award (2002)
- Listed in Best Doctors in the U.S.®
- Listed in Guide to America’s Top Physicians, Consumers’ Research Council
- NIH Research Career Development Award
- Meller Award for Outstanding Research (Memorial Sloan-Kettering)
- Clinical Research Fellowship (Memorial Sloan-Kettering Cancer Center)
- American Cancer Society Postdoctoral Scholarship (Albert Einstein College)
- UB Distinguished Professor
Research Expertise:
- Allergy and Immunology: Asthma, allergic rhinitis, urticaria, atopic dermatitis, cutaneous vasculitis, primary immunodeficiency, hereditary angioedema
- Immunology: Pathogenesis of HIV Encephalopathy Role of Angiogenesis in Cancer Mechanisms of Airway Remodeling in Asthma
Grants and Sponsored Research:
- July 2009–June 2011
Integration of Clinical, Genomic and Proteomic Data using Bioinformatic Approach
National Institute of Health
Role: Principal Investigator - July 1999–June 2009
Cocaine in the Immuno- and Neuropathogenesis of HIV Infections
NIH: National Institute on Drug Abuse
Role: Co-Investigator - August 2006
Endowment for the Division of Allergy, Immunology, and Rheumatolgoy
Kaleida Health Foundation
Role: Principal Investigator - January 2001
Development of a Center of Excellence in Tumor Immunology: Regulation of Angiogenesis in Prostate Cancer
Margaret Duffy and Robert Cameron Troup Memorial Fund
Role: Principal Investigator
Patents:
- Method of Using Gold Nonorods-SiRNA Complexes #8, 035, 016 (2011)
Journal Articles:
- Anu Sharma, Anita Yadav, Sandeep Sharma, Rita Kakkar, Katherine Cwiklinski, Elizabeth Quaye, Supriya Mahajan, Stanley A. Schwartz, Rakesh Kumar Sharma. Multifunctional mesoporous curcumin encapsulated iron-phenanthroline nanocluster: A new Anti-HIV agent. Colloids and Surfaces B: Biointerfaces. 2019; 180.
- Patel S, Parikh NU, Aalinkeel R, Reynolds JL, Dmello R, Schwartz SA, Mahajan SD. United States National Trends in Mortality, Length of Stay (LOS) and Associated Costs of Cognitive Impairment in HIV Population from 2005 to 2014. AIDS Behav. 2018; 22(10).
- Sharikova AV, Quaye E*, Aalinkeel R, Park JY, Maloney MC, Desta H, Thiyagarajan R, Seldeen K, Khmaladze A, Troen B, Schwartz SA and Mahajan SD. Methamphetamine-induced mitochondrial toxicity is a major determinant of microglial apoptosis.. J Neuroimmune Pharmacol. 2018; 13(3).
- Mammen MJ, Sands MF, Abou-Jaoude E, Aalinkeel R, Reynolds JL, Parikh NU, Sharma U, Schwartz SA, Mahajan SD. Role of Galectin-3 in the pathophysiology underlying allergic lung inflammation in a tissue inhibitor of metalloproteinases 1 knockout model of murine asthma.. Immunology. 2018; 153(3).
- Schwartz SA. Mitochondrial dysfunction in an aging HIV patient cohort with HIV associated neurological disorders (HAND). Journal of Neurovirology. 2018; 24.
- Sharma RK, Cwiklinski K, Aalinkeel R, Reynolds JL, Sykes DE, Quaye E, Oh J, Mahajan SD, Schwartz SA. Immunomodulatory activities of curcumin-stabilized silver nanoparticles: Efficacy as an antiretroviral therapeutic. Immunol Invest. 2017; 46(8).
- Mahajan SD, Aalinkeel R, Parikh NU, Jacob A, Cwiklinski K, Sandhu P, Le K, Loftus AW, Schwartz SA, Quigg RJ, Alexander JJ. Immunomodulatory Role of Complement Proteins in the Neuropathology Associated with Opiate Abuse and HIV-1 Co-Morbidity. Immunol Invest. 2017; 46(8).
- Aalinkeel R, Kutscher HL, Singh A, Cwiklinski K, Khechen N, Schwartz SA, Prasad PN, Mahajan SD. Neuroprotective effects of a biodegradable poly(lactic-co-glycolic acid)-ginsenoside Rg3 nanoformulation: a potential nanotherapy for Alzheimer‘s disease? J Drug Targeting. 2017; 26(2).
- Aalinkeel R, Mangum CS, Abou-Jaoude E, Reynolds JL, Liu M, Sundquist K, Parikh NU, Chaves LD, Mammen MJ, Schwartz SA, Mahajan SD. Galectin-1 Reduces Neuroinflammation via Modulation of Nitric Oxide-Arginase Signaling in HIV-1 Transfected Microglia: a Gold Nanoparticle-Galectin-1 "Nanoplex" a Possible Neurotherapeutic?. J Neuroimmune Pharmacol. 2017; 12(1).
- Aalinkeel R, Nair B, Chen CK, Mahajan SD, Reynolds JL, Zhang H, Sun H, Sykes DE, Chadha KC, Turowski SG, Bothwell KD, Seshadri M, Cheng C, Schwartz SA. Nanotherapy silencing the interleukin-8 gene produces regression of prostate cancer by inhibition of angiogenesis. Immunology. 2016; 148(4).
- Chadha KC, Nair B, Godoy A, Rajnarayanan R, Nabi E, Zhou R, Patel NR, Aalinkeel R, Schwartz SA, Smith GJ. Anti-angiogenic activity of PSA-derived peptides. Prostate. 2015; 75(12).
- Mahajan SD, Parikh NU, Woodruff TM, Jarvis JN, Lopez M, Hennon TR, Cunningham P, Quigg RJ, Schwartz SA, Alexander JJ. C5a Alters Blood-brain Barrier Integrity in a Human in Vitro Model of Systemic Lupus Erythematosus. Immunology. 2015; 146(1).
- Parikh N, Aalinkeel R, Reynolds JL, Nair BB, Sykes DE, Mammen MJ, Schwartz SA, Mahajan SD. Galectin-1 suppresses methamphetamine induced neuroinflammation in human brain microvascular endothelial cells: Neuroprotective role in maintaining blood brain barrier integrity. Brain Res. 2015.
- Ignatowski TA, Aalinkeel R, Reynolds JL, Nair BB, Sykes DE, Gleason CP, Law WC, Mammen MJ, Prasad PN, Schwartz SA, Mahajan SD. Nanotherapeutic Approach for Opiate Addiction Using DARPP-32 Gene Silencing in an Animal Model of Opiate Addiction. J Neuroimmune Pharmacol. 2015; 10(1).
- Mahajan SD, Gaekwad A, Pawar J, Tripathy S, Ghate M, Bhattacharya J, Singh HO, Schwartz SA, Paranjape R, Gangakhedkar R. Cardiac morbidity in an HIV-1 lipodystrophy patient cohort expressing the TNF-α-238 G/A single nucleotide gene polymorphism. Curr HIV Res. 2015; 13(2).
- Mahajan SD, Gaekwad A, Pawar J, Tripathy S, Ghate M, Bhattacharya J, Singh HO, Schwartz SA, Paranjape R, Gangakhedkar R. Cardiac morbidity in an HIV-1 lipodystrophy patient cohort expressing the TNF-a-238 G/A single nucleotide gene polymorphism. Curr HIV Res. 2015; 13(2).
- Dai L, Li N, Wei F, Li J, Liu Y, Xia W, Zhang T, Guo C, Wang W, Schwartz SA, Mahajan SD, Hsiao CB, Wu H. Transmitted antiretroviral drug resistance in the men who have sex with men HIV patient cohort, Beijing, China, 2008-2011. Viral Immunol. 2014; 27(8).
- Chadha KC, Miller A, Nair BB, Schwartz SA, Trump DL, Underwood W. New serum biomarkers for prostate cancer diagnosis. Clin Cancer Investig J. 2014; 3(1).
- Chen CK, Law WC, Aalinkeel R, Yu Y, Nair B, Wu J, Mahajan S, Reynolds JL, Li Y, Lai CK, Tzanakakis ES, Schwartz SA, Prasad PN, Cheng C. Biodegradable cationic polymeric nanocapsules for overcoming multidrug resistance and enabling drug-gene co-delivery to cancer cells. Nanoscale. 2014; 6(3).
- Liu L, Hu R, Roy I, Lin G, Ye L, Reynolds JL, Liu J, Liu J, Schwartz SA, Zhang X, Yong KT. Synthesis of luminescent near-infrared AgInS2 nanocrystals as optical probes for in vivo applications. Theranostics. 2013; 3(2).
- Chen CK, Law WC, Aalinkeel R, Nair B, Kopwitthaya A, Mahajan SD, Reynolds JL, Zou J, Schwartz SA, Prasad PN, Cheng C. Well-defined degradable cationic polylactide as nanocarrier for the delivery of siRNA to silence angiogenesis in prostate cancer. Adv Healthc Mater. 2012; 1(6).
- Brown P, Nair B, Mahajan SD, Sykes DE, Rich G, Reynolds JL, Aalinkeel R, Wheeler J, Schwartz SA. Single nucleotide polymorphisms (SNPs) in key cytokines may modulate food allergy phenotypes. Eur Food Res Technol. 2012; 235(5).
- Mahajan SD, Aalinkeel R, Law WC, Reynolds JL, Nair BB, Sykes DE, Yong KT, Roy I, Prasad PN, Schwartz SA. Anti-HIV-1 nanotherapeutics: promises and challenges for the future. Int J Nanomedicine. 2012; 7.
- Law WC, Mahajan SD, Kopwitthaya A, Reynolds JL, Liu M, Liu X, Chen G, Erogbogbo F, Vathy L, Aalinkeel R, Schwartz SA, Yong KT, Prasad PN. Gene Silencing of Human Neuronal Cells for Drug Addiction Therapy using Anisotropic Nanocrystals. Theranostics. 2012; 2(7).
- Reynolds JL, Law WC, Mahajan SD, Aalinkeel R, Nair B, Sykes DE, Yong KT, Hui R, Prasad PN, Schwartz SA. Nanoparticle Based Galectin-1 Gene Silencing, Implications in Methamphetamine Regulation of HIV-1 Infection in Monocyte Derived Macrophages. J Neuroimmune Pharmacol. 2012.
- Aalinkeel R, Nair B, Reynolds JL, Sykes DE, Law WC, Mahajan SD, Prasad PN, Schwartz SA. Quantum rods as nanocarriers of gene therapy. Drug Deliv. 2012; 19(4).
- Reynolds JL, Law WC, Mahajan SD, Aalinkeel R, Nair B, Sykes DE, Mammen MJ, Yong KT, Hui R, Prasad PN, Schwartz SA. Morphine and galectin-1 modulate HIV-1 infection of human monocyte-derived macrophages. J Immunol. 2012; 188(8).
- Mahajan SD, Law WC, Aalinkeel R, Reynolds J, Nair BB, Yong KT, Roy I, Prasad PN, Schwartz SA. Nanoparticle-mediated targeted delivery of antiretrovirals to the brain. Methods Enzymol. 2012; 509.
- Chadha KC, Nair BB, Chakravarthi S, Zhou R, Godoy A, Mohler JL, Aalinkeel R, Schwartz SA, Smith GJ. Enzymatic activity of free-prostate-specific antigen (f-PSA) is not required for some of its physiological activities. Prostate. 2011; 71(15).
- Nair B, Wheeler JC, Sykes DE, Brown P, Reynolds JL, Aalinkeel R, Mahajan SD, Schwartz SA. Proteomic Approach to Evaluate Mechanisms That Contribute to Food Allergenicity: Comparative 2D-DIGE Analysis of Radioallergosorbent Test Positive and Negative Patients. Int J Proteomics. 2011; 2011.
- Mahajan SD, Aalinkeel R, Reynolds JL, Nair B, Sykes DE, Bonoiu A, Roy I, Yong KT, Law WC, Bergey EJ, Prasad PN, Schwartz SA. Suppression of MMP-9 expression in brain microvascular endothelial cells (BMVEC) using a gold nanorod (GNR)-siRNA nanoplex. Immunol Invest. 2011; 41(4).
- Mahajan SD, Aalinkeel R, Reynolds JL, Nair B, Sykes DE, Law WC, Ding H, Bergey EJ, Prasad PN, Schwartz SA. Nanotherapeutics Using an HIV-1 Poly A and Transactivator of the HIV-1 LTR-(TAR-) Specific siRNA. Patholog Res Int. 2011; 2011.
- Reynolds JL, Mahajan SD, Aalinkeel R, Nair B, Sykes DE, Schwartz SA. Methamphetamine and HIV-1 gp120 effects on lipopolysaccharide stimulated matrix metalloproteinase-9 production by human monocyte-derived macrophages. Immunol Invest. 2011; 40(5).
- Aalinkeel R, Nair BB, Reynolds JL, Sykes DE, Mahajan SD, Chadha KC, Schwartz SA. Overexpression of MMP-9 contributes to invasiveness of prostate cancer cell line LNCaP. Immunol Invest. 2011; 40(5).
- Mahajan SD, Roy I, Xu G, Yong KT, Ding H, Aalinkeel R, Reynolds J, Sykes D, Nair BB, Lin EY, Prasad PN, Schwartz SA. Enhancing the delivery of anti retroviral drug "Saquinavir" across the blood brain barrier using nanoparticles. Curr HIV Res. 2010; 8(5).
- Aalinkeel R, Hu Z, Nair BB, Sykes DE, Reynolds JL, Mahajan SD, Schwartz SA. Genomic Analysis Highlights the Role of the JAK-STAT Signaling in the Anti-proliferative Effects of Dietary Flavonoid-'Ashwagandha' in Prostate Cancer Cells. Evid Based Complement Alternat Med. 2010; 7(2).
- Mahajan SD, Agosto-Mojica A, Aalinkeel R, Reynolds JL, Nair BB, Sykes DE, Martinez J, Adams J, Singh N, Bernstein Z, Hsiao CB, Schwartz SA, Hsiao C. Role of chemokine and cytokine polymorphisms in the progression of HIV-1 disease. Biochem Biophys Res Commun. 2010; 396(2).
- Reynolds JL, Mahajan SD, Aalinkeel R, Nair B, Sykes DE, Agosto-Mujica A, Hsiao CB, Schwartz SA, Hsiao C. Modulation of the proteome of peripheral blood mononuclear cells from HIV-1-infected patients by drugs of abuse. J Clin Immunol. 2009; 29(5).
- Bonoiu A, Mahajan SD, Ye L, Kumar R, Ding H, Yong KT, Roy I, Aalinkeel R, Nair B, Reynolds JL, Sykes DE, Imperiale MA, Bergey EJ, Schwartz SA, Prasad PN. MMP-9 gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier. Brain Res. 2009; 1282.
- Bonoiu AC, Mahajan SD, Ding H, Roy I, Yong KT, Kumar R, Hu R, Bergey EJ, Schwartz SA, Prasad PN. Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons. Proc Natl Acad Sci U S A. 2009; 106(14).
- Sands MF, Ohtake PJ, Mahajan SD, Takyar SS, Aalinkeel R, Fang YV, Blume JW, Mullan BA, Sykes DE, Lachina S, Knight PR, Schwartz SA. Tissue inhibitor of metalloproteinase-1 modulates allergic lung inflammation in murine asthma. Clin Immunol. 2009; 130(2).
- Reynolds JL, Mahajan SD, Aalinkeel R, Nair B, Sykes DE, Schwartz SA. Proteomic analyses of the effects of drugs of abuse on monocyte-derived mature dendritic cells. Immunol Invest. 2009; 38(6).
- Mahajan SD, Aalinkeel R, Reynolds JL, Nair BB, Sykes DE, Hu Z, Bonoiu A, Ding H, Prasad PN, Schwartz SA. Therapeutic targeting of "DARPP-32": a key signaling molecule in the dopiminergic pathway for the treatment of opiate addiction. Int Rev Neurobiol. 2009; 88.
- Aalinkeel R, Bindukumar B, Reynolds JL, Sykes DE, Mahajan SD, Chadha KC, Schwartz SA. The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90. Prostate. 2008; 68(16).
- Schwartz SA. Proteomic profiling of the effect of prostate-specific antigen on prostate cancer cells Prostate. 2008; 68(14).
- Mahajan SD, Aalinkeel R, Sykes DE, Reynolds JL, Bindukumar B, Fernandez SF, Chawda R, Shanahan TC, Schwartz SA. Tight junction regulation by morphine and HIV-1 tat modulates blood-brain barrier permeability. J Clin Immunol. 2008; 28(5).
- Xu G, Yong KT, Roy I, Mahajan SD, Ding H, Schwartz SA, Prasad PN. Bioconjugated quantum rods as targeted probes for efficient transmigration across an in vitro blood-brain barrier. Bioconjug Chem. 2008; 19(6).
- Mahajan SD, Aalinkeel R, Sykes DE, Reynolds JL, Bindukumar B, Adal A, Qi M, Toh J, Xu G, Prasad PN, Schwartz SA. Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuse. Brain Res. 2008; 1203.
- Bernstein ZP, Dougherty T, Gollnick S, Schwartz SA, Mahajan SD, Kepner J, Sumlin A, Stewart C, Wallace P, Adal A, Walder H, Poiesz B. Photopheresis in HIV-1 infected patients utilizing benzoporphyrin derivative (BPD) verteporfin and light. Curr HIV Res. 2008; 6(2).
- Bindukumar B, Mahajan SD, Reynolds JL, Hu Z, Sykes DE, Aalinkeel R, Schwartz SA. Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008; 1191.
- Sands MF, Blume JW, Schwartz SA. Successful treatment of 3 patients with recurrent idiopathic angioedema with omalizumab. J Allergy Clin Immunol. 2007; 120(4).
- Reynolds JL, Mahajan SD, Sykes DE, Schwartz SA, Nair MP. Proteomic analyses of methamphetamine (METH)-induced differential protein expression by immature dendritic cells (IDC). Biochim Biophys Acta. 2007; 1774(4).
- Reynolds JL, Mahajan SD, Bindukumar B, Sykes D, Schwartz SA, Nair MP. Proteomic analysis of the effects of cocaine on the enhancement of HIV-1 replication in normal human astrocytes (NHA). Brain Res. 2006; 1123(1).
- Ludwig LB, Ambrus JL, Krawczyk KA, Sharma S, Brooks S, Hsiao CB, Schwartz SA. Human Immunodeficiency Virus-Type 1 LTR DNA contains an intrinsic gene producing antisense RNA and protein products. Retrovirology. 2006; 3.
- Nair MP, Mahajan S, Reynolds JL, Aalinkeel R, Nair H, Schwartz SA, Kandaswami C. The flavonoid quercetin inhibits proinflammatory cytokine (tumor necrosis factor alpha) gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappa beta system. Clin Vaccine Immunol. 2006; 13(3).
- Mahajan SD, Hu Z, Reynolds JL, Aalinkeel R, Schwartz SA, Nair MP. Methamphetamine modulates gene expression patterns in monocyte derived mature dendritic cells: implications for HIV-1 pathogenesis. Mol Diagn Ther. 2006; 10(4).
- Nair MP, Reynolds JL, Mahajan SD, Schwartz SA, Aalinkeel R, Bindukumar B, Sykes D. RNAi-directed inhibition of DC-SIGN by dendritic cells: prospects for HIV-1 therapy. AAPS J. 2005; 7(3).
- Mahajan SD, Aalinkeel R, Reynolds JL, Nair BB, Fernandez SF, Schwartz SA, Nair MP. Morphine exacerbates HIV-1 viral protein gp120 induced modulation of chemokine gene expression in U373 astrocytoma cells. Curr HIV Res. 2005; 3(3).
- Nair MP, Mahajan SD, Schwartz SA, Reynolds J, Whitney R, Bernstein Z, Chawda RP, Sykes D, Hewitt R, Hsiao CB, Hsiao C. Cocaine modulates dendritic cell-specific C type intercellular adhesion molecule-3-grabbing nonintegrin expression by dendritic cells in HIV-1 patients. J Immunol. 2005; 174(11).
- Mahajan SD, Schwartz SA, Aalinkeel R, Chawda RP, Sykes DE, Nair MP. Morphine modulates chemokine gene regulation in normal human astrocytes. Clin Immunol. 2005; 115(3).
- Bindukumar B, Schwartz SA, Nair MP, Aalinkeel R, Kawinski E, Chadha KC. Prostate-Specific Antigen Modulates the Expression of Genes Involved in Prostate Tumor Growth. Neoplasia. 2005; 7(5).
- Bindukumar B, Kawinski E, Cherrin C, Gambino LM, Nair MP, Schwartz SA, Chadha KC. Two step procedure for purification of enzymatically active prostate-specific antigen from seminal plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2004; 813(1-2).
- Nair MP, Schwartz SA, Mahajan SD, Tsiao C, Chawda RP, Whitney R, Don Sykes BB, Hewitt R. Drug abuse and neuropathogenesis of HIV infection: role of DC-SIGN and IDO. J Neuroimmunol. 2004; 157(1-2).
- Aalinkeel R, Nair MP, Sufrin G, Mahajan SD, Chadha KC, Chawda RP, Schwartz SA. Gene expression of angiogenic factors correlates with metastatic potential of prostate cancer cells. Cancer Res. 2004; 64(15).
- Nair MP, Mahajan S, Hewitt R, Whitney ZR, Schwartz SA. Association of drug abuse with inhibition of HIV-1 immune responses: studies with long-term of HIV-1 non-progressors. J Neuroimmunol. 2004; 147(1-2).
- Nair HK, Rao KV, Aalinkeel R, Mahajan S, Chawda R, Schwartz SA. Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004; 11(1).
- Chadha KC, Schwartz SA, Nair MP, Demeter LR, Hewitt RG. Serum interferon inhibitor declines in patients with HIV-1 infection after a change in antiretroviral therapy. Immunol Invest. 2003; 32(4).
- Mahajan SD, Aalinkeel R, Schwartz SA, Chawda RP, Nair MP. Effector cell mediated cytotoxicity measured by intracellular Granzyme B release in HIV infected subjects. Biol Proced Online. 2003; 5.
- Mahajan SD, Schwartz SA, Nair MP. Immunological assays for chemokine detection in in-vitro culture of CNS cells. Biol Proced Online. 2003; 5.
- Nair MP, Kandaswami C, Mahajan S, Chadha KC, Chawda R, Nair H, Kumar N, Nair RE, Schwartz SA. The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Biochim Biophys Acta. 2002; 1593(1).
- Mahajan SD, Schwartz SA, Shanahan TC, Chawda RP, Nair MP. Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu receptor. J Immunol. 2002; 169(7).
- Nesbit CE, Schwartz SA. In vitro and animal models of human immunodeficiency virus infection of the central nervous system. Clin Diagn Lab Immunol. 2002; 9(3).
- Nair N, Mahajan S, Chawda R, Kandaswami C, Shanahan TC, Schwartz SA. Grape seed extract activates Th1 cells in vitro. Clin Diagn Lab Immunol. 2002; 9(2).
- Nair MP, Kandaswami C, Mahajan S, Nair HN, Chawda R, Shanahan T, Schwartz SA. Grape seed extract proanthocyanidins downregulate HIV-1 entry coreceptors, CCR2b, CCR3 and CCR5 gene expression by normal peripheral blood mononuclear cells. Biol Res. 2002; 35(3-4).
- Nair MP, Mahajan S, Chadha KC, Nair NM, Hewitt RG, Pillai SK, Chadha P, Sukumaran PC, Schwartz SA. Effect of cocaine on chemokine and CCR-5 gene expression by mononuclear cells from normal donors and HIV-1 infected patients. Adv Exp Med Biol. 2001; 493.
- Schwartz SA. Intravenous immunoglobulin treatment of immunodeficiency disorders. Pediatr Clin North Am. 2000; 47(6).
- Mahajan S, Hou J, Sweet AM, Schwartz SA. The stress hormone, cortisol, synergizes with HIV-1 gp-120 to induce apoptosis of normal human peripheral blood mononuclear cells. Cell Mol Biol (Noisy-le-grand). 2000; 46(7).
- Nair MP, Schwartz SA. Reversal of human immunodeficiency virus type 1 protein-induced inhibition of natural killer cell activity by alpha interferon and interleukin-2. Clin Diagn Lab Immunol. 2000; 7(1).
- Nair MPN, Schwartz SA. Reversal of human immunodeficiency virus type I protein-induced inhibition of natural killer cell activity by alpha interferon and interleukin-2.. Clin Diagn Lab Immunol. 2000; 7.
- Madhavan Nair, Chadha KC, Ross Hewitt, Mahajan S, Sweet A, Stanley Schwartz. Cocaine differentially modulates chemokine production by mononuclear cells from normal donors and human immunodeficiency virus type 1-infected patients.. Clin Diagn Lab Immunol. 2000; 7(1).
- Schwartz SA, Nair MP. Current concepts in human immunodeficiency virus infection and AIDS. Clin Diagn Lab Immunol. 1999; 6(3).
- Madhavan Nair, Mahajan, Supriya, Chadha, Kailash C., Ross Hewitt, Stanley Schwartz. Immunopathogenesis of HIV infection. Role of recreational drugs. Recent Research Developments in Immunology. 1999; 1.
- Nair MP, Schwartz SA. Inhibition of natural killer cell activities from normal donors and AIDS patients by envelope peptides from human immunodeficiency virus type I. Cell Mol Biol (Noisy-le-grand). 1997; 43(7).
- Schwartz SA, Nair MP. Molecular mechanisms in the pathogenesis of AIDS encephalopathy. Cell Mol Biol (Noisy-le-grand). 1997; 43(7).
- el-Solh A, Kumar NM, Nair MP, Schwartz SA, Lwebuga-Mukasa JS. An RGD containing peptide from HIV-1 Tat-(65-80) modulates protooncogene expression in human bronchoalveolar carcinoma cell line, A549. Immunol Invest. 1997; 26(3).
- Nair MP, Kumar NM, Kronfol ZA, Greden JF, Lwebuga-Mukasa JS, Schwartz SA. Alcohol inhibits lipopolysaccharide-induced tumor necrosis factor alpha gene expression by peripheral blood mononuclear cells as measured by reverse transcriptase PCR in situ hybridization. Clin Diagn Lab Immunol. 1996; 3(4).
- Nair, M.P.N., Kumar, N., Kronfol, Z.A., Greden, J.F., Lwebuga-Mukasa, J.S, and Schwartz, S.A.. Alcohol inhibits lipopolysaccaride-induced tumor necrosis factor alpha gene expression by peripheral blood mononuclear cells as measured by reverse transcriptase PCR in situ hybridization Clinical and Diagnostic Laboratory Immunology. 1996; 3(4).
- Nair MP, Schwartz SA. Immunopathogenesis of HIV infection: role of alcohol and HIV peptides. Adv Exp Med Biol. 1996; 402.
- Nair MP, Schwartz SA. Substance P induces tumor necrosis factor in an ex vivo model system. Cell Immunol. 1995; 166(2).
- Ramesh S, Schwartz SA. Therapeutic uses of intravenous immunoglobulin (IVIG) in children. Pediatr Rev. 1995; 16(11).
- Ludwig LB, Hughes BJ, Schwartz SA. Biotinylated probes in the electrophoretic mobility shift assay to examine specific dsDNA, ssDNA or RNA-protein interactions. Nucleic Acids Res. 1995; 23(18).
- Nair MP, Saravolatz LD, Schwartz SA. Selective inhibitory effects of stress hormones on natural killer (NK) cell activity of lymphocytes from AIDS patients. Immunol Invest. 1995; 24(5).
- Schwartz SA. Selective inhibitory effects of stress hormones on natural killer (NK) cell activity of lympocytes from AIDS patients Immunological Investigations. 1995; 24(5).
- Nair MP, Chadha KC, Stadler I, Sweet A, Schwartz SA. Differential effects of human immunodeficiency virus type 1 envelope protein gp120 on interferon production by mononuclear cells from adults and neonates. Clin Diagn Lab Immunol. 1995; 2(4).
- Nair MP, Schwartz SA. Synergistic effect of cortisol and HIV-1 envelope peptide on the NK activities of normal lymphocytes. Brain Behav Immun. 1995; 9(1).
- Schwartz DG, Schwartz SA. MEDLINE training for medical students integrated into the clinical curriculum. Med Educ. 1995; 29(2).
- Nair MP, Schwartz SA. Substance P induces tumor necrosis factor in an ex vivo model system. Cell Immunol. 1995; 166.
- Abdeljaber MH, Nair MP, Schork MA, Schwartz SA. Depressed natural killer cell activity in schizophrenic patients. Immunol Invest. 1994; 23(4-5).
- Nair MP, Schwartz SA, Kronfol ZA, Hill EM, Sweet AM, Greden JF. Suppression of tumor necrosis factor production by alcohol in lipopolysaccharide-stimulated culture. Alcohol Clin Exp Res. 1994; 18(3).
- Nair MP, Kumar NM, Kronfol ZA, Saravolatz LA, Pottathil R, Greden JF, Schwartz SA. Selective effect of alcohol on cellular immune responses of lymphocytes from AIDS patients. Alcohol. 1994; 11(2).
- Nair MP, Sweet AM, Schwartz SA. Immunoregulation of tumor necrosis factor production by HIV-1 gp-120 in neonates and adults. Ann N Y Acad Sci. 1993; 693.
- Barks JD, Nair MP, Schwartz SA, Silverstein FS. Potentiation of N-methyl-D-aspartate-mediated brain injury by a human immunodeficiency virus-1-derived peptide in perinatal rodents. Pediatr Res. 1993; 34(2).
- Nair MP, Schwartz SA, Wu K, Kronfol Z. Effect of neuropeptide Y on natural killer activity of normal human lymphocytes. Brain Behav Immun. 1993; 7(1).
- Schwartz DG, Schwartz SA. MEDLINE training for medical students in the clinical curriculum. Acad Med. 1992; 67(7).
- Schwartz SA. Clinical use of immune serum globulin as replacement therapy in patients with primary immunodeficiency syndromes. Clin Rev Allergy. 1992; 10(1-2).
- Halpern MT, Schwartz SA. Modulation of a human immunosuppressive lymphokine by monosaccharides. Cell Immunol. 1991; 136(1).
- Adib SM, Joseph JG, Ostrow DG, Tal M, Schwartz SA. Relapse in sexual behavior among homosexual men: a 2-year follow-up from the Chicago MACS/CCS. AIDS. 1991; 5(6).
- Nair MP, Schwartz SA. Immunoregulation of natural and lymphokine-activated killer cells by selenium. Immunopharmacology. 1990; 19(3).
- Nair MP, Kronfol ZA, Schwartz SA. Effects of alcohol and nicotine on cytotoxic functions of human lymphocytes. Clin Immunol Immunopathol. 1990; 54(3).
- Schwartz SA. Intravenous immunoglobulin (IVIG) for the therapy of autoimmune disorders. J Clin Immunol. 1990; 10(2).
- Bharucha-Reid R, Schork MA, Schwartz SA. Data linkage and subject anonymity for HIV testing. AIDS Public Policy J. 1990; 5(4).
- Nair MP, Schwartz SA, Kronfol ZA, Heimer EP, Pottathil R, Greden JF. Immunoregulatory effects of alcohol on lymphocyte responses to human immunodeficiency virus proteins. Prog Clin Biol Res. 1990; 325.
- Schwartz SA, Gordon KE, Johnston MV, Goldstein GW. Use of intravenous immune globulin in the treatment of seizure disorders. J Allergy Clin Immunol. 1989; 84(4 Pt).
- Slade HB, Greenwood JH, Beekman RH, McCoy JP, Hudson JL, Pahwa S, Schwartz SA. Flow cytometric analysis of lymphocyte subpopulations in infants with congenital heart disease. J Clin Lab Anal. 1989; 3(1).
- Nair MP, Schwartz SA. Immunoregulation of human natural killer cells (NK) by corticosteroids: inhibitory effect of culture supernatants. J Allergy Clin Immunol. 1988; 82(6).
- Nair MP, Schwartz SA. Immunoregulation of lymphokine-activated killer cells. Clin Immunol Immunopathol. 1988; 49(1).
- Nair MP, Pottathil R, Heimer EP, Schwartz SA. Immunoregulatory activities of human immunodeficiency virus (HIV) proteins: effect of HIV recombinant and synthetic peptides on immunoglobulin synthesis and proliferative responses by normal lymphocytes. Proc Natl Acad Sci U S A. 1988; 85(17).
- Slade HB, Schwartz SA. Mucosal immunity: the immunology of breast milk. J Allergy Clin Immunol. 1987; 80(3 Pt).
- Slade HB, Lopatin DE, Schwartz SA. Measurement of immunoglobulin concentration in cell culture supernates by computer-assisted ELISA. J Immunol Methods. 1986; 94(1-2).
- Monto AS, Shope TC, Schwartz SA, Albrecht JK. Intranasal interferon-alpha 2b for seasonal prophylaxis of respiratory infection. J Infect Dis. 1986; 154(1).
- Nair MP, Cilik JM, Schwartz SA. Histamine-induced suppressor factor inhibition of NK cells: reversal with interferon and interleukin 2. J Immunol. 1986; 136(7).
- Hanash SM, Baier LJ, McCurry L, Schwartz SA. Lineage-related polypeptide markers in acute lymphoblastic leukemia detected by two-dimensional gel electrophoresis. Proc Natl Acad Sci U S A. 1986; 83(3).
- Nair MP, Laing TJ, Schwartz SA. Decreased natural and antibody-dependent cellular cytotoxic activities in intravenous drug abusers. Clin Immunol Immunopathol. 1986; 38(1).
- Bishop GA, Kümel G, Schwartz SA, Glorioso JC. Specificity of human natural killer cells in limiting dilution culture for determinants of herpes simplex virus type 1 glycoproteins. J Virol. 1986; 57(1).
- Shou L, Liu JY, Schwartz SA, Peng R, Chen LK, Good RA. Separation and further characterization of early and late rosette-forming cells. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1985; 18(4).
- Nair MP, Schwartz SA, Menon M. Association of decreased natural and antibody-dependent cellular cytotoxicity and production of natural killer cytotoxic factor and interferon in neonates. Cell Immunol. 1985; 94(1).
- Kurup VP, Nair MP, Schwartz SA, Fink JN. Serum antibodies and their role in antibody-dependent cell-mediated cytotoxicity in aspergillosis. Immunobiology. 1985; 169(4).
- Nair MP, Schwartz SA. Association of decreased T-cell-mediated natural cytotoxicity and interferon production in Down's syndrome. Clin Immunol Immunopathol. 1984; 33(3).
- Bishop GA, Marlin SD, Schwartz SA, Glorioso JC. Human natural killer cell recognition of herpes simplex virus type 1 glycoproteins: specificity analysis with the use of monoclonal antibodies and antigenic variants. J Immunol. 1984; 133(4).
- Nair MP, Schwartz SA. Immunomodulatory effects of corticosteroids on natural killer and antibody-dependent cellular cytotoxic activities of human lymphocytes. J Immunol. 1984; 132(6).
- Nair MP, Schwartz SA. Effect of histamine and histamine antagonists on natural and antibody-dependent cellular cytotoxicity of human lymphocytes in vitro. Cell Immunol. 1983; 81(1).
- Bishop GA, Glorioso JC, Schwartz SA. Role of interferon in human natural killer activity against target cells infected with HSV-1. J Immunol. 1983; 131(4).
- Bishop GA, Glorioso JC, Schwartz SA. Relationship between expression of herpes simplex virus glycoproteins and susceptibility of target cells to human natural killer activity. J Exp Med. 1983; 157(5).
- Bishop GA, Schwartz SA. Enhancement of human natural killer cells by interferon requires RNA and protein synthesis. Clin Immunol Immunopathol. 1982; 25(3).
- Nair MP, Schwartz SA. Suppression of human natural and antibody-dependent cytotoxicity by soluble factors from unstimulated normal lymphocytes. J Immunol. 1982; 129(6).
- King AJ, Schwartz SA, Lopatin D, Voorhees JJ, Diaz LA. Suppressor cell function is preserved in pemphigus and pemphigoid. J Invest Dermatol. 1982; 79(3).
- Nair MP, Schwartz SA. Immunomodulatory effects of amphotericin-B on cellular cytotoxicity of normal human lymphocytes. Cell Immunol. 1982; 70(2).
- King AJ, Schwartz SA, Lopatin DE, Voorhees JJ, Diaz LA. Autoimmunity. Int J Dermatol. 1981; 20(10).
- Nair MP, Schwartz SA. Suppression of natural killer activity and antibody-dependent cellular cytotoxicity by cultured human lymphocytes. J Immunol. 1981; 126(6).
- Nair MP, Schwartz SA, Fernandes G, Pahwa R, Ikehara S, Good RA. Suppression of natural killer (NK) cell activity of spleen cells by thymocytes. Cell Immunol. 1981; 58(1).
- Shou L, Schwartz SA, Good RA, Peng R, Chen CL. A human soluble suppressor factor affecting lymphocyte responses in vitro. Proc Natl Acad Sci U S A. 1980; 77(10).
- Rao KM, Schwartz SA. Zinc modulates mitogenic responses of human lymphocytes by affecting structures influenced by cytochalasin B. Clin Immunol Immunopathol. 1980; 16(4).
- Schwartz SA. Heavy chain-specific suppression of immunoglobulin synthesis and secretion by lymphocytes from patients with selective IgA deficiency. J Immunol. 1980; 124(4).
- Rao KM, Schwartz SA, Good RA. Modulation of the mitogenic response of lymphocytes from young and aged individuals by prostaglandins and indomethacin. Cell Immunol. 1979; 48(1).
- Gupta S, Schwartz SA, Good RA. Subpopulations of human T lymphocytes. VII. Cellular basis of concanavalin A-induced T cell-mediated suppression of immunoglobulin production by B lymphocytes from normal humans. Cell Immunol. 1979; 44(2).
- Schwartz SA, Choi YS, Shou L, Good RA. Modulatory effects on immunoglobulin synthesis and secretion by lymphocytes from immunodeficient patients. J Clin Invest. 1977; 59(6).
- Schwartz SA, Shou L, Good RA, Choi YS. Suppression of immunoglobulin synthesis and secretion by peripheral blood lymphocytes from normal donors. Proc Natl Acad Sci U S A. 1977; 74(5).
- Shou L, Schwartz SA, Good RA. Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors. J Exp Med. 1976; 143(5).
- O‘Reilly, R.J., Everson, L.K., Emodi, G., Hansen, J., Smithwick, E.M., Grimes, E., Pahwa, S., Schwartz, S.A., Armstrong, D., Siegal, F.P., Gupta, S., Dupont, B. and Good, R.A.. Effects of exogenous interferon in cytomegalovirus infections complicating bone marrow transplantation. Clin Immunol Immunpathol.. 1976; 6.
- Boumsell, L., Incefy, G.S., Bernard, A., Schwartz, S., Smithwick, E. and Good, R.A.. Thymocyte differentiation in vitro in ataxia-telangiectasia associated with lymphosarcoma. J Pediatrics. 1975; 87(3).
- Schwartz SA, Helinski DR. Purification and characterization of colicin E1. J Biol Chem. 1971; 246(20).
- Doolittle RF, Schubert D, Schwartz SA. Amino acid sequence studies on artiodactyl fibrinopeptides. I. Dromedary camel, mule deer, and cape buffalo. Arch Biochem Biophys. 1967; 118(2).
- Schwartz SA, Braun W. Bacteria as an Indicator of Formation of Antibodies by Single Spleen Cells in Agar. Science. 1965; 149(3680).
Books and Book Chapters:
- Mahajan SD, You Y, Aalinkeel R, Reynolds JL, Nair, Bindukumar B, Mammen MJ, Ignatowski TA, Cheng, Chong, Schwartz SA. Biodegradable Nanoparticle-Based Antiretroviral Therapy across the Blood-Brain Barrier. Handbook of Clinical Nanomedicine Nanoparticles, Imaging, Therapy, and Clinical Applications. 2016.
- Mahajan SD, Aalinkeel R, Reynolds JL, Nair BB, Mammen MJ, Dai L, Prasad PN, Schwartz SA. Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases. Nanotherapeutic Approach to Targeting HIV-1 in the CNS: Role of Tight Junction Permeability and Blood. 2015.
Abstracts:
- Parikh NU, Aalinkeel R, Reynolds JL, Quaye E, Cwiklinski K, Sykes DE, Mammen MJ, Sharijkova, A, Khmaladze A, Schwartz SA, Mahajan SD. Methamphetamine (METH) and HIV-tat mediated oxidative stress contributes to Mitochondrial dysfunction in microglia. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 2017; 12.
- Parikh NU, Mammen MJ, Cumella JC, Rockoff JB, Schwartz SA. Impact of Lung Flute Therapy on Asthma: A Pilot Study. Journal of Allergy and Clinical Immunology. 2017.
- Aalinkeel R, Abou-Jaoude E, Parikh, N, Reynolds JL, Sykes DE, Mammen MJ, Mahajan SD, Schwartz SA. Galectin-3 in prostate cancer proliferation and metastasis. European Journal of Immunology. 2016.
- Parikh NU, Mahajan SD, Aalinkeel R, Reynolds JL, Nair BN, Sykes DE, Mammen MJ, Schwartz SA. Galectin-1 is Neuroprotectice and Reverses Methamphetamine Induced Blood Brain Barrier Breakdown. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2015.
- Kumar M.N., El Solh AA, Nair M.P.N., Schwartz SA, Lwebuga-Mukasa JS. Induction of protooncogenes and apoptosis in uninfected lung alveolar epithelial cells by HIV-1 derived peptides. (abstract). Great Lakes Lung Conference, Ontario, Canada.. 1995.
- Kumar, N.M., El Solh AA, Schwartz SA, Lwebuga-Mukasa JS. HIV-1 TAT and GP120-derived peptides modulate rat lung alveolar epithelial cell protooncogenes, and cytokine gene expression. (Abstract). Great Lakes Lung Conference, Ontario, Canada. 1994.
Evaluative Studies and Case Reports:
- Taki HN, Schwartz SA. Levamisole as an immunopotentiator for T cell deficiency. Immunopharmacol Immunotoxicol. 1994; 16(2).
- Taki HN, Schwartz SA. Two siblings with recurrent infections. Ann Allergy. 1993; 71(5).
- Pahwa R, Chatila T, Pahwa S, Paradise C, Day NK, Geha R, Schwartz SA, Slade H, Oyaizu N, Good RA. Recombinant interleukin 2 therapy in severe combined immunodeficiency disease. Proc Natl Acad Sci U S A. 1989; 86(13).
- Nair MP, Gray RH, Boxer LA, Schwartz SA. Deficiency of inducible suppressor cell activity in the Chediak-Higashi syndrome. Am J Hematol. 1987; 26(1).
- Slade HB, Schwartz SA. Selective antibody deficiency and recurrent pneumococcal bacteremia in a patient with Sjögren's syndrome, hyperimmunoglobulinemia G, and deficiencies of IgG2 and IgG4. N Engl J Med. 1985; 313(14).
- Slade HB, Schwartz SA. Selective antibody deficiency and recurrent pneumococcal bacteremia in a patient with Sjögren's syndrome, hyperimmunoglobulinemia G, and deficiencies of IgG2 and IgG4. N Engl J Med. 1985; 313(14).
- Slepian IK, Schwartz SA, Weiss JJ, Roth SL, Mathews KP. Immunodeficiency with hyper IgM after systemic lupus erythematosus. J Allergy Clin Immunol. 1984; 73(6).
Professional Memberships:
- American Association of Immunologists
- American Federation for Clinical Research
- American Pediatric Society
- American Society for Clinical Investigation
- American Society for Microbiology
- Buffalo Collegium of Immunology (Secretary 2004-present)
- Chilean Society for Allergy and Immunology, Honorary Member
- Indian Society for Immunology
- Society for Pediatric Research
- Buffalo Allergy Society
- Buffalo Academy of Medicine (Past President)
- Fellow of the American Academy of Allergy, Asthma and Immunology