Ion channel kinetics and structure; Membrane Transport (Ion Transport); Molecular and Cellular Biology; Neurobiology; Neuropharmacology; Signal Transduction
Synaptic transmission is a fundamental mechanism that mediates communication between neurons in the brain. My Laboratory is interested in delineating the mechanisms and regulation of synaptic transmission in the central nervous system. In particular, we investigate the mechanisms by which G-protein coupled receptors, including endocannabinoid receptors, gate synaptic transmission and plasticity. We are also interested in the mechanisms of synaptic homeostasis induced by prenatal and postnatal exposure to stress and drugs of abuse. We use a electrophysiological, genetic, optogenetic and behavioral approaches the delineate the synaptic mechanisms underlying addiction and other mental disorders.