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Umesh                          Sharma

Umesh Sharma MD, PhD

Department of Medicine

Assistant Professor

Specialty/Research Focus

Cardiac pharmacology; Cardiology; Cardiopulmonary physiology; Cardiovascular Disease; Gene Expression; Immunology; Internal Medicine; Radiology; Stem Cells

 
Professional Summary:

I am a cardiologist with specialized training in advanced cardiac imaging. I see outpatients at the Heart and Lung Center of Buffalo General Medicine Center (BGMC), and I care for inpatients through the cardiology consult and inpatient services at BGMC. As an advanced imaging cardiologist, I am responsible for developing and advancing the cardiac computed tomography (CT) and magnetic resonance imaging (MRI) programs at the Gates Vascular Institute (GVI) and providing these services to patients. These advanced, noninvasive imaging techniques allow physicians to perform in-depth, 3-D evaluation of the coronary tree, myocardium, heart valves, pericardium and great vessels. These imaging tools allow for the best possible diagnoses and care of patients.

My research spans basic science, translational and clinical fields and combines the cross-discipline expertise on magnetic resonance (MR) technology with molecular biology. My overall goal is to study the consequences of ischemia-induced myocardial injury, with a focus on their therapeutic reversal. My research laboratory at UB’s Clinical and Translational Research Center (CTRC) is devoted to the development of novel time-and-tissue-targeted MRI methods for integrative understanding of cardiovascular pathophysiology in preclinical models. We have several interesting research projects, e.g., we have recently discovered that the presence of high-risk plaques in the carotid arteries predict future incidence of myocardial infarction and stroke. The results emphasize that the nature of atherosclerosis and the use of comprehensive non-invasive computed tomography angiography (CTA) will help identify patients who are at higher risk of developing ischemic stroke. These research results will help physicians employ early therapeutic strategies for these high-risk patients.

I mentor medical students, residents and fellows both in clinical and research settings, and I precept cardiology fellows at the Heart and Lung Center at BGMC. In addition, I am deeply engaged in furthering the research and clinical education of our house staff. Our trainees have published their research in highly esteemed peer-reviewed journals, and many have routinely presented their work at national and international scientific conferences. I am committed to facilitating the career goals of my mentees while I continue to advance my own career as a clinician, researcher and mentor.

Education and Training:
  • Fellowship, Advanced Cardiac Imaging, Massachusetts General Hospital (2013)
  • Fellowship, Cardiovascular Medicine, University of Louisville (2012)
  • Residency, Internal Medicine, Chicago Medical School, Outstanding Graduating Resident (2009)
  • PhD, Molecular mechanisms of heart failure, University of Maasricht (2005)
  • MS, Medical Immunology, University of London (2002)
  • MBBS, Tribhuvan University (2000)
Employment:
  • Assistant Professor, University at Buffalo (2013-present)
  • Postdoctoral Research Associate, Henry Ford Health System (2004–2006)
Awards and Honors:
  • Professionalism Award (2009)
  • Outstanding Resident (2009)

Research Expertise:
  • Atherosclerotic plaque vulnerability
  • Biomarkers
  • Cardiac fibrosis and remodeling
  • Cardiac MRI and CT
Grants and Sponsored Research:
  • July 2017–June 2022
    National Institutes of Health/NHLBI, 1K08HL131987
    NHLBI
    Role: Principal Investigator
    $986,850
  • April 2014–April 2015
    Innovative Micro-Programs Accelerating Collaboration in Themes (IMPACT)
    University of Buffalo
    Role: Principal Investigator
    $29,000
  • January 2006–June 2006
    American Heart Association, Pre-Doctoral Fellowship Grant
    Americah Heart Association
    Role: Principal Investigator
    $50,000

Journal Articles:
  • Gandhi S, Mosleh W, Sharma UC, Demers C, Farkouh ME, Schwalm JD, Sharma U. Multidisciplinary Heart Failure Clinics Are Associated With Lower Heart Failure Hospitalization and Mortality: Systematic Review and Meta-analysis. Can J Cardiol. 2017.
  • Mosleh W, Sharma A, Sidhu MS, Page B, Sharma UC, Farkouh ME, Sharma U. The Role of SGLT-2 Inhibitors as Part of Optimal Medical Therapy in Improving Cardiovascular Outcomes in Patients with Diabetes and Coronary Artery Disease. Cardiovasc Drugs Ther. 2017.
  • Sharma UC, W Mosleh, MR Chaudhari, R Katkar, B Weil, C Evelo, TR Cimato, S Pokharel, WM Blenkesteijn, G Suzuki.. Myocardial and serum galectin-3 expression dynamics marks post-myocardial infarction cardiac remodeling.. Heart Lung Circulation. 2017; 26(7).
  • Celeng, C, Vadvala, H, Puchner, S, Pursnani, A, Sharma U, Kovacs, A, Maurovich-Horvat, P, Hoffmann, U, Ghoshhajra, B. Defining the Optimal Systolic Phase Targets Using Absolute Delay Time for Reconstractions in Dual-source Coronary CT Angiography. Int J Cardiovasc Imaging. 2016; 32.
  • Bhatia, N, Voelkel, AJ, Sharma, UC, Hussain, Z, Slaughter, MS, Birks, EJ, McCants, KC. Safety and Feasibility of Induction Immunosuppression when Driveline Infection is an Indication for Cardiac Transplantation.. Thorac Cardiovasc Surg. 2015; 63.
  • Carmona-Rubio, AE, Lee, AM, Puchner, S, Ghoshhajra, B, Sharma UC,. A Review of Adherence to the Guidelines for Coronary CT Angiography Quantitative Stenosis Grading Thresholds in Published Research. Postgraduate Medicine. 2015; 127.
  • Januzzi JL, Sharma UC, Zakroysky P, Truong QA, Woodare PK, Pope JH, Hauser T, Mayrhofer T, Nagurney JT, Schoenfeld D, Peacock WF, Fleg JL, Wiviott S, Pang PS, Udelson J and Hoffmann U. Sensitive troponin assays in patients with suspected acute coronary syndrome: results from the multicenter rule out myocardial infarction using computer assisted tomography (ROMICAT) II trial.. Am Heart J. 2015; 169(4).
  • Carmona-Rubio AE, Puchner S, Lee AM, Li T, Holmvang G, Ghoshhajra B, Hoffmann U, Abbara S and Sharma UC. Utility of cardiac magnetic resonance imaging and follow-up of defibrillator events to identify the etiology and natural history of sudden cardiac arrest. Jacobs J Exper Cardiol Res. 2015; 1(2).
  • Truong QA, Januzzi JL, Szymonifka J, Thai WE, Wai B, Lavender Z, Sharma U, Sandoval RM, Grunau ZS, Basnet S, Babatunde A, Ajijola OA, Min JK, Singh JP. Coronary sinus biomarker sampling compared to peripheral venous blood for predicting outcomes in patieints iwth severe heart failure undergoing cardiac resynchronization therapy: The BIOCRT study.. Heart Rhythm. 2014; 11.
  • Liu T, A Pursnani, UC Sharma, Y Vorasettakarnkij, D Verdini, P Deepraserkul, AM Lee, H Lumish, M Sidhu, H Medina, S Danik, S Abbara, G Holmvang, U Hoffmann, BB Ghoshhajra. Effect of the 2010 task force criteria on reclassification of cardiovascular magnetic resonance criteria for arrhythmogenic right ventricular cardiomyopathy. J Cardiovasc Magn Reson. 2014; 16.
  • Sharma UC and Canty JM Jr. Myocardial repair around-the-clock. Circ Res. 2014; 114(11).
  • Pursnani A, AM Lee, T Mayrhofe, M Panagia, U Sharma, U Hoffmann, S Abbara, B Ghoshhajra. Feasibility of a radiation dose conserving CT protocol for myocardial function assessment. Br J Radiol. 2014.
  • Azzalini L, Sharma U, Ghoshhajra BB, Elmariah S, Inglessis I, Palacios IF, Abbara S.. Feasibility of C-arm computed tomography for transcatheter aortic valve replacement planning. J Cardiovasc Comput Tomogr. 2014; 8(1).
  • Rhaleb NE, Pokharel S, Sharma UC, Peng H, Peterson E, Harding P, Yang XP, Carretero OA. N-acetyl-ser-asp-lyspro inhibits interleukin-1beta-mediated matrix metalloproteinase activation in cardiac fibroblasts. Pflugers Arch. 2013; 10.
  • Sharma UC, W Mosleh, K Adib, P Natdanai, A Carmona-Rubio, R Karki, J Paily, MA Ahmed, S Vakkalanka, N Madam, GD Gudleski, C Chung.. High-risk carotid plaques identified by CT-angiogram can predict acute myocardial infarction. Int J Cardiovasc Imaging. ; 33(4).
See all (5 more)
Abstracts:
  • Papadopoulos G, Vakkalanka S, Adib K, Sharma U,Page BJ. Clinical utility of coronary computed tomography angiography to evaluate patients with mildly elevated troponins without clinically manifest acute coronary syndrome. J Am College of Card. 2016; 67(13).


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Contact Information

Clinical & Translational Research Center
Buffalo, NY 14203
Phone: 716-829-2663
Fax: 716-854-1840
Email: sharmau@buffalo.edu

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