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Satyan                         Lakshminrusimha

Satyan Lakshminrusimha MD

Department of Pediatrics

Professor of Pediatrics and Chief, Neonatology

Specialty/Research Focus

Neonatal-Perinatal Medicine; Neonatology; Pediatrics

 
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Professional Summary:

As the chief of the division of neonatology in the Department of Pediatrics, I oversee clinical, teaching, research and administrative tasks related to the evaluation and treatment of critically ill preterm and term newborn infants, and I am actively involved in teaching medical students, pediatric residents and fellows in neonatal-perinatal medicine. My practice is primarily located at the Neonatal Intensive Care Unit (NICU) at the Women and Children’s Hospital of Buffalo. My division provides high-risk newborn care at Millard Fillmore Suburban Hospital, plus telephone consultation and transport services for sick newborn infants throughout Western New York.

Over the past decade, I have developed an interest in managing newborn infants with hypoxic respiratory failure and persistent pulmonary hypertension of the newborn (PPHN). I have investigated the role oxygen free radicals, nitric oxide and antioxidants play in the pathogenesis and management of PPHN. More recently, I have focused my attention on optimal strategies for neonatal resuscitation. Based on this work, I have published and co-authored more than 40 peer-reviewed manuscripts.

As the director of the Center for Developmental Biology of the Lung, my research focuses on the pathophysiology of the cardio-pulmonary transition – how fetal lungs change at birth in order to breathe air – and disorders of this transition such as birth asphyxia, PPHN, retained lung liquid and respiratory distress syndrome. My laboratory’s translational research aims primarily at preventing and treating these disorders with optimal neonatal resuscitation techniques, steroids, nitric oxide, surfactant and judicious use of oxygen.

In 2011, our division joined the NICHD Neonatal Research Network – a group of 18 Academic Neonatal Centers to conduct multicenter trials with the goal of improving outcomes in sick preterm and term neonates. Together, we work to transfer innovative discoveries from our laboratory to the bedside through clinical trials, improving outcomes for this vulnerable population.

Education and Training:
  • Fellowship, Neonatal-Perinatal Medicine, University at Buffalo (1999)
  • Residency, Pediatrics, Brooklyn Hospital Center (1996)
  • MD, Pediatric Medicine, University of Mysore Medical College, Top rank in the university (highest score) (1994)
  • Residency, Pediatrics, Cheluvamba Hospital for Women and Children (1994)
  • Internship, Surgery, Pediatrics and Obstetrics/Gynecology, K.R. Hospital and Combined Hospitals/Mysore Medical College (University of Mysore) (1989)
  • MBBS, Medicine/Surgery, University of Mysore Medical College, First class with distinction (scores exceeding 70%) in all subjects (1988)
Employment:
  • Chief, Division of Neonatology, Pediatrics, Women and Children‘s Hospital of Buffalo (2011-present)
  • Director, Center for Developmental Biology of the Lung (CDBL), Women and Children's Hospital of Buffalo (2011-present)
  • Associate Professor, Pediatrics, University at Buffalo (2009-present)
  • Attending Neonatologist, Women and Children's Hospital of Buffalo (2003-present)
  • Attending Neonatologist, Millard Fillmore Suburban Hospital
  • Associate Program Director, Neonatal-Perinatal Medicine Fellowship Program, University at Buffalo (2006–2011)
  • Assistant Professor, Pediatrics, University at Buffalo (2003–2008)
  • Pediatrician/Neonatologist, Pediatric Associates of Southern Colorado (2000–2003)
  • Clinical Assistant Professor, Pediatrics, University at Buffalo (1999–2003)
  • Clinical Instructor, Pediatrics, University at Buffalo (1996–1999)
  • Division Medical Officer and Pediatrician, Golden Rock Railway Hospital, India (1994)
  • Assistant Division Medical Officer, Railway Hospital, India (1989–1991)
See All (12 Total) >
Awards and Honors:
  • Eastern Society for Pediatric Research: Faculty Young Investigator Award (2008)
  • Yearbook of Neonatal-Perinatal Medicine: Two Refereed Manuscripts (2008)
  • Southern Colorado Emergency Physicians Association: Happy Gram Award (2003)
  • American Board of Pediatrics - Neonatal-Perinatal Medicine Subspecialty Examination: Highest Score Nationally (1999)
  • American Board of Pediatrics: 99.3% on Examination (1996)
  • 75th Annual Convocation of the University of Mysore: Professor K. Ankegowda‘s Cash Prize (1995)
  • 75th Annual Convocation of the University of Mysore: Little Fellow ("Mahesh") Award (1995)
  • Nestle India Limited: Winner of Breastfeeding and Infant Nutrition Quiz (1993)
  • Indian Academy of Pediatrics: Winner of State Level Pediatric Quiz (1992)
  • University of Mysore: 3rd Rank in Final Year (among 300 medical students) (1989)
  • Best Doctors in America (2007-2012)

Research Expertise:
  • Fetal surgery: Ligation of fetal ductus arteriosus
  • Isolated vessel bath studies: Use of tissue baths to study isolated vessels and airways
Grants and Sponsored Research:
  • August 2012–August 2017
    Optimal oxygenation in neonatal lung injury
    NICHD
    Role: Principal Investigator
    $1,163,817
  • April 2011–March 2016
    Capitation from Neonatal Research Network studies
    NICHD
    Role: Principal Investigator
    $129,750
  • April 2011–March 2016
    Neonatal Research Network
    NICHD
    Role: Co-Principal Investigator
    $608,655
  • December 2014–December 2015
    Canadian Pediatric Society
    Canada
    Role: Principal Investigator
    $20,000
  • July 2010–June 2015
    Redox regulation in the perinatal pulmonary vasculature
    NIH (NHLBI)
    Role: Co-Investigator
    $568,750
  • March 2012–February 2014
    Tracheal suctioning in spontaneous meconium aspiration
    American Academy of Pediatrics
    Role: Principal Investigator
    $40,000
  • September 2010–June 2013
    Phase II trial of sildenafil in newborns with persistent pulmonary hypertension
    NHLBI
    Role: Co-Investigator
    $150,853
  • January 2012–January 2013
    The Use of Pulse Oximetry in the Assessment of Effective Chest Compressions During Neonatal Resuscitation
    American Academy of Pediatrics
    Role: Consultant
    $10,000
  • November 2010–December 2012
    Early initiation of inhaled nitric oxide improves oxygenation in PPHN
    Ikaria LLC
    Role: Principal Investigator
    $160,000
  • January 2010–December 2011
    Study of optimal ventilation to chest compression ration in resuscitation of neonatal piglets
    American Academy of Pediatrics
    Role: Consultant
    $10,000
  • May 2009–April 2011
    Antenatal betamethasone in late-preterm gestation lambs
    NICHD
    Role: Principal Investigator
    $146,000
  • July 2006–April 2010
    cGMP Regulation in the developing Pulmonary Circulation
    NHLBI
    Role: Co-Investigator
    $528,000
  • January 2007–December 2007
    Effect of oxygen concentration of resuscitative gas on pulmonary hemodynamics in term lambs
    American Academy of Pediatrics
    Role: Principal Investigator
    $25,000
See All (13 Total) >

Evaluative Studies and Case Reports:
Journal Articles:
See All (57 Total) >
Abstracts:
  • Kumar VH, Elberson VD, Gugino SF, Wang H, Nielsen L, Lakshminrusimha S. Systemic Hypertension and Vascular Reactivity Following Neonatal Hypoxia-Hyperoxia Exposure in Adult Mice. E-PAS. 2014.
  • Elberson VD, Mathew B, Prasanna P, Ma C, Kumar VH, Lakshminrusimha S. Pharmacological Factors and Risk of Spontaneous Intestinal Perforation (SIP). E-PAS. 2014.
  • Nath S, Reynolds AM, Lakshminrusimha S, Ryan RM. Comparison of Postnatal Steroids (PNS) on Respiratory Severity Scores (RSS) in Bronchopulmonary Dysplasia. PAS Meeting Abstracts. 2012; 71(4523).
  • Sambalingam D, Swartz DD, Mathew B, Gugino SF, Koenigsknecht C, Nair J, Wedgwood S, Steinhorn RH, Lakshminrusimha S. Effect of Early Initiation Inhaled Nitric Oxide (iNO) on Oxygenation and Oxidative Stress in PPHN. PAS Meeting Abstracts. 2012; 71(3842).
  • Nair J, Mathew B, Nayak SP, Gugino SF, Wedgwood S, Steinhorn RH, Lakshminrusimha S. Antenatal Betamethasone Decreases Hypoxic Pulmonary Vasoconstriction in Late Preterm Lambs Delivered by Elective C-Section. PAS Meeting Abstracts. 2012; 71(1160).
  • Lakshminrusimha S, Mathew B, Gugino SF, Koenigsknecht C, Steinhorn RH, Swartz DD. Perinatal Pulmonary Hemodynamics in Acute and Chronic Models of Persistent Pulmonary Hypertension of Newborn (PPHN). PAS Meeting Abstracts. 2012; 71(3842).
  • Lakshminrusimha S, Mathew B, Ma CX, Nair J, Gugino SF, Koenigsknecht C, Steinhorn RH, Swartz DD. Does Parenchymal Lung Disease Alter the Relationship Between PO2 and Pulmonary Vascular Resistance (PVR)?. PAS Meeting Abstracts. 2012; 71(3842).
  • Mathew B, Swartz DD, Gugino SF, Sambalingam D, Koenigsknecht C, Lakshminrusimha S. Gas Exchange at Different Compression to Ventilation Ratios During Neonatal Resuscitation. PAS Meeting Abstracts. 2012; 71(4525).
  • Nair J, Gugino SF, Mathew B, Carmen M, Swartz DD, Lakshminrusimha S. PRBC Transfusion Increases Mesenteric Vasoconstriction in Preterm Lambs. PAS Meeting Abstracts. 2012; 71(2860).
  • Mathew B, Swartz DD, Nair J, Gugino SF, Carmen MF, Nielsen LC, Lakshminrusimha S. Pre-Oxygenation with 100% Oxygen Does Not Impact Time to Asystole in Newborn Piglets. PAS Meeting Abstracts. 2012; 71(2855).
  • Carmen MF, Gugino SF, Koenigsknecht C, Lakshminrusimha S, Swartz DD. Prenatal Glycine Supplementation Improves Weight Gain and Endogenous NO Production in the Pulmonary Arteries of IUGR Rats. PAS Meeting Abstracts. 2012; 71(2860).
  • Wedgwood S, Lakshminrusimha S, Gugino SF, Farrow KN, Schumacker P, Steinhorn RH. Hyperoxia Increases Lung NOx1 Expression and Pulmonary Artery ROS. PAS Meeting Abstracts. 2012; 71(3842).
  • Perez M, Wedgwood S, Lakshminrusimha S, Gugino SF, Farrow KN, Steinhorn RH. Hydrocortisone Increases IKB Expression and Decreases NFKB Activity in an Ovine Model of PPHN. PAS Meeting Abstracts. 2012; 71(3650).
  • Bazacliu C, Carmen M, Lakshminrusimha S, Basu-Ray J, Ryan RM, Swartz DD. IUGR Alters Lung Morphology and Function During Postnatal Growth in Rats. PAS Meeting Abstracts. 2011; 69(4445).
  • Farrow KN, Wedgwood S, Lee KJ, Czech L, Gugino SF, Lakshminrusimha S, Schumacker PT, Steinhorn RH. Hydrogen Peroxide from Mitochondrial Sources Increases PDE5 Activity in Pulmonary Artery Smooth Muscle Cells from PPHN Lambs. Circulation. 2010; 122.
  • Wedgwood S, Lakshminrusimha S, Gugino SF, Schumacker PT, Steinhorn RH. Hydrogen Peroxide and Peroxynitrite Mediate Extracellular Superoxide Dismutase Inactivation in PPHN. Circulation. 2010; 122.
  • Bazacliu C, Carmen M, Mathew B, Ryan RM, Lakshminrusimha S, Swartz DD. Intrauterine Growth Restriction Decreases Airway Responsiveness to Methacholine in Female Rats. PAS Meeting Abstracts. 2010; 67(2720).
  • Wedgwood S, Lakshminrusimha S, Gugino SF, Schumacker PT, Steinhorn RH. Increased ROS Generation is Associated with Increased p22/Nox4 Expression in PPHN. PAS Meeting Abstracts. 2010; 67(1375).
  • Bazacliu C, Carmen M, Mathew B, Ryan RM, Lakshminrusimha S, Swartz DD. Intrauterine Growth Restriction Alters Norepinephrine Response in Rat Aortas in a Developmental and Gender Specific Manner. PAS Meeting Abstracts. 2010; 67(4416).
  • Mathew B, Lakshminrusimha S, Ryan RM. Retrospective Study of Epinephrine Use in the Delivery Room Resuscitation of Infants Born <= 25 Weeks. PAS Meeting Abstracts. 2010; 67.
  • Savorgnan F, Swartz DD, Mathew B, Wynn KA, Ryan RM, Lakshminrusimha S. Pulmonary Hemodynamics in Asphyxiated Lambs Resuscitated with 21% and 100% Oxygen. PAS Meeting Abstracts. 2010; 67(3713).
  • Swartz DD, Arter A, Nielsen LC, Lakshminrusimha S. Model of Persistent Pulmonary Hypertension of the Newborn Results in Remodeling of the Umbilical Vasculature. PAS Meeting Abstracts. 2010; 67(2847).
  • Farrow KN, Wedgwood S, Lee KJ, Czech L, Gugino SF, Lakshminrusimha S, Schumacker PT, Steinhorn RH. Hyperoxia-induced PDE5 Activity is Amplified in Fetal Pulmonary Artery Smooth Muscle Cells (FPASMC). PAS Meeting Abstracts. 2010; 67(1465).
  • Wedgwood S, Lakshminrusimha S, Gugino SF, Schumacker PT, Steinhorn RH. Increased Peroxynitrite is Associated with Decreased ecSOD Activity in PPHN. PAS Meeting Abstracts. 2010; 67(4335).
  • Nair J, Mathew B, Carmen M, Russell JA, Lakshminrusimha S. Norepinephrine Induced Ovine Mesenteric Artery Constriction Peaks in Late Preterm Gestation: Implications in Pathogenesis of Necrotizing Enterocolitis. PAS Meeting Abstracts. 2010; 67(4421).
  • Lakshminrusimha S, Mathew B, Russell JA, Wynn KA, Ryan RM, Nair J, Swartz DD. Pulmonary Vascular Resistance (PVR) Response to Oxygen is Altered by Inhaled Nitric Oxide (iNO) in Lambs with PPHN. PAS Meeting Abstracts. 2010; 67(3294).
  • Sengupta S, Herrmann A, Carrion V, Ryan RM, Shelton J, Lakshminrusimha S. The Incidence of Morbidities and NICU Admissions Among Early Term (37-38 6/7 Weeks) and Late Term (39-41 Weeks) Neonates at Women and Children's Hospital of Buffalo (WCHOB). PAS Meeting Abstracts. 2010; 67(3723).
  • Sengupta S, Ma CX, Ryan RM, Lakshminrusimha S. Survival without ECMO in Neonatal Hypoxemic Respiratory Failure (HRF) is Associated with Lower Oxygenation Index (OI) and Higher Peak Methemoglobin (MHb) Level. PAS Meeting Abstracts. 2010; 67(1466).
  • Perez M, Lakshminrusimha S, Gugino SF, Schumacker PT, Steinhorn RH, Farrow KN. Hydrocortisone Decreases PDE5 Activity and Expression in Ovine Fetal Pulmonary Artery Smooth Muscle Cells. PAS Meeting Abstracts. 2010; 67(3294).
  • Lakshminrusimha S, Sengupta S, Ma CX. Survival without ECMO in Neonatal Hypoxemic Respiratory Failure is Associated with Lower Oxygenation Index (OI) and Higher Peak Methemoglobin (MHb) Levels. Am J Respir Crit Care Med. 2010; 181.
  • Lakshminrusimha S, Mathew B, Wynn KA, Nair J, Ryan RM, Russell JA, Swartz DD. Inhaled Nitric Oxide (iNO) Prevents Hypoxic Pulmonary Vasoconstriction in Lambs with Persistent Pulmonary Hypertension of the Newborn (PPHN). Am J Respir Crit Care Med. 2010; 181.
  • Swartz DD, Russell JA, Bazacliu C, Carmen M, Mathew B, Ryan RM, Lakshminrusimha S. Intrauterine Growth Restriction Abolishes Airway Hyperresponsiveness to Methacholine in Female Rats. Am J Respir Crit Care Med. 2010; 181.
  • Ryan RM, Sheehan DW, Kumar V, Caty MG, Lakshminrusimha S. First Do No Harm: Conservative Treatment of Acquired Lobar Emphysema in a Premature Neonate. Am J Respir Crit Care Med. 2010; 181.
  • Kumar V, Kishkurno S, Ryan RM, Nielsen LC, Wang H, Lakshminrusimha S. Neonatal Hyperoxia Increases Leukotriene B4 (LTB4) Production and Bronchial Ring Constriction in Recovered Adult Mice. Am J Respir Crit Care Med. 2010; 181.
  • Ahmed Q, Pryhuber GS, D‘Angelis CA, Kumar V, Lakshminrusimha S, Metlay LA, Wang H, Ryan RM. CD8+ T-Lymphocytes in Infants with Bronchopulmonary Dysplasia (BPD). PAS Meeting Abstracts. 2009; 65(3858).
  • Ryan RM, Ahmed Q, D'Angelis CA, Kumar V, Lakshminrusimha S, Metlay LA, Wang H, Pryhuber GS. CD8+ T-Lymphocytes in Infants with Bronchopulmonary Dysplasia (BPD). Am J Respir Crit Care Med. 2009; 179.
  • Lakshminrusimha S, Russell JA, Gugino SF, Swartz DD, Wynn KA, Steinhorn RH. Optimal PaO2 Levels in PPHN. PAS Meeting Abstracts. 2009; 65(2540).
  • Pabalan MJ, Nayak SP, Ryan RM, Lakshminrusimha S. Methemoglobin Levels and Response to Inhaled NO in PPHN. PAS Meeting Abstracts. 2009; 65(3857).
  • Perez M, Lakshminrusimha S, Czech L, Wedgwood S, Gugino SF, Russell JA, Steinhorn RH, Farrow KN. Hydrocortisone Normalizes Hyperoxia Induced PDE5 Activity in Lambs with PPHN. PAS Meeting Abstracts. 2009; 65(3857).
  • Wedgwood S, Lakshminrusimha S, Fukai T, Russell JA, Steinhorn RH. Extracellular Superoxide Dismutase (EC-SOD) Activity is Decreased in Neonatal Pulmonary Hypertension (PPHN). PAS Meeting Abstracts. 2009; 65(5420).
  • Farrow KN, Smith CL, Czech L, Lakshminrusimha S, Gugino SF, Russell JA, Schumacker PT, Steinhorn RH. Mitochondrial Oxidant Stress Increases PDE5 Expression and Activity in Ovine Fetal Pulmonary Artery Smooth Muscle Cells (FPASMC). PAS Meeting Abstracts. 2009; 65(5755).
  • Ryan RM, Pabalan MJ, Nayak SP, Lakshminrusimha S. Can Methemoglobin Levels be Used to Predict Response to Inhaled Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn (PPHN)?. Am J Respir Crit Care Med. 2009; 179.
  • Lakshminrusimha S, Swartz DD, Gugino SF, Wynn KA, Steinhorn RH, Russell JA. Resuscitation of Neonatal Lambs with Pulmonary Hypertension with 21% or 100% Oxygen - Effect of Pulmonary Hemodynamics. PAS Meeting Abstracts. 2008; 63(3415).
  • Soares FA, Lakshminrusimha S, Farrow KN, Wedgwood S, Gugino SF, Czech L, Russell JA, Steinhorn RH. Effect of NADPH Oxidase Inhibition in Lambs with Persistent Pulmonary Hypertension of the Newborn (PPHN). PAS Meeting Abstracts. 2008; 63(3415).
  • Mohamed ISI, Garrison N, Wynn RJ, Lakshminrusimha S, Ryan RM. An Interventional Nutritional Protocol Improved Osteopenia of Prematurity Independent of Other Clinical Practice Changes. PAS Meeting Abstracts. 2008; 63(3778).
  • Mathew B, Lakshminrusimha S, Carrion V. Vinyl Bag vs. Thermal Mattress to Prevent Hypothermia in Extremely Low Birth Weight Infants. PAS Meeting Abstracts. 2008; 63(4458).
  • Farrow KN, Lakshminrusimha S, Czech L, Wedgwood S, Gugino SF, Russell JA, Steinhorn RH. Hydrocortisone Restores the Normal Pulmonary Vascular Transition in an Ovine Model of PPHN. PAS Meeting Abstracts. 2008; 63(5635).
  • Lakshminrusimha S, Davidson BA, Ryan RM, Helinski JD, Raghavendran K. Lung Contusion Alters Pulmonary Vasoreactivity in Rats. PAS Meeting Abstracts. 2008; 63(6110).
  • Farrow KN, Lakshminrusimha S, Wedgwood S, Czech L, Smith CL, Gugino SF, Russell JA, Steinhorn RH. PEG - Catalase Decreases PDE5 Activity and Improves Oxygenation in an Ovine Model of PPHN. PAS Meeting Abstracts. 2008; 65(2540).
  • Ahmed Q, Pryhuber GS, D‘Angelis CA, Kumar V, Lakshminrusimha S, Metlay LA, Wang H, Ryan RM. T-Lymphocytes in Human Infants with Bronchopulmonary Dysplasia. PAS Meeting Abstracts. 2008; 63(3766).
  • Lakshminrusimha S. Ventilation with 50% Oxygen Preserves cGMP in the Neonatal Pulmonary Vasculature versus 95% Oxygen. PAS Meeting Abstracts. 2007; 61(5580).
  • Lakshminrusimha S, Russell JA, Soares F, Gugino SF, Wynn KA, Steinhorn RH. Effect of Intratracheal Catalase in Neonatal Lambs with PPHN. PAS Meeting Abstracts. 2007; 61(6291).
  • Farrow KN, Groh BS, Lakshminrusimha S, Czech L, Gugino SF, Russell JA, Steinhorn RH. Soluble Guanylate Cyclase Expression is Increased by Mechanical Forces in Neonatal Pulmonary Vasculature. PAS Meeting Abstracts. 2007; 61(6291).
  • Chen B, Farrow KN, Lakshminrusimha S, Czech L, Groh BS, Russell JA, Steinhorn RH. NO and Mechanical Stretch Increase Phosphodiesterase 3A Expression in Ovine Fetal Pulmonary Arterial Smooth Muscle Cells. PAS Meeting Abstracts. 2007; 61(7740).
  • Lakshminrusimha S, Davidson BA, Helinski J, Ryan RM, Raghavendran K. Alterations in Pulmonary Vasoreactivity Following Lung Contusion in Rats. Circulation. 2007; 116(16).
  • Lakshminrusimha S, Swartz DD, Gugino SF, Ryan RM, Wynn KA, Steinhorn RH, Russell JA. Pulmonary Hemodynamics in Neonatal Lambs with Pulmonary Hypertension - Effect of Resuscitation with 21% or 100% Oxygen. Circulation. 2007; 116(16).
  • Ryan RM, Mohamed ISI, Bland R, Swartz DD, Ballard PL, Nielsen LC, Wang H, Wynn KA, Lakshminrusimha S, Kumar V. The Effect of Gestational Age: Postnatal Age and Inhaled Nitric Oxide (iNO) on Lung Interleukin (IL)-6 and IL-8 mRNA in Newborn Lambs. PAS Meeting Abstracts. 2007; 61(7740).
  • Ryan RM, El Abiad MT, Reynolds AM, Kumar V, Wynn RJ, Lakshminrusimha S. Are Ventilator-associated Pneumonia and Gastroesophageal Reflux Risk Factors for Bronchopulmonary Dysplasia?. PAS Meeting Abstracts. 2007; 61(5555).
  • Kirmani KI, Ryan RM, Morin FC, Russell JA, Swartz DD, Gugino SF, Wynn KA, Kumar V, Lakshminrusimha S. Effect of Dopamine on Pulmonary and Systemic Pressures in Control and PPHN Neonatal Lambs. PAS Meeting Abstracts. 2007; 61(6291).
  • Lakshminrusimha S, Morin FC, Steinhorn RH, Ryan RM, Gugino SF, Kumar V, Russell JA. Effect of Nitric Oxide Synthase (NOS) Inhibition on Ovine Bronchial Derived Relaxing Factor (BrDRF): Changes with Development and Hyperoxia. PAS Meeting Abstracts. 2006; 59(4832).
  • Lakshminrusimha S, Porta NFM, Russell JA, Gugino SF, Kumar V, Steinhorn RH. Milrinone Enhances Relaxation to Prostacyclin and Iloprost in Pulmonary Arteries Isolated from Lambs with Persistent Pulmonary Hypertension of the Newborn. PAS Meeting Abstracts. 2006; 59(4832).
  • El Abiad MT, Reynolds AM, Nader ND, Yu W, Lakshminrusimha S, Kumar V, Blessing-Hanagan K, Rich G, Ballow M, Ryan RM. Tracheal Pepsin Activity in Intubated Very Low Birth Weight (VLBW) Infants. PAS Meeting Abstracts. 2006; 59(5561).
  • Ryan RM, El Abiad MT, Swartz DD, Reynolds SD, Kumar V, Lakshminrusimha S, Wang H, Nielsen LC, Stripp BR. Interaction Between Tamoxifen and Hyperoxia in B10C3H and C57B16 Mice. PAS Meeting Abstracts. 2006; 59(4841).
  • Lakshminrusimha S, Kumar V, Morin FC, Ryan RM, Gugino SF, Patel A, Russell JA. Pulmonary Arterial Contractility Correlates with Oxygen Exposure in Ventilated Preterm Lambs. PAS Meeting Abstracts. 2006; 59(4842).
  • Patel A, Ryan RM, Lakshminrusimha S, Wynn KA, Nielsen LC, Wang H, Kumar V. Resuscitation in 21% versus 100% Oxygen - Effects on Arterial Blood Gases and Antioxidant Enzyme Activities in Preterm Newborn Lambs. PAS Meeting Abstracts. 2006; 59(5560).
  • Kumar V, Lakshminrusimha S, Hutchison A, Keleher K, Ryan RM. Characteristics of Pulmonary Hypertension in Infants < 37 Week Gestation. PAS Meeting Abstracts. 2006; 59(5560).
  • Kumar V, Lakshminrusimha S, Wang H, Wynn KA, Silbak NM, Ryan RM. Oxidant and Inflammatory Markers Following Short Term and Long Term Oxygen Exposure in Term and Preterm Newborn Lambs. Proc Am Thor Soc. 2006; 3.
  • El Abiad MT, Reynolds AM, Nader ND, Lakshminrusimha S, Kumar V, Blessing-Hanagan K, Rich G, Ballow M, Ryan RM. Tracheal Pepsin Activity in Intubated Very Low Birth Weight (VLBW) Infants. Proc Am Thor Soc. 2006; 3.
  • Ryan RM, El Abiad MT, Swartz DD, Reynolds SD, Kumar V, Lakshminrusimha S, Wang H, Nielsen LC, Stripp BR. Interaction Between Tamoxifen and Hyperoxia in B10C3H and C57BI6 Mice. Proc Am Thor Soc. 2006; 3.
  • Lakshminrusimha S, Morin FC, Steinhorn RH, Ryan RM, Gugino SF, Kumar V, Russell JA. Developmental Changes and the Effect of Hyperoxic Ventilation on Bronchial Epithelium Derived Relaxing Factor in Lambs. Proc Am Thor Soc. 2006; 3.
  • Lakshminrusimha S, Russell JA, Gugino SF, Steinhorn RH. Recombinant Human Superoxide Dismutase (rhSOD) Enhances the Response to Inhaled Nitric Oxide (iNO) in an Ovine Model of Persistent Pulmonary Hypertension of Newborn (PPHN). Proc Am Thor Soc. 2006.
  • Lakshminrusimha S, Morin FC, Steinhorn RH, Swartz DD, Ryan RM, Gugino SF, Russell JA. Neonatal Resuscitation in Lambs with 100% O2 Enhances Pulmonary Arterial (PA) Contractility and Decreases Pulmonary Vasodilator Response to Inhaled Nitric Oxide (NO). Proc Am Thor Soc. 2006.
  • Mathew B, Russell JA, Steinhorn RH, Gugino SF, Nielsen LC, Ryan RM, Lakshminrusimha S. B-type Natriuretic Peptide (BNP) System in an Ovine Model of Persistent Pulmonary Hypertension of the Newborn (PPHN). PAS Meeting Abstracts. 2006; 59(3875).
  • Lakshminrusimha S, Morin FC, Steinhorn RH, Swartz DD, Ryan RM, Gugino SF, Mathew B, Wynn KA, Russell JA. Neonatal Resuscitation in Lambs with 100% O2 Decreases Pulmonary Vasodilator Response to Inhaled Nitric Oxide (NO) and Acetylcholine (ACh). PAS Meeting Abstracts. 2006; 59(4365).
  • Lakshminrusimha S, Russell JA, Steinhorn RH, Gugino SF, Fineman JR. Alterations in Superoxide-Nitric Oxide (NO) Pathway in Pulmonary Hypertension (PH) with High Pulmonary Blood Flow (Qp). PAS Meeting Abstracts. 2006; 59(4835).
  • Lakshminrusimha S, Russell JA, Gugino SF, Davis JM, Steinhorn RH. Delayed Administration of Intratracheal (IT) Recombinant Human Superoxide Dismutase (rhSOD) Improves Oxygenation in Ovine Model of Persistent Pulmonary Hypertension of the Newborn (PPHN). PAS Meeting Abstracts. 2006; 59(3875).
  • Mohamed ISI, Garrison N, Wynn RJ, Lakshminrusimha S, Ryan RM. Initiation of Nutritional Protocols in a Levell III NICU Decreases Osteopenia of Prematurity. PAS Meeting Abstracts. 2006; 59(5572).
  • Chen B, Farrow KN, Lakshminrusimha S, Czech L, Islam SN, Russell JA, Steinhorn RH. Regulation of Phosphodiesterase 3 Expression and Activity in a Fetal Ovine Model of Persistent Pulmonary Hypertension of the Newborn: Effects of Treatment. PAS Meeting Abstracts. 2006; 59(4365).
  • Farrow KN, Reda W, Lakshminrusimha S, Czech L, Wedgwood S, Gugino SF, Kazzaz J, Russell JA, Davis JM, Steinhorn RN. Recombinant Human Superoxide Dismutase (rhSOD) Decreases ROS and Increases eNOS Expression in Persistent Pulmonary Hypertension (PPHN). PAS Meeting Abstracts. 2006; 59(4365).
  • Farrow KN, Czech LK, Lakshminrusimha S, Gugino SF, Russell JA, Steinhorn RH. Effects of Hyperoxia and Nitric Oxide on PDE5 Expression and Activity in Persistent Pulmonary Hypertension (PPHN). PAS Meeting Abstracts. 2006; 59(3875).
  • Mathew B, Ryan RM, Gugino SF, Russell JA, Morin FC, Nielsen LC, Lakshminrusimha S. Activation of Natriuretic Peptide Receptor C Inhibits Adenylate Cyclase Mediated Relaxation in Juvenile Ovine Pulmonary Arteries (PA). PAS Meeting Abstracts. 2005; 57.
  • Reda WJ, Wedgwood S, DeVol JM, Lakshminrusimha S, Russell JA, Gugino SF, Porta NFM, Steinhorn RH. Inhaled Nitric Oxide Restores eNOS Protein Levels in PPHN Lambs. PAS Meeting Abstracts. 2005; 57.
  • Porta NFM, Czech LK, Lakshminrusimha S, Gugino SF, Russell JA, Steinhorn RH. Effects of Oxygen and Nitric Oxide on Prostanoid Synthesis and Signaling in Lambs with Persistent Pulmonary Hypertension of the Newborn. PAS Meeting Abstracts. 2005; 57.
  • Farrow KN, Czech LK, Lakshminrusimha S, Gugino SF, Russell JA, Steinhorn RH. Hyperoxia Upregulates PDE5 Expression in Persistent Pulmonary Hypertension (PPHN) and Nitric Oxide (NO) is Protective. PAS Meeting Abstracts. 2005; 57.
  • Mathew B, Lakshminrusimha S, Cominsky K, Schroeder E, Carrion V. Use of Vinyl Bags in the Delivery Room Prevents Hypothermia in Preterm Very Low Birth Weight Infants. PAS Meeting Abstracts. 2005; 57.
  • Gugino SF, Morin FC, Russell JA, Mathew B, Ryan RM, Lakshminrusimha S. Bronchial Epithelium Derived Relaxing Factor is More Effective on the Adventitial Side than Luminal Side of Pulmonary Artery (PA). PAS Meeting Abstracts. 2005; 57.
  • Lakshminrusimha S, Gugino SF, Mathew B, Swartz DD, Russell JA, Wynn KA, Morin FC, Davis JM, Steinhorn RH. Recombinant Human Superoxide Dismutase Improves Oxygenation Similar to Inhaled Nitric Oxide in Ovine Ductal Ligation Model of Persistent Pulmonary Hypertension of Newborn (PPHN). PAS Meeting Abstracts. 2005; 57.
  • Lakshminrusimha S, Gugino SF, Mathew B, Nielsen LC, Goldsby TS, Morin FC, Davis JM, Russell JA, Steinhorn RH. Intratracheal Recombinant Human Superoxide Dismutase (IT-rhSOD) Prevents Increased Pulmonary Arterial Contractility Following Ventilation with 100% O2 in Neonatal Control and Persistent Pulmonary Hypertension (PPHN) Lambs. PAS Meeting Abstracts. 2005; 57.
  • Mathew B, Ryan RM, Gugino SF, Russell JA, Morin FC, Nielsen LC, Lakshminrusimha S. Natriuretic Peptide Receptor-Type C Distribution and Function in Juvenile Ovine Pulmonary Arteries. Proc Am Thor Soc. 2005; 2.
  • Lakshminrusimha S, Steinhorn RH, Gugino SF, Swartz DD, Morin FC, Russell JA. Pulmonary Arterial Contractility Response to Norepinephrine in Persistent Pulmonary Hypertension of Newborn: Effect of Mechanical Ventilation. Proc Am Thor Soc. 2005; 2.
  • Lakshminrusimha S, Steinhorn RH, Swartz DD, Gugino SF, Ryan RM, Russell JA, Morin FC, Kumar V. Pulmonary Arterial Contractility in Neonatal Lambs Increases with 100% Oxygen Resuscitation. PAS Meeting Abstracts. 2005; 57.
  • Kumar V, Rashid N, Swartz DD, Wynn KA, Wang H, Lakshminrusimha S, Koru-Sengul T, Ryan RM, Morin FC. Effect of Aerosolized Prostacyclin (Ar-PGI2) and Milrinone (Ar-MLR) on Pulmonary Hemodynamics in Newborn Lambs with Experimental Pulmonary Hypertension (PHT). Proc Am Thor Soc. 2005; 2.
  • Rashid N, Swartz DD, Lakshminrusimha S, Wynn KA, Wang H, Ryan RM, Morin FC, Koru-Sengul T, Kumar V. Effects of Intratracheal Prostacyclin (IT-PGI2) Alone and in Combination with IV Milrinone (IV MLR) on Pulmonary Hemodynamics in Ductal-Ligated Newborn Lambs with Pulmonary Hypertension. Proc Am Thor Soc. 2005; 2.
  • Lakshminrusimha S, Gugino SF, Russell JA, Mathew B, Kumar V, Ryan RM, Morin FC. Pulmonary Arterial Vasoreactivity is Decreased by the Adjacent Bronchus in Juvenile Lambs. Proc AmThor Soc. 2005; 2.
  • Nagaraja V, Lakshminrusimha S, Gugino SF, Russell JA, Ryan RM, Steinhorn RH. Systemic Hypertension in Premature Newborn: Role of Steroids and Race. PAS Meeting Abstracts. 2003.
  • Nagaraja V, Russell JA, Lakshminrusimha S, Steinhorn RH. Soluble Guanylyl Cyclase Inhibitor ODQ Does Not Inhibit the Vasorelaxation Mediated by YC-1 on the Ovine Fetal Pulmonary Artery. J Investig Med. 2002; 50(2).
  • Nagaraja V, Lakshminrusimha S, Russell JA, Gugino SF, Steinhorn RH, Fineman JR. Enhancement of Nitric Oxide (NO) Donor Mediated Relaxation of Pulmonary Arteries (PA) Isolated from Juvenile Lambs with Congenital Heart Disease (CHD) and High Pulmonary Blood Flow Using a Soluble Guanylyl Cyclase Sensitizer. Pediatr Res. 2001; 49(4 Pt2).
  • Lakshminrusimha S, Gugino SF, Russell JA, Steinhorn RH. Pulmonary Veins Isolated from Near-term Gestation Ovine Fetus Respond Uniquely in Soluble Guanylyl Cyclase (sGC) Inhibitor. Pediatr Res. 2001; 49(4 Pt2).
  • Lakshminrusimha S, Gugino SF, Nielsen LC, Russell JA, Steinhorn RH, Fineman JR. Developmental Differences in Atrial Natriuretic Peptide (ANP) Mediated Relaxation of Pulmonary Arteries (PA) Isolated from Juvenile Lambs with Congenital Heart Disease (CHD) and High Pulmonary Blood Flow. Pediatr Res. 2001; 49(4 Pt2).
  • Steinhorn RH, Wedgwood S, Russell JA, Gugino SF, Lakshminrusimha S, Black SM. Increased Production of Reactive Oxygen Species in a Lamb Model of Persistent Pulmonary Hypertension. Pediatr Res. 2001; 49(4 Pt2).
  • Steinhorn RH, Lakshminrusimha S, Russell JA, Black SM, Fineman JR. Superoxide Produced by Nitric Oxide Synthase (NOS) Impairs Vascular Relaxations in Pulmonary Arteries Isolated from Lambs with Congenital Heart Disease and High Pulmonary Blood Flow. Pediatr Res. 2001; 49(4 Pt2).
  • Lakshminrusimha S, Steinhorn RH, Gugino SF, Russell JA, Fineman JR. Decreased Relaxations to ET-B Receptor Stimulation in Pulmonary Vessels Isolated from an Ovine Model of Congenital Heart Disease with High Pulmonary Blood Flow. PAS Meeting Abstracts. 2000.
  • Lakshminrusimha S, Steinhorn RH, Dukarm RC, Gugino SF, Nielsen LC, Russell JA. Mechanism of Endogenous Cyclic GMP Production Differ in Fetal Ovine Pulmonary Arteries versus Veins. PAS Meeting Abstracts. 2000.
  • Steinhorn RH, Russell JA, Lakshminrusimha S, Gugino SF, Fineman JR. Superoxide Dismutase and Catalase Reverse Impaired Endothelium-dependent Pulmonary Arterial Relaxations in an Ovine Model of CHD with High Pulmonary Blood Flow. PAS Meeting Abstracts. 2000.
  • Gugino SF, Steinhorn RH, Lakshminrusimha S, Fineman JR, Russell JA. Altered Relaxations to Superoxide Dismutase in Pulmonary Arteries from Lambs with Congenital Heart Disease with Pulmonary Hypertension. PAS Meeting Abstracts. 2000.
  • Steinhorn RH, Lakshminrusimha S, Gugino SF, Russell JA. Superoxide Dismutase Relaxes Pulmonary Arteries from Fetal Sheep by a Mechanism Independent of NO-Guanylate Cyclase Signaling. Nitric Oxide. 2000; 4.
  • Steinhorn RH, Gugino SF, Lakshminrusimha S, Russell JA. Superoxide Contributes to Resting Tone in Pulmonary Arteries by a Mechanism Independent of Nitric Oxide - Soluble Guanylate Cyclase Signaling. Pediatr Res. 1999; 45(4 Pt2).
  • D'Angelis CA, Lakshminrusimha S, Russell JA, Fineman JR, Nickerson PA, Rosenkranz ER, Gugino SF, Steinhorn RH. Alterations in the Natriuretic Peptide System in an Ovine Model of Congenital Heart Disease (CHD) with High Pulmonary Blood Flow. Pediatr Res. 1999; 45(4 Pt2).
  • Mundakel GT, Lakshminrusimha S, Swartz DD, Russell JA, Gugino SF, Steinhorn RH. The Effect of UK 114542-27, a Novel cGMP Phosphodiesterase (PDE5) Inhibitor, in Newborn Lambs with Persistent Pulmonary Hypertension. Pediatr Res. 1999; 45(4 Pt2).
  • Lakshminrusimha S, Nielsen LC, D'Angelis CA, Nickerson PA, Russell JA, Steinhorn RH. Mechanisms of Action of Natriuretic Peptides in the Developing Ovine Lung. Pediatr Res. 1999; 45(4 Pt2).
  • Lakshminrusimha S, Nielsen LC, Gugino SF, Russell JA, Steinhorn RH. Alterations in the Pulmonary Vascular Natriuretic Peptide System in an Ovine Model of Persistent Pulmonary Hypertension of the Newborn. Circulation. 1999; 99.
  • Steinhorn RH, Gugino SF, Lakshminrusimha S, Russell JA. Superoxide Dismutase Relaxes Pulmonary Arteries from Fetal Sheep by a Mechanism Independent of NO-Guanylate Cyclase Signaling. Circulation. 1999; 99.
  • D'Angelis CA, Nickerson PA, Lakshminrusimha S, Hamra K, Russell JA, Steinhorn RH. Localization and Distribution of C-type Natriuretic Peptide and Its Receptor in Fetal and Six Week Old Ovine Lung. Am J Respir Crit Care Med. 1999; 159(3 Pt2).
  • Lakshminrusimha S, Russell JA, Rosenkranz ER, Fineman JR, Steinhorn RH. The Natriuretic Peptide System is Altered in a Model of Congenital Heart Disease (CHD) with High Pulmonary Blood Flow. Circulation. 1998; 98.
  • Lakshminrusimha S, Russell JA, Fineman JR, Gugino SF, Steinhorn RH. Developmental Differences in Relaxation to Natriuretic Peptides in Isolated Ovine Pulmonary Vessels. Pediatr Res. 1998; 43(4 Pt2).
  • Lakshminrusimha S, Steinhorn RH, Black SM, Fineman JR, D'Angelis CA, Nickerson PA, Russell JA. Early Endothelial Dysfunction in an Ovine Model of Congenital Heart Disease with High Pulmonary Blood Flow. The Physiologist. 1998; 41(4).
See All (116 Total) >
Books and Book Chapters:
  • Lakshminrusimha S, Kumar V. "Diseases of Pulmonary Circulation". Textbook of Pediatric Critical Care, Fourth Edition. 2010.
  • Lakshminrusimha S. "Cardiovascular Disorders in the Neonate". Manual of Neonatology. 2008.
  • Ryan RM, Bommaraju M, Lakshminrusimha S, Kumar V, Morin FC. "Vascular Therapies in Acute Lung Injury". Lung Injury: Mechanisms, Pathophysiology, and Therapy. 2005.
  • Lakshminrusimha S, Morin FC. "Persistent Pulmonary Hypertension in the Newborn". Fetal and Neonatal Secrets. 2001.
  • Lakshminrusimha S, Heard CM. "Anesthesia Outside the Operating Room". Textbook of Neonatal Anesthesia..

Professional Memberships:
  • American Academy of Pediatrics: Fellow (FAAP) (2006)
  • American Thoracic Society (2005–2007)
  • Eastern Society for Pediatric Research
  • American Academy of Pediatrics
  • Soceity for Pediatric Research
  • Indian Academy of Pediatrics
Presentations:
  • "Ontogeny of Nitric Oxide Pathway in Ovine Fetal Mesenteric Arteries: Correlation with Age at Onset of NEC" Annual Conference, Eastern Society for Pediatric Research (2014)
  • "Persistent Pulmonary Hypertension of the Newborn" 30th Conference on High Frequency Ventilation of Infants, Children, and Adults, Intermountain Healthcare Continuing Medical Education (2013)
  • "Management of Hypoxic Respiratory Failure" Neonatology 2013 Conference, Emory University (2013)
  • "Physiological Basis of NRP Guidelines" Neonatology 2013 Conference, Emory University (2013)
  • "Management of Hypoxic Respiratory Failure" Contemporary Management of Neonatal Pulmonary Disorders Conference, Neonatology Associates, Ltd. (2012)
  • "Neonatal Resuscitation - Science Behind the Guidelines" Contemporary Management of Neonatal Pulmonary Disorders Conference, Neonatology Associates, Ltd. (2012)
  • "Oxygen, Nitric Oxide and Neonatal Pulmonary Circulation" Pulmonary Biology Seminar Series, Medical University of South Carolina, Division of Neonatology (2012)
  • "Pulmonary Vasodilator Therapy in Neonatal Hypoxic Respiratory Failure" Pediatric Grand Rounds, Medical University of South Carolina (2012)
  • "Advances in the Management of PPHN" 3rd Symposium on Functional Echocardiography and Neonatal Hemodynamics, Monash Children's Hospital (2012)
  • "Sildenafil Use: Indications and Evidence" 3rd Symposium on Functional Echocardiography and Neonatal Hemodynamics, Monash Children's Hospital (2012)
  • "Got Milk? - Neonatal Enteral Nutrition" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (2012)
  • "Persistent Pulmonary Hypertension of the Newborn" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (2012)
  • "Comparison of Postnatal Steroids (PNS) on Respiratory Severity Scores (RSS) in Bronchopulmonary Dysplasia" Annual Meeting, Pediatric Academic Societies, Neonatal Pulmonology (2012)
  • "Gas Exchange at Different Compression to Ventilation Ratios During Neonatal Resuscitation" Annual Meeting, Pediatric Academic Societies, Neonatology - General (2012)
  • "Physiological Basis of Neonatal Resuscitation" 7th Annual Neonatal Symposium (2012)
  • "Antenatal Betamethasone Decreases Hypoxic Pulmonary Vasoconstriction in Late Preterm Lambs Delivered by Elective C-Section" Annual Meeting, Pediatric Academic Societies, Neonatal Pulmonology Vascular Biology (2012)
  • "Does Parenchymal Lung Disease Alter the Relationship Between PO2 and Pulmonary Vascular Resistance (PVR)?" Annual Meeting, Pediatric Academic Societies, Neonatal Pulmonology (2012)
  • "Effect of Early Initiation Inhaled Nitric Oxide (iNO) on Oxygenation and Oxidative Stress in PPHN" Annual Meeting, Pediatric Academic Societies, Neonatal Pulmonology (2012)
  • "Hydrocortisone Increases IKB Expression and Decreases NFKB Activity in an Ovine Model of PPHN" Annual Meeting, Pediatric Academic Societies, Pulmonary Vascular Biology Session (2012)
  • "Hyperoxia Increases Lung NOx1 Expression and Pulmonary Artery ROS" Annual Meeting, Pediatric Academic Societies, Neonatal Pulmonology (2012)
  • "Perinatal Pulmonary Hemodynamics in Acute and Chronic Models of Persistent Pulmonary Hypertension of Newborn (PPHN)" Annual Meeting, Pediatric Academic Societies, Neonatal Pulmonology (2012)
  • "PRBC Transfusion Increases Mesenteric Vasoconstriction in Preterm Lambs" Annual Meeting, Pediatric Academic Societies, Neonatal Fetal Nutrition and Metabolism II (2012)
  • "Pre-Oxygenation with 100% Oxygen Does Not Impact Time to Asystole in Newborn Piglets" Annual Meeting, Pediatric Academic Societies, Neonatal-Patient Oriented Research: Resuscitation (2012)
  • "Prenatal Glycine Supplementation Improves Weight Gain and Endogenous NO Production in the Pulmonary Arteries of IUGR Rats" Annual Meeting, Pediatric Academic Societies, Neonatal Fetal Nutrition and Metabolism II (2012)
  • "Antenatal Betamethasone Decreases Hypoxic Pulmonary Vasoconstriction in Late Preterm Lambs Delivered by Elective C-Section" Annual Conference, Eastern Society for Pediatric Research (2012)
  • "Comparison of Postnatal Steroids (PNS) on Respiratory Severity Scores (RSS) in Bronchopulmonary Dysplasia" Annual Conference, Eastern Society for Pediatric Research (2012)
  • "Does Parenchymal Lung Disease Alter the Relationship Between PO2 and Pulmonary Vascular Resistance (PVR)?" Annual Conference, Eastern Society for Pediatric Research (2012)
  • "Effect of Early Initiation Inhaled Nitric Oxide (iNO) on Oxygenation and Oxidative Stress in PPHN" Annual Conference, Eastern Society for Pediatric Research (2012)
  • "Gas Exchange at Different Compression to Ventilation Ratios During Neonatal Resuscitation" Annual Conference, Eastern Society for Pediatric Research (2012)
  • "Management of PPHN/HRF and Neonatal Resuscitation" Neonatology Research Rounds, Georgetown University (2012)
  • "Perinatal Pulmonary Hemodynamics in Acute and Chronic Models of Persistent Pulmonary Hypertension of Newborn (PPHN)" Annual Conference, Eastern Society for Pediatric Research (2012)
  • "PRBC Transfusion Increases Mesenteric Vasoconstriction in Preterm Lambs" Annual Conference, Eastern Society for Pediatric Research (2012)
  • "Pre-Oxygenation with 100% Oxygen Does Not Impact Time to Asystole in Newborn Piglets" Annual Conference, Eastern Society for Pediatric Research (2012)
  • "Prenatal Glycine Supplementation Improves Weight Gain and Endogenous NO Production in the Pulmonary Arteries of IUGR Rats" Annual Conference, Eastern Society for Pediatric Research (2012)
  • "Dilating the Pulmonary Vascular Bed" Neo Conference, Pediatrix, Respiratory Section (2012)
  • "Neonatal Lung - Science Behind Our Therapies: Pulmonary Vasodilation" ECMO Conference, Children‘s National Medical Center (2012)
  • "Recent Advances in Neonatology" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (2012)
  • "Changes in Ovine Mesenteric Vascular Reactivity with Gestation: A Vascular Theory for Age at Onset of NEC" Annual Conference, Mead Johnson (2011)
  • "Neonatal Pulmonary Hemodynamics" Neonatal Research Rounds, Westchester Medical Center (2011)
  • "Neonatal Resuscitation" Grand Rounds, Penn State Hershey Medical Center (2011)
  • "Persistent Pulmonary Hypertension of the Newborn" Grand Rounds, Westchester Medical Center (2011)
  • "Changes in Neonatal Resuscitation Guidelines - Practical Issues" Neonatal Seminar, Winthrop Hospital (2011)
  • "How to Prepare for Pediatric Board Examinations" Pediatric Resident Noon Lecture, Winthrop Hospital (2011)
  • "Is Oxygen a Pulmonary Vasodilator?" Dinner Symposium, American Academy of Pediatrics, Fetus and Newborn Chapter (2011)
  • "Neonatal Hypoxic Respiratory Failure" Pediatric Grand Rounds, Floating Hospital for Children/Tufts University (2011)
  • "Challenges in Neonatal Resuscitation and Oxygen Use" Neonatology Research Seminar, Rush University Medical Center (2011)
  • "Early Inhaled Nitric Oxide Improves Oxygenation in Lambs with PPHN" Mid-Atlantic Conference on Perinatal Research (2011)
  • "Hemodynamics in Neonatal Hypoxemic Respiratory Failure" Pediatric Grand Rounds, Rush Medical Center (2011)
  • "Oxygenation and Hemodynamics in Neonatal Lung Injury" Pulmonary Biology Seminar Series, Women and Children‘s Hospital of Buffalo (2011)
  • "What is New in Neonatal Resuscitation?" Emergency Medicine Grand Rounds, Buffalo General Hospital (2011)
  • "Neonatal Resuscitation Guidelines 2011" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (2011)
  • "Persistent Pulmonary Hypertension of the Newborn" Core Curriculum Lecture Series, Women and Children‘s Hospital of Buffalo (2011)
  • "Advances in the Management of PPHN" Perinatal Symposium, Westchester Medical Center (2011)
  • "Antenatal Betamethasone Improves Pulmonary Transition in Late Preterm Lambs Delivered by Elective Cesarean Section" Annual Meeting, Pediatric Academic Societies (2011)
  • "Changes in Neonatal Resuscitation Program 2011 - A Brief Overview" Annual Meeting, Pediatric Academic Societies/Society for Pediatric Research, State-of-the-Art Plenary Session: 2011 National Resuscitation Guidelines - Physiologic Basis (2011)
  • "Early Fortification of Expressed Breast Milk (EBM) Improves Calcium (Ca) and Phosphorus (P) Intake and Reduces Peak Alkaline Phosphatase (AlkP) Level in Premature Neonates" Annual Meeting, Pediatric Academic Societies (2011)
  • "Effect of FiO2 and NO on Oxygenation and Pulmonary Vascular Resistance at Birth" Annual Meeting, Pediatric Academic Societies (2011)
  • "Effect of Inspired Oxygen and Inhaled Nitric Oxide (iNO) on Oxygen Uptake from the Lung and Arterial Oxygen Content in Newborn Lambs and Lambs with Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Meeting, Pediatric Academic Societies (2011)
  • "Enteral Feeding and Antenatal Betamethasone Alter Mesenteric Vascular Reactivity in Late Preterm Lambs" Annual Meeting, Pediatric Academic Societies (2011)
  • "Gas Exchange in the First Minute of CPR Following Asphyxial Cardiac Arrest in Newborn Piglets" Annual Meeting, Pediatric Academic Societies (2011)
  • "Hydrocortisone Decreases Hyperoxia-Induced PDE5 Activity in Pulmonary Artery Smooth Muscle Cells from Persistent Pulmonary Hypertension (PPHN) Lambs" Annual Meeting, SPR/PAS (2011)
  • "Increased Methemoglobin (MHb) Level Predict Response to Inhaled Nitric Oxide (iNO) in Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Meeting, Pediatric Academic Societies (2011)
  • "Increased Peroxynitrite is Associated with Increased Nox2 and iNOS Expression in Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Meeting, Pediatric Academic Societies (2011)
  • "Intravenous Sildenafil Improves Oxygenation and Suppresses PDE5 Activity in Lambs with PPHN" Annual Meeting, Pediatric Academic Societies (2011)
  • "IUGR Alters Lung Morphology and Function During Postnatal Growth in Rats" Annual Meeting, Pediatric Academic Societies (2011)
  • "Location of Spontaneous Intestinal Perforation (SIP) - Role of Initial Peristalsis" Annual Meeting, Pediatric Academic Societies (2011)
  • "Morbidity and NICU Admissions Among Early Term (37-38 Weeks) and Term (39-41 Weeks) Neonates in Erie County (NY)" Annual Meeting, Pediatric Academic Societies (2011)
  • "Superoxide Anions Mediate Increased Pulmonary Arterial Contractility in 100% O2 Resuscitated Asphyxiated Lambs" Annual Meeting, Pediatric Academic Societies (2011)
  • "Hemodynamic Attributes in Hypoxemic Respiratory Failure" Annual Meeting, Pediatric Academic Societies/Society for Pediatric Research (2011)
  • "Increased H202 Generation is Associated with Increased Nox4/p22phox Expression in Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Meeting, SPR/PAS (2011)
  • "Intrauterine Growth Restriction Alters Lung Morphology and Function During Postnatal Growth in Rats" Annual Meeting, Pediatric Academic Societies (2011)
  • "Intrauterine Growth Restriction Alters Vascular Reactivity in Adult Female Rats" Annual Meeting, Pediatric Academic Societies (2011)
  • "Early Fortification of Expressed Breast Milk (EBM) Improves Calcium (Ca) and Phosphorus (P) Intake and Reduces Peak Alkaline Phosphatase (AlkP) Level in Premature Neonates" Annual Conference, Eastern Society for Pediatric Research (2011)
  • "Effect of Inspired Oxygen and Inhaled Nitric Oxide (iNO) on Oxygen Uptake from the Lung and Arterial Oxygen Content in Newborn Lambs and Lambs with Persistent Pulmonary Hypertension (PPHN)" Annual Conference, Eastern Society for Pediatric Research (2011)
  • "Enteral Feeding and Antenatal Betamethasone Alter Mesenteric Vascular Reactivity in Late Preterm Lambs" Annual Conference, Eastern Society for Pediatric Research (2011)
  • "Gas Exchange in the First Minute of CPR Following Asphyxial Cardiac Arrest in Newborn Piglets" Annual Conference, Eastern Society for Pediatric Research (2011)
  • "Increased Methemoglobin (MHb) Level Predict Response to Inhaled Nitric Oxide (iNO) in Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Conference, Eastern Society for Pediatric Research (2011)
  • "Location of Spontaneous Intestinal Perforation (SIP) - Role of Initial Peristalsis" Annual Conference, Eastern Society for Pediatric Research (2011)
  • "Superoxide Anions Mediate Increased Pulmonary Arterial Contractility in 100% O2 Resuscitated Asphyxiated Lambs" Annual Conference, Eastern Society for Pediatric Research (2011)
  • "The Increase in Neonatal Morbidity Associated with Cesarean Birth Varies with Gestational Age Among Full Term Neonates" Annual Conference, Eastern Society for Pediatric Research (2011)
  • "Hyperoxia, Nitric Oxide in the Neonatal Pulmonary Circulation" Neonatal Research Grand Rounds, Nationwide Children‘s Hospital (2011)
  • "Neonatal Resuscitation Guidelines 2011" Grand Rounds, Women and Children's Hospital of Buffalo (2011)
  • "Use of Inhaled Nitric Oxide at Birth" Pulmonary Biology Seminar Series, Women and Children‘s Hospital of Buffalo (2011)
  • "Effective Oxygen Uptake by the Lung is Not Directly Proportional to Inspired Oxygen Concentration in Healthy Newborn Lambs and Lambs with Pulmonary Hypertension" Annual Conference, Mead Johnson (2010)
  • "Hypoxic Respiratory Failure in Early Term and Term Neonates - Use of Echocardiography" Joint Obstetrics and Neonatology Conference, Jacobi Medical Center (2010)
  • "Pulmonary Hemodynamics - Effect of Oxygen and Nitric Oxide" Research Rounds, Columbia-Presbyterian Hospital for Children, Division of Neonatology (2010)
  • "Severe Anemia with Hydrops Fetalis" National Conference and Exhibition, American Academy of Pediatrics (2010)
  • "Oxygen, Nitric Oxide and the Neonatal Pulmonary Ciculation" Research Rounds, Hospital for Sick Children/University of Toronto (2010)
  • "Physiology of Pulmonary Transition at Birth" Karolinska Developmental Exchange Program, University of Toronto (2010)
  • "Hypoxic Respiratory Failure in the Neonate" Annual Conference of Respiratory Therapists, St. Barnabas Medical Center (2010)
  • "Oxygen and Pulmonary Vasodilation" 15th Annual Extracorporeal Life Support (ECLS) Symposium: ECMO and Other Specialized Therapies for the Neonatal Patient (2010)
  • "Phosphodiesterase 5 Inhibitors in PPHN" Pulmonary Biology Seminar Series, Women and Children‘s Hospital of Buffalo (2010)
  • "Norepinephrine Induced Ovine Mesenteric Artery Constriction Peaks in Late Preterm Gestation: Implications in Pathogenesis of Necrotizing Enterocolitis" Annual Meeting, Pediatric Academic Societies (2010)
  • "Norepinephrine Induced Ovine Mesenteric Artery Constriction Peaks in Late Preterm Gestation: Implications in Pathogenesis of Necrotizing Enterocolitis" Annual Conference, Eastern Society for Pediatric Research (2010)
  • "Congenital Heart Disease in Newborn" Mini-Medical School, University at Buffalo (2009)
  • "Can Methemoglobin Levels be Used to Predict Response to Inhaled Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn?" Annual International Conference, American Thoracic Society (2009)
  • "CD8+ T-Lymphocytes in Infants with Bronchopulmonary Dysplasia (BPD)" Annual Meeting, Pediatric Academic Societies, Neonatal Pulmonology (2009)
  • "Extracellular Superoxide Dismutase (EC-SOD) Activity is Decreased in Neonatal Pulmonary Hypertension (PPHN)" Annual Meeting, Pediatric Academic Societies, PPHN Mechanisms to Therapeutic Intervention (2009)
  • "Hydrocortisone Normalizes Hyperoxia Induced PDE5 Activity in Lambs with PPHN" Annual Meeting, Pediatric Academic Societies, PPHN Mechanisms to Therapeutic Intervention (2009)
  • "Methemoglobin Levels and Response to Inhaled NO in PPHN" Annual Meeting, Pediatric Academic Societies, Neonatal Pulmonology (2009)
  • "Mitochondrial Oxidant Stress Increases PDE5 Expression and Activity in Ovine Fetal Pulmonary Artery Smooth Muscle Cells (FPASMC)" Annual Meeting, Pediatric Academic Societies, Oxidant Signaling and Injury (2009)
  • "Optimal PaO2 Levels in PPHN" Annual Meeting, Pediatric Academic Societies, Pulmonary Vascular Biology Session (2009)
  • "PEG - Catalase Decreases PDE5 Activity and Improves Oxygenation in an Ovine Model of PPHN" Annual Meeting, Pediatric Academic Societies, Pulmonary Vascular Biology Session (2009)
  • "Room Air or Oxygen in the Delivery Room" Perinatal Outreach Program, University at Buffalo (2009)
  • "Recombinant Human Superoxide Dismutase in the Management of PPHN" Pediatric Origins of Lung Disease International Symposium, Children‘s Hospital of Manitoba (2009)
  • "Advances in Vasodilator Therapy in PPHN" Symposium, Mead Johnson (2009)
  • "Oxygen - A Pulmonary Vasodilator?" Extracorporeal Membrane Oxygenation (ECMO) Symposium, Children‘s National Medical Center (2009)
  • "Superoxides are Responsible for Hypoxia in Lung Contusion" Annual Conference, Society for Critical Care Medicine (2009)
  • "Methemoglobin as a Predictor of Response to NO in PPHN" New York Neonatology Thruway Conference (2008)
  • "An Interventional Nutritional Protocol Improved Osteopenia of Prematurity Independent of Other Clinical Practice Changes" Annual Meeting, Pediatric Academic Societies, Neonatal Fetal Nutrition and Metabolism (2008)
  • "Effect of NADPH Oxidase Inhibition in Lambs with Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Meeting, Pediatric Academic Societies, Pulmonary Hypertension Bench to Bedside (2008)
  • "Hydrocortisone Restores the Normal Pulmonary Vascular Transition in an Ovine Model of PPHN" Annual Meeting, Pediatric Academic Societies, Animal Models of Pathophysiology and Treatment (2008)
  • "Lung Contusion Alters Pulmonary Vasoreactivity in Rats" Annual Meeting, Pediatric Academic Societies, Critical Care II (2008)
  • "Resuscitation of Neonatal Lambs with Pulmonary Hypertension with 21% or 100% Oxygen - Effect of Pulmonary Hemodynamics" Annual Meeting, Pediatric Academic Societies, Pulmonary Hypertension Bench to Bedside (2008)
  • "T-Lymphocytes in Human Infants with Bronchopulmonary Dysplasia" Annual Meeting, Pediatric Academic Societies, Neonatal Pulmonology (2008)
  • "Vinyl Bag vs. Thermal Mattress to Prevent Hypothermia in Extremely Low Birth Weight Infants" Annual Meeting, Pediatric Academic Societies, Neonatology (2008)
  • "Alterations in Pulmonary Vasoreactivity Following Lung Contusion in Rats" Scientific Sessions 2007, American Heart Association, Best Original Resuscitation Science (2007)
  • "Approach to Newborn with Cyanosis" Grand Rounds, Women and Children‘s Hospital of Buffalo (2007)
  • "Pulmonary Hemodynamics in Neonatal Lambs with Pulmonary Hypertension - Effect of Resuscitation with 21% or 100% Oxygen" Scientific Sessions 2007, American Heart Association, Best Original Resuscitation Science (2007)
  • "Effect of Intratracheal Apocynin on Oxygenation in Lambs with PPHN" Annual Conference, Mead Johnson (2007)
  • "Is Room Air Safe for Resuscitation of Neonatal Lambs with PPHN?" New York Neonatology Thruway Conference (2007)
  • "Pulmonary Hemodynamics in Neonatal Lambs with Pulmonary Hypertension - Effect of Resuscitation with 21% or 100% Oxygen" Mid-Atlantic Conference on Perinatal Research (2007)
  • "Pulmonary Vascular Reactivity in PPHN" Pulmonary Biology Seminar Series, Women and Children‘s Hospital of Buffalo (2007)
  • "Are Ventilator-associated Pneumonia and Gastroesophageal Reflux Risk Factors for Bronchopulmonary Dysplasia?" Annual Meeting, Pediatric Academic Societies, Clinical BPD Markers, Mediators and Measurements (2007)
  • "Effect of Dopamine on Pulmonary and Systemic Pressures in Control and PPHN Neonatal Lambs" Annual Meeting, Pediatric Academic Societies, Neonatal Pulmonology (2007)
  • "Effect of Intratracheal Catalase in Neonatal Lambs with PPHN" Annual Meeting, Pediatric Academic Societies, Neonatal Pulmonology (2007)
  • "NO and Mechanical Stretch Increase Phosphodiesterase 3A Expression in Ovine Fetal Pulmonary Arterial Smooth Muscle Cells" Annual Meeting, Pediatric Academic Societies, NO and Newborn Lung: Beyond Vasodilation (2007)
  • "Soluble Guanylate Cyclase Expression is Increased by Mechanical Forces in Neonatal Pulmonary Vasculature" Annual Meeting, Pediatric Academic Societies, Neonatal Pulmonology (2007)
  • "The Effect of Gestational Age: Postnatal Age and Inhaled Nitric Oxide (iNO) on Lung Interleukin (IL)-6 and IL-8 mRNA in Newborn Lambs" Annual Meeting, Pediatric Academic Societies, NO and Newborn Lung: Beyond Vasodilation (2007)
  • "Ventilation with 50% Oxygen Preserves cGMP in the Neonatal Pulmonary Vasculature versus 95% Oxygen" Annual Meeting, Pediatric Academic Societies, New Mechanisms of Neonatal Pulmonary Vascular Disease (2007)
  • "Bronchial Derived Relaxing Factor - Role in Transition at Birth" New York Neonatology Thruway Conference (2006)
  • "Reactive Oxygen Species (ROS) Induce Phosphodiesterase 5 (PDE5) Expression and Activity in Ovine Fetal Pulmonary Artery Smooth Muscle Cells (FPASMC)" Scientific Sessions 2006, American Heart Association (2006)
  • "Hazards of Prematurity" Grand Rounds, Mysore Medical School (2006)
  • "Neonatal Ventilator Management" Neonatal Faculty, JSS Medical School (2006)
  • "Alterations in Superoxide-Nitric Oxide (NO) Pathway in Pulmonary Hypertension (PH) with High Pulmonary Blood Flow (Qp)" Annual Meeting, Pediatric Academic Societies (2006)
  • "B-type Natriuretic Peptide (BNP) System in an Ovine Model of Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Meeting, Pediatric Academic Societies (2006)
  • "Characteristics of Pulmonary Hypertension (PH) in Infants <37 Week Gestation (GA)" Annual Meeting, Pediatric Academic Societies (2006)
  • "Delayed Administration of Intratracheal (IT) Recombinant Human Superoxide Dismutase (rhSOD) Improves Oxygenation in Ovine Model of Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Meeting, Pediatric Academic Societies (2006)
  • "Effect of Nitric Oxide Synthase (NOS) Inhibition on Ovine Bronchial Derived Relaxing Factor (BrDRF): Changes with Development and Hyperoxia" Annual Meeting, Pediatric Academic Societies (2006)
  • "Effects of Hyperoxia and Nitric Oxide on PDE5 Expression and Activity in Persistent Pulmonary Hypertension (PPHN)" Annual Meeting, Pediatric Academic Societies (2006)
  • "Initiation of Nutritional Protocols in a Levell III NICU Decreases Osteopenia of Prematurity" Annual Meeting, Pediatric Academic Societies (2006)
  • "Interaction Between Tamoxifen and Hyperoxia in B10C3H and C57B16 Mice" Annual Meeting, Pediatric Academic Societies (2006)
  • "Milrinone Enhances Relaxation to Prostacyclin and Iloprost in Pulmonary Arteries Isolated from Lambs with Persistent Pulmonary Hypertension of the Newborn" Annual Meeting, Pediatric Academic Societies (2006)
  • "Neonatal Resuscitation in Lambs with 100% O2 Decreases Pulmonary Vasodilator Response to Inhaled Nitric Oxide (NO) and Acetylcholine (ACh)" Annual Meeting, Pediatric Academic Societies (2006)
  • "Pulmonary Arterial Contractility Correlates with Oxygen Exposure in Ventilated Preterm Lambs" Annual Meeting, Pediatric Academic Societies (2006)
  • "Recombinant Human Superoxide Dismutase (rhSOD) Decreases ROS and Increases eNOS Expression in Persistent Pulmonary Hypertension (PPHN)" Annual Meeting, Pediatric Academic Societies (2006)
  • "Regulation of Phosphodiesterase 3 Expression and Activity in a Fetal Ovine Model of Persistent Pulmonary Hypertension of the Newborn: Effects of Treatment" Annual Meeting, Pediatric Academic Societies (2006)
  • "Resuscitation in 21% versus 100% Oxygen - Effects on Arterial Blood Gases and Antioxidant Enzyme Activities in Preterm Newborn Lambs" Annual Meeting, Pediatric Academic Societies (2006)
  • "Tracheal Pepsin Activity in Intubated Very Low Birth Weight Infants (VLBW)" Annual Meeting, Pediatric Academic Societies (2006)
  • "Use of Supplemental Oxygen in the Delivery Room" Perinatal Outreach Program, University at Buffalo (2006)
  • "Arterial Stenosis Causes Remodeling and Reactivity Changes in Pre and Post Segments" Experimental Biology 2006, Federation of American Societies for Experimental Biology (FASEB) (2006)
  • "Oxygen and the Pulmonary Artery" Neonatology Faculty Seminar, Medical College of Wisconsin (2006)
  • "Oxygen, Nitric Oxide and the Pulmonary Artery" Pulmonary Biology Seminar Series, Women and Children‘s Hospital of Buffalo (2005)
  • "Resuscitation with 100% Oxygen Reduces Relaxation to Acetylcholine and Nitric Oxide" New York Neonatology Thruway Conference, Women and Children‘s Hospital of Buffalo (2005)
  • "Increased Pulmonary Arterial Contractility with Oxygen Ventilation is Attenuated by an Adjacent Bronchus in Newborn Lambs" Leonard Farhi Symposium, University at Buffalo (2005)
  • "Pulmonary Arterial (PA) Contractility is Not Altered Following Initial Room Air vs. Oxygen Resuscitation in Preterm Lambs but Correlates with Overall Oxygen Exposure" 29th Mid-Atlantic Conference on Perinatal Research (2005)
  • "Resuscitation in Room Air Does Not Produce Arterial Blood Gas Derangements Compared to 100% Oxygen in Preterm Newborn Lambs" 29th Mid-Atlantic Conference on Perinatal Research (2005)
  • "Persistent Fetal Circulation (PFC)/PPHN" Pediatric Surgery Conference, Women and Children‘s Hospital of Buffalo (2005)
  • "Activation of Natriuretic Peptide Receptor C Inhibits Adenylate Cyclase Mediated Relaxation in Juvenile Ovine Pulmonary Arteries (PA)" Annual Meeting, Pediatric Academic Societies, Vascular Mediators in Persistent Pulmonary Hypertension (2005)
  • "Bronchial Epithelium Derived Relaxing Factor is More Effective on the Adventitial Side than Luminal Side of Pulmonary Artery (PA)" Annual Meeting, Pediatric Academic Societies (2005)
  • "Effects of Oxygen and Nitric Oxide on Prostanoid Synthesis and Signaling in Lambs with Persistent Pulmonary Hypertension of the Newborn" Annual Meeting, Pediatric Academic Societies (2005)
  • "Hyperoxia Upregulates PDE5 Expression in Persistent Pulmonary Hypertension (PPHN) and Nitric Oxide (NO) is Protective" Annual Meeting, Pediatric Academic Societies (2005)
  • "Inhaled Nitric Oxide Restores eNOS Protein Levels in PPHN Lambs" Annual Meeting, Pediatric Academic Societies (2005)
  • "Intratracheal Recombinant Human Superoxide Dismutase (IT-rhSOD) Prevents Increased Pulmonary Arterial Contractility Following Ventilation with 100% O2 in Neonatal Control and Persistent Pulmonary Hypertension (PPHN) Lambs" Annual Meeting, Pediatric Academic Societies (2005)
  • "Pulmonary Arterial (PA) Contractility in Neonatal Lambs Increases with 100% O2 Resuscitation" Annual Meeting, Pediatric Academic Societies, Issues in Neonatal Resuscitation Session (2005)
  • "Recombinant Human Superoxide Dismutase Improves Oxygenation Similar to Inhaled Nitric Oxide in Ovine Ductal Ligation Model of Persistent Pulmonary Hypertension of Newborn (PPHN)" Annual Meeting, Pediatric Academic Societies, Pulmonary Vascular Biology Session (2005)
  • "Use of Vinyl Bags in the Delivery Room Prevents Hypothermia in Preterm Very Low Birth Weight Infants" Annual Meeting, Pediatric Academic Societies (2005)
  • "Strategies to Minimize Free Radical Formation in the Management of PPHN" New York Neonatology Thruway Conference (2004)
  • "Systemic Hypertension in Premature Newborn: Role of Steroids and Race" Annual Meeting, Pediatric Academic Societies, Neonatal Pharmacology (2003)
  • "Cyanosis in Newborns" Grand Rounds, St. Mary Corwin Hospital Center (2003)
  • "Developmental Differences in Atrial Natriuretic Peptide (ANP) Mediated Relaxation of Pulmonary Arteries (PA) Isolated from Juvenile Lambs with Congenital Heart Disease (CHD) and High Pulmonary Blood Flow" Annual Meeting, Pediatric Academic Societies (2001)
  • "Enhancement of Nitric Oxide (NO) Donor Mediated Relaxation of Pulmonary Arteries (PA) Isolated from Juvenile Lambs with Congenital Heart Disease (CHD) and High Pulmonary Blood Flow Using a Soluble Guanylyl Cyclase Sensitizer" Annual Meeting, Pediatric Academic Societies, Neonatal Pulmonology (2001)
  • "Increased Production of Reactive Oxygen Species in a Lamb Model of Persistent Pulmonary Hypertension" Annual Meeting, Pediatric Academic Societies (2001)
  • "Pulmonary Veins Isolated from Near-term Gestation Ovine Fetus Respond Uniquely in Soluble Guanylyl Cyclase (sGC) Inhibitor" Annual Meeting, Pediatric Academic Societies (2001)
  • "Superoxide Produced by Nitric Oxide Synthase (NOS) Impairs Vascular Relaxations in Pulmonary Arteries Isolated from Lambs with Congenital Heart Disease and High Pulmonary Blood Flow" Annual Meeting, Pediatric Academic Societies, Cardiology I (2001)
  • "Endothelial Dysfunction and Alteration in NO - Superoxide Pathway in Congenital Heart Disease with High Pulmonary Blood Flow" New York Neonatology Thruway Conference (2000)
  • "Superoxide Dismutase Significantly Enhances Vasodilation Mediated by Nitric Oxide Donors in Pulmonary Arteries Isolated from Lambs with Congential Heart Disease with High Pulmonary Blood Flow" 73rd Scientific Sessions, American Heart Association, Cardiovascular Disease of the Young (2000)
  • "Altered Relaxations to Superoxide Dismutase in Pulmonary Arteries from Lambs with Congenital Heart Disease with Pulmonary Hypertension" Joint Meeting, Pediatric Academic Societies/American Academy of Pediatrics, Neonatal Pulmonology (2000)
  • "Decreased Relaxations to ET-B Receptor Stimulation in Pulmonary Vessels Isolated from an Ovine Model of Congenital Heart Disease with High Pulmonary Blood Flow" Joint Meeting, Pediatric Academic Societies/American Academy of Pediatrics, Cardiology (2000)
  • "Mechanism of Endogenous Cyclic GMP Production Differ in Fetal Ovine Pulmonary Arteries versus Veins" Joint Meeting, Pediatric Academic Societies/American Academy of Pediatrics, Neonatal Pulmonology (2000)
  • "Superoxide Dismutase and Catalase Reverse Impaired Endothelium-dependent Pulmonary Arterial Relaxations in an Ovine Model of CHD with High Pulmonary Blood Flow" Joint Meeting, Pediatric Academic Societies/American Academy of Pediatrics, Cardiology (2000)
  • "Early Pulmonary Endothelial Dysfunction in Congenital Heart Disease with High Pulmonary Blood Flow" Faculty Research Seminar, Women and Children's Hospital of Buffalo (2000)
  • "Early Endothelial Dysfunction in Congenital Heart Disease with High Pulmonary Blood Flow" Upstate Perinatal Research Meeting, Cornell University (2000)
  • "Alterations in the Pulmonary Vascular Natriuretic Peptide System in an ovine model of Persistent Pulmonary Hypertension of the Newborn" Council of Arteriosclerosis, Thrombosis and Vascular Biology, American Heart Association, Young Investigators' Invitation (1999)
  • "Alterations in the Pulmonary Vascular Natriuretic Peptide System in an Ovine Model of Persistent Pulmonary Hypertension of the Newborn" 72nd Scientific Sessions, American Heart Association, Regulation of Vascular Responses in the Pulmonary Circulation (1999)
  • "Natriuretic Peptides in Perinatal Pulmonary Circulation" New York Neonatology Thruway Conference (1999)
  • "Superoxide Dismutase Relaxes Pulmonary Arteries from Fetal Sheep by a Mechanism Independent of NO-Guanylate Cyclase Signaling" 72nd Scientific Sessions, American Heart Association, Redox Signaling in Pulmonary Circulation (1999)
  • "Alterations in the Natriuretic Peptide System in an Ovine Model of Congenital Heart Disease (CHD) with High Pulmonary Blood Flow" Annual Meeting, Pediatric Academic Societies/Society for Pediatric Research, Cardiology (1999)
  • "Mechanisms of Action of Natriuretic Peptides in the Developing Ovine Lung" Annual Meeting, Pediatric Academic Societies/Society for Pediatric Research, Neonatal Pulmonology (1999)
  • "Superoxide Contributes to Resting Tone in Pulmonary Arteries by a Mechanism Independent of Nitric Oxide - Soluble Guanylate Cyclase Signaling" Annual Meeting, Pediatric Academic Societies/Society for Pediatric Research, Pulmonary - General Lung Biology (1999)
  • "The Effect of UK 114542-27, a Novel cGMP Phosphodiesterase (PDE5) Inhibitor, in Newborn Lambs with Persistent Pulmonary Hypertension" Annual Meeting, Pediatric Academic Societies/Society for Pediatric Research, Neonatal Pulmonology (1999)
  • "Localization and Distribution of C-type Natriuretic Peptide and Its Receptor in Fetal and Six Week Old Ovine Lung" Annual International Conference, American Thoracic Society (1999)
  • "The Natriuretic Peptide System is Altered in a Model of Congenital Heart Disease (CHD) with High Pulmonary Blood Flow" 71st Scientific Sessions, American Heart Association, Cardiovascular Disease of the Young (Pediatric Congenital amd Acquired Cardiovascular Disease) (1998)
  • "Early Endothelial Dysfunction in an Ovine Model of Congenital Heart Disease with High Pulmonary Blood Flow" Annual Conference, American Physiological Society, Endothelial Regulation of Vascular Tone: Molecular to Integrative Physiology (1998)
  • "Effect of Natriuretic Peptides on Isolated Ovine Pulmonary Vessels: Developmental Differences" Perinatal and Developmental Medicine Symposium, Mead Johnson, Fetal and Neonatal Cardiology (1998)
  • "Developmental Differences in Relaxation to Natriuretic Peptides in Isolated Ovine Pulmonary Vessels" Annual Meeting, Pediatric Academic Societies/Society for Pediatric Research, Developmental Pharmacology Poster Symposium (1998)
  • "Responsivity to Natriuretic Peptides in Ovine Pulmonary Circulation" New York Neonatology Thruway Conference (1997)
See All (197 Total) >
Service Activities:
  • School of Medicine & Biomedical Sciences Faculty Council; Member (2008–2010)
  • School of Medicine & Biomedical Sciences Apppointment, Promotions,Tenure & Privileges; Member
  • 3rd Symposium on Functional Echocardiography and Neonatal Hemodynamics; Chair and Speaker (2012)
  • HRSA National Teleconference: Pulse Oximeter Screeing in the NICU; Case Presenter and Reviewer of Literature (2012)
  • Perinatal Outreach Meeting, Niagara Falls, NY; Participant (2012)
  • ECMO Conference: "Neonatal Lung - Science Behind Our Therapies: Pulmonary Vasodilation; Moderator (2012)
  • Manitoba Health Research Council; Grant Reviewer (2012)
  • University Pediatric Associates, Inc.; Secretary (2012)
  • American Journal of Perinatology; Ad Hoc Reviewer (2011)
  • World Journal of Pediatrics; Ad Hoc Reviewer (2011)
  • Current Pediatric Reviews; Ad Hoc Reviewer (2011)
  • Free Radical Biology and Medicine; Ad Hoc Reviewer (2011)
  • Pediatric Academic Societies Annual Meeting: Physiologic Basis of Neonatal Resuscitation Guidelines 2011; Chair and Speaker - State-of-the-Art Symposium with Dr. Patrick McNamara, University of Toronto (2011)
  • Women and Children‘s Hospital of Buffalo: Physician Strategic Planning Committee; Involved in planning the new hospital adjacent to the Gates Vascular Research Building in Buffalo, NY; Committee Member (2011)
  • Pediatric Pulmonology; Ad Hoc Reviewer (2009)
  • Journal of Translational Medicine; Ad Hoc Reviewer (2009)
  • American Academy of Pediatrics National Conference and Exhibition: Neonatal Resuscitation Seminar; Faculty Speaker - "Climbing the Olympic Hill to Better Evidence, Implementation, and Outcomes" (2008)
  • American Journal of Physiology; Ad Hoc Reviewer (2008)
  • Perinatal Outreach Meeting, Jamestown, NY; Participant (2008)
  • Eastern Society for Pediatric Research Conference: "Neonatal Pulmonology"; Moderator (2008)
  • Thorax; Ad Hoc Reviewer (2007)
  • Pediatric Academic Societies Annual Meeting: "Nitric Oxide and Oxygen - Marriage Made in Heaven or Hell"; with Dr. Lief Nelin, Nationwide Children‘s Hospital; Moderator (2006)
  • Journal of Vascular Research; Ad Hoc Reviewer (2006)
  • Microcirculation; Ad Hoc Reviewer (2006)
  • Pediatric Academic Societies Annual Meeting: Bronchopulmonary Dysplasia Poster Session; Moderator (2005)
  • Women and Children‘s Hospital of Buffalo: Morbidity and Mortality Conference; For neonatal patients and includes resident lectures; Reviewer (2004)
  • Health-Professional Shortage Area, Pueblo, CO; Primary Care Pediatrician - 75% Medicaid patients (2000–2003)
  • Vivekananda Tribal Center, B.R. Hills, India; Provided medical care to tribal forest dwellers without access to health care facilities; Volunteer (1989)
  • Journal of Perinatology (2005, 2007-2009); Ad Hoc Reviewer
  • Neonatology (2009-2011); Ad Hoc Reviewer
  • Pediatric Academic Societies: "Neonatal Disease Oriented Research" (2005, 2006, 2010, 2011); Reviewer
  • Pediatric Research (2005, 2008-2011); Ad Hoc Reviewer
  • Women and Children‘s Hospital of Buffalo: Medical Advisory Council; Member
  • Women and Children‘s Hospital of Buffalo: Neonatal Intensive Care Unit; Developer of protocols: "Inhaled Nitric Oxide for Premature Infants" and "Weaning Nitric Oxide in Term and Near-term Infants with Hypoxic Respiratory Failure"

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

Women and Children‘s Hospital of Buffalo
Division of Neonatology
219 Bryant Street
Buffalo, NY 14222
Phone: (716) 878-7673
Fax: (716) 878-7945
Email: slakshmi@buffalo.edu

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