Students Residents Faculty and StaffAlumni

Satyan Lakshminrusimha MD

Department of Pediatrics

Associate Professor and Chief, Neonatology

Specialty/Research Focus

Neonatal-Perinatal Medicine; Neonatology; Pediatrics

Overview Research Publications Activities

Professional Summary:

As the chief of the division of neonatology in the Department of Pediatrics, I oversee clinical, teaching, research and administrative tasks related to the evaluation and treatment of critically ill preterm and term newborn infants, and I am actively involved in teaching medical students, pediatric residents and fellows in neonatal-perinatal medicine. My practice is primarily located at the Neonatal Intensive Care Unit (NICU) at the Women and Children’s Hospital of Buffalo. My division provides high-risk newborn care at Millard Fillmore Suburban Hospital, plus telephone consultation and transport services for sick newborn infants throughout Western New York.

Over the past decade, I have developed an interest in managing newborn infants with hypoxic respiratory failure and persistent pulmonary hypertension of the newborn (PPHN). I have investigated the role oxygen free radicals, nitric oxide and antioxidants play in the pathogenesis and management of PPHN. More recently, I have focused my attention on optimal strategies for neonatal resuscitation. Based on this work, I have published and co-authored more than 40 peer-reviewed manuscripts.

As the director of the Center for Developmental Biology of the Lung, my research focuses on the pathophysiology of the cardio-pulmonary transition – how fetal lungs change at birth in order to breathe air – and disorders of this transition such as birth asphyxia, PPHN, retained lung liquid and respiratory distress syndrome. My laboratory’s translational research aims primarily at preventing and treating these disorders with optimal neonatal resuscitation techniques, steroids, nitric oxide, surfactant and judicious use of oxygen.

In 2011, our division joined the NICHD Neonatal Research Network – a group of 18 Academic Neonatal Centers to conduct multicenter trials with the goal of improving outcomes in sick preterm and term neonates. Together, we work to transfer innovative discoveries from our laboratory to the bedside through clinical trials, improving outcomes for this vulnerable population.

Education and Training:

MD, Pediatric Medicine, Mysore Medical College, Top rank in the university (highest score) (1995)
MBBS, Medicine/Surgery, Mysore Medical College (1990)

Employment:

Chief, Division of Neonatology, Pediatrics, Women and Children‘s Hospital of Buffalo (2011-present)
Director, Center for Developmental Biology of the Lung (CDBL), Women and Children's Hospital of Buffalo (2011-present)
Associate Professor, Pediatrics, University at Buffalo (2009-present)
Associate Director, Neonatal-Perinatal Medicine Fellowship Program, University at Buffalo (2003-present)
Assistant Professor, Pediatrics, University at Buffalo (2003–2008)
Pediatrician/Neonatologist, Pediatric Associates of Southern Colorado (2000–2003)
Clinical Assistant Professor, Pediatrics, University at Buffalo (1999–2003)
Clinical Instructor, Pediatrics, University at Buffalo (1996–1999)

Awards and Honors:

Eastern Society for Pediatric Research: Faculty Young Investigator Award (2008)
Best Doctors in America (2007)

Research Expertise:

Fetal surgery: Ligation of fetal ductus arteriosus
Isolated vessel bath studies: Use of tissue baths to study isolated vessels and airways

Grants and Sponsored Research:

August 2012–August 2017
OPTIMAL OXYGENATION IN NEONATAL LUNG INJURY
NICHD
Role: Principal Investigator
$1,163,817
April 2011–March 2016
Capitation from Neonatal Research Network studies
NICHD
Role: Principal Investigator
$129,750
July 2010–June 2015
REDOX REGULATION IN THE PERINATAL PULMONARY VASCULATURE
NIH (NHLBI)
Role: Co-Investigator
$568,750
April 2011–March 2014
Neonatal Research Network - NICHD
NICHD
Role: Co-Principal Investigator
$608,655
March 2012–February 2014
AAP - NRP 2012 GrantTracheal suctioning in spontaneous meconium aspiration
American Academy of Pediatrics
Role: Principal Investigator
$40,000
January 2012–December 2013
AAP Young Investigator Grant - MentorThe Use of Pulse Oximetry in the Assessment of Effective Chest Compressions During Neonatal Resuscitation.
American Academy of Pediatrics
Role: Consultant
$10,000
September 2010–June 2013
Phase II trial of sildenafil in newborns with persistent pulmonary hypertension
NHLBI
Role: Co-Investigator
$150,853
November 2010–October 2012
Ikaria Investigator sponsored grant : Early initiation of inhaled nitric oxide improves oxygenation in PPHN
Ikaria LLC
Role: Principal Investigator
$160,000
January 2010–December 2011
AAP/NRP Young Investigator Grant
American Academy of Pediatrics
Role: Consultant
$10,000
May 2009–April 2011
Antenatal betamethasone in late-preterm gestation lambs
NICHD
Role: Principal Investigator
$146,000
January 2006–April 2010
cGMP Regulation in the developing Pulmonary Circulation
NHLBI
Role: Co-Investigator
$528,000
January 2007–December 2007
American Academy of Pediatrics / Neonatal Resuscitation Program Award
American Academy of Pediatrics
Role: Principal Investigator
$25,000

See All (12 Total) >

Evaluative Studies and Case Reports:

Lakshminrusimha S, Wynn RJ, Youssfi M, Pabalan MJ, Bommaraju M, Kirmani K, Carrion V. Use of CT angiography in the diagnosis of total anomalous venous return. J Perinatol. 2009; 29(6).
Nornhold E, Li A, Rothman IL, Lakshminrusimha S, Helm TN. Vesiculopustular eruption associated with transient myeloproliferative disorder. Cutis. 2009; 83(5).
Paturi B, Ryan RM, Michienzi KA, Lakshminrusimha S. Galactorrhea with metoclopramide use in the neonatal unit. J Perinatol. 2009; 29(5).
Pabalan MJ, Wynn RJ, Reynolds AM, Ryan RM, Youssfi M, Manja V, Lakshminrusimha S. Pleural effusion with parenteral nutrition solution: an unusual complication of an "appropriately" placed umbilical venous catheter. Am J Perinatol. 2007; 24(10).
Wynn RJ, Boneberg A, Lakshminrusimha S. Unexpected source of latex sensitization in a neonatal intensive care unit. J Perinatol. 2007; 27(9).
Mohamed IS, Wynn RJ, Cominsky K, Reynolds AM, Ryan RM, Kumar VH, Lakshminrusimha S. White blood cell left shift in a neonate: a case of mistaken identity. J Perinatol. 2006; 26(6).

Journal Articles:

Lakshminrusimha S. The pulmonary circulation in neonatal respiratory failure. Clin Perinatol. 2012; 39(3).
Lakshminrusimha S, Steinhorn RH, Wedgwood S, Savorgnan F, Nair J, Mathew B, Gugino SF, Russell JA, Swartz DD. Pulmonary hemodynamics and vascular reactivity in asphyxiated term lambs resuscitated with 21 and 100% oxygen. J Appl Physiol. 2011; 111(5).
Lampkin SJ, Turner AM, Lakshminrusimha S, Mathew B, Brown J, Fominaya CE, Johnson KK. Association between caffeine citrate exposure and necrotizing enterocolitis in preterm infants. Am J Health Syst Pharm. 2013; 70(7).
Shah MR, Wedgwood S, Czech L, Kim GA, Lakshminrusimha S, Schumacker PT, Steinhorn RH, Farrow KN. Cyclic stretch induces inducible nitric oxide synthase and soluble guanylate cyclase in pulmonary artery smooth muscle cells. Int J Mol Sci. 2013; 14(2).
Wedgwood S, Lakshminrusimha S, Czech L, Schumacker PT, Steinhorn RH. Increased p22(phox)/Nox4 Expression Is Involved in Remodeling Through Hydrogen Peroxide Signaling in Experimental Persistent Pulmonary Hypertension of the Newborn. Antioxid Redox Signal. 2013.
Farrow KN, Lee KJ, Perez M, Schriewer JM, Wedgwood S, Lakshminrusimha S, Smith CL, Steinhorn RH, Schumacker PT. Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells. Antioxid Redox Signal. 2012; 17(3).
Perez M, Lakshminrusimha S, Wedgwood S, Czech L, Gugino SF, Russell JA, Farrow KN, Steinhorn RH. Hydrocortisone normalizes oxygenation and cGMP regulation in lambs with persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol. 2012; 302(6).
Wedgwood S, Lakshminrusimha S, Farrow KN, Czech L, Gugino SF, Soares F, Russell JA, Steinhorn RH. Apocynin improves oxygenation and increases eNOS in persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol. 2012; 302(6).
Farrow KN, Lee KJ, Perez M, Schriewer JM, Wedgwood S, Lakshminrusimha S, Smith CL, Steinhorn RH, Schumacker PT. BRIEF HYPEROXIA INCREASES MITOCHONDRIAL OXIDATION AND INCREASES PDE5 ACTIVITY IN FETAL PULMONARY ARTERY SMOOTH MUSCLE CELLS. Antioxid Redox Signal. 2012.
Wedgwood S, Lakshminrusimha S, Fukai T, Russell JA, Schumacker PT, Steinhorn RH. Hydrogen Peroxide Regulates Extracellular Superoxide Dismutase Activity and Expression in Neonatal Pulmonary Hypertension. Antioxid Redox Signal. 2011.
Wedgwood S, Lakshminrusimha S, Fukai T, Russell JA, Schumacker PT, Steinhorn RH. HYDROGEN PEROXIDE REGULATES EXTRACELLULAR SUPEROXIDE DISMUTASE ACTIVITY AND EXPRESSION IN NEONATAL PULMONARY HYPERTENSION. Antioxid Redox Signal. 2010.
Farrow KN, Wedgwood S, Lee KJ, Czech L, Gugino SF, Lakshminrusimha S, Schumacker PT, Steinhorn RH. Mitochondrial oxidant stress increases PDE5 activity in persistent pulmonary hypertension of the newborn. Respir Physiol Neurobiol. 2010.
Farrow KN, Lakshminrusimha S, Czech L, Groh BS, Gugino SF, Davis JM, Russell JA, Steinhorn RH. SOD and inhaled nitric oxide normalize phosphodiesterase 5 expression and activity in neonatal lambs with persistent pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2010; 299(1).
Deshmukh HS, Caty MG, Ryan RM, Lakshminrusimha S. Intermittent 'bulge' in the umbilical cord. J Perinatol. 2010; 30(7).
Kumar V, Swartz DD, Rashid N, Lakshminrusimha S, Ma C, Ryan RM, Morin FC. Prostacyclin and Milrinone by Aerosolization Improve Pulmonary Hemodynamics in Newborn Lambs with Experimental Pulmonary Hypertension. J Appl Physiol. 2010.
Chen B, Lakshminrusimha S, Czech L, Groh BS, Gugino SF, Russell JA, Farrow KN, Steinhorn RH. Regulation of phosphodiesterase 3 in the pulmonary arteries during the perinatal period in sheep. Pediatr Res. 2009; 66(6).
Lakshminrusimha S, Swartz DD, Gugino SF, Ma CX, Wynn KA, Ryan RM, Russell JA, Steinhorn RH. Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension. Pediatr Res. 2009; 66(5).
Pabalan MJ, Nayak SP, Ryan RM, Kumar V, Lakshminrusimha S. Methemoglobin to cumulative nitric oxide ratio and response to inhaled nitric oxide in PPHN. J Perinatol. 2009; 29(10).
Guglani L, Lakshminrusimha S, Ryan RM. Transient tachypnea of the newborn. Pediatr Rev. 2008; 29(11).
Ryan RM, Ahmed Q, Lakshminrusimha S. Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia. Clin Rev Allergy Immunol. 2008; 34(2).
D'Angelis CA, Holm BA, Lakshminrusimha S, Nickerson PA, Swartz DD, Sokolowski J, Nielsen LC, Ryan RM. Ontogeny of atrial natriuretic peptide and its receptor in the lung: effects on perinatal surfactant release. Pediatr Res. 2008; 63(3).
Farrow KN, Groh BS, Schumacker PT, Lakshminrusimha S, Czech L, Gugino SF, Russell JA, Steinhorn RH. Hyperoxia increases phosphodiesterase 5 expression and activity in ovine fetal pulmonary artery smooth muscle cells. Circ Res. 2008; 102(2).
Chan A, Lakshminrusimha S, Heffner R, Gonzalez-Fernandez F. Histogenesis of retinal dysplasia in trisomy 13. Diagn Pathol. 2007; 2.
Lakshminrusimha S, Wiseman D, Black SM, Russell JA, Gugino SF, Oishi P, Steinhorn RH, Fineman JR. The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow. Am J Physiol Heart Circ Physiol. 2007; 293(3).
Lakshminrusimha S, Russell JA, Steinhorn RH, Swartz DD, Ryan RM, Gugino SF, Wynn KA, Kumar V, Mathew B, Kirmani K, Morin FC. Pulmonary hemodynamics in neonatal lambs resuscitated with 21%, 50%, and 100% oxygen. Pediatr Res. 2007; 62(3).
Turebylu R, Salis R, Erbe R, Martin D, Lakshminrusimha S, Ryan RM. Genetic prothrombotic mutations are common in neonates but are not associated with umbilical catheter-associated thrombosis. J Perinatol. 2007; 27(8).
Kumar V, Hutchison AA, Lakshminrusimha S, Morin FC, Wynn RJ, Ryan RM. Characteristics of pulmonary hypertension in preterm neonates. J Perinatol. 2007; 27(4).
Lakshminrusimha S, Russell JA, Wedgwood S, Gugino SF, Kazzaz JA, Davis JM, Steinhorn RH. Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension. Am J Respir Crit Care Med. 2006; 174(12).
Rashid N, Morin FC, Swartz DD, Ryan RM, Wynn KA, Wang H, Lakshminrusimha S, Kumar V. Effects of prostacyclin and milrinone on pulmonary hemodynamics in newborn lambs with persistent pulmonary hypertension induced by ductal ligation. Pediatr Res. 2006; 60(5).
Lakshminrusimha S, Morin FC, Steinhorn RH, Gugino SF, Ryan RM, Kumar V, Russell JA. Ovine bronchial-derived relaxing factor: changes with development and hyperoxic ventilation. J Appl Physiol. 2006; 101(1).
Mata-Greenwood E, Jenkins C, Farrow KN, Konduri GG, Russell JA, Lakshminrusimha S, Black SM, Steinhorn RH. eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally. Am J Physiol Lung Cell Mol Physiol. 2006; 290(2).
Lakshminrusimha S, Russell JA, Steinhorn RH, Ryan RM, Gugino SF, Morin FC, Swartz DD, Kumar V. Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation. Pediatr Res. 2006; 59(1).
Dukarm RC, Steinhorn RH, Russell JA, Lakshminrusimha S, Swartz D, Cummings JJ. Selective type 5 phosphodiesterase inhibition alters pulmonary hemodynamics and lung liquid production in near-term fetal lambs. J Appl Physiol. 2005; 99(6).
Wedgwood S, Steinhorn RH, Bunderson M, Wilham J, Lakshminrusimha S, Brennan LA, Black SM. Increased hydrogen peroxide downregulates soluble guanylate cyclase in the lungs of lambs with persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol. 2005; 289(4).
Kumar V, Lakshminrusimha S, El Abiad MT, Chess PR, Ryan RM. Growth factors in lung development. Adv Clin Chem. 2005; 40.
Black SM, Bekker JM, McMullan DM, Parry AJ, Ovadia B, Reinhartz O, Lakshminrushimha S, Mata-Greenwood E, Steinhorn RH, Fineman JR, Lakshminrusimha S. Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow.. Pediatr Res. 2002; 52(2).
Lakshminrusimha S, D'Angelis CA, Russell JA, Nielsen LC, Gugino SF, Nickerson PA, Steinhorn RH. C-type natriuretic peptide system in fetal ovine pulmonary vasculature.. Am J Physiol Lung Cell Mol Physiol. 2001; 281(2).
Steinhorn RH, Russell JA, Lakshminrusimha S, Gugino SF, Black SM, Fineman JR. Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension.. Am J Physiol Heart Circ Physiol. 2001; 280(1).
Lakshminrusimha S, Steinhorn RH. Pulmonary vascular biology during neonatal transition.. Clin Perinatol. 1999; 26(3).

See All (39 Total) >

Books and Book Chapters:

Bommaraju M, Kumar VH, Lakshminrusimha S, Ryan RM, Morin FC III. Vascular therapies in acute lung injury. Lung injury: mechanism – pathophysiology – therapy. 2003.

Professional Memberships:

Soceity for Pediatric Research (2006)
American Academy of Pediatrics (1996)

Presentations:

"Dilating the Pulmonary Vascular Bed" Neo Conference for Neonatologists, Pediatrix, Respiratory Section (2012)
"Dilating the Pulmonary Vascular Bed" ECMO Conference, Children‘s National Medical Center, Neonatal lung - science behind our therapies (2012)
"Pulmonary Vasodilation" ECMO Conference, Children‘s National Medical Center (2012)
"Recent Advances in Neonatology" Pediatric Grand Rounds, Women & Children‘s Hospital of Buffalo (2012)
"Neonatal Pulmonary Hemodynamics" Neonatal Research Presentation - Westchester Medical Center (2011)
"Neonatal Resuscitation" Grand Rounds - Penn State Hershey Medical Center (2011)
"Persistent Pulmonary Hypertension of the Newborn" Grand Rounds - Westchester Medical Center (2011)
"How to Prepare for Pediatric Board Examinations" Pediatric Resident Noon Talks - Winthrop, Winthrop Hospital (2011)
"Is Oxygen a Pulmonary Vasodilator?" American Academy of Pediatrics - Chapter 2 (2011)
"Neonatal Hypoxic Respiratory Failure" Grand Rounds - Tufts University, Tufts University Medical Center, Pediatrics (2011)
"Challenges in Neonatal Resuscitation and Oxygen Use" Neonatology Research - Rush University Medical Center, Chicago IL (2011)
"Hemodynamics in Neonatal Hypoxemic Respiratory Failure" Grand Rounds - Rush Medical Center Chicago IL, Rush Medical Center, Pediatrics (2011)
"Oxygenation and Hemodynamics in Neonatal Lung Injury" Pulmonary Biology Seminar, Women & Children's Hospital of Buffalo (2011)
"What is New in Neonatal Resuscitation" Emergency Medicine Grand Rounds, Buffalo General Hospital (2011)
"Neonatal Resuscitation Guidelines 2011" Grand Rounds, Women & Children's Hospital of Buffalo (2011)
"Persistent Pulmonary Hypertension of the Newborn" Core Curriculum Lecture Series, Women & Children's Hospital of Buffalo (2011)
"Advances in management of PPHN" Perinatal Symposium at Westchester Medical Center (2011)
"Antenatal Betamethasone Improves Pulmonary Transition in Late Preterm Lambs Delivered by Elective Cesarean Section" SPR/PAS (2011)
"Changes in NRP 2011 - A Brief Overview" SPR/PAS (2011)
"Effect of FiO2 and NO on Oxygenation and Pulmonary Vascular Resistance at Birth" SPR/PAS (2011)
"Effect of Inspired Oxygen and Inhaled Nitric Oxide (iNO) on Oxygen Uptake from the Lung and Arterial Oxygen Content in Newborn Lambs and Lambs with Persistent Pulmonary Hypertension of the Newborn (PPHN)" SPR/PAS (2011)
"Gas Exchange in the First Minute of CPR Following Asphyxial Cardiac Arrest in Newborn Piglets" SPR/PAS (2011)
"Hydrocortisone Decreases Hyperoxia-Induced PDE5 Activity in Pulmonary Artery Smooth Muscle Cells from Persistent Pulmonary Hypertension (PPHN) Lambs" SPR/PAS (2011)
"Increased Methemoglobin (MHb) Levels Predict Response to Inhaled Nitric Oxide (iNO) in Persistent Pulmonary Hypertension of the Newborn (PPHN)" SPR/PAS (2011)
"Increased Peroxynitrite is Associated with Increased Nox2 and iNOS Expression in Persistent Pulmonary Hypertension of the Newborn (PPHN)" SPR/PAS (2011)
"Intrauterine Growth Restriction Alters Lung Morphology and Function During Postnatal Growth in Rats" SPR/PAS (2011)
"Intravenous Sildenafil Improves Oxygenation and Suppresses PDE5 Activity in Lambs with PPHN" SPR/PAS (2011)
"Morbidity and NICU Admissions among Early Term (37-38 wk) and Term (39-41 wk) Neonates in Erie County (NY)" SPR/PAS (2011)
"Superoxide Anions Mediate Increased Pulmonary Arterial Contractility in 100% O2 Resuscitated Asphyxiated Lambs" SPR/PAS (2011)
"Early Fortification of Expressed Breast Milk (EBM) Improves Calcium (Ca) and Phosphorus (P) Intake and Reduces Peak Alkaline Phosphatase (AlkP) Level in Premature Neonates" SPR/PAS (2011)
"Enteral Feeding and Antenatal Betamethasone Alter Mesenteric Vascular Reactivity in Late Preterm Lambs" SPR/PAS (2011)
"Hemodynamic Attributes in HRF" SPR/PAS (2011)
"Increased H202 Generation is Associated with Increased Nox4/p22phox Expression in Persistent Pulmonary Hypertension of the Newborn (PPHN)" SPR/PAS (2011)
"Intrauterine Growth Restriction Alters Vascular Reactivity in Adult Female Rats" SPR/PAS (2011)
"Hyperoxia, Nitric Oxide in the Neonatal Pulmonary Circulation" Neonatal Research Grand Rounds, Nationwide Children's Hospital (2011)
"Neonatal Resuscitation Guidelines 2011" Grand Rounds, Women & Children's Hospital of Buffalo (2011)
"Use of Inhaled Nitric Oxide at Birth" Pulmonary Biology Seminar, Women & Children's Hospital of Buffalo (2011)
"Hypoxic Respiratory Failure in Early Term and Term Neonates - Use of Echocardiography" Joint Obstetrics and Neonatology Conference, Jacobi Medical Center (2010)
"Pulmonary Hemodynamics - Effect of Oxygen and Nitric Oxide" Research Rounds, Columbia-Presbyterian Hospital for Children (2010)
"Oxygen, Nitric Oxide and the Neonatal Pulmonary Ciculation" Research Rounds, Hospital for Sick Children (2010)
"Physiology of Pulmonary Transition at Birth" Karolinska Developmental Exchange Program, University of Toronto (2010)
"Hypoxic Respiratory Failure in the Neonate" Annual Conference of Respiratory Therapists, St. Barnabas Medical Center (2010)
"Oxygen and Pulmonary Vasodilation" 15th Annual ECLS Symposium (2010)
"Phosphodiesterase 5 Inhibitors in PPHN" Pulmonary Biology Seminar, Women & Children's Hospital (2010)
"Congenital Heart Disease in Newborn" Mini-Medical School, University at Buffalo (2009)
"Room Air or Oxygen in the Delivery Room" Perinatal Outreach Program, University at Buffalo (2009)
"Recombinant Human Superoxide Dismutase in the Management of PPHN" Pediatric Origins of Lung Disease International Symposium, Children's Hospital of Manitoba (2009)
"Advances in Vasodilator Therapy in PPHN" Mead Johnson Symposium (2009)
"Oxigen - A Pulmonary Vasodilator" ECMO Symposium, Children's National Medical Center (2009)
"Methemoglobin as a Predictor of Response to NO in PPHN" Neonatal Thruway Conference (2008)
"Approach to Newborn with Cyanosis" Grand Rounds, Women & Children's Hospital of Buffalo (2007)
"Is Room Air Safe for Resuscitation of Neonatal Lambs with PPHN?" New York Neonatal Thruway Conference (2007)
"Pulmonary Vascular Reactivity in PPHN" Pulmonary Biology Seminar, Women & Children's Hospital of Buffalo (2007)
"Bronchial Derived Relaxing Factor - Role in Transition at Birth" New York Neonatal Thruway Conference (2006)
"Hazards of Prematurity" Grand Rounds, Mysore Medical School (2006)
"Neonatal Ventilator Management" , JSS Medical School (2006)
"Use of Supplemental Oxygen in the Delivery Room" Perinatal Outreach Program, University at Buffalo (2006)
"Oxygen and the Pulmonary Artery" Neonatology Faculty Seminar, Medical College of Wisconsin (2006)
"Oxygen, Nitric Oxide and the Pulmonary Artery" Pulmonary Biology Seminar Series, Women & Children's Hospital of Buffalo (2005)
"Resuscitation with 100% Oxygen Reduces Relaxation to Acetylcholine and Nitric Oxide" Neonatology Thruway Conference, Women and Children‘s Hospital of Buffalo (2005)
"Persistent Fetal Circulation (PFC)/PPHN" Pediatric Surgery Conference, Women & Children's Hospital of Buffalo (2005)
"Systemic hypertension in premature newborn: role of steroids and race" Pediatric Academic Society, Society for Pediatric Research, Neonatal Pharmacology (2003)
"Superoxide produced by Nitric Oxide Synthase (NOS) impairs vascular relaxations in pulmonary arteries isolated from lambs with congenital heart disease and high pulmonary blood flow" Pediatric Academic Society, Society for Pediatric Research, Cardiology (2002)
"Superoxide dismutase significantly enhances vasodilation mediated by nitric oxide donors in pulmonary arteries isolated from lambs with congential heart disease with high pulmonary blood flow" AHA 73rd Scientific Sessions, American Heart Association, Cardiovascular disease of the young (2001)
"Developmental differences in atrial natriuretic peptide (ANP) mediated relaxation of pulmonary arteries (PA) isolated from juvenile lambs with congenital heart disease (CHD) and high pulmonary blood flow" Pediatric Academic Society, Society for Pediatric Research (2001)
"Enhancement of Nitric Oxide (NO) Donor Mediated Relaxation of Pulmonary Arteries (PA)Isolated from Juvenile Lambs with Congenital Heart Disease (CHD) and High Pulmonary Blood Flow Using a Soluble Guanylyl Cyclase Sensitizer" Pediatric Academic Society, Society for Pediatric Research, Neonatal Pulmonology (2001)
"Increased Production of Reactive Oxygen Species in a Lamb Model of Persistent Pulmonary Hypertension" Pediatric Academic Society, Society for Pediatric Research (2001)
"Pulmonary veins isolated from near-term gestation ovine fetus respond uniquely in soluble guanylyl cyclase (sGC) inhibitor" Pediatric Academic Society, Society for Pediatric Research (2001)
"Altered relaxations to superoxide dismutase in pulmonary arteries from lambs with congenital heart disease with pulmonary hypertension" Pediatric Academic Society, American Academy of Pediatrics and Society for Pediatric Research, Neonatal Pulmonology (2000)
"Decreased relaxations to ET-B receptor stimulation in pulmonary vessels isolated from an ovine model of congential heart disease with high pulmonary blood flow" Pediatric Academic Societies, Society for Pediatric Research and American Academy of Pediatrics, Cardiology (2000)
"Mechanism of endogenous cyclic GMP production differ in fetal ovine pulmonary arteries versus veins" Pediatric Academic Society, American Academy of Pediatrics and Society for Pediatric Research, Neonatal Pulmonology (2000)
"Superoxide dismutase and catalase reverse impaired endothelium-dependent pulmonary arterial relaxations in an ovine model of CHD with high pulmonary blood flow" Pediatric Academic Society, American Academy of Pediatrics and Society for Pediatric Research, Cardiology (2000)
"Alterations in the Pulmonary Vascular Natriuretic peptide System in an ovine model of Persistent Pulmonary Hypertension of the newborn" AHA - 72nd Scientific Sessions, American Heart Association, Regulation of vascular responses in the pulmonar (1999)
"Superoxide dismutase relaxes pulmonary arteries from fetal sheep by a mechanism independent of NO-guanylate cyclase signaling" AHA 72nd Scientific Sessions, American Heart Association, Redox signaling in pulmonary circulation (1999)
"Alterations in the natriuretic peptide system in an ovine model of congenital heart disease" Pediatric Academic Societies, Society for Pediatric Research, Cardiology (1999)
"Mechanisms of action of natriuretic peptides in the developing ovine lung" Pediatric Academic Societies, Society for Pediatric Research (1999)
"Superoxide contributes to resting tone in pulmonary arteries by a mechanism independent of nitric oxide" Pediatric Academic Societies, Society for Pediatric Research, Pulmonary - general lung biology (1999)
"The effect of UK 114542-27, a novel cGMP phosphodiesterase inhibitor, in newborn lambs with persistent pulmonary hypertension of newborn" Pediatric Academic Societies, Society for Pediatric Research, Neonatal Pulmonology (1999)
"Localization and distribution of C-type natriuretic peptide and its receptor in fetal and six week old ovine lung" ATS Annual Conference, American Thoracic Society (1999)
"The natriuretic peptide system is altered in a model of congenital heart disease" AHA-71st Scientific Sessions, American Heart Association, Cardiovascular disease of the young (1998)
"Early endothelial dysfunction in an ovine model of congenital heart disease with high pulmonary blood flow" American Physiological Society, Endothelial regulation of vascular tone (1998)
"Developmental Differences in relaxation to natriuretic peptides in isolated ovine pulmonary vessels" Pediatric Academic Society, Society for Pediatric Research, Pharmacology (1998)

See All (82 Total) >

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Contact Information

Women and Children‘s Hospital of Buffalo
Division of Neonatology
219 Bryant Street
Buffalo, NY 14222
Phone: (716) 878-7673
Fax: (716) 878-7945
Email: slakshmi@buffalo.edu

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Satyan Lakshminrusimha MD

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