Department of Pediatrics
Associate Professor and Chief, Neonatology
Neonatal-Perinatal Medicine; Neonatology; Pediatrics
As the chief of the division of neonatology in the Department of Pediatrics, I oversee clinical, teaching, research and administrative tasks related to the evaluation and treatment of critically ill preterm and term newborn infants, and I am actively involved in teaching medical students, pediatric residents and fellows in neonatal-perinatal medicine. My practice is primarily located at the Neonatal Intensive Care Unit (NICU) at the Women and Children’s Hospital of Buffalo. My division provides high-risk newborn care at Millard Fillmore Suburban Hospital, plus telephone consultation and transport services for sick newborn infants throughout Western New York.
Over the past decade, I have developed an interest in managing newborn infants with hypoxic respiratory failure and persistent pulmonary hypertension of the newborn (PPHN). I have investigated the role oxygen free radicals, nitric oxide and antioxidants play in the pathogenesis and management of PPHN. More recently, I have focused my attention on optimal strategies for neonatal resuscitation. Based on this work, I have published and co-authored more than 40 peer-reviewed manuscripts.
As the director of the Center for Developmental Biology of the Lung, my research focuses on the pathophysiology of the cardio-pulmonary transition – how fetal lungs change at birth in order to breathe air – and disorders of this transition such as birth asphyxia, PPHN, retained lung liquid and respiratory distress syndrome. My laboratory’s translational research aims primarily at preventing and treating these disorders with optimal neonatal resuscitation techniques, steroids, nitric oxide, surfactant and judicious use of oxygen.
In 2011, our division joined the NICHD Neonatal Research Network – a group of 18 Academic Neonatal Centers to conduct multicenter trials with the goal of improving outcomes in sick preterm and term neonates. Together, we work to transfer innovative discoveries from our laboratory to the bedside through clinical trials, improving outcomes for this vulnerable population.