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Sangita                        Patel

Sangita P. Patel MD, PhD

Department of Ophthalmology

Research Assistant Professor

Specialty/Research Focus

Cornea & External Disease; Ophthalmology; Vision science

 
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Professional Summary:

As a specialist in cornea and external diseases of the eye, I treat a wide range of eye problems and perform a variety of surgical procedures including corneal transplantation, cataract surgery, conjunctival tumor surgery, and transplantation of the artificial cornea when standard corneal transplantation has failed.

One of the most common reasons for corneal transplantation is corneal edema. Edema of the cornea develops from loss of corneal endothelial cells and causes irreversible vision loss in thousands of people yearly. Beyond surgical transplantation of the endothelial cell layer with human donor corneal tissue, no vision-restoring treatments are available. My research investigates the physiology regulating corneal hydration to advance future treatments for these patients. There are two main projects in my lab. The first looks at characterizing changes occurring in endothelial cell monolayer intercellular junctions and passive paracellular transport properties at low and high cell densities. Clinically, patients do not experience deterioration in vision or corneal edema until very low densities. The molecular basis for this observation is unknown. This project investigates changes in the apical junctional complex and monolayer permeability of the endothelium. The second project examines the mechanisms and regulation of active water transport out of the cornea. Using Ussing chamber physiology techniques, my lab is isolating the contributions and regulation of various ionic currents across the corneal endothelium with a focus on the contributions of potassium channels, bicarbonate and carbonic anhydrase inhibitors.

Education and Training:
  • Fellowship, Cornea, Refractive Surgery and External Diseases, Massachusetts Eye and Ear Infirmary, Harvard Medical School (2009)
  • Residency, Ophthalmology, Mayo Clinic College of Medicine (2008)
  • Internship, Internal Medicine, Winthrop University Hospital (2005)
  • MD, Physiology (Ph.D.), University at Buffalo, School of Medicine and Biomedical Sciences, Cum Laude (2004)
  • BA, Biology, New York University, Magna Cum Laude (1997)
Employment:
  • Research Assistant Professor, University at Buffalo (2010-present)
  • Clinical Instructor of Ophthalmology, University at Buffalo (2009–2010)
  • Post Doctoral Fellow, University at Buffalo (2003–2004)
  • Electron Microscopy Technician, Biology, New York University (1995–1997)
  • Summer Intern, Chemical Industry Institute of Toxicology (1996)
Awards and Honors:
  • John Dyer Award (2008)
  • Heed Ophthalmic Foundation (2007)
  • E.J. Weisenheimer Award (2004)
  • Alpha Omega Alpha (2003)
  • Gilbert D. Moore Fellowship (1999)
  • Dean's Letter of Commendation (1999)
  • New York University Honors Scholar (1996)
  • Phi Beta Kappa (1996)
  • Dean's Honor List (1996)
  • Trustee Scholarship (1996)


Evaluative Studies and Case Reports:
Journal Articles:

Professional Memberships:
  • The Association for Research in Vision and Ophthalmology (2010)
  • American Academy of Ophthalmology (2005)
Presentations:
  • "Expression of Aquaporin 4 in corneal endothelial cells" Association for Research in Vision and Ophthalmology Annua Meeting (2010)
  • "A practice model for trabecular meshwork surgery" 8th Congress of the European Glaucoma Society. P274 (2008)
  • "Effects of EDTA on corneal endothelial cell proliferation" Association for Research in Vision and Ophthalmology Annual meeting (2007)
  • "Insights into Kv4.3 channel inactivation gained from KChIP2 isoforms." Biophysical Society Annual Meeting (2003)
  • "Anomalouseffects of varying K+o on inactivation and recovery kinetics of ferret left ventricular Ito." Biopysical Society Annual Meeting (2002)
  • "Kv4.3 intracellurar S6 mutations modulate the effects of KChIp2b" Biopysical Society Annual Meeting (2002)
  • "Cloning and characterization of KChIP isoforms from ferret heart." Biphysical Society Annual Meeting (2001)
  • "KChIP expression parallels rapidly recovering Ito phenotype distribution in ferret heart" American Heart Association Scientific Sessions (2001)
  • "Effects of 2-methozyethanol and L-serine on neural tube morphology, neuroepithelial cell kinetics and proliferation cell nuclear antigen immunostaining in CD-1 mouse embryos." (1997)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

Ross Eye Institute
1176 Main Street
Buffalo, NY 14209
Phone: 716-881-7900
Fax: (716)887-2991
Email: sppatel@buffalo.edu

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