Sangita P. Patel MD, PhD

Sangita Patel

Sangita P. Patel
MD, PhD

Assistant Professor

Department of Ophthalmology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Cornea & External Disease; Ophthalmology; Vision science

Contact Information
Ross Eye Institute
1176 Main Street
Buffalo, NY 14209
Phone: 716-881-7900
Fax: (716)887-2991
sppatel@buffalo.edu


Patient Care

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Professional Summary:

As a clinician-scientist, I provide care for patients with medical and surgical problems of the cornea and perform clinical and laboratory research on corneal diseases. My goal is to discover treatments and preventive strategies for diseases causing corneal swelling (such as Fuchs endothelial corneal dystrophy and bullous keratopathy) that currently can only be treated by corneal transplantation.

As a specialist in cornea and external diseases of the eye, I treat a wide range of eye problems and perform a variety of surgical procedures including corneal transplantation, cataract surgery, conjunctival tumor surgery, and transplantation of the artificial cornea when standard corneal transplantation has failed.

One of the most common reasons for corneal transplantation is corneal edema. Edema of the cornea develops from loss of corneal endothelial cells and causes irreversible vision loss in thousands of people yearly. Beyond surgical transplantation of the endothelial cell layer with human donor corneal tissue, no vision-restoring treatments are available.

The most common reason for corneal edema in the United States is Fuchs’ endothelial corneal dystrophy. My current research focuses on understanding why Fuchs endothelial corneal dystrophy is more common in women than men. We are using techniques in clinical epidemiology to study the distribution of Fuchs dystrophy in the population and to identify risk factors for Fuchs dystrophy. In the laboratory, we use techniques in molecular biology and cell physiology to investigate the physiology of the corneal endothelium and to elucidate the roles of estradiol in corneal endothelial health and disease.

Education and Training:

  • Fellowship, Cornea, Refractive Surgery and External Diseases, Massachusetts Eye and Ear Infirmary, Harvard Medical School (2009)
  • Residency, Ophthalmology, Mayo Clinic College of Medicine (2008)
  • Internship, Internal Medicine, Winthrop University Hospital (2005)
  • MD, Physiology (Ph.D.), University at Buffalo, School of Medicine and Biomedical Sciences, Cum Laude (2004)
  • BA, Biology, New York University, Magna Cum Laude (1997)

Employment:

  • Assistant Professor, Ophthalmology, University at Buffalo (2019-present)
  • Ophthalmologist, Ophthalmology, Veterans Health Administration, Western New York Health Care System (2016-present)
  • Clinical Assistant Professor, Ophthalmology, University at Buffalo (2015–2019)
  • Assistant Professor, Ophthalmology, University at Buffalo (2013–2014)
  • Research Assistant Professor, Ophthalmology, University at Buffalo (2010–2013)
  • Clinical Instructor of Ophthalmology, Ophthalmology, University at Buffalo (2009–2010)
  • Post Doctoral Fellow, Physiology, University at Buffalo (2003–2004)
  • Electron Microscopy Technician, Biology, New York University (1995–1997)
  • Summer Intern, Chemical Industry Institute of Toxicology (1996)

Awards and Honors:

  • Alcon Research Institute Young Investigator Award (2012)
  • Buswell Fellow, University at Buffalo (2010)
  • John Dyer Award (2008)
  • Heed Ophthalmic Foundation (2007)
  • E.J. Weisenheimer Award (2004)
  • Alpha Omega Alpha (2003)
  • Gilbert D. Moore Fellowship (1999)
  • Dean's Letter of Commendation (1999)
  • New York University Honors Scholar (1996)
  • Phi Beta Kappa (1996)
  • Dean's Honor List (1996)
  • Trustee Scholarship (1996)

Grants and Sponsored Research:

  • February 2018–January 2023
    Investigating the Action and Physiological Role of Slc4a11 in the Cornea
    NIH National Eye Institute
    Role: Co-Investigator
    $1,972,804
  • January 2018–January 2023
    NIH K08 (EY029007) Sex disparity and estradiol in Fuchs‘ endothelial corneal dystrophy
    NIH
    Role: Principal Investigator
    $854,900
  • January 2018–January 2023
    Investigating the Action and Physiological Role of Slc4a11 in the Cornea (NIH R01 EY028580)
    NIH
    Role: Co-Investigator
  • January 2012–January 2013
    Carbonic Anhydrases in Human Corneal Endothelial Transport
    Alcon Research Institute Young Investigator Grant
    Role: Principal Investigator
    $50,000
  • January 2010–January 2013
    Buswell Fellowship, University at Buffalo
    Role: Principal Investigator
    $240,000

Journal Articles:

See all (11 more)

Evaluative Studies and Case Reports:


Professional Memberships:

  • The Association for Research in Vision and Ophthalmology (2010–present)
  • American Academy of Ophthalmology (2005–present)

Presentations:

  • "Cornea Grand Rounds" Department of Ophthalmology, University at Buffalo (2014)
  • "Carbonic anhydrases in human corneal endothelial transport" Spring Clinical Day, University at Buffalo (2013)
  • "Carbonic anhydrases in human corneal endothelial transport" Alcon Research Institute Symposium (2013)
  • "Cornea Grand Rounds" Department of Ophthalmology, University at Buffalo (2013)
  • "Dry eye" Optical Society of Western New York (2012)
  • "The corneal endothelium: Diseases, treatments and the future" Optical Society of Western New York (2012)
  • "The bull’s eye: Are we off-target for corneal endothelial cell physiology?" 4th Annual SUNY Eye Institute Meeting (2012)
  • "Is your cornea on drugs?" Buffalo Ophthalmology Symposium, University at Buffalo (2012)
  • "Cornea Grand Rounds" Department of Ophthalmology, University at Buffalo (2012)
  • "The molecular basis to fluid transport in the cornea" Spring Clinical Day, University at Buffalo (2011)
  • "Cornea Grand Rounds" Department of Ophthalmology, University at Buffalo (2010)
  • "Corneal Storage in Optisol GS: Molecular Changes in the Endothelium" Buffalo Ophthalmology Symposium, University at Buffalo (2010)
  • "Cornea Grand Rounds" Department of Ophthalmology, University at Buffalo (2010)
  • "Grand Rounds: Diabetic Retinopathy: A Review of the Basics" Department of Internal Medicine, Buffalo General Hospital (2010)
  • "Expression of Aquaporin 4 in corneal endothelial cells" Association for Research in Vision and Ophthalmology Annua Meeting (2010)
  • "A practice model for trabecular meshwork surgery" 8th Congress of the European Glaucoma Society. P274 (2008)
  • "Effects of EDTA on corneal endothelial cell proliferation" Association for Research in Vision and Ophthalmology Annual meeting (2007)
  • "Insights into Kv4.3 channel inactivation gained from KChIP2 isoforms." Biophysical Society Annual Meeting (2003)
  • "Anomalouseffects of varying K+o on inactivation and recovery kinetics of ferret left ventricular Ito." Biopysical Society Annual Meeting (2002)
  • "Kv4.3 intracellurar S6 mutations modulate the effects of KChIp2b" Biopysical Society Annual Meeting (2002)
  • "Cloning and characterization of KChIP isoforms from ferret heart." Biphysical Society Annual Meeting (2001)
  • "KChIP expression parallels rapidly recovering Ito phenotype distribution in ferret heart" American Heart Association Scientific Sessions (2001)
  • "Effects of 2-methozyethanol and L-serine on neural tube morphology, neuroepithelial cell kinetics and proliferation cell nuclear antigen immunostaining in CD-1 mouse embryos." (1997)
  • "Cornea Grand Rounds" Department of Ophthalmology, University at Buffalo
See all (14 more)

Service Activities:

  • Representing the School of Medicine and Biomedical Sciences on the University at Buffalo Faculty Senate; Senator (2015–2017)
  • Medical Research Council, UK; Ad Hoc Reviewer (2015)
  • ARVOConnect Champions Group, Association for Research in Vision and Ophthalmology; Committee Member (2015–present)
  • Faculty mentor for Ophthalmology Resident needing academic support; Counselor (2015–present)
  • Experimental Biology and Medicine; Reviewer (2014)
  • Members Networking Group, Association for Research in Vision and Ophthalmology; Committee Member (2014)
  • SUNY Brain Network of Excellence, Collaboration Pilot Grants Program; Ad Hoc Reviewer (2014)
  • Board Member of the Buffalo Eye Bank Foundation; Board Member (2014–present)
  • Member of Subcommittee on Research Safety; Committee Member (2014–present)
  • Muscle and Nerve; Reviewer (2014–present)
  • Cornea Fellowship Interviews; Participant (2013–present)
  • IRB Proposal Scientific Review; Veterans Administration; Other (2013–present)
  • Co-Organizer, Buffalo Ophthalmology Symposium; Organizing Committee Member (2010)
  • The Wellcome Trust/DBT India Alliance; Ad Hoc Reviewer (2010)
  • Reviewer, Digital Journal of Ophthalmology; Reviewer (2009–2011)
  • Investigative Ophthalmology & Visual Science; Reviewer (2009–present)
  • Residency Interviews; Participant (2009–present)
  • Israel Science Foundation; Ad Hoc Reviewer (2004)

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Contact Information

Ross Eye Institute
1176 Main Street
Buffalo, NY 14209
Phone: 716-881-7900
Fax: (716)887-2991
sppatel@buffalo.edu

Looking for a doctor? This faculty member is affiliated with UBMD, the group comprised of practicing physicians who are also professors in the UB Jacobs School of Medicine and Biomedical Sciences.

View this faculty on UBMD