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Satrajit                       Sinha

Satrajit Sinha PhD

Department of Biochemistry

Associate Professor

Specialty/Research Focus

Gene Expression; Genomics and proteomics; Molecular and Cellular Biology

 
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Professional Summary:

My laboratory is interested in understanding the transcriptional control mechanisms that dictate epithelial cell development and differentiation. Specifically, we seek to understand the functional role of a p53-family member, p63 and Ets family of proteins in epithelial cells such as those of the skin and mammary glands. Towards this end, we have developed and characterized transgenic mice in which the normal expression pattern of these crucial factors is altered by both gain-of-function (Tet-inducible transgenic system) and loss-of-function (knockout) experiments. Our broad objectives are to elucidate the molecular mechanism by which transcription factors such as p63 and Ets proteins regulate their target genes and how such regulation of specific pathways dictate cell fate, development and differentiation. We utilize broad biochemical and genetic approaches, cell culture systems and state of the art genome-wide interrogation techniques to answer questions about differentiation of progenitor/stem populations and to examine molecular consequences of altered expression of transcription factors. These studies will not only help better understand the normal physiological processes but also lead to novel mechanistic insights into the pathophysiology of wide range of disease including cancer.

Education and Training:
  • PhD, Biochemistry, University of Texas Health Science Center Houston (1995)
  • MBBS, Calcutta Medical College (1989)
Employment:
  • Associate Professor (Tenured), State University of New York at Buffalo (2007–2011)
  • Assistant Professor, State University of New York at Buffalo (2001–2007)
Awards and Honors:
  • Young Investigator Award, SUNY at Buffalo (2005)
  • Postdoctoral Fellowship. NRSA Award (1998)
  • John P. McGovern Student Award, GSBS Univ. of Texas Health Science Center (1995)
  • Outstanding Accomplishments Award, University of Texas (1994)
  • 1st Prize Univ. of Texas M.D. Anderson Grad. Student Symposium (1994)

Research Expertise:
  • Molecular Biology

Journal Articles:
See All (31 Total) >

Professional Memberships:
  • Open Dermatology Journal; Editorial Board Member (2008–2009)
Service Activities:
  • IGPBS Admission Committee; The members of the admission committe review applicantions for the Ph.D program of the IGPBS; Member (2002)
  • Mini-Med School Talk; Guest Lecturer (2001)
  • Talk; Oral Biology, Feb 2003

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

701 Ellicott Street
Buffalo, NY 14203
Phone: (716) 881-7994
Fax: 716 849-6655
Email: ssinha2@buffalo.edu


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