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Daniel                         Swartz

Daniel D. Swartz PhD

Department of Pediatrics

Assistant Professor

Specialty/Research Focus

Neonatal-Perinatal Medicine; Neonatology; Pediatrics

 
Professional Summary:

Dr. Swartz’s basic research focuses on the mechanisms involved in vascular remodeling during development and disease. He is currently developing an in-vitro model system to study the effects of various flow parameters on vascular remodeling. This in-vitro flow system involves the use of a tissue-engineered blood vessel (TEBV) that has also been developed by Dr. Swartz. The TEBV is comprised of a medial layer of vascular smooth muscle cells, an adventitial layer of fibroblast and an endothelium possessing a monolayer of vascular endothelial cells. Developmental remodeling is studied using the TEBV by the addition of various growth factors and changes in flow patterns. Native vasculature from late term to adult animal models is also studied and compared to the in-vitro model system. Differential development and response to disease is being studied looking at arterial vs. venous and systemic vs. pulmonary vascular beds through histological examination and functional reactivity.

Education and Training:
  • PhD, Physiology/Biophysics, University at Buffalo (2004)
  • MS, Biochemistry, University of Rochester (1988)
  • BS, Biochemistry, University of Rochester (1984)
Awards and Honors:
  • Perinatal Research Society: Young Investigator Award (2004)
  • Annual Department of Chemical/Biological Engineering Symposia: Poster Award (2002)

Grants and Sponsored Research:
  • February 2009–February 2014
    Hemodynamic Induction of Pathologic Remodeling Leading to Intracranial Aneurysms
    National Institutes of Health/National Institute of Neurological Disorder and Stroke
    Role: Co-Investigator
    $1,733,595

Journal Articles:
See All (31 Total) >
Abstracts:
  • Sambalingam D, Swartz DD, Mathew B, Gugino SF, Koenigsknecht C, Nair J, Wedgwood S, Steinhorn RH, Lakshminrusimha S. Effect of Early Initiation Inhaled Nitric Oxide (iNO) on Oxygenation and Oxidative Stress in PPHN. PAS Meeting Abstracts. 2012; 71(3842).
  • Lakshminrusimha S, Mathew B, Gugino SF, Koenigsknecht C, Steinhorn RH, Swartz DD. Perinatal Pulmonary Hemodynamics in Acute and Chronic Models of Persistent Pulmonary Hypertension of Newborn (PPHN). PAS Meeting Abstracts. 2012; 71(3842).
  • Lakshminrusimha S, Mathew B, Ma CX, Nair J, Gugino SF, Koenigsknecht C, Steinhorn RH, Swartz DD. Does Parenchymal Lung Disease Alter the Relationship Between PO2 and Pulmonary Vascular Resistance (PVR)?. PAS Meeting Abstracts. 2012; 71(3842).
  • Mathew B, Swartz DD, Gugino SF, Sambalingam D, Koenigsknecht C, Lakshminrusimha S. Gas Exchange at Different Compression to Ventilation Ratios During Neonatal Resuscitation. PAS Meeting Abstracts. 2012; 71(4525).
  • Nair J, Gugino SF, Mathew B, Carmen M, Swartz DD, Lakshminrusimha S. PRBC Transfusion Increases Mesenteric Vasoconstriction in Preterm Lambs. PAS Meeting Abstracts. 2012; 71(2860).
  • Mathew B, Swartz DD, Nair J, Gugino SF, Carmen MF, Nielsen LC, Lakshminrusimha S. Pre-Oxygenation with 100% Oxygen Does Not Impact Time to Asystole in Newborn Piglets. PAS Meeting Abstracts. 2012; 71(2855).
  • Carmen MF, Gugino SF, Koenigsknecht C, Lakshminrusimha S, Swartz DD. Prenatal Glycine Supplementation Improves Weight Gain and Endogenous NO Production in the Pulmonary Arteries of IUGR Rats. PAS Meeting Abstracts. 2012; 71(2860).
  • Bazacliu C, Carmen M, Lakshminrusimha S, Basu-Ray J, Ryan RM, Swartz DD. IUGR Alters Lung Morphology and Function During Postnatal Growth in Rats. PAS Meeting Abstracts. 2011; 69(4445).
  • Bazacliu C, Carmen M, Mathew B, Ryan RM, Lakshminrusimha S, Swartz DD. Intrauterine Growth Restriction Decreases Airway Responsiveness to Methacholine in Female Rats. PAS Meeting Abstracts. 2010; 67(2720).
  • Bazacliu C, Carmen M, Mathew B, Ryan RM, Lakshminrusimha S, Swartz DD. Intrauterine Growth Restriction Alters Norepinephrine Response in Rat Aortas in a Developmental and Gender Specific Manner. PAS Meeting Abstracts. 2010; 67(4416).
  • Savorgnan F, Swartz DD, Mathew B, Wynn KA, Ryan RM, Lakshminrusimha S. Pulmonary Hemodynamics in Asphyxiated Lambs Resuscitated with 21% and 100% Oxygen. PAS Meeting Abstracts. 2010; 67(3713).
  • Swartz DD, Arter A, Nielsen LC, Lakshminrusimha S. Model of Persistent Pulmonary Hypertension of the Newborn Results in Remodeling of the Umbilical Vasculature. PAS Meeting Abstracts. 2010; 67(2847).
  • Lakshminrusimha S, Mathew B, Russell JA, Wynn KA, Ryan RM, Nair J, Swartz DD. Pulmonary Vascular Resistance (PVR) Response to Oxygen is Altered by Inhaled Nitric Oxide (iNO) in Lambs with PPHN. PAS Meeting Abstracts. 2010; 67(3294).
  • Lakshminrusimha S, Mathew B, Wynn KA, Nair J, Ryan RM, Russell JA, Swartz DD. Inhaled Nitric Oxide (iNO) Prevents Hypoxic Pulmonary Vasoconstriction in Lambs with Persistent Pulmonary Hypertension of the Newborn (PPHN). Am J Respir Crit Care Med. 2010; 181.
  • Swartz DD, Russell JA, Bazacliu C, Carmen M, Mathew B, Ryan RM, Lakshminrusimha S. Intrauterine Growth Restriction Abolishes Airway Hyperresponsiveness to Methacholine in Female Rats. Am J Respir Crit Care Med. 2010; 181.
  • Lakshminrusimha S, Russell JA, Gugino SF, Swartz DD, Wynn KA, Steinhorn RH. Optimal PaO2 Levels in PPHN. PAS Meeting Abstracts. 2009; 65(2540).
  • Lakshminrusimha S, Swartz DD, Gugino SF, Wynn KA, Steinhorn RH, Russell JA. Resuscitation of Neonatal Lambs with Pulmonary Hypertension with 21% or 100% Oxygen - Effect of Pulmonary Hemodynamics. PAS Meeting Abstracts. 2008; 63(3415).
  • Lakshminrusimha S, Swartz DD, Gugino SF, Ryan RM, Wynn KA, Steinhorn RH, Russell JA. Pulmonary Hemodynamics in Neonatal Lambs with Pulmonary Hypertension - Effect of Resuscitation with 21% or 100% Oxygen. Circulation. 2007; 116(16).
  • Ryan RM, Mohamed ISI, Bland R, Swartz DD, Ballard PL, Nielsen LC, Wang H, Wynn KA, Lakshminrusimha S, Kumar V. The Effect of Gestational Age: Postnatal Age and Inhaled Nitric Oxide (iNO) on Lung Interleukin (IL)-6 and IL-8 mRNA in Newborn Lambs. PAS Meeting Abstracts. 2007; 61(7740).
  • Kirmani KI, Ryan RM, Morin FC, Russell JA, Swartz DD, Gugino SF, Wynn KA, Kumar V, Lakshminrusimha S. Effect of Dopamine on Pulmonary and Systemic Pressures in Control and PPHN Neonatal Lambs. PAS Meeting Abstracts. 2007; 61(6291).
  • Lakshminrusimha S, Morin FC, Steinhorn RH, Swartz DD, Ryan RM, Gugino SF, Russell JA. Neonatal Resuscitation in Lambs with 100% O2 Enhances Pulmonary Arterial (PA) Contractility and Decreases Pulmonary Vasodilator Response to Inhaled Nitric Oxide (NO). Proc Am Thor Soc. 2006.
  • Lakshminrusimha S, Morin FC, Steinhorn RH, Swartz DD, Ryan RM, Gugino SF, Mathew B, Wynn KA, Russell JA. Neonatal Resuscitation in Lambs with 100% O2 Decreases Pulmonary Vasodilator Response to Inhaled Nitric Oxide (NO) and Acetylcholine (ACh). PAS Meeting Abstracts. 2006; 59(4365).
  • Kumar V, Swartz DD, Patel A, Nielsen LC, Wang H, Wynn KA, Ryan RM. MMP-2 and MMP-9 Activity in Lung Homogenates Following Resuscitation in Room Air or Oxygen in Term and Preterm Lambs. PAS Meeting Abstracts. 2006; 59(4132).
  • Ryan RM, El Abiad MT, Swartz DD, Reynolds SD, Kumar V, Lakshminrusimha S, Wang H, Nielsen LC, Stripp BR. Interaction Between Tamoxifen and Hyperoxia in B10C3H and C57B16 Mice. PAS Meeting Abstracts. 2006; 59(4841).
  • Patel A, Ryan RM, Swartz DD, Wang H, Silbak NM, Wynn KA, Kumar V. Oxidant and Inflammatory Markers Following Short Term Oxygen Exposure in Term and Preterm Newborn Lambs. PAS Meeting Abstracts. 2006; 59(5168).
  • Ryan RM, El Abiad MT, Swartz DD, Reynolds SD, Kumar V, Lakshminrusimha S, Wang H, Nielsen LC, Stripp BR. Interaction Between Tamoxifen and Hyperoxia in B10C3H and C57BI6 Mice. Proc Am Thor Soc. 2006; 3.
  • Rashid N, Morin FC, Swartz DD, Wynn K, Ryan RM, Kumar V. Aerosolized Prostacyclin and Milirinone Decrease Pulmonary Vascular Resistance in Newborn Lambs with L-NAME Induced Pulmonary Hypertension. PAS Meeting Abstracts. 2005; 57.
  • Kumar V, Swartz DD, Nielsen LC, Bevilacqua B, Wynn KA, Wang H, Morin FC, Ryan RM. Resuscitation in Room Air Compared to 100% Oxygen Lowers Oxidative Stress without Increasing Metabolic Acidosis in Term Newborn Lambs. PAS Meeting Abstracts. 2005; 57.
  • Lakshminrusimha S, Steinhorn RH, Swartz DD, Gugino SF, Ryan RM, Russell JA, Morin FC, Kumar V. Pulmonary Arterial Contractility in Neonatal Lambs Increases with 100% Oxygen Resuscitation. PAS Meeting Abstracts. 2005; 57.
  • McDevitt TM, Ryan RM, Bland R, Kumar V, Wynn K, Swartz DD, Ballard PL. Effect of Inhaled Nitric Oxide on Lung Inflammation in Ventilated Premature Lambs. PAS Meeting Abstracts. 2005; 57.
  • Kumar V, Rashid N, Swartz DD, Wynn KA, Wang H, Lakshminrusimha S, Koru-Sengul T, Ryan RM, Morin FC. Effect of Aerosolized Prostacyclin (Ar-PGI2) and Milrinone (Ar-MLR) on Pulmonary Hemodynamics in Newborn Lambs with Experimental Pulmonary Hypertension (PHT). Proc Am Thor Soc. 2005; 2.
  • Rashid N, Swartz DD, Lakshminrusimha S, Wynn KA, Wang H, Ryan RM, Morin FC, Koru-Sengul T, Kumar V. Effects of Intratracheal Prostacyclin (IT-PGI2) Alone and in Combination with IV Milrinone (IV MLR) on Pulmonary Hemodynamics in Ductal-Ligated Newborn Lambs with Pulmonary Hypertension. Proc Am Thor Soc. 2005; 2.
  • Lakshminrusimha S, Gugino SF, Mathew B, Swartz DD, Russell JA, Wynn KA, Morin FC, Davis JM, Steinhorn RH. Recombinant Human Superoxide Dismutase Improves Oxygenation Similar to Inhaled Nitric Oxide in Ovine Ductal Ligation Model of Persistent Pulmonary Hypertension of Newborn (PPHN). PAS Meeting Abstracts. 2005; 57.
  • Lakshminrusimha S, Steinhorn RH, Gugino SF, Swartz DD, Morin FC, Russell JA. Pulmonary Arterial Contractility Response to Norepinephrine in Persistent Pulmonary Hypertension of Newborn: Effect of Mechanical Ventilation. Proc Am Thor Soc. 2005; 2.
  • Mathew B, D'Angelis CA, Swartz DD, Kumar V, Nickerson PA, Wang H, Wynn KA, Holm BA, Ryan RM. Natriuretic Peptide Clearance Receptor is Down Regulated in the Pulmonary Epithelium After Birth in Preterm and Full Term Lambs. Pediatr Res. 2004; 255(4).
  • Bland R, Xu L, Kolansky S, Rabinovitch M, Ryan RM, Kumar V, Wynn K, Swartz DD, Albertine K, Dahl M, Williams M. Neonatal Chronic Lung Disease (CLD) in Term vs. Preterm Lambs: Differing Paradigms of Lung Injury and Repair. Pediatr Res. 2004; 55(4).
  • Mundakel GT, Lakshminrusimha S, Swartz DD, Russell JA, Gugino SF, Steinhorn RH. The Effect of UK 114542-27, a Novel cGMP Phosphodiesterase (PDE5) Inhibitor, in Newborn Lambs with Persistent Pulmonary Hypertension. Pediatr Res. 1999; 45(4 Pt2).
See All (37 Total) >

Professional Memberships:
  • North American Vascular Biology Organization (NAVBO) (2006)
  • American Society of Chemical Engineers (AICHE) (2000–2005)
  • Biomedical Engineering Society (BMES) (1999)
Presentations:
  • "Continuous Capnography (End Tidal CO2) Monitoring During Neonatal Resuscitation" Annual Meeting, Pediatric Academic Societies (2015)
  • "Optimal Target Oxygen Saturation (SpO2) in Term Lambs with Meconium Aspiration Syndrome (MAS) and Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Meeting, Pediatric Academic Societies (2015)
  • "Continuous Capnography (End Tidal CO2) Monitoring During Neonatal Resuscitation" Annual Conference, Eastern Society for Pediatric Research (2015)
  • "Optimal Target Oxygen Saturation (SpO2) in Term Lambs with Meconium Aspiration Syndrome (MAS) and Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Conference, Eastern Society for Pediatric Research (2015)
  • "Antenatal Betamethasone Improves Pulmonary Transition in Late Preterm Lambs Delivered by Elective Cesarean Section" Annual Meeting, Pediatric Academic Societies (2011)
  • "Effect of FiO2 and NO on Oxygenation and Pulmonary Vascular Resistance at Birth" Annual Meeting, Pediatric Academic Societies (2011)
  • "Effect of Inspired Oxygen and Inhaled Nitric Oxide (iNO) on Oxygen Uptake from the Lung and Arterial Oxygen Content in Newborn Lambs and Lambs with Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Meeting, Pediatric Academic Societies (2011)
  • "Gas Exchange in the First Minute of CPR Following Asphyxial Cardiac Arrest in Newborn Piglets" Annual Meeting, Pediatric Academic Societies (2011)
  • "Intrauterine Growth Restriction Alters Lung Morphology and Function During Postnatal Growth in Rats" Annual Meeting, Pediatric Academic Societies (2011)
  • "Location of Spontaneous Intestinal Perforation (SIP) - Role of Initial Peristalsis" Annual Meeting, Pediatric Academic Societies (2011)
  • "Neonatal Hyperoxia Restricts Somatic Growth, Induces Chronic Lung Disease (CLD) & Pulmonary Hypertension (PH) in Adult Mice" Annual Meeting, Pediatric Academic Societies (2011)
  • "Intrauterine Growth Restriction Alters Vascular Reactivity in Adult Female Rats" Annual Meeting, Pediatric Academic Societies (2011)
  • "Effect of Inspired Oxygen and Inhaled Nitric Oxide (iNO) on Oxygen Uptake from the Lung and Arterial Oxygen Content in Newborn Lambs and Lambs with Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Conference, Eastern Society for Pediatric Research (2011)
  • "Gas Exchange in the First Minute of CPR Following Asphyxial Cardiac Arrest in Newborn Piglets" Annual Conference, Eastern Society for Pediatric Research (2011)
  • "Location of Spontaneous Intestinal Perforation (SIP) - Role of Initial Peristalsis" Annual Conference, Eastern Society for Pediatric Research (2011)
See All (15 Total) >

Clinical Specialties:
Clinical Offices:
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Contact Information

University at Buffalo School of Medicine and Biomedical Sciences
124 Sherman Hall
Buffalo, NY 14214
Phone: (716) 829-2536
Email: swartzda@buffalo.edu


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