Department of Pediatrics
Neonatal-Perinatal Medicine; Neonatology; Pediatrics
Dr. Swartz’s basic research focuses on the mechanisms involved in vascular remodeling during development and disease. He is currently developing an in-vitro model system to study the effects of various flow parameters on vascular remodeling. This in-vitro flow system involves the use of a tissue-engineered blood vessel (TEBV) that has also been developed by Dr. Swartz. The TEBV is comprised of a medial layer of vascular smooth muscle cells, an adventitial layer of fibroblast and an endothelium possessing a monolayer of vascular endothelial cells. Developmental remodeling is studied using the TEBV by the addition of various growth factors and changes in flow patterns. Native vasculature from late term to adult animal models is also studied and compared to the in-vitro model system. Differential development and response to disease is being studied looking at arterial vs. venous and systemic vs. pulmonary vascular beds through histological examination and functional reactivity.