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Daniel                         Swartz

Daniel D. Swartz PhD

Department of Pediatrics

Assistant Professor

Specialty/Research Focus

Neonatal-Perinatal Medicine; Neonatology; Pediatrics

 
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Professional Summary:

Dr. Swartz’s basic research focuses on the mechanisms involved in vascular remodeling during development and disease. He is currently developing an in-vitro model system to study the effects of various flow parameters on vascular remodeling. This in-vitro flow system involves the use of a tissue-engineered blood vessel (TEBV) that has also been developed by Dr. Swartz. The TEBV is comprised of a medial layer of vascular smooth muscle cells, an adventitial layer of fibroblast and an endothelium possessing a monolayer of vascular endothelial cells. Developmental remodeling is studied using the TEBV by the addition of various growth factors and changes in flow patterns. Native vasculature from late term to adult animal models is also studied and compared to the in-vitro model system. Differential development and response to disease is being studied looking at arterial vs. venous and systemic vs. pulmonary vascular beds through histological examination and functional reactivity.

Education and Training:
  • PhD, Physiology/Biophysics, University at Buffalo (2004)
  • MS, Biochemistry, University of Rochester (1988)
  • BS, Biochemistry, University of Rochester (1984)
Awards and Honors:
  • Perinatal Research Society: Young Investigator Award (2004)
  • Annual Department of Chemical/Biological Engineering Symposia: Poster Award (2002)

Grants and Sponsored Research:
  • February 2009–February 2014
    Hemodynamic Induction of Pathologic Remodeling Leading to Intracranial Aneurysms
    National Institutes of Health/National Institute of Neurological Disorder and Stroke
    Role: Co-Investigator
    $1,733,595

Journal Articles:
See All (19 Total) >

Professional Memberships:
  • North American Vascular Biology Organization (NAVBO) (2006)
  • American Society of Chemical Engineers (AICHE) (2000–2005)
  • Biomedical Engineering Society (BMES) (1999)
Presentations:
  • "Antenatal Betamethasone Improves Pulmonary Transition in Late Preterm Lambs Delivered by Elective Cesarean Section" Annual Meeting, Pediatric Academic Societies (2011)
  • "Effect of FiO2 and NO on Oxygenation and Pulmonary Vascular Resistance at Birth" Annual Meeting, Pediatric Academic Societies (2011)
  • "Effect of Inspired Oxygen and Inhaled Nitric Oxide (iNO) on Oxygen Uptake from the Lung and Arterial Oxygen Content in Newborn Lambs and Lambs with Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Meeting, Pediatric Academic Societies (2011)
  • "Gas Exchange in the First Minute of CPR Following Asphyxial Cardiac Arrest in Newborn Piglets" Annual Meeting, Pediatric Academic Societies (2011)
  • "Intrauterine Growth Restriction Alters Lung Morphology and Function During Postnatal Growth in Rats" Annual Meeting, Pediatric Academic Societies (2011)
  • "Location of Spontaneous Intestinal Perforation (SIP) - Role of Initial Peristalsis" Annual Meeting, Pediatric Academic Societies (2011)
  • "Neonatal Hyperoxia Restricts Somatic Growth, Induces Chronic Lung Disease (CLD) & Pulmonary Hypertension (PH) in Adult Mice" Annual Meeting, Pediatric Academic Societies (2011)
  • "Intrauterine Growth Restriction Alters Vascular Reactivity in Adult Female Rats" Annual Meeting, Pediatric Academic Societies (2011)
  • "Effect of Inspired Oxygen and Inhaled Nitric Oxide (iNO) on Oxygen Uptake from the Lung and Arterial Oxygen Content in Newborn Lambs and Lambs with Persistent Pulmonary Hypertension of the Newborn (PPHN)" Annual Conference, Eastern Society for Pediatric Research (2011)
  • "Gas Exchange in the First Minute of CPR Following Asphyxial Cardiac Arrest in Newborn Piglets" Annual Conference, Eastern Society for Pediatric Research (2011)
  • "Location of Spontaneous Intestinal Perforation (SIP) - Role of Initial Peristalsis" Annual Conference, Eastern Society for Pediatric Research (2011)
See All (11 Total) >

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

University at Buffalo School of Medicine and Biomedical Sciences
124 Sherman Hall
Buffalo, NY 14214
Phone: (716) 829-2536
Email: swartzda@buffalo.edu


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