Faculty Profile - UB School of Medicine and Biomedical Sciences

Professional Summary:

Dr. Swartz’s basic research focuses on the mechanisms involved in vascular remodeling during development and disease. He is currently developing an in-vitro model system to study the effects of various flow parameters on vascular remodeling. This in-vitro flow system involves the use of a tissue-engineered blood vessel (TEBV) that has also been developed by Dr. Swartz. The TEBV is comprised of a medial layer of vascular smooth muscle cells, an adventitial layer of fibroblast and an endothelium possessing a monolayer of vascular endothelial cells. Developmental remodeling is studied using the TEBV by the addition of various growth factors and changes in flow patterns. Native vasculature from late term to adult animal models is also studied and compared to the in-vitro model system. Differential development and response to disease is being studied looking at arterial vs. venous and systemic vs. pulmonary vascular beds through histological examination and functional reactivity.

Education and Training:

PhD, Physiology/Biophysics, University at Buffalo (2004)
MS, Biochemistry, University of Rochester (1988)
BS, Biochemistry, University of Rochester (1984)

Awards and Honors:

Young Investigator Award, Perinatal Research Society (2004)
Poster Award, Annual Department of Chemical/Biological Engineering Symposia (2002)

Grants and Sponsored Research:

February 2009–February 2014
Hemodynamic Induction of Pathologic Remodeling Leading to Intracranial Aneurysms
National Institutes of Health/National Institute of Neurological Disorder and Stroke
Role: Co-Investigator
$1,733,595

Journal Articles:

Peng HF, Liu JY, Andreadis ST, Swartz DD. Hair follicle-derived smooth muscle cells and small intestinal submucosa for engineering mechanically robust and vasoreactive vascular media. Tissue Eng Part A. 2011; 17(7-8).
Kumar V, Swartz DD, Rashid N, Lakshminrusimha S, Ma C, Ryan RM, Morin FC. Prostacyclin and Milrinone by Aerosolization Improve Pulmonary Hemodynamics in Newborn Lambs with Experimental Pulmonary Hypertension. J Appl Physiol. 2010.
Han J, Liu JY, Swartz DD, Andreadis ST. Molecular and functional effects of organismal aging on smooth muscle cells derived from bone marrow mesenchymal stem cells. Cardiovasc Res. 2010.
Kumar V, Patel A, Swartz DD, Wang H, Wynn KA, Nielsen LC, Ryan RM. Exposure to supplemental oxygen and its effects on oxidative stress and antioxidant enzyme activity in term newborn lambs. Pediatr Res. 2010; 67(1).
Lakshminrusimha S, Swartz DD, Gugino SF, Ma CX, Wynn KA, Ryan RM, Russell JA, Steinhorn RH. Oxygen concentration and pulmonary hemodynamics in newborn lambs with pulmonary hypertension. Pediatr Res. 2009; 66(5).
Kransler KM, McGarrigle BP, Swartz DD, Olson JR. Lung development in the Holtzman rat is adversely affected by gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 2009; 107(2).
D'Angelis CA, Holm BA, Lakshminrusimha S, Nickerson PA, Swartz DD, Sokolowski J, Nielsen LC, Ryan RM. Ontogeny of atrial natriuretic peptide and its receptor in the lung: effects on perinatal surfactant release. Pediatr Res. 2008; 63(3).
Lakshminrusimha S, Russell JA, Steinhorn RH, Swartz DD, Ryan RM, Gugino SF, Wynn KA, Kumar V, Mathew B, Kirmani K, Morin FC. Pulmonary hemodynamics in neonatal lambs resuscitated with 21%, 50%, and 100% oxygen. Pediatr Res. 2007; 62(3).
Bland RD, Xu L, Ertsey R, Rabinovitch M, Albertine KH, Wynn KA, Kumar V, Ryan RM, Swartz DD, Csiszar K, Fong KS. Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease. Am J Physiol Lung Cell Mol Physiol. 2007; 292(6).
Rashid N, Morin FC, Swartz DD, Ryan RM, Wynn KA, Wang H, Lakshminrusimha S, Kumar V. Effects of prostacyclin and milrinone on pulmonary hemodynamics in newborn lambs with persistent pulmonary hypertension induced by ductal ligation. Pediatr Res. 2006; 60(5).
D'Angelis CA, Nickerson PA, Ryan RM, Swartz DD, Holm BA. C-type natriuretic peptide and its receptor are downregulated in pulmonary epithelium following birth. Histochem Cell Biol. 2006; 126(3).
Lakshminrusimha S, Russell JA, Steinhorn RH, Ryan RM, Gugino SF, Morin FC, Swartz DD, Kumar V. Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation. Pediatr Res. 2006; 59(1).
Geer DJ, Swartz DD, Andreadis ST. Biomimetic delivery of keratinocyte growth factor upon cellular demand for accelerated wound healing in vitro and in vivo. Am J Pathol. 2005; 167(6).
Yao L, Swartz DD, Gugino SF, Russell JA, Andreadis ST. Fibrin-based tissue-engineered blood vessels: differential effects of biomaterial and culture parameters on mechanical strength and vascular reactivity. Tissue Eng. 2005; 11(7-8).
Swartz DD, Russell JA, Andreadis ST. Engineering of fibrin-based functional and implantable small-diameter blood vessels. Am J Physiol Heart Circ Physiol. 2005; 288(3).
Geer DJ, Swartz DD, Andreadis ST. In vivo model of wound healing based on transplanted tissue-engineered skin. Tissue Eng. 2004; 10(7-8).
Tzao C, Nickerson PA, Steinhorn RH, Noble BK, Swartz DD, Russell JA. Type I nitric oxide synthase is decreased in the fetal pulmonary circulation of hypertensive lambs. Pediatr Pulmonol. 2002; 33(6).
Steinhorn RH, Albert G, Swartz DD, Russell JA, Levine CR, Davis JM. Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension. Am J Respir Crit Care Med. 2001; 164(5).
Wei CI, Cohen MD, Swartz DD, Fernando SY, Corbett MD. Mutagenicity of some monoaromatic hydroxamic acids. Toxicol Lett. 1985; 24(1).

See All (19 Total) >

Professional Memberships:

North American Vascular Biology Organization (NAVBO) (2006)
American Society of Chemical Engineers (AICHE) (2000–2005)
Biomedical Engineering Society (BMES) (1999)

Presentations:

"Antenatal Betamethasone Improves Pulmonary Transition in Late Preterm Lambs Delivered by Elective Cesarean Section" SPR/PAS (2011)
"Effect of FiO2 and NO on Oxygenation and Pulmonary Vascular Resistance at Birth" SPR/PAS (2011)
"Effect of Inspired Oxygen and Inhaled Nitric Oxide (iNO) on Oxygen Uptake from the Lung and Arterial Oxygen Content in Newborn Lambs and Lambs with Persistent Pulmonary Hypertension of the Newborn (PPHN)" SPR/PAS (2011)
"Gas Exchange in the First Minute of CPR Following Asphyxial Cardiac Arrest in Newborn Piglets" SPR/PAS (2011)
"Intrauterine Growth Restriction Alters Lung Morphology and Function During Postnatal Growth in Rats" SPR/PAS (2011)
"Neonatal Hyperoxia Restricts Somatic Growth, Induces Chronic Lung Disease (CLD) & Pulmonary Hypertension (PH) in Adult Mice" SPR/PAS (2011)
"Intrauterine Growth Restriction Alters Vascular Reactivity in Adult Female Rats" SPR/PAS (2011)

Daniel D. Swartz PhD

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