Taosheng Huang MD, PhD

Taosheng Huang

Taosheng Huang
MD, PhD

Division Chief of Human Genetics, University at Buffalo

Department of Pediatrics

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Clinical Biochemical Genetics; Clinical Genetics; Clinical Molecular Genetics; Genomics and proteomics; Inherited Metabolic Disorders; Molecular and Cellular Biology; Molecular Basis of Disease; Molecular genetics; Pediatric Genetics; Pediatrics; Regulation of metabolism

Contact Information
UBMD Pediatrics
Division of Genetics
1001 Main Street
Buffalo, NY 14203
Phone: (716) 323-0041
Fax: (716) 323-0292
thuang29@buffalo.edu


Patient Care

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Professional Summary:

I am a physician-scientist with substantial experience in translational research and mitochondrial medicine. My focus is on the integration of research, molecular testing and clinical service to improve the care of patients. Recently, I have been recruited to be the Chief of Genetics for Pediatrics at SUNY Buffalo, Director of Genetics & Metabolism at Oishei Children’s Hospital and Program Director of Clinical Cancer Genetics at Great Lakes Cancer Center. Previously, I served for eight years as Professor in Human Genetics, Director of the Program of Mitochondrial Medicine and Director of the Molecular Diagnostic laboratory at Cincinnati Children‘s Hospital Medical Center. My goal is to advance both UB and Oishei Children’s Hospital by bringing my cutting-edge research program and personnel from my previous institute, along with my 25 years of experience in clinical genetics. In addition, as the Chief of Genetics, I will help recruit additional experts in the field and attract new trainees to build up the research and clinical genetics environment at UB.

Clinically, I am interested in the genetics of mitochondrial diseases, genetic syndromes with congenital cardiac defects, newborn screening, and prenatal screening and diagnosis. I am also actively committed to the training of junior faculty, clinical and research fellows, a commitment that I will continue to follow at UB. Many of my trainees have become independent investigators and/or serve as lab directors in molecular diagnostic labs and cytogenetic labs.

My primary research interest is in ground-breaking translational research into the basis of mitochondrial disease. My group has published over 120 articles on a variety of topics, ranging from genetic syndromes to molecular mechanisms. Our research on mitochondrial replacement therapy in collaboration with Dr. John Zhang was ranked among the top 10 stories in 2016 by Nature and Science. Our discovery on paternal mtDNA was also ranked in the top 10 publications from 2019 by Nature. We plan to continue our research into novel disease-causing genes related to mitochondrial dysfunction, studying their pathogenic mechanisms and developing therapeutic treatments. Recently, we have shown that gene therapy based on the adeno-associated virus system can dramatically rescue the neurodegenerative phenotype in several of our mouse models of mitochondrial disease. Given these exciting results, we hope to eventually conduct clinical trials that will help translate these approaches into viable bedside treatments. In the long term, my vision is to apply these discoveries from rare, primary mitochondrial disorders to common conditions, such as aging, neurodegeneration and diabetes.

Education and Training:

  • PhD, Biomedical Science, Mount Sinai Medical School (1991)
  • MD, Fujian Medical College (1983)

Employment:

  • Division Chief of Human Genetics, Pediatrics, University at Buffalo (2020-present)
  • Medical Director of Genetics & Metabolism, Oishei Children’s Hospital (2020-present)
  • Program Director of Clinical Cancer Genetics, Great Lakes Cancer Center (2020-present)
  • Guest Professor, Nanchang University, China (2019-present)
  • Director, Molecular Diagnostic Laboratory, Division of Human Genetics, Cincinnati Children’s Hospital Medical Center (2016–2020)
  • Professor, Division of Human Genetics, Cincinnati Children’s Hospital Medical Center (2012–2020)
  • Director, Program of Mitochondrial Medicine, Division of Human Genetics, Cincinnati Children’s Hospital Medical Center (2012–2020)
  • Professor, Nanchang University, China (2017–2019)
  • Associate Director, Molecular Diagnostic Laboratory, Division of Human Genetics, Cincinnati Children’s Hospital Medical Center (2012–2016)
  • Honorable Professor, Peking Union Medical College, China (2011–2016)
  • Staff physician, Department of Pediatrics and Genetics, Orange County Children’s Hospital (2009–2012)
  • Associate Professor (joint appointment), Department of Pathology, Department of Pathology, University of California, Irvine, College of Medicine (2008–2012)
  • Associate Professor (joint appointment), Department of Ophthalmology, Department of Ophthalmology, University of California, Irvine, College of Medicine (2008–2012)
  • Associate Professor (Tenured), Attending Physician in Human Genetics/Metabolism, Departments of Pediatrics and Genetics, University of California, Irvine, College of Medicine (2008–2012)
  • Associate Professor (joint appointment), Department of Developmental Biology, Department of Developmental Biology, University of California, Irvine, School of Biological Science (2008–2012)
  • Consultant physician, Department of Pediatrics/Genetics, Long Beach Memorial Hospital (2007–2012)
  • Director, MitoMed Molecular Diagnostic Laboratory, University of California, Irvine, College of Medicine (2004–2012)
  • Medical staff, Long Beach Memorial Medical Center (2004–2012)
  • Attending Physician, Departments of Pediatrics and Genetics, University of California, Irvine, College of Medicine (2001–2012)
  • Director of Cardiovascular Genetic Clinic, Department of Pediatrics and Genetics, University of California, Irvine, College of Medicine (2001–2012)
  • Medical Director and Consultant, Ambry Genetics (2008–2010)
  • Assistant Professor, Department of Pathology, University of California, Irvine, College of Medicine (2004–2008)
  • Assistant Professor (Tenure track), Attending physician in Human Genetics and Metabolism, Department of Pediatrics and Genetics, University of California, Irvine, College of Medicine (2001–2008)
  • Assistant Professor, Department of Developmental Biology, University of California, Irvine, School of Biological Science (2001–2008)
  • Instructor in Genetics, Harvard Medical School (1999–2001)
  • Attending Physician and Assistant in Medicine, Boston Children’s Hospital, Harvard Medical School (1999–2001)
See all (16 more)

Awards and Honors:

  • SCAPE Achievement in Discovery Award (2017)
  • Junior Physician-Scientist Award, Dean of College of Medicine, University of California, Irvine (2004)
  • The Second Place Research Award, College of Medicine, University of California, Irvine (2003)
  • Clinical Associate Physician Award, National Health Institute (1999)
  • Farley Fellowship, Boston Children’s Hospital, Harvard Medical School (1998)
  • Resident Research Award, Georgetown University's Children's Medical Center (1996)
  • Fellowship Training Grant, National Health Institute/Harvard Medical School (1996)
  • Third Place SCBA Poster Competition, Society of Chinese Biomedical Scientists in America (1990)
  • Predoctoral Travel Fellowship, American Society of Virology (1989)

Research Expertise:

  • Clinical Genetics
  • Human Genetics
  • Metabolism
  • Mitochondrial Medicine
  • Pathogenic Mechanisms
  • Translational Research

Grants and Sponsored Research:

  • April 2019–March 2024
    Molecular Mechanism of Biallelic Mutations of FDXR Causing Novel Mitochondriopathy with Optic Atrophy
    NIH-National Eye Institute
    Role: Principal Investigator
    $1,250,000
  • April 2018–March 2023
    Exploration of the genetic basis and molecular mechanism for paternal mitochondrial DNA inheritance.
    NIH-National Institute of Child Health & Development
    Role: Principal Investigator
    $1,200,000
  • April 2019–March 2021
    Causal Role of Mitochondrial Dysfunctions in Aging by Analyzing an Epigenetic Clock in Patients with Mitochondrial DNA Mutations
    NIH-National Institute of Aging
    Role: Principal Investigator
    $250,000
  • September 2012–August 2019
    Cincinnati Children’s Hospital Research Foundation Grant.
    Cincinnati Children’s Hospital Research Foundation
    Role: Principal Investigator
    $2,000,000
  • April 2016–March 2018
    Molecular pathogenesis of SLC25A46 mutations in optic atrophy, axonal neuropathy, and cerebellar neurodegeneration
    Role: Principal Investigator
    $500,000
  • April 2008–March 2014
    Genetics studies of optic atrophy
    NIH-National Eye Institute
    Role: Principal Investigator
    $1,000,000
  • January 2011–January 2013
    Genetic and iPS Cell studies.
    Role: Principal Investigator
    $150,000
  • July 2005–December 2011
    Studies of the TBX5 targets
    Larry & Helen Hoag Foundation
    Role: Principal Investigator
    $300,000
  • March 2008–June 2011
    The role of TBX3 in Human Embryos Stem Cell Differentiation Minority Supplement for Taraneh Esmailpour
    NIH-National Cancer Institute
    Role: Principal Investigator
    $250,000
  • July 2007–June 2011
    Intracellular Network of TBX3 in breast cancer
    NIH-National Cancer Institute
    Role: Principal Investigator
    $750,000
  • April 2006–March 2008
    Transgenic TBX3 Animal Model to study breast cancer
    Susan Komen Breast Cancer Foundation
    Role: Principal Investigator
    $240,000
  • July 2001–June 2004
    Faculty Development (Howard Hughes)
    Howard Hughes Medical Research Program
    Role: Principal Investigator
    $180,000
  • April 1999–March 2004
    Clinical Associate Physician Award (K23): The Molecular Basis of Phenotypic Variability in Holt-Oram Syndrome.
    NIH
    Role: Co-Investigator
    $650,000
See all (3 more)

Journal Articles:

See all (70 more)

Books and Book Chapters:

Evaluative Studies and Case Reports:

See all (7 more)

Professional Memberships:

  • The Association of Chinese Geneticists in America (ACGA); President (2019–2021)
  • International Society of Reproductive Genetics; Board of Director (2019–2023)
  • The Association of Chinese Geneticists in America (ACGA); President-elect (2018–2019)
  • American Medical Association (2005–present)
  • Fellow, American College of Medical Genetics (2003–present)
  • Western Society for Pediatric Research (2001–present)
  • American Society of Human Genetics (1999–present)
  • American Academy of Pediatrics (1995–present)
  • American Association for Advancement of Science (1988–present)

Presentations:

  • "GENE THERAPY & GENETIC DISEASES" PRECISION MEDICINE AND BIG DATA ZOOM CONFERENCE (2020)
  • "GENE THERAPY & GENETIC DISEASES" ZOOM CONFERENCE, SHANGHAI CHILDREN’S HOSPITAL (2020)
  • "Organizing Committee Member" 5th Global Congress on Pediatrics & Neonatology (2020)
  • "Mitochondria and Reproductive Medicine" , International Society of Reproductive Genetics (ISRG) (2019)
  • "New Insights into Mitochondrial Medicine, Keynote Speaker" The Association of Chinese Geneticists in America (ACGA) Annual Meeting, The Association of Chinese Geneticists in America (ACGA) (2019)
  • "Mitochondria Health and Diseases" (2019)
  • "New Insights into Mitochondrial Medicine" , Jiangxi Children's Hospital (2019)
  • "New Insights into Mitochondrial Medicine" , Xinhua Hospital (2019)
  • "New Insights into Mitochondrial Medicine" , Shanghai Children Hospital (2019)
  • "New Insights into Mitochondrial Medicine" , Jiangxi Agricultural University (2019)
  • "New Insights into Mitochondrial Medicine, Keynote Speaker" World Chinese Pediatrician Conference-Qingdao (2019)
  • "Carrier Screening" , Sichuan University, School of Medicine (2019)
  • "New Insights into Mitochondrial Medicine" , Tulane University (2019)
  • "Mitochondria Health and Diseases" , Wenzhou Medical University (2018)
  • "Mitochondria Health and Diseases" , University of Iowa (2018)
  • "First Live Birth of Mitochondrial Replacement Therapy" The 30th Anniversary of ART in China (2018)
  • "Medical Genetic System in USA" Annual Meeting National Society of Genetic Counseling (2018)
  • "Genetics of Mitochondrial Diseases, Keynote speaker" Annual meeting on Women and Children’s Health (2018)
  • "Mitochondria Health and Diseases" CAMA Annual Lecture (2018)
  • "Mitochondrial Diseases" AY19 Neurogenetics Lectures (2018)
  • "Mitochondrial-Related Retinopathy" , National Eye Institute, NIH (2017)
  • "First Live birth derived from oocyte spindle transfer to prevent mitochondrial disease" American Society of Human Genetics Annual Meeting, American Society of Human Genetics (2017)
  • "Organizing Committee Member" 3rd Annual Congress on Rare Diseases and Orphan Drugs (2017)
  • "Mitochondria in Health & Disease" , University at Buffalo (2017)
  • "Mitochondria in Health & Disease, Departmental Seminar" , Indiana University (2017)
  • "Biallelic mutations in the ferredoxin reductase gene cause novel mitochondriopathy with optic atrophy" ACMGG annual meeting, ACMGG (2017)
See all (16 more)

Service Activities:

  • Editorial Board member for American Journal of Aging Science and Research (AJASR); Editorial Board Member (2020–present)
  • Editorial Board member for the Journal of Embryology & Stem Cell Research (JES); Editorial Board Member (2020–present)
  • Editorial Board member for the Journal of Genome Research and Genetic Therapies; Editorial Board Member (2020–present)
  • Reviewer Board member for Gene; Board Member (2020–present)
  • Editorial Board member for Mitochondrion; Editorial Board Member (2019–present)
  • Congressionally Directed Medical Research Program (CDMRP), Department of Defense. USA; Panel Member (2017–present)
  • Editorial Board member for Pediatric Research and Neonatal Care; Editorial Board Member (2017–present)
  • Editorial Board member for Progress in Ophthalmology and Vision research Journal; Editorial Board Member (2017–present)
  • Editorial Board member for the Annals of Pediatric Research; Editorial Board Member (2017–present)
  • Editorial Board member for the Journal of Gene Therapy and Research; Editorial Board Member (2017–present)
  • Editorial Board member for the Journal of Genetic, Molecular and Cellular Biology; Editorial Board Member (2017–present)
  • Editorial Board member for the Journal of Genetics and Genomes; Executive Board (2017–present)
  • Editorial Board member for the Journal of Neuro-Ophthalmology Research; Editorial Board Member (2017–present)
  • Editorial Board member for the Journal of Ocular Diseases and Therapeutics; Editorial Board Member (2017–present)
  • National Institute of Health Study Section, NIH Regenerative Medicine Innovation project (RMIP); Panel Member (2017–present)
  • Editorial Board member for Current Updates in Ophthalmology; Editorial Board Member (2016–present)
  • Editorial Board member for Henry Journal of Perinatology and Pediatrics; Editorial Board Member (2016–present)
  • Editorial Board member for JSM Biology; Editorial Board Member (2016–present)
  • Editorial Board member for Nature Genomic Medicine; Editorial Board Member (2016–present)
  • Editorial Board member for Ophthalmic Surgery; Editorial Board Member (2016–present)
  • Editorial Board member for SOJ Ophthalmology; Editorial Board Member (2016–present)
  • Editorial Board member for the Gavin Journal of Pediatrics; Editorial Board Member (2016–present)
  • Editorial Board member for the Journal CRESSCO Journal of Reproductive Science (CJRS); Editorial Board Member (2016–present)
  • Editorial Board member for the Journal of Genetics and Molecular Biology; Editorial Board Member (2016–present)
  • Editorial Board member for The Journal of Perinatology and Pediatrics; Editorial Board Member (2016–present)
  • Editorial Board member for the Journal of Ophthalmology and Visual Sciences (JOVS); Editorial Board Member (2015–present)
  • Editorial Board member for the World Journal of Complex Medicine; Editorial Board Member (2015–present)
  • Steering committee member, standardized residency and fellowship training, Chinese Medical Doctor Association; Committee Member (2015–present)
  • 2014- Scientific Advisor to Chinese Ministry of Health on Birth Defect Control; Advisor (2014–present)
  • Advisory committee member to Chinese Ministry of Health on Medical Genetic program; Committee Member (2014–present)
  • Committee Chair, Advisory Committee, Beijing International Medical Center; Chair (2013–present)
  • Editorial Board member for the American Journal of Stem Cells (AJSC); Editorial Board Member (2013–present)
  • Grant Reviewer, Icelandic Research Fund; Grant Reviewer (2012–present)
  • Council On Research, Computing And Libraries, University of California, Irvine; Committee Member (2011–present)
  • Grant Reviewer for Wellcome Trust; Grant Reviewer (2011–present)
  • Grant Reviewer, South Africa’s National Research Foundation (NRF); Grant Reviewer (2011–present)
  • Scientific advisory committee member to Chinese Ministry of Health on Target Therapy.; Committee Member (2010–2012)
  • Canada Foundation for Innovation, Canada; Other (2010–present)
  • Grant Reviewer for Italian Ministry of Health, Republic of Italy; Grant Reviewer (2010–present)
  • The Research Committee, the Committee on Committees, School of Medicine, University of California, Irvine; Committee Member (2010–present)
  • 2009 National Institute of Health Study Section, Emphasis Panel (SEP- ZRG1 OBT A 58); Member (2009–present)
  • Mentoring committee, School of Medicine, University of California, Irvine; Committee Member (2009–present)
  • Scholarship Oversight Committee Neonatal-Perinatal Medicine Fellowship Program, University of California, Irvine; Committee Member (2006–2012)
  • Western Review Consortium, Peer Review Committee Member, American Heart Association, Western States Affiliate; Committee Member (2005–2012)
  • Medical Research Council Grant Reviewer, England; Grant Reviewer (2005–present)
  • Special Committee Member of Yusheng Youyu, People’s Republic of China; Committee Member (2005–present)
  • Peer Reviewer of National Natural Science Foundation of China (NSFC), People’s Republic of China; Peer Reviewer (2004–2012)
  • Member, Data safety committee, General Clinical Research Center, UCI; Member (2004–present)
  • School of Medicine Representative Assembly member; Member (2003–2006)
  • Member, Advisory committee, General Clinical Research Center, UCI; Member (2001–2004)

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Contact Information

UBMD Pediatrics
Division of Genetics
1001 Main Street
Buffalo, NY 14203
Phone: (716) 323-0041
Fax: (716) 323-0292
thuang29@buffalo.edu

Looking for a doctor? This faculty member is affiliated with UBMD, the group comprised of practicing physicians who are also professors in the UB Jacobs School of Medicine and Biomedical Sciences.

View this faculty on UBMD