Thomas J. Langan MD

Thomas Langan

Thomas J. Langan
MD

Clinical Director, Hunter James Kelly Research Institute; Associate Professor of Neurology, Pediatrics, and Physiology and Biophysics

Department of Neurology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Child Neurology; Children and Adults; Developmental Neurology; Neurology; Pediatrics

Contact Information
Conventus
1001 Main St.
5th Floor
Buffalo, NY 14203
Phone: (716) 932-6080, ext. 100
tjlangan@buffalo.edu


Patient Care

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Professional Summary:

My research was focused originally on using astrocyte cell cultures to shed light upon processes related to astro-gliosis, the key response of developing and mature brain to injury. The laboratory succeeded in modeling many immunochemical features of gliosis in primary brain cell culture. More recently, I have been involved in the clinical care of, and research regarding, children with leukodystrophies. This includes coordinating several clinical research projects in roles as Clinical Director of the Hunter James Kelly Research Institute (HJKRI), and as President of the New York State Krabbe Disease Consortium. Projects include expansion of the World Wide Registry for Krabbe Disease (WWR), a database maintained at HJKRI that now has clinical and genetic information for over 150 affected patients afflicted with this rare disease, and examining ways to involve the WWR in national data-sharing initiatives promoted by the NIH, including the Newborn Screening Translational Research Network (NBSTRN). HJKRI is also conducting long-term follow-up studies of affected children, in conjunction with the Rare Clinical Disease Research Network (RDCRN) examining neuro-developmental parameters before and after therapeutic transplantation. Additional projects include exploration of the genotype/phenotype relationship in Krabbe, including exome and whole genome analyses with collaborators, and participating in research to uncover new biomarkers and to develop novel therapies. I am also the Director of the Headache and Concussion clinics at Children’s Hospital of Buffalo. These clinical leadership roles in Western New York and New York State can facilitate significant recruitment into multi-center research studies.

Education and Training:

  • Research, Neuro-Chemistry, Washington University (1986)
  • Residency, Neurology, Washington University (1984)
  • Residency, Pediatrics, Washington University (1981)
  • MD, Medicine, Brown University (1979)
  • AB, Biology, Brown University (1976)

Awards and Honors:

  • Castle Conolly Best Doctor (2015)
  • Data Safety and Monitoring Board (2015)
  • President of Medical Advisory Committee (2014)
  • Examiner, American Board of Psychiatry and Neurology (2013)
  • Secretary of Governing Board of Faculty Practice Management Plan (2009)
  • President of Governing Board of Faculty Practice Management Plan (2005)
  • Nominated as Counselor for the East, Child Neurology Society (2001)
  • Elected to Best Doctors in America (1999)
  • Director, Division of Child Neurology, Neurologist-in-Chief, Children’s Hospital of Buffalo (1998)
  • Elected chairperson of the Interdepartmental Graduate Group in Neuroscience, SUNY at Buffalo (1997)
  • Symposium Organizer, 1997 Meeting of Child Neurology Society. “Neuronal-Glial Interaction." (1997)
  • Symposium Organizer, 1996 Meeting of Child Neurology Society. “In vivo Assessment of Cognition and Learning.” (1996)
  • Symposium Organizer, 1996 Meeting of Child Neurology Society. “Advances in Developmental Neurology” (1996)
  • Appointed Chairperson of Scientific Selection Committee, Child Neurology Society (1995)
  • Appointed Organizer, Cellular Neuroscience Research Group, School of Medicine and Biomedical Sciences (1994)
  • Appointed to Scientific Selection Committee for the National Meeting of the Child Neurology Society (1994)
  • Elected to regular membership, American Society for Neurochemistry (1993)
  • Elected chairperson, Committee for Biomedical Research, Faculty Council, SUNY at Buffalo (1992)
  • Ad hoc reviewer, Journal of Cellular Physiology (1992)
  • Named to Steering Committee, Center for Molecular and Cellular Neuroscience, SUNY at Buffalo (1991)
  • Nominee- Junior investigatorship of Howard Hughes Medical Institute. One of two nominees from School of Medicine (1990)
  • Nominee- Sinsenheimer Research Award. Single nominee of School of Medicine (1988)
  • Honorable Mention - S. Weir Mitchell Competition (1986)

Research Expertise:

  • Hereditary neuropathy
  • Leukodystrophy

Research Centers:

  • Center of Excellence in Bioinformatics and Life Sciences

Grants and Sponsored Research:

  • September 2014–August 2019
    Lysosomal Disease Network (U54) NINDS. Local PI
    Role: Co-Investigator
  • June 2007–June 2013
    A Center of Excellence for Pediatric Multiple Sclerosis
    National Mutiple Sclerosis Society
    Role: Co-Principal Investigator
  • June 2009–May 2012
    A Multi-Disciplinary Program in Autism
    Children’s Guild
    Role: Co-Investigator

Journal Articles:

See all (12 more)

Presentations:

  • "Update on Concussion" Parent Talk-radio 1230 am broadcast (2015)
  • "Preventing Brain Injury in Winter Sports" Parent Talk-radio 1230 am broadcast (2014)
  • "Newborn Screening for Krabbe Disease" Parent Talk-radio 1230 am broadcast (2013)
  • "Overview of Autism" Parent Talk- radio 1230 am broadcast (2012)
  • "Risk Management Seminar for coaches and teachers, Preventing Brain Injury" Genesee County BOCES, (2012)
  • "Brain Injuries and How to Prevent Them" Daemen College Parents Network (Public Lecture) (2011)
  • "Concussion and Brain Injury" Erie County BOCES teachers (2011)
  • "Concussion and the Role of Pre- Injury Testing" Western NY Association of Nurse Practitioners (2011)
  • "Overview of Learning Disabilities" Parent Talk- radio 1230 am broadcast (2011)
  • "Preventing Brain Injury in Children" Parent Talk- radio 1230 am broadcast (2011)
  • "Risk Management Seminar for coaches and teachers" Erie County BOCES (2011)
  • "Concussion and Responses of the Brain to Injury" Kissing Bridge Ski Patrol (2010)
  • "New Views of Brain Plasticity" Buffalo, N.Y. Research Seminar, Center for Biobehavioral and Social Aspects of Health (1994)
  • "Techniques for Brain Plasticity and Regeneration" , Women's and Children's Health Research Foundation (1994)
See all (4 more)

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Contact Information

Conventus
1001 Main St.
5th Floor
Buffalo, NY 14203
Phone: (716) 932-6080, ext. 100
tjlangan@buffalo.edu

Looking for a doctor? This faculty member is affiliated with UBMD, the group comprised of practicing physicians who are also professors in the UB Jacobs School of Medicine and Biomedical Sciences.

View this faculty on UBMD