Thaer Khoury MD
Thaer Khoury
MD
Clinical Professor
Department of Pathology and Anatomical Sciences
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Anatomic Pathology; Clinical Pathology
Education and Training:
- Oncologic Surgical Pathology Fellowship, Roswell Park Cancer Institute (2006)
- Anatomic and Clinical Pathology Residency (PGY1-5), University at Buffalo, SUNY (2005)
- Surgical Pathology Residency, Damascus Unversity Hospitals (1998)
- MD, Damascus University (1995)
Employment:
- Professor of Oncology, Pathology and Anatomical Sciences, Roswell Parl Cancer Center, Damascus University (2016-present)
- Associate Professor of Oncology, Department of Pathology, Roswell Park Cancer Institute (2012–2016)
- Assistant Professor, Department of Pathology, Roswell Park Cancer Institute (2006–2012)
Awards and Honors:
- Top Doctor's list Buffalo Spree Magazine (2020)
- Edith Sproul Teaching Award (2014)
Research Expertise:
- Breast cancer: breast cancer and diseases
Journal Articles:
- Benefield HC, Zirpoli GR, Allott EH, Shan Y, Hurson AN, Omilian AR, Khoury T, Hong CC, Olshan AF, Bethea TN, Bandera EV, Palmer JR, Ambrosone CB, Troester MA. Epidemiology of Basal-like and Luminal Breast Cancers among Black Women in the AMBER Consortium. Cancer Epidemiol Biomarkers Prev. 2020.
- Cheng TD, Omilian AR, Yao S, Sanchez PV, Polk LZ, Zhang W, Datta S, Bshara W, Ondracek RP, Davis W, Liu S, Hong CC, Bandera EV, Khoury T, Ambrosone CB. Body fatness and mTOR pathway activation of breast cancer in the Women's Circle of Health Study. NPJ Breast Cancer. 2020; 6.
- Omilian AR, Wei L, Hong CC, Bandera EV, Liu S, Khoury T, Ambrosone CB, Yao S. Somatic mutations of triple-negative breast cancer: a comparison between Black and White women. Breast Cancer Res Treat. 2020; 182(2).
- Bertrand KA, Bethea TN, Rosenberg L, Bandera EV, Khoury T, Troester MA, Ambrosone CB, Palmer JR. Risk factors for estrogen receptor positive ductal carcinoma in situ of the breast in African American women. Breast. 2020; 49.
- Khoury T, Mendez ALR, Peng X, Yan L, Racila E. Clinicopathologic characteristics of malignant non-hematopoietic tumors first presented as an axillary mass with emphasis on occult breast carcinoma. Int J Clin Oncol. 2020; 25(2).
- Khoury T, Fang Y, Karabakhtsian R, Mokhtar Desouki M, Nayak A, Hanna M, Sanati S, Peng X, Yan L, Li X, Fadare O, Ambrosone C, Jabbour N, Gaudioso C. The clinical significance of metastatic breast carcinoma to intramammary lymph node. Breast J. 2020; 26(2).
- Llanos AAM, Lin Y, Chen W, Yao S, Norin J, Chekmareva MA, Omene C, Cong L, Omilian AR, Khoury T, Hong CC, Ganesan S, Foran DJ, Higgins M, Ambrosone CB, Bandera EV, Demissie K. Immunohistochemical analysis of adipokine and adipokine receptor expression in the breast tumor microenvironment: associations of lower leptin receptor expression with estrogen receptor-negative status and triple-negative subtype. Breast Cancer Res. 2020; 22(1).
- Cheng TD, Yao S, Omilian AR, Khoury T, Buas MF, Payne-Ondracek R, Sribenja S, Bshara W, Hong CC, Bandera EV, Davis W, Higgins MJ, Ambrosone CB. FOXA1 Protein Expression in ER+ and ER- Breast Cancer in Relation to Parity and Breastfeeding in Black and White Women. Cancer Epidemiol Biomarkers Prev. 2020; 29(2).
- Abdou Y, Attwood K, Cheng TD, Yao S, Bandera EV, Zirpoli GR, Ondracek RP, Stein L, Bshara W, Khoury T, Ambrosone CB, Omilian AR. Racial differences in CD8+ T cell infiltration in breast tumors from Black and White women. Breast Cancer Res. 2020; 22(1).
- Khoury T, Peng X, Yan L, Wang D, Nagrale V. Tumor-Infiltrating Lymphocytes in Breast Cancer: Evaluating Interobserver Variability, Heterogeneity, and Fidelity of Scoring Core Biopsies. Am J Clin Pathol. 2018; 150(5).
- Li Y, Opyrchal M, Yao S, Peng X, Yan L, Jabbour H, Khoury T. The role of programmed death ligand-1 and tumor-infiltrating lymphocytes in breast cancer overexpressing HER2 gene. Breast Cancer Res Treat. 2018; 170(2).
- Khoury T. Delay to Formalin Fixation (Cold Ischemia Time) Effect on Breast Cancer Molecules. Am J Clin Pathol. 2018; 149(4).
- Allott EH, Geradts J, Cohen SM, Khoury T, Zirpoli GR, Bshara W, Davis W, Omilian A, Nair P, Ondracek RP, Cheng TD, Miller CR, Hwang H, Thorne LB, O'Connor S, Bethea TN, Bell ME, Hu Z, Li Y, Kirk EL, Sun X, Ruiz-Narvaez EA, Perou CM, Palmer JR, Olshan AF, Ambrosone CB, Troester MA. Frequency of breast cancer subtypes among African American women in the AMBER consortium. Breast Cancer Res. 2018; 20(1).
- Khoury T, Gaudioso C, Fang YV, Sanati S, Opyrchal M, Desouki MM, Karabakhtsian RG, Li Z, Wang D, Yan L, Jacobson R. The role of skin ulceration in breast carcinoma staging and outcome. Breast J. 2018; 24(1).
- Khoury T, Nagrale V, Opyrchal M, Peng X, Wang D, Yao S. Prognostic Significance of Stromal Versus Intratumoral Infiltrating Lymphocytes in Different Subtypes of Breast Cancer Treated With Cytotoxic Neoadjuvant Chemotherapy. Appl Immunohistochem Mol Morphol. 2018; 26(8).
- Chollet-Hinton L, Olshan AF, Nichols HB, Anders CK, Lund JL, Allott EH, Bethea TN, Hong CC, Cohen SM, Khoury T, Zirpoli GR, Borges VF, Rosenberg LA, Bandera EV, Ambrosone CB, Palmer JR, Troester MA. Biology and Etiology of Young-Onset Breast Cancers among Premenopausal African American Women: Results from the AMBER Consortium. Cancer Epidemiol Biomarkers Prev. 2017; 26(12).
- Espinal AC, Buas MF, Wang D, Cheng DT, Sucheston-Campbell L, Hu Q, Yan L, Payne-Ondracek R, Cortes E, Tang L, Gong Z, Zirpoli G, Khoury T, Yao S, Omilian A, Demissie K, Bandera EV, Liu S, Ambrosone CB, Higgins MJ. FOXA1 hypermethylation: link between parity and ER-negative breast cancer in African American women? Breast Cancer Res Treat. 2017; 166(2).
- Coignet MV, Zirpoli GR, Roberts MR, Khoury T, Bandera EV, Zhu Q, Yao S. Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study. PLoS One. 2017; 12(10).
- Khoury T, Zirpoli G, Cohen SM, Geradts J, Omilian A, Davis W, Bshara W, Miller R, Mathews MM, Troester M, Palmer JR, Ambrosone CB. Ki-67 Expression in Breast Cancer Tissue Microarrays: Assessing Tumor Heterogeneity, Concordance With Full Section, and Scoring Methods. Am J Clin Pathol. 2017; 148(2).
- Wintrob ZA, Hammel JP, Khoury T, Nimako GK, Fu HW, Fayazi ZS, Gaile DP, Forrest A, Ceacareanu AC. Insulin use, adipokine profiles and breast cancer prognosis. Cytokine. 2017; 89.
- Khoury T, Huang X, Chen X, Wang D, Liu S, Opyrchal M. Comprehensive Histologic Scoring to Maximize the Predictability of Pathology-generated Equation of Breast Cancer Oncotype DX Recurrence Score. Appl Immunohistochem Mol Morphol. 2016; 24(10).
- Allott EH, Cohen SM, Geradts J, Sun X, Khoury T, Bshara W, Zirpoli GR, Miller CR, Hwang H, Thorne LB, O'Connor S, Tse CK, Bell MB, Hu Z, Li Y, Kirk EL, Bethea TN, Perou CM, Palmer JR, Ambrosone CB, Olshan AF, Troester MA. Performance of Three-Biomarker Immunohistochemistry for Intrinsic Breast Cancer Subtyping in the AMBER Consortium. Cancer Epidemiol Biomarkers Prev. 2016; 25(3).
- Ruszczyk M, Zirpoli G, Kumar S, Bandera EV, Bovbjerg DH, Jandorf L, Khoury T, Hwang H, Ciupak G, Pawlish K, Schedin P, Masso-Welch P, Ambrosone CB, Hong CC. Breast cancer risk factor associations differ for pure versus invasive carcinoma with an in situ component in case-control and case-case analyses. Cancer Causes Control. 2016; 27(2).
- Allott EH, Geradts J, Sun X, Cohen SM, Zirpoli GR, Khoury T, Bshara W, Chen M, Sherman ME, Palmer JR, Ambrosone CB, Olshan AF, Troester MA. Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification. Breast Cancer Res. 2016; 18(1).
- Gong Z, Yao S, Zirpoli G, David Cheng TY, Roberts M, Khoury T, Ciupak G, Davis W, Pawlish K, Jandorf L, Bovbjerg DH, Bandera EV, Ambrosone CB. Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women. Int J Cancer. 2015; 137(3).
- Khoury T, Liu Q, Liu S. Delay to formalin fixation effect on HER2 test in breast cancer by dual-color silver-enhanced in situ hybridization (Dual-ISH). Appl Immunohistochem Mol Morphol. 2014; 22(9).
- Quan L, Hong CC, Zirpoli G, Roberts MR, Khoury T, Sucheston-Campbell LE, Bovbjerg DH, Jandorf L, Pawlish K, Ciupak G, Davis W, Bandera EV, Ambrosone CB, Yao S. Variants of estrogen-related genes and breast cancer risk in European and African American women. Endocr Relat Cancer. 2014; 21(6).
- Ambrosone CB, Zirpoli GR, Bovbjerg DH, Shankar J, Hong CC, McCann SE, Ruszczyk M, Khoury T, Yao S, Ciupak GL, Jandorf L, Pawlish KS, Bandera EV. Associations between estrogen receptor-negative breast cancer and timing of reproductive events differ between African American and European American women. Cancer Epidemiol Biomarkers Prev. 2014; 23(6).
- Purrington KS, Slager S, Eccles D, Yannoukakos D, Fasching PA, Miron P, Carpenter J, Chang-Claude J, Martin NG, Montgomery GW, Kristensen V, Anton-Culver H, Goodfellow P, Tapper WJ, Rafiq S, Gerty SM, Durcan L, Konstantopoulou I, Fostira F, Vratimos A, Apostolou P, Konstanta I, Kotoula V, Lakis S, Dimopoulos MA, Skarlos D, Pectasides D, Fountzilas G, Beckmann MW, Hein A, Ruebner M, Ekici AB, Hartmann A, Schulz-Wendtland R, Renner SP, Janni W, Rack B, Scholz C, Neugebauer J, Andergassen U, Lux MP, Haeberle L, Clarke C, Pathmanathan N, Rudolph A, Flesch-Janys D, Nickels S, Olson JE, Ingle JN, Olswold C, Slettedahl S, Eckel-Passow JE, Anderson SK, Visscher DW, Cafourek VL, Sicotte H, Prodduturi N, Weiderpass E, Bernstein L, Ziogas A, Ivanovich J, Giles GG, Baglietto L, Southey M, Kosma VM, Fischer HP, Reed MW, Cross SS, Deming-Halverson S, Shrubsole M, Cai Q, Shu XO, Daly M, Weaver J, Ross E, Klemp J, Sharma P, Torres D, Rüdiger T, Wölfing H, Ulmer HU, Försti A, Khoury T, Kumar S, Pilarski R, Shapiro CL, Greco D, Heikkilä P, Aittomäki K, Blomqvist C, Irwanto A, Liu J, Pankratz VS, Wang X, Severi G, Mannermaa A, Easton D, Hall P, Brauch H, Cox A, Zheng W, Godwin AK, Hamann U, Ambrosone C, Toland AE, Nevanlinna H, Vachon CM, Couch FJ. Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. Carcinogenesis. 2014; 35(5).
- Ambrosone CB, Zirpoli G, Ruszczyk M, Shankar J, Hong CC, McIlwain D, Roberts M, Yao S, McCann SE, Ciupak G, Hwang H, Khoury T, Jandorf L, Bovbjerg DH, Pawlish K, Bandera EV. Parity and breastfeeding among African-American women: differential effects on breast cancer risk by estrogen receptor status in the Women's Circle of Health Study. Cancer Causes Control. 2014; 25(2).
- Khoury T, Hu Q, Liu S, Wang J. Intracystic papillary carcinoma of breast: interrelationship with in situ and invasive carcinoma and a proposal of pathogenesis: array comparative genomic hybridization study of 14 cases. Mod Pathol. 2014; 27(2).
- Yao S, Graham K, Shen J, Campbell LE, Singh P, Zirpoli G, Roberts M, Ciupak G, Davis W, Hwang H, Khoury T, Bovbjerg DH, Jandorf L, Pawlish KS, Bandera EV, Liu S, Ambrosone CB, Zhao H. Genetic variants in microRNAs and breast cancer risk in African American and European American women. Breast Cancer Res Treat. 2013; 141(3).
- Mukhopadhyay A, Khoury T, Stein L, Shrikant P, Sood AK. Prostate derived Ets transcription factor and Carcinoembryonic antigen related cell adhesion molecule 6 constitute a highly active oncogenic axis in breast cancer. Oncotarget. 2013; 4(4).
- Khoury T. Delay to formalin fixation alters morphology and immunohistochemistry for breast carcinoma. Appl Immunohistochem Mol Morphol. 2012; 20(6).
- Monhollen L, Morrison C, Ademuyiwa FO, Chandrasekhar R, Khoury T. Pleomorphic lobular carcinoma: a distinctive clinical and molecular breast cancer type. Histopathology. 2012; 61(3).
- Kulkarni S, Augoff K, Rivera L, McCue B, Khoury T, Groman A, Zhang L, Tian L, Sossey-Alaoui K. Increased expression levels of WAVE3 are associated with the progression and metastasis of triple negative breast cancer. PLoS One. 2012; 7(8).
- Khoury T, Ademuyiwa FO, Chandrasekhar R, Chandraseekhar R, Jabbour M, Deleo A, Ferrone S, Wang Y, Wang X. Aldehyde dehydrogenase 1A1 expression in breast cancer is associated with stage, triple negativity, and outcome to neoadjuvant chemotherapy. Mod Pathol. 2012; 25(3).
- Khoury T, Zakharia Y, Tan W, Kulkarni S, Liu W, Zhang S, Wilding GE, Edge S. Breast hormonal receptors test should be repeated on excisional biopsy after negative core needle biopsy. Breast J. 2011; 17(2).
- Kanehira K, Khoury T. Neuroendocrine markers expression in pancreatic serous cystadenoma. App Immunohistochem. 2011; 19(2).
- Khoury T, Chandrasekhar R, Wilding G, Tan D, Cheney RT. Tumor eosinophilia combined with an immunohistochemistry panel is useful in the differentiation of type B3 thymoma from thymic carcinoma. International J Exper Pathol. 2011; 92(2).
- Khoury T. . HER2 testing: How to reach a high concordance rate between immunohistochemistry and fluorescence in situ hybridization. App Immunohistochem. 2011.
- Zhou Z, Peters J, Khoury T, Zhai Q, Wei Q, Truong C, Wei Song S, Tan D. Expression of Insulin-Like Growth Factor II mRNA-Binding Protein 3 (IMP3) in Human Esophageal Adenocarcinoma and Its Precursor Lesions. Arch pathol. 2011; 135(8).
- Khoury T, Mojica WD, Hicks D, Starostik P, Ademuyima F, Janarthan B, Cheney RT. ERBB2 juxtamembrane domain (trastuzumab binding site) gene mutation is a rare event in invasive breast cancers over-expressing the ERBB2 gene Mod Pathol.. 2011; 24.
- Dhingra S, Feng W, Brown RE, Zhou Z, Khoury T, Zhang R, Tan D. Clinicopathologic significance of putative stem cell markers, CD44 and nestin, in gastric adenocarcinoma.. Int J Clin Exp Path. 2011; 4(8).
- Qiu J, Kulkarni S, Chandrasekhar R, Rees M, Hyde K, Wilding G, Tan D, Khoury T. Effect of delayed formalin fixation on estrogen and progesterone receptors in breast cancer: a study of three different clones. Am J Clin Pathol. 2010; 134(5).
- Wang X, Osada T, Wang Y, Yu L, Sakakura K, Katayama A, McCarthy JB, Brufsky A, Chivukula M, Khoury T, Hsu DS, Barry WT, Lyerly HK, Clay TM, Ferrone S. CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer. J Natl Cancer Inst. 2010; 102(19).
- Hicks DG, Janarthanan BR, Vardarajan R, Kulkarni SA, Khoury T, Dim D, Budd GT, Yoder BJ, Tubbs R, Schreeder MT, Estopinal NC, Beck RA, Wang Y, Ring BZ, Seitz RS, Ross DT. The expression of TRMT2A, a novel cell cycle regulated protein, identifies a subset of breast cancer patients with HER2 over-expression that are at an increased risk of recurrence. BMC Cancer. 2010; 10.
- Khoury T, Sait S, Hwang H, Chandrasekhar R, Wilding G, Tan D, Kulkarni S. Delay to formalin fixation effect on breast biomarkers. Mod Pathol. 2009; 22(11).
- Khoury T. An Eighty-One Year Old with Distant Metastasis of Invasive Lobular Carcinoma Occurring 41 Years after Mastectomy.. Clinical Breast Cancer..
- Kulkarni S, Augoff K, Rivera L, McCue B, Khoury T, Zang L, Tan D, Plow EF, Sossey-Alaoui K. Increased Expression Levels of WAVE3 are Associated with the Progression and Metastasis of TNBCs PLoS ONE..
Evaluative Studies and Case Reports:
- Evren S, Khoury T, Neppalli V, Cappuccino H, Hernandez-Ilizaliturri FJ, Kumar P. Breast Implant-Associated Anaplastic Large Cell Lymphoma (ALCL): A Case Report. Am J Case Rep. 2017; 18.
- Hamad L, Khoury T, Vona K, Nestico J, Opyrchal M, Salerno KE. A Case of Metaplastic Breast Cancer with Prolonged Response to Single Agent Liposomal Doxorubicin. Cureus. 2016; 8(1).
- Francescutti V, Khoury T, Kulkarni S. Foreign body reaction mimicking breast carcinoma in patient with stage IV ovarian cancer. Breast J. 2012; 18(5).
- Kumar PR, Grossman Z, Scorza L, Khoury T, Nayyar R. Isolated extramedullary relapse of acute lymphoblastic leukemia in the breast of an adolescent girl: radiologic findings and discussion. Pediatr Radiol. 2010; 40(5).
Presentations:
- "Atypical Ductal Hyperplasia and Those Boarding on Ductal Carcinoma in Situ Should be Included in the Active Surveillance Clinical Trials" United States and Canadian Academy of Pathologists, Breast Pathology (2020)
- "Papillary Lesions of the Breast" Annual Teaching Conference of Residents and Fellows (2020)
- "Preneoplastic ductal lesions" Annual Teaching Conference of Residents and Fellows (2020)
- "Spindle Cell Lesions of the Breast" Annual Teaching Conference of Residents and Fellows (2020)
- "Molecular Testing of Breast Cancer: Implication on Patent's Management" 7th Annual Pathology Conference, Chinese Society of Pathology (2017)
- "Breast Pathology Case Studies: Pitfalls and Clues" Western New York Society of Pathologists, Western New York Society of Pathologists (2017)
- "Breast Pathology, Guidelines, Criteria, Pitfalls and Clues" Annual Teaching Conference of Residents and Fellows (2017)
- "Breast Pathology-Overview" Annual Teaching Conference of Residents and Fellows, core lecture (2017)
- "Papillary Lesions of the Breast" 7th Annual Pathology Conference, Chinese Society of Pathology (2017)
- "Spindle Cell Lesions of the Breast" 7th Annual Pathology Conference, Chinese Society of Pathology (2017)
- "Breast Cancer Pathology, overview" Graduate Students, PTR 536 (2016)
- "Breast Pathology" Medical School Teaching, IMC216 reproductive Module (2016)
- "Breast Cancer Pathology, overview" Graduate Students, PTR 536 (2015)
- "Breast Pathology" Medical School Teaching, IMC216 reproductive Module (2015)
- "Breast Cancer Pathology, overview" Graduate Students, Roswell Park Cancer Institute, PTR 536 (2014)
- "Nomograms To Predict The Likelihood Of Upgrade Of Atypical Ductal Hyperplasia Diagnosed On A Core Needle Biopsy In Mammographically Detected Lesions" United States and Canadian Academy of Pathologists (2014)
- "Pleomorphic lobular carcinoma in situ of the breast: clinicopathological review of 47 cases and a proposal for a clinical trial" Alliance Breast Committee (2013)
- "Pleomorphic lobular carcinoma in situ of the breast: clinicopathological review of 57 cases and a proposed new histopathologic classification" United States and Canadian Academy of Pathologists (2013)
- "Breast Pathology 1-Spindle Cell lesion of the Breast" Annual Teaching Conference of Residents and Fellows, University of Buffalo, Pathology Department (2012)
- "Breast Pathology 2-Precancerous Ductal Epithelial Lesions" Annual Teaching Conference of Residents and Fellows (2012)
- "Unnecessary Subsequent Surgery Might be Avoided for a Diagnosis of Atypical Ductal Hyperplasia on a Core Needle Biopsy by Evaluating Histologic Features: A Study of 71 Cases" United States and Canadian Academy of Pathologists (2011)
- "Breast hormonal receptors test should be repeated on excisional biopsies after negative core biopsy" United States and Canadian Academy of Pathologists (2010)
- "Premalignant breast lesions" Annual Teaching Conference of Residents and Fellows (2009)
- "Cytoplasmic and nuclear expressions of Survivin predict worse outcome of thymic neoplasms" United States and Canadian Academy of Pathologists (2007)