Bruce R. Troen MD
Bruce R. Troen
MD
Professor of Medicine & Chief, Division of Geriatrics and Palliative Medicine
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Geriatric Medicine
Education and Training:
- Clinical Fellowship in Geriatric Medicine, Geriatrics, University of Michigan School of Medicine (1990)
- Research Fellowship, Molecular Biology, Laboratory of Molecular Biology, NCI, NIH (1988)
- Residency, Internal Medicine, Barnes Hospital (1984)
- MD, Harvard Medical School, cum laude in special studies (1981)
- AB, Biochemistry, Harvard College, cum laude (1976)
Employment:
- Director, Medicine, University at Buffalo Center of Excellence for Alzheimer‘s Disease (2018-present)
- Director, University at Buffalo Center for Successful Aging (2016-present)
- Director, Geriatric Services, Medicine, Erie County Medical Center (2015-present)
- Professor, Department of Medicine, University at Buffalo, University of Buffalo (2013-present)
- Physician-Investigator, VA Western New York Healthcare System (VAWNYHS) (2013-present)
- Chief, Division of Geriatrics and Palliative Medicine, University at Buffalo (2013-present)
- Director, Medicine, University at Buffalo Center of Excellence for Alzheimer's Disease
- Co-Director, University at Buffalo Center of Excellence for Alzheimer‘s Disease (2016–2018)
- Professor of Medicine, Geriatrics, University of Miami Miller School of Medicine, University of Miami (2007–2013)
- Physician-Investigator, Miami VA Healthcare System (2002–2013)
- Associate Professor, Geriatrics, University of Miami Miller School of Medicine, University of Miami (2002–2007)
- Associate Professor, Mount Sinai School of Medicine (2000–2002)
- Physician-Invesigator, Bronx VA Medical Center (2000–2002)
Awards and Honors:
- American Geriatrics Society Fellow (2015)
- Best Paper Award, Biology of Aging - American Geriatrics Society (2002)
- Bristol Myers Award for Excellence in Oncology Research (1991)
Research Expertise:
- Biology of Aging
- Frailty
- Geriatrics & Gerontology
- Osteoporosis
- Vitamin D
Research Centers:
- Clinical and Translational Research Center (CTRC)
UB 2020 Strategic Strengths:
- Health and Wellness Across the Lifespan
Grants and Sponsored Research:
- May 2019–May 2024
Enhancing Geroscience Faculty Development and Scholarship in Order to Minimize Frailty and Maximize Healthspan
NIH / National Institute of Aging
Role: Principal Investigator
$750,000 - October 2018–September 2023
Post-Transcriptional Control of Aging-Associated Inflammation and Bone Homeostasis
NIH - National Institute of Dental and Craniofacial Research
Role: Co-Investigator
$1,187,500 - July 2019–June 2023
High intensity interval training and nicotinamide riboside treatment to enhance functional capacity and reduce frailty during aging
Veterans Affairs
Role: Principal Investigator
$645,000 - March 2016–February 2021
Center of Excellence for Alzheimer’s Disease
State of New York, Department of Health
Role: Co-Principal Investigator
$2,400,000 - October 2018–September 2020
Enhancing functional capacity in older adults with short session high intensity interval training
Veterans Affairs
Role: Principal Investigator
$200,000 - September 2018–June 2020
Alzheimer’s and related dementias Care improvement Through Data Science Education (ACT-DSE): Custom training for Research
National Institutes of Health
Role: Co-Investigator
$270,000 - June 2018–June 2019
Collaborative Drug Safety Management with Frail Elders & Caregivers for Successful Aging
University at Buffalo, Innovative Micro-Programs Accelerating Collaboration in Themes (IMPACT)
Role: Co-Investigator
$35,000 - April 2017–March 2018
Exosomal biomarkers as predictors of sarcopenia and frailty in WHI participants
University at Buffalo Clinical Translational Scientific Institute
Role: Principal Investigator
$49,350 - November 2015–October 2017
Integrated Therapies to Reduce Threats to Function among Older Patients Managing Cerebrovascular Disease
CTSA / NIH
Role: Contributor
$200,000 - April 2011–March 2015
Differential impact of resveratorol and resveratrol mimetics upon aging bone
Department of Veterans Affairs
Role: Principal Investigator
$618,780 - January 2013–December 2014
Physical performance in an animal model of vitamin D insufficiency
Dep;artment of Veterans Affairs
Role: Principal Investigator
$200,000 - November 2010–October 2012
An animal model to study molecular determinants and modulators of aging and age related diseases
Indian TRail Foundation
Role: Principal Investigator
$190,000
Journal Articles:
- Bermeo S, Al Saedi A, Vidal C, Khalil M, Pang M, Troen BR, Myers D, Duque G. Treatment with an inhibitor of fatty acid synthase attenuates bone loss in ovariectomized mice. Bone. 2019; 122.
- Seldeen KL, Redae YZ, Thiyagarajan R, Berman RN, Leiker MM, Troen BR. High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools. Mech Ageing Dev. 2019; 180.
- Pang M, RodrÃguez-Gonzalez M, Hernandez M, Recinos CC, Seldeen KL, Troen BR. AP-1 and Mitf interact with NFATc1 to stimulate cathepsin K promoter activity in osteoclast precursors. J Cell Biochem. 2019.
- Seldeen KL, Redae YZ, Thiyagarajan R, Berman RN, Leiker MM, Troen BR. Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice. J Vis Exp. 2019; (144).
- Sharikova AV, Quaye E*, Aalinkeel R, Park JY, Maloney MC, Desta H, Thiyagarajan R, Seldeen K, Khmaladze A, Troen B, Schwartz SA and Mahajan SD. Methamphetamine-induced mitochondrial toxicity is a major determinant of microglial apoptosis.. J Neuroimmune Pharmacol. 2018; 13(3).
- Sharikova AV, Quaye E, Park JY, Maloney MC, Desta H, Thiyagarajan R, Seldeen KL, Parikh NU, Sandhu P, Khmaladze A, Troen BR, Schwartz SA, Mahajan SD. Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway. J Neuroimmune Pharmacol. 2018; 13(3).
- Alexander JJ, Sankaran JS, Seldeen KL, Thiyagarajan R, Jacob A, Quigg RJ, Troen BR, Judex S. Absence of complement factor H alters bone architecture and dynamics. Immunobiology. 2018.
- Seldeen KL, Pang M, Leiker MM, Bard JE, RodrÃguez-Gonzalez M, Hernandez M, Sheridan Z, Nowak N, Troen BR. Chronic vitamin D insufficiency impairs physical performance in C57BL/6J mice. Aging (Albany NY). 2018; 10(6).
- Seldeen KL, Lasky G, Leiker MM, Pang M, Personius KE, Troen BR. High Intensity Interval Training Improves Physical Performance and Frailty in Aged Mice. J Gerontol A Biol Sci Med Sci. 2018; 73(4).
- Seldeen KL, Halley PG, Volmar CH, RodrÃguez MA, Hernandez M, Pang M, Carlsson SK, Suva LJ, Wahlestedt C, Troen BR, Brothers SP. Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density. Neuropeptides. 2018; 67.
- Seldeen KL, Halley PG, Volmar CH, RodrÃguez MA, Hernandez M, Pang M, Carlsson SK, Suva LJ, Wahlestedt C, Troen BR, Brothers SP. Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density. Neuropeptides. 2017.
- Seldeen KL, Lasky G, Leiker MM, Pang M, Personius KE, Troen BR. High Intensity Interval Training (HIIT) improves physical performance and frailty in aged mice. J Gerontol A Biol Sci Med Sci. 2017.
- Seldeen KL, Pang M, RodrÃguez-Gonzalez M, Hernandez M, Sheridan Z, Yu P, Troen BR. A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity? Nutr Metab (Lond). 2017; 14.
- Seldeen KL, Pang M, Troen BR. Mouse Models of Frailty: an Emerging Field. Curr Osteoporos Rep. 2015; 13(5).
- Cherniack, E.P. and Troen, B.R.. Resveratrol: Effects on Lipids and Cardiovascular Risk. Curr Cardiovasc Risk Rep. 2013; 7.
- Cherniack, E.P., Seldeen, K., and Troen, B.R. Vitamin D: a regulator of metabolism and inflammation. Current Nutrition. 2013; 9.
- Balkan W, Rodríguez-Gonzalez M, Pang M, Fernandez I, Troen BR. Retinoic acid inhibits NFATc1 expression and osteoclast differentiation. J Bone Miner Metab. 2011; 29(6).
- Cherniack, E.P., Florez, H., Hollis, B.W., Roos, B.A., Troen, B.R., Levis, S. The Response of Elderly Veterans to Daily Vitamin D3 Supplementation of 2000 IU: A Pilot Efficacy Study Journal of the American Geriatrics Society. 2011; 59(2).
- Cherniack, E.P., Florez, H.J., and Troen, B.R.. Impact of Vitamin D on the Aging Population. Trans Endo Metab. 2011; 2(2).
- Duque G, Close JJ, de Jager JP, Ebeling PR, Inderjeeth C, Lord S, McLachlan AJ, Reid IR, Troen BR, Sambrook PN. Treatment for osteoporosis in Australian residential aged care facilities: consensus recommendations for fracture prevention. Med J Aust. 2010; 193(3).
- Yamazaki Y, Kamei Y, Sugita S, Akaike F, Kanai S, Miura S, Hirata Y, Troen BR, Kitamura T, Nishino I, Suganami T, Ezaki O, Ogawa Y. The cathepsin L gene is a direct target of FOXO1 in skeletal muscle. Biochem J. 2010; 427(1).
- Balkan W, Martinez AF, Fernandez I, Rodriguez MA, Pang M, Troen BR. Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand. Gene. 2009; 446(2).
- Cherniack EP, Troen BR, Florez HJ, Roos BA, Levis S. Some new food for thought: the role of vitamin D in the mental health of older adults. Curr Psychiatry Rep. 2009; 11(1).
- Duque G, Demontiero O, Troen BR. Prevention and treatment of senile osteoporosis and hip fractures. Minerva Med. 2009; 100(1).
- Cherniack EP, Florez H, Roos BA, Troen BR, Levis S. Hypovitaminosis D in the elderly: from bone to brain. J Nutr Health Aging. 2008; 12(6).
- Duque G, Troen BR. Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome. J Am Geriatr Soc. 2008; 56(5).
- Cherniack EP, Levis S, Troen BR. Hypovitaminosis D: a widespread epidemic. Geriatrics. 2008; 63(4).
- Yang G, Zaidi M, Zhang W, Zhu LL, Li J, Iqbal J, Varbanov A, Gross G, Phipps R, Troen BR, Sun L. Functional grouping of osteoclast genes revealed through microarray analysis. Biochem Biophys Res Commun. 2008; 366(2).
- Pang M, Martinez AF, Fernandez I, Balkan W, Troen BR. AP-1 stimulates the cathepsin K promoter in RAW 264.7 cells. Gene. 2007; 403(1-2).
- Cherniack EP, Florez HJ, Troen BR. Emerging therapies to treat frailty syndrome in the elderly. Altern Med Rev. 2007; 12(3).
- Troen BR. The regulation of cathepsin K gene expression. Ann N Y Acad Sci. 2006; 1068.
- Pang M, Martinez AF, Jacobs J, Balkan W, Troen BR. RANK ligand and interferon gamma differentially regulate cathepsin gene expression in pre-osteoclastic cells. Biochem Biophys Res Commun. 2005; 328(3).
- Zhu LL, Zaidi S, Moonga BS, Troen BR, Sun L. RANK-L induces the expression of NFATc1, but not of NFkappaB subunits during osteoclast formation. Biochem Biophys Res Commun. 2005; 326(1).
- Troen BR. The role of cathepsin K in normal bone resorption. Drug News Perspect. 2004; 17(1).
- Troen BR. Molecular mechanisms underlying osteoclast formation and activation. Exp Gerontol. 2003; 38(6).
- Sun L, Moonga BS, Lu M, Zaidi N, Iqbal J, Blair HC, Epstein S, Abe E, Troen BR, Huang CL, Zaidi M. Molecular cloning, expression, and function of osteoclastic calcineurin Aalpha. Am J Physiol Renal Physiol. 2003; 284(3).
- Troen BR. The biology of aging. Mt Sinai J Med. 2003; 70(1).
- Moonga BS, Adebanjo OA, Wang HJ, Li S, Wu XB, Troen B, Inzerillo A, Abe E, Minkin C, Huang CL, Zaidi M, Troen BR. Differential effects of interleukin-6 receptor activation on intracellular signaling and bone resorption by isolated rat osteoclasts. J Endocrinol. 2002; 173(3).
- Corisdeo S, Gyda M, Zaidi M, Moonga BS, Troen BR. New insights into the regulation of cathepsin K gene expression by osteoprotegerin ligand. Biochem Biophys Res Commun. 2001; 285(2).
- Gyda M, Corisdeo S, Zaidi M, Troen BR. Macrophage colony-stimulating factor suppresses osteoblast formation. Biochem Biophys Res Commun. 2001; 285(2).
- Yan S, Berquin IM, Troen BR, Sloane BF. Transcription of human cathepsin B is mediated by Sp1 and Ets family factors in glioma. DNA Cell Biol. 2000; 19(2).
- Berquin IM, Yan S, Katiyar K, Huang L, Sloane BF, Troen BR. Differentiating agents regulate cathepsin B gene expression in HL-60 cells. J Leukoc Biol. 1999; 66(4).
- Sun L, Adebanjo OA, Moonga BS, Corisdeo S, Anandatheerthavarada HK, Biswas G, Arakawa T, Hakeda Y, Koval A, Sodam B, Bevis PJ, Moser AJ, Lai FA, Epstein S, Troen BR, Kumegawa M, Zaidi M. CD38/ADP-ribosyl cyclase: A new role in the regulation of osteoclastic bone resorption. J Cell Biol. 1999; 146(5).
- Troen BR. The Gene Construction Kit. DNA sequence analysis and presentation. Methods Mol Biol. 1997; 70.
- Atkins KB, Troen BR. Comparative responsiveness of HL-60, HL-60R, and HL-60R+ (LRARSN) cells to retinoic acid, calcitriol, 9 cis-retinoic acid, and sodium butyrate. Blood. 1995; 86(7).
- Atkins KB, Troen BR. Regulation of cathepsin D gene expression in HL-60 cells by retinoic acid and calcitriol. Cell Growth Differ. 1995; 6(7).
- Atkins KB, Troen BR. Phorbol ester stimulated cathepsin L expression in U937 cells. Cell Growth Differ. 1995; 6(6).
- Chauhan SS, Popescu NC, Ray D, Fleischmann R, Gottesman MM, Troen BR. Cloning, genomic organization, and chromosomal localization of human cathepsin L. J Biol Chem. 1993; 268(2).
- Troen BR, Chauhan SS, Ray D, Gottesman MM. Downstream sequences mediate induction of the mouse cathepsin L promoter by phorbol esters. Cell Growth Differ. 1991; 2(1).
- Kane SE, Troen BR, Gal S, Ueda K, Pastan I, Gottesman MM. Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease. Mol Cell Biol. 1988; 8(8).
- Troen BR, Ascherman D, Atlas D, Gottesman MM. Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation. J Biol Chem. 1988; 263(1).
- Troen BR, Gal S, Gottesman MM. Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin. Biochem J. 1987; 246(3).
- Troen BR. Colony screening of genomic cosmid libraries. Methods Enzymol. 1987; 151.
- Segal J, Troen BR. Effect of age on the 3,5,3'-tri-iodothyronine-induced increase in sugar uptake in rat thymocytes. J Endocrinol. 1986; 110(3).
- Segal J, Troen BR, Ingbar SH. Effects of age and sex on certain metabolic functions and mitogenic activity in rat thymocytes. Thymus. 1985; 7(4).
- Segal J, Troen BR, Ingbar SH. Influence of age and sex on the concentrations of thyroid hormone in serum in the rat. J Endocrinol. 1982; 93(2).
- Rowe JW, Troen BR. Sympathetic nervous system and aging in man. Endocr Rev. 1980; 1(2).
- Johnson MD, Fahri ER, Troen BR, Barger AC. Plasma epinephrine and control of plasma renin activity: possible extrarenal mechanisms. Am J Physiol. 1979; 236(6).
- Fan DF, Oshima H, Troen BR, Troen P. Studies of the human testis. IV. Testicular 20 alpha-hydroxysteroid dehydrogenase and steroid 17 alpha-hydroxylase. Biochim Biophys Acta. 1974; 360(1).
- Yanaihara T, Troen P, Troen BR, Troen ML. Studies of the human testis. 3. Effect of estrogen on testosterone formation in human testis in vitro. J Clin Endocrinol Metab. 1972; 34(6).
Books and Book Chapters:
- Duque G and Troen BR. Skeletal Aging..
Professional Memberships:
- American Federation for Aging Research - Florida; President of the Scientific Advisory Council. Founding board member (2008–present)
- American Society for Bone and Mineral Researh (1996–present)
- Gerontological Society of America (1992–present)
- American Federation for Aging Research (1991–present)
- American Geriatrics Society; Program committee. Chair for the 2010 annual meeting and Vice Chair for the 2009 annual meeting. (1991–present)
Presentations:
- "Osteoporosis: Falls and Fractures" UB Department of Medicine City Wide Grand Rounds, Jacobs School of Medicine and Biomedical Sciences (2017)
- "Endocrinology of Aging" Jacobs School of Medicine and Biomedical Sciences, Jacobs School of Medicine and Biomedical Sciences (2017)
- "Falls and Their Prevention: A Geriatrics and Pharmacological Imperative" Public Health Live, NY State Department of Health, University at Albany School of Public Health and the New York Department of Health (2016)
- "Healthspan and Frailty: Bedside to Benchtop (and Back?)" Geriatrics Division Grand Rounds, St. Louis University Medical School, St. Louis University School of Medicine, Department of Medicine (2016)
- "Healthspan and Frailty: Bones, Muscles, and Aging?" Grand Rounds, Department of Medicine, Western University, Western University (2016)
- "Osteoporosis: Thinking Beyond Bone" American Geriatrics Society Annual Scientific Meeting, American Geriatrics Society, Plenary Symposium: That Was The Year That Will Be (2016)
- "Falls and Their Prevention: A Geriatrics Imperative" Grand Rounds, Buffalo Psychiatric Center, Buffalo Psychiatric Center (2015)
- "Healthspan and Frailty: Bones, Muscles, and Aging?" Grand Rounds, University of Maryland, University of Maryland, Department of Epidemiology and Public Health (2015)
- "Frailty and musculoskeletal system: From bench to bedside" International Conference on Frailty & Sarcopenia Research, Plenary Symposium: Frailty, Falls, and Fractures: Common Pathophysiology and Therapeutic Approach (2015)
- "Healthspan and Frailty: Bedside to Benchtop (and Back)?" City-Wide Grand Rounds Department of Medicine, University At Buffalo, Professor & Chief, Geriatrics & Palliative Medicine (2013)
- "Vitamin D: Beyond Skeletal Health - Implications for Frailty" Interprofessional Geriatrics Symposium (2012)
- "Multidisciplinary Strategies for Preventing and Managing Osteoporosis in Frail High Risk Elderly in Long Term Care" Gerontological Society of America Annual Meeting, Gerontological Society of America (2011)
- "Science of Aging Bone & Medical Management" Gerontological Society of American Annual Meeting, Gerontological Society of American (2011)
- "Bone Biology During Aging: Impact on the Development of Osteoporosis and Subsequent Treatment Strategies - Understanding the RANK-RANKL-OPG Pathway & its Importance in Bone Matabolism" American Geriatrics Society Annual Meeting, American Geriatrics Society (2011)
- "New Advances in Osteoporosis Therapy in the Very Old, Frail, and Institutionalized Elderly: Reduction in Fractures and Improved Quality of Life" American Geriatrics Society Annual Meeting, American Geriatrics Society (2011)
- "Vitamin D: Skeletal Heath and Beyond (A Stealthy Epidemic)" American Geriatrics Society Annual Meeting, American Geriatrics Society (2011)
- "Osteoporosis: State of the Art Clinical Updates" American Geriatrics Society Annualk Meeting, American Geriatrics Society (2010)
- "Prolongevity Compounds and Aging Bone" Dept. of Medicine Research Conference, University of Texas health ScienceCenter at San Antonio (2010)
- "Why Do We Grow Old: Perspectives on the Biology of Aging" American Federation for Aging Research, American Federation for Aging Research (2010)
- "Vitamin D and Osteoporosis" VISN8 Ambulatory Care Forum (2009)
- "Frailty Syndrome: Assessment, Correlates, and Approach" Division of Aging Grand Rounds, University of Sydney, Nepean Clinical School (2009)
- "Osteoporosis in the Nursing HOme: What is the Best Approach?" Consensus Conference ont eh Treatment of Osteoporosis in Long Term Care, Univeristy of Sydney, Nepean Clinical School (2009)