Reaching Others University at Buffalo - The State University of New York
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Xiuqian                        Mu

Xiuqian Mu PhD

Department of Ophthalmology

Assistant Professor

Specialty/Research Focus

Bioinformatics; Cell growth, differentiation and development; Gene Expression; Genomics and proteomics; Molecular genetics; Stem Cells; Transcription and Translation; Transgenic organisms; Vision science

 
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Professional Summary:

My lab is interested in how global gene expression advances from one state to the next in time and space during development to promote the specification and differentiation of individual retinal cell types from multi-potent neural progenitor cells. We focus on the gene regulatory network (GRN) involved in the formation of one retinal cell type, retinal ganglion cells (RGCs). RGCs are the only projection neurons in the retina and connect the retina to the brain through the optic nerve. Death of RGCs is cause of vision loss in glaucoma and other retinal diseases. Several key transcription factors (TFs) functioning at different stages of RGC development have been identified; Math5 is essential for RGC fate specification, whereas Pou4f2 and Isl1 are required for their differentiation. Our previous study has established a tentative model for the RGC GRN, in which these TFs occupy key node positions. Current projects in the lab are aimed at further understanding how these transcription factors specifically regulate their target genes and how they interact with each other. Considerable efforts are also placed on identifying novel key regulators in the GRN. Our studies employ a combined approach of genetics, genomics and bioinformatics. Our eventual goal is to use the knowledge learned from our studies to develop new therapies for various retinal diseases.

Education and Training:
  • PhD, Biochemistry and Molecular Biology, Peking Union Medical College (1994)
  • MD, Medicine, Qingdao Medical College (1989)
Employment:
  • Assistant Professor, Biochemistry and Molecular Biology, The University of Texa M. D. Anderson Cancer Center (2003–2008)
  • Instructor, Biochemistry and Molecular Biology, The University of Texa M. D. Anderson Cancer Center (2002–2003)
  • Postdoctoral Associate, Biochemistry and Molecular Biology, The University of Texa M. D. Anderson Cancer Center (1999–2001)
  • Postdoctoral Fellow, National Institutes of Health (1994–1999)

Grants and Sponsored Research:
  • February 2010–December 2013
    Biological Response to Change in Air Quality Pre-, Mid-, Post-Olympics
    NIH/NIEHS
    Role: Principal Investigator
    $848,133
  • Interaction of Isl1 and Pou4f2 in retinal development
    National Institutes of Health
    Role: Principal Investigator
    $1,250,000

Journal Articles:
See All (25 Total) >


Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

701 Ellicott Street
Rm B4-307
Buffalo, NY 14203
Phone: 716-881-7463
Fax: 716-849-6651
Email: xmu@buffalo.edu


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