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Xiuqian                        Mu

Xiuqian Mu MD, PhD

Department of Ophthalmology

Associate Professor

Specialty/Research Focus

Bioinformatics; Cell growth, differentiation and development; Gene Expression; Genomics and proteomics; Molecular genetics; Stem Cells; Transcription and Translation; Transgenic organisms; Vision science

 
Professional Summary:

We are interested in the fundamental mechanisms underlying the shift of cellular states from progenitors to fully functional mature cell types along individual cell lineages during development. We address this issue by studying cell fate specification and differentiation in the developing neural retina. Our efforts are on identifying key regulators, uncovering their roles in individual lineages, and understanding how they carry out these roles. Current projects are emphasized on how transcription factors influence the epigenetic landscape along the retinal ganglion cell lineage. We conduct our research using a combined approach of genetics, molecular biology, genomics, single cell analysis and bioinformatics.

Education and Training:
  • PhD, Biochemistry and Molecular Biology, Peking Union Medical College (1994)
  • MD, Medicine, Qingdao Medical College (1989)
Employment:
  • Associate Professor (with tenure), Ophthalmology, University at Buffalo, School of Medicine and Biological Sciences (2015-present)
  • Assistant Professor, Ophthalmology, University at Buffalo, School of Medicine and Biological Sciences (2008–2015)
  • Assistant Professor, Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center (2003–2008)
  • Instructor, Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center (2002–2003)
  • Postdoctoral Associate, Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center (1999–2001)
  • Postdoctoral Fellow, National Institutes of Health (1994–1999)

Research Centers:
  • Ira G. Ross Eye Institute Research Center
  • Center of Excellence in Bioinformatics and Life Sciences
UB 2020 Strategic Strengths:
  • Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
  • September 2017–May 2022
    Regulatory mechanisms for retinal ganglion cell genesis
    National Institutes of Health
    Role: Principal Investigator
    $1,954,515
  • March 2011–February 2016
    Interaction of Isl1 and Pou4f2 in retinal development
    National Institutes of Health
    Role: Principal Investigator
    $1,950,000
  • February 2010–December 2013
    Biological Response to Change in Air Quality Pre-, Mid-, Post-Olympics
    NIH/NIEHS
    Role: Principal Investigator
    $848,133

Journal Articles:
See all (21 more)


School News:
In the Media:

Clinical Specialties:
Clinical Offices:
Insurance Accepted:


Contact Information

701 Ellicott Street
Rm B4-307
Buffalo, NY 14203
Phone: 716-881-7463
Fax: 716-849-6651
Email: xmu@buffalo.edu


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