Animesh A. Sinha MD, PhD

Animesh Sinha

Animesh A. Sinha
MD, PhD

Professor of Dermatology

Department of Dermatology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Autoimmunity; Dermatology; Gene Expression; Genomics and proteomics; Immunology

Contact Information
6078 Clinical and Translational Research Center
875 Ellicott, Street
Buffalo, New York 14203
Phone: 716-204-8730
Fax: 716-276-9249
aasinha@buffalo.edu


Patient Care

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD


Education and Training:

  • PhD, Medical Sciences (Immunology), University of Alberta (1986)
  • MD, University of Alberta (1982)

Employment:

  • Associate Professor, Dermatology, Cornell University (2005-present)
  • Professor and Chair, Dermatology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2011–2017)
  • Associate Professor, Dermatology, Michigan State University (2005–2011)
  • Director, Dermatology, Michigan State University (2005–2011)
  • Assistant Professor, Dermatology, Cornell University (1998–2005)
  • Associate Scientist, Dermatology, Yale University (1995–1998)
  • Associate Scientist, Medicine, University at Alberta (1992–1995)
  • Research Fellow, Microbiology and Immunology, Stanford University (1986–1992)
  • Research Fellow, University of Alberta (1982–1986)

Awards and Honors:

  • Doctor of the Year/Excellence in Research Award, (2009)
  • Women's Dermatology Society Mentorship Award (1997)
  • Medical Research Council of Canada Centennial Fellowship Award (1989)
  • AHFMR Independent Research Allowance Fellowship Award (1986)
  • Alberta Heritage Foundation for Medical Research Summer Studentship Award (1982)
  • AHFMR Part-time Studentship Award (1982)
  • Searle Research Scholarship in Pharmacology (1979)
  • Arthritis Foundation Fellowship Award (1989 - 1990)
  • Arthritis Foundation Investigator Award (1990 - 1994)
  • Dermatology Foundation Career Development Award (2000 - 2003)
  • AHFMR Research Fellowship Award (1982 - 1986)
  • Province of Alberta Scholarship (1976 - 1978)

Research Expertise:

  • Immunological Tolerance and Autoimmunity.: To pinpoint targets for immune intervention and potentially gene therapy in autoimmune disease

Grants and Sponsored Research:

  • January 2010–December 2011
    Monitoring Autoimmune Activity in Pemphigus
    Crescent Healthcare, Inc.
    Role: Co-Investigator
    $3,000
  • February 2007–January 2009
    Functional Analysis of IFN-Y Regulated OAS1 Over-Expression in Cutaneous LE
    Alliance for Lupus Research
    Role: Co-Investigator
    $75,000
  • February 2007–January 2009
    Mechanisms of Autoimmunity in the Skin
    Role: Co-Investigator
    $75,000
  • July 2004–June 2006
    Gene Expression Analysis in Vitiligo
    American Vitiligo Research Foundation
    Role: Co-Investigator
    $30,000
  • May 2002–December 2005
    Human Gene Expression Profiling in Vitiligo by Microarray
    National Vitiligo Foundation
    Role: Co-Investigator
    $30,000
  • January 2002–January 2005
    Identifying And Characterizing Human Skin Genes Using DNA Chip Technology
    Colgate-Palmolive, Co
    Role: Co-Investigator
    $75,000
  • July 2000–July 2004
    Genome Wide Expression Analysis in Lupus Erythematosus
    Mary Kirkland Center for Lupus Research
    Role: Co-Investigator
    $143,850
  • July 2001–June 2004
    Genetic Basis of Cutaneous Lupus Erthematosus
    Colleck Research Fund
    Role: Co-Investigator
    $400,000
  • February 2002–January 2004
    Genome Wide Expression Analysis in Psoriasis
    National Psoriasis Foundation
    Role: Co-Investigator
    $150,000
  • September 1998–September 2001
    Mapping of Genes for Alopecia Areata in the General Population
    NIH/NIAMS
    Role: Co-Investigator
    $150,000
  • July 1998–June 2001
    Genetic Basis of Autoimmunity
    Colleck Research Fund
    Role: Principal Investigator
    $390,000
See all (1 more)

Journal Articles:

See all (114 more)

Books and Book Chapters:

  • Sinha A.A, Shylankevich, M., Offers, M., Moesta, A., Lin, M, Diaz, L., Tigelaar, R., Janeway, C. (1999) A polymerase chain reaction-based approach in search of potential T-cell epitopes in Pemphigus Vulgaris. In: A polymerase chain reaction-based approach in search of potential T-cell epitopes in Pemphigus Vulgaris. Monduzzi Editore, 1635-1669.
  • McDevitt, H.O., Sinha AA. (1990) Allelic Polymorphism of HLA class ll antigens: clues to the moleular basis of autoimmunity. In: Allelic Polymorphism of HLA class ll antigens: clues to the moleular basis of autoimmunity. Academic Press,, 39-52.
  • Sinha, A.A, Mietzner, T, Lock, C.B., McDevitt, H.O. (1993) Fluorescence-activated cell sorter analysis of peptide-major histocompatibility complex. In: Fluorescence-activated cell sorter analysis of peptide-major histocompatibility complex. Academic Press,, 187-192.
  • Sinha AA. (1990) Molecular Biology of HLA Class ll Antigens. In: Functional Importance of MHC class ll Polymorphism in normal immune responses and autoimmune disease. CRC Press, Inc, 147-168.
  • Sinha AA, Brautbar C, Szafer F, Friedmann A, Tzfoni E, Steinman, L, McDevitt, H.O. (1989) HLA-DR and HLA-DQ ALLELES ASSOCIATED WITH PEMPHIGUS VULGARIS. In: HLA-DR and HLA-DQ ALLELES ASSOCIATED WITH PEMPHIGUS VULGARIS. , 465-468.
  • Diener, E., Fotedar, R., Sinha, A.A. (1990) Regulation of the B cell response: activation and differentiation. In: Regulation of the B cell response: activation and differentiation. Oxford University Press
  • Paget, S, Gibofsky, A, A., Sulco, Beary, J, Sinha AA. (2006) Rash and Arthritis. In: Rash and Arthritis. Lippincot, Williams, and Wilkins, Inc., 109-122.
  • Diener, U., Diener, E., Sinha, A.A, Xie, S., Vergidis, R. (1986) Selective suppression of murine lymphocyte function by daunomycin conjugated via an acid sensitive spacer to target specific carriers. In: Selective suppression of murine lymphocyte function by daunomycin conjugated via an acid sensitive spacer to target specific carriers. Elsevier Science Publications, 177-181.

Abstracts:

  • Sinha AA. (2010) Microfixture enabled in-situ imaging manipulation of cell membrane protein. (Jan)
  • Sinha AA. (2007) Response Criteria for Cutaneous SLE in clinical trials. (Jan) 666-671
  • Sinha AA. (2009) Analysis of Keratinocytes stiffness aafter desmosome disruption using Atomic Force Microscopy. (Jan)
  • Sinha AA. (2009) Development of cell fixture for in-situ imaging and manipulation of membran protein structure. (Jan) 397-400
  • Sinha AA. (2010) Investigations on Biomarkers for Human Lymphoblastoid Cells using atomic force microscopy. (Jan)

Professional Memberships:

  • NIH ZRG1 Moss G02 (2010–present)
  • Alliance for Lupus Research (2008–present)
  • American Association for the Advancement of Science (2006–present)
  • Arthritis Foundation - Cellular Immunology Study Section (2006–present)
  • Association of Professors of Dermatology (2006–present)
  • Chicago Dermatological Society (2006–present)
  • International Society of Dermatology (2006–present)
  • Michigan Dermatology Society (2006–present)
  • Michigan State Medical Society (2006–present)
  • Fellow, American Academy of Dermatology (2005–present)
  • Society for Investigative Dermatology (1998–present)
See all (1 more)

Presentations:

  • "Autoimmunity in the skin: systems medicine approach to disease." All India Institute of Medical Sciences (2013)
  • "Cutaneous lupus: clinical features and pathogenesis." Hampton University Skin of Color Research Symposium.; Hampton University; Huscri (2013)
  • "Understanding autoimmunity in the skin: a systems approach to complex dermatologic disease." Clinical and Translational Research Colloquium; University at Buffalo (2013)
  • "The Genetics of Pemphigus" International Symposium in Autoimmune Bullous Disorders; International Investigative DermatologyI; IID (2013)
  • "Diagnosis and genetics of autoimmune bullous disease." International Pemphigus and Pemphigoid Foundation 16th Annual Patient -Doctor Meeting.; International Pemphigus and Pemphigoid Foundation (2013)
  • "Novel multiplex auto antigen arrays for biomarker discovery in skin autoimmunityf" Clinical and Translational Research Colloquium; University at Buffalo; University at Buffalo (2013)
  • "Pemphigus: clinical features and pathogenesis of disease." International Pemphigus and Pemphigoid Foundation 16th Annual Patient -Doctor Meeting.; International Pemphigus and Pemphigoid Foundation; International Pemphigus and Pemphigoid Foundation (2013)
  • "Probing autoantibody diversity in Pemphigus vulgaris: proteomic strategies" Grand Rounds, Dept of Dermatology, Loma Linda University Medical Center,; Loma Linda University Medical Center; Grand Rounds, Dept of Dermatology, Loma Linda University Medical Center, (2013)
  • "Systems medicine for Dermatology: the new interface between biology, medicine, and technology." Grand Rounds Dept. of Dermatology, University of Southern California; University of Southern California; Dept. of Dermatology, University of Southern California (2013)
  • "Pemphigus and pemhigoid: clinical features and approach to management." Webinar; Nufactor; Nufactor (2013)
  • "Emerging strategies for understanding autoimmunity in the skin: lessons from pemphigus." Grand Rounds, Dept. Surgery, University at Buffalo; University at Buffalo; Dept. of Surgery (2013)
  • "How a better understandig of disease etiology is paving the way to new therapies in Pemphigus" Meeting of the Canadian Pemphigus and Pemphigus Foundation; Sunnybrook Health Sciences; Sunnybrook Health Sciences (2012)
  • "New tools to understand the scope and action of autoantibodies in Pemphigus vulgaris (PV)" Basic Science Seminar Series; Yale University; Dept of Dermatology (2012)
  • "Shifting paradigms in complex cutaneous disease: how systems medicine is creating the new interface between biology, medicine, and technology to imp at clinical decision making" Grand Rounds; Yale University; Dermatology Dept. Yale University (2012)
  • "Investigation of autoimmune blistering disease: from genetics to immune-mediated pathology" Immunology Seminar Series; University of California, Irvine; Immunology (2012)
  • "Autoimmunity and the skin: intergration of biological and clinical profiles to understand disease processes in Pemphigus vulgarism" Immunology Grand Rounds, University at Buffalo; University at Buffalo; Dept. of Immunology (2012)
  • "Genetics of Pemphigus" International Pemphigus and Pemphigoid Foundation 15th Annual Patient - Doctor Meeting; IPPF; International Pemphigus and Pemphigoid Foundation (2012)
  • "Strategies for understanding autoimmunity in the skin." Dept. of Cancer Pathology and Prevention; Roswell Park Cancer Institute; Dept. of Cancer Pathology and Prevention (2012)
  • "Dermatology - Career Paths" Medical Student Forum; University at Buffalo; University at Buffalo, Medical Student Forum (2012)
  • "Skin, aging, and autoimmunity." Women's Health Symposium on Aging and Wellness across the Lifespan; University at Buffalo (2012)
  • "Cutaneous lupus: clinical and etiologic considerations" Hampton University Skin of Color Symposium; Hampton, University (2011)
  • "Autoimmunity of the skin: investigating immune disturbances in Pemhigus vulgaris" Veterans Administration Western NY Healthcare System; Veterans Administration Western NY Healthcare System; Veterans Administration Western NY Healthcare System (2011)
  • "Constructing immunoprofiles to deconstruct disease complexity in pemphigus" Buffalo-Rochester Dermatology Meeting; Buffalo- Rochester Dermatology Society; Buffalo- Rochester Dermatology Society (2011)
  • "Management of Pemphigus and Pemphigoid" Buffalo-Rochester Dermatology Meeting; Buffalo- Rochester Dermatology Society; Buffalo- Rochester Dermatology Society (2011)
  • "Developing disease registry for pemphigus" 14th Annual Meeting of the International Pemphigus and Pemphigoid Foundation.; IPPF; International Pemphigus and Pemphigoid Foundation (2011)
  • "Genetic basis of pemphigus" 14th Annual Meeting of the International Pemphigus and Pemphigoid Foundation; IPPF; IPPF (2011)
  • "Shifting Paradigms in complex cutaneous disease: harnessing biological and clinical information to impact disease management" ; ; University at Buffalo (2011)
  • "Current Concepts in The Treatment of Blistering Disorders" Grand Rounds; Eastern Virginia Medical School; Department of Dermatology (2011)
  • "Systems Medicine and Dermatology: merging clinical and biological data to develop new tools for disease management" Hampton University Skin of Color Symposium; Hampton University Skin of Color Institute; Hampton University Skin of Color Institute (2011)
  • "Biomarkers and Immunoprofiling in Pemphigus" ; Biogen/IDEC (2010)
  • "Immunoprofiling to unravel disease complexity in pemphigus" Pemphigus and Pemhigoid: From the Bench to the Bedside Meeting; National Institutes of Health (2010)
  • "Systems approach to investigate immune dysregulation in pemphigus vulgaris." Grand Rounds; Wayne State University; Department of Dermatology (2010)
  • "Dermatology: Career Perspectives and Academic Horizons" Internal Medicine Club and Dermatology Interest Group Meeting; Michigan State University (2010)
  • "Systems strategies to study skin autoimmunity" Grand Rounds; University of Florida; Department of Dermatology (2010)
  • "New Concepts and Experimental Stategies to Understand Pemphigus" Symposio Internationale de Dermatologica (2010)
  • "Why Do Patients Flare? How new technologies are helping us to understand disease mechanisms." 12th Annual Meeting of the International Pemphigus and Pemphigoid Foundation (2010)
  • "Genetic Basis of Pemphigus" Symposium on Autoimmune Bullous Disease, 68th Annnual Meeting of the American Academy of Dermatology; American Academy of Dermatology (2010)
  • "Systems Medicine and Dermatology: integrating high throughput genetic, genomic, and proteomic strategies to tackle biological complexity and disease hetergeneity" Grand Rounds; State University of New York at Buffalo; Department of Dermatology (2010)
  • "How New Genetic Technologies Are Changing Clinical Medicine" ; Rotary Club (2003)
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Service Activities:

  • Hampton University Skin of Color Research Instititute; Advisory Board (2010–present)
  • Foundation for Global Skin Health Strategies; Advisory Board (2009–present)
  • Guest, Today Show, Segment on Genetic Testing; Invited Participant (2008–present)
  • MD-PHD Committee; Board Member (2007–present)
  • Search Committee for Faculty position in Genetics; Committee Member (2007–present)
  • Guest, "Please Explain - Hair" National Public Radio (WNYC); Invited Participant (2005–present)
  • Guest column, "Serious Skin Disorders Often Go Undetected" Bottom Line/Health, Standford CT; Invited Participant (2003)
  • Webcast on Cutaneous Lupus Erythematosus; Invited Participant (2002)
  • Guest expert of hair loss webcast. Healthology, Inc; Invited Participant (2001)
  • Guest on ‘The Bald Truth" radio show (WOR), Spencer Kobren, host, NY, NY; Invited Participant (2000–present)
  • Guest expert on the genetics of hair loss.; Invited Participant (2000–present)
  • PhD Thesis Advisory Committee; Advisor
  • MSc Thesis Advisory Committee; Advisor

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Contact Information

6078 Clinical and Translational Research Center
875 Ellicott, Street
Buffalo, New York 14203
Phone: 716-204-8730
Fax: 716-276-9249
aasinha@buffalo.edu

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD